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Great post Tred! You hit the nail on the head a couple of times.
Never thought of more than 1 dose per day. That's an interesting thought/idea. Maybe a lower dose, but 2 times a day? I like it.
My Mom's dosage of donepezil is 10mg. Not sure if there are other dosage sizes, but bottom line is that I'm basically throwing $ down the drain and spitting in the wind with other drugs that are currently out there. We need A2-73 NOW!
Well said MC!
Agree, the anticipation is killing me. Can't wait for AF to eat crow.
I wouldn't doubt that one bit.
3rd time c/b a charm for the longs though.
The poster also laid out the timeline as to when the options were granted, when BIIB signed the MTA and when the other options were granted in late September. The timeline was/is quite convincing.
Someone asked if Missling could be tapped to fill the BIIB CEO position and mentioned the phrase about all options being automatically vested when there was a change in control of the company, which I believe was previously discussed I believe stated in the option grant. Sorry for the late reply, staying home from work with my Mom as my caregiver couldn't make it today.
They aren't getting my shares anytime soon. Only about 3500, but no one is getting in the near future, unless there is a very high premium.
I recall several posts that stated avxl presentation was moved from Friday to Saturday right before keynote. Has this ever been confirmed? I apologize if I missed it.
I tend to agree and hope that it is a very good price, or just a good price with shares in the acquiring company.
I almost hate to say it, but think Missling is giving the shorts the most obvious clue(s). If they don't get it, well.... good luck with those go fund me pages.
Why do they keep asking the CEO of a former Thrifty Printing Co with only 7 employees to a roundtable in DC? They must have not consulted with AF, JF, Melissa and the other Fools or read their inspiring pieces. WOW.
Lets just get this straight, though I know some of you get it. My Mom moved in with my wife and I @ last xmas. The decline is real, as I see it first hand. I don't know if she has ALZ, dementia, fronttemporal whatever the hell it is, but she has something that is robbing her of her memory. If A2-73 is showing improvement in 7 out of 32 patients (almost 25%), then why wouldn't the FDA grant approval? Placebo, BS. There ain't no improvement or stabilization is this GD F'ing disease with what is out there. I asked several months ago if there were any drugs that could help. The doctor said Namenda "may" help, but the potential improvement would most likely be .00000000000000000000001%. WTF is that? The drug was like $120 month for that slight possibility of maybe improving or slowing down the progression. Give me a break. If the data is "somewhat" good at the conference, which is supposed to include 52 week data, then my $ is on a BO in the very near future versus splitting the kitty.
Great post, Bio.
Love the theory, and could be feasible! BTW, I'm in another group that has a contact within the SEC and he indicated that "things" were being reviewed regarding this matter. Don't ask me any more, as I will disclose anything further.
$4 or $5B is not $60 or $70/share BO. Just saying.
Kinda like Enron, right? Or, were you being sarcastic?
Not sure. How would he know if they are testing for indications?
I'm saying BIIB indicated they wanted to test the drug for MS, but they (i.e. BIIB) may have ulterior motives since our drug has shown better results over the amyloid hypothesis, including pre-trial results with other indications.
Agree, everyone/everything has a price. The question is, how bad do you want it? BIIB may be testing for MS (though I believe they are testing for more than that) to see how much they really want to pay for the drug(s)/company.
Reyeton, I appreciate your posts along with a lot of others on this board. Does anyone really think that BIIB is merely testing A2-73 for just MS? Give me a break. I'd bet my life they are testing it on other indications and/or trying to replicate it.
I'm sure the company would receive revenue from those taking it, and I would gladly pay for it so that my Mom could get it!!!!
I'm pretty sure that particular study has been aired in the last couple/few years (I'm not saying that this isn't another look at it). I really have to wonder when BP is going to realize that treating plaque alone is not the answer. I ain't no rocket scientist, but IT AIN'T WORKING!!!!!
A boatload of $ and shares in the acquiring company keeps them in the game and maybe even a position within the acquiring company to oversee avxl's compounds to fruition. I truly believe our compounds and moa are revolutionary. Obviously, I have skin in the game both financially and with my Mom's condition. We are close. I can feel it!
Agree Mr. Jones. Though not sure why he'd give the shorts time to cover. Screw them.
I'd definitely take that in heart beat.
I'll send her one. Though I would think December results could be the shot heard around the world.
Thank you powerwalker. It really pisses me off that BP has been focused on plaque for so long with failure after failure and our approach gets no attention. Unfortunately, I think even if A2-73 gets approved "soon", it will be too late for my Mom. I do believe that positive data at the conference will most likely turn heads, and that someone will make an offer. I personally feel that we are worth $5B minimum, but much more. Only time will tell.
My Mom has ALZ and has gone from functional with memory brain farts to semi-functional with minimal memory in 1 year. She moved in with my wife and I around Christmas of last year. She has declined rapidly in the last eleven months. We are currently on a waiting list for a memory unit at an assisted living facility. It’s quite amazing that there are forces and people out there that would bet so heavily against a drug that has the potential to at least slow or stop the progression. Some of you have probably dealt with this or do deal with it. Walk a mile in my shoes, and then come back and tell me that it is a piece of junk. HOPE!
Our day will come, and I'll definitely rub it in AF and JF's face like the squids they are.
I would be very very happy with 11 figures.
I totally agree, but $ talks and bull$hit walks.
If someone buys out AVXL for $1 to $1.5B, then I want shares in the stock of the acquirer in addition to cash. Like I said earlier, our potential cash stream s/b huge if A2-73 does what most of us think it will do and I would not be happy with $1.5B. Hell, I might even file a lawsuit if that happens. JK, maybe not.
My opinion is that $1.5B is a little low. I think at a minimum it s/b $3 to 4B considering all of the diseases that just A2-73 may have an impact on. That doesn't even consider 3-71 or 1066.
AVXL will be BO before it finishes any Phase III.
A LOT!!!!
Available to who? The general public or those who have deep pockets?
Exactly!