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Don’t know your age, but I had mine replaced at 63yo. Anterior procedure with a combination titanium, ceramic and a teflon transplant. My biggest challenge is to remember I have the hip when I go thru airport security. Surprisingly many times the alarms do not go off. Anyway 2 months of walking and hip movements and I was/am good to go. As Georgie says get it done, you will soon forget the pain!! Good Luck!!
Sorry for the loss of your brother nidan!
Not all stem cells are the same , not all conditions are the same and not all responses are guaranteed the same.
Harvested stem cells from one’s own fat especially at an elder age is seriously flawed in thinking it will reverse MS or be as effective as a more viable stem cell. Donated umbilical cord stem cells used in combination with PRP in a self contained joint like the knee is a potent combination that provides symptomatic relief and quality of life changes. Most clinics may or may not be taking advantage as you have described, but an honest clinic will be open in discussing the cost and benefits without hesitation. I would love to see more research done and less snake oil salesman involved , but that does not dismiss the good work being done and the benefits gained by many. Waiting on the established medical community to lead the way for promising treatments like this is well .. Covid comes to mind
I've personally had stem cells injected into both knees. I have personally seen 20 plus patients utilize this same procedure. My conclusion is that this procedure done properly is a game changer in improving symptomatic relief as well as allowing me to regain my quality of life. In my opinion if you would like to know more about this procedure and how it may help you, you would need to see a doctor or clinic that is an advocate of this treatment with experience in providing. Any routine/ ortho MD will not be of help. Rooster shots, HA shots, cortisone shots may or may not give relief like any treatment. But the stem cell shots in addition to PRP therapy have helped me tremendously. It's been 2 years now since I had this done and I am still good to go! Disclaimer: I am not a MD, nor am I giving medical advice. This treatment has its limitations and by all accounts is still considered experimental. However, like investing in AVXL, I was looking for a new paradigm in the treatment of degenerative conditions like the knees. Stem Cell treatments definitely qualify!
Awesome, Thank You!
I guess ChatGPT is waiting for the peer review like the rest of us!!!
I hope you stay. I appreciate all your input and Rockne inspiration! Go Irish! Ty!!!
Now that is as true of a statement of fact as I have ever read on this board! So many posts by everyone just to get to this point of clarity.
Nah…AVXL is the one!
You are right about the humbling experience. I was early in loving the natural gas story and invested in CHK...Chesapeake with Aubrey McClendon. Great CEO until he decided to crash his Escalade into a concrete barrier to end his Federal investigation. Ouch!!!
Be able to see it even longer with 2-73 to take!
When people realize AVXL potential , we will wake up to gap up with frenzied buying… maybe today, but close!!!!
It's fairly obvious to me, due to the fact that A2-73 has beneficial affects at the mitochondrial level, it goes to reason that anywhere mitochondrial dysfunction exists in the body A2-73 has the potential to better health in any number of diseases. So it matters not to me how the company discloses which disease they intend to pursue, either teased or straight out declared, A2-73 has the potential to be the fixer. We have our hands full with getting 3 diseases across the finish line in gaining approval, but the potential exists for an unlimited disease altering treatment literally.
So did BHO...need I say more!
I'm sure its not like the data is not available. The endpoints were re-prioritized per FDA/Anavex requests through continual guidance to design, implement and adapt for statistical relevance and real life benefits for an approved pathway to approval for patients. Nicely associated with the FDA requesting meeting with Rett organization this March to discuss real life benefits and emphasis on quality of life issue improvements that are important to patients.
Can't imagine all the overuse antibiotic caused diseases?
https://www.frontiersin.org/articles/10.3389/fphar.2021.705747/full
under materials and methods you will find the herb combination used in this
study
2-73 also breaks down to produce a metabolite which by itself may have lasting therapeutic benefits. Could be addition by subtraction. tip of the iceberg?
WOW a Musk quote... must mean AVXL sucks! Thanks for connecting the dots!
Loved my 2011 335xi stick!! Transmission died
I voted yes to all requests. Would rather Missling have the flexibility to do what he sees fit for AVXL. I feel he has done a terrific job during difficult times. Whatever the reason for the perceived delays, I’m sure it’s not deliberate on his part. Looking back on his decisions to double down on Australia and bringing the drug through multiple studies for multiple indications...I believe he has demonstrated he is the right CEO for the job! Still have confidence that he holds shareholder and patient interests in high regard!
Yes mitochondrial are everywhere, so the possibilities are endless??????!
Nice!! Did not do that. Great trade!!!
Well hopefully it all turns out just as well for all here and the screaming need by all concerned across the CNS spectrum. When asked how are we doing "I am having a great day" is all we should hear from patients and investors alike!!
I personally began investing in AVXL during the day of up listing. Got whippsawed from the quick spike and sell off. But survived the days ahead to keep buying and holding. For me, it was understanding how fixing the mitochondria dysfunction to create a healthy atmosphere for a healthy environment to heal and function that crosses over to all body functions. Gotta love the upstream/downstream affects!!
Congrats...9 in a row!! Wow!! Plus AVXL!!! Reminds me of the movie with Richard Dreyfus.. let it Ride!!!
When asked how he was doing at the track ... all he could say was ..pretty good!!! I loved the movie. Great many. Other actors too! Any way great to hear about your behind the scenes , board room like reasons why AVXL is in great position to provide treatment for many . Let it ride to the finish line! We are having a great day!!!
Wow at $50,000 treatment per year , I would say Avxl future stock price upon approval would/ should be recalculated!!!
Concentrating studies overseas was a prescient move thatI I think will saves this company many of headaches! Gottlieb reasons for leaving the FDA comes to mind .. why? Anyway Dr Missling science back ground and business savy will give of this company the best chance fo Succeed! Still waiting for the answer to ‘you’ll know why we did it the way we did it in the end ‘... happily!
https://pubmed.ncbi.nlm.nih.gov/32405162/?fbclid=IwAR25MaLMSvZWPhX9kcMHQQzH932ZMLoBG0e5Eqn69_OkYFvYvDxta3oJ1yA
Asymptomatic spread or Not so much
Where's the Zinc???
Believe anyone can get shares long or cover short with this volume traded!
Or as Regenerative therapies are providing, introduce younger exosomes into the body to create a healing environment. Exosomes with their unique package of genetic material have been shown to aid in the reversal of a degenerative state to one of healing. Disclaimer.. there is no FDA approved treatment for CNS diseases with exosomes ...but the research and potential for clinical use sounds similar to the potential of 2-73. IMO
This law suit I remember.
However, Tom Skarpelos and Dr Alexander Vamvakides
being associated with a company Amarantus(AMBS) back in 2014 talking about Endoplasmic reticulum, neuro degeneration and using Lincoln Park for financing deals for a company that is now listed @.015.. I do not remember. Or ever heard a mention here. I also don't remember a company called Acrongenomics(AGNM), as far back as 2004 and is now delisted.
Can someone please explain what these two companies have to do with our founder and how AMBS sounds just like AVXL. I missed this discussion.
You've mentioned a few days ago about Texas A&M, not football, doing a study showing MSC and Exosomes helping identifying biomarkers disease specific like epilepsy and helping with symptoms for the same. Could use of MSC or exosomes from MSC be a potential co-treatment with a2-73 for neurodegenerative diseases, Different MOA, but with both working to restore homeostasis seems promising? Just thinking outside the box! Any thoughts from anyone would be helpful, Thanks!
Mitochondria...without it, We are dead. All cascade effects are useless. MOA of 2-73 starts and ends here, I agree.
"I know how to manipulate debt to build wealth'... please explain without divulging your situation if you'd like. Seems like there is a good story here! Thanks!
Well I'm thinking, for those whose brains are deficient in mitochondrial function, 2-73 is a great first step. Seeing without normal function of your mitochondria nothing else really matters! So 2-73 is a prerequisite for any expected improvement of any other pathology. IMHO
Got to give the guy credit, when all else failed, Dr. M had a plan and is executing it with efficient energy and no BS! My favorite pivot was initiating all trials outside of FDA morass! If all comes together(risk acknowledged), he and his plan will be studied for years to come!
Wait and see quick confirmation from PDD or Rett trials, matter of weeks! Studies were designed for confirmation of MOA to further boost confidence of ALZ trial! Follow the bread crumbs...Nice! Preferred shares to strengthen company's position!
An alternative to replacement surgery is regenerative therapy treatment with stem cells and variations of this. Been doing this for many patients during the last year and getting great results. With any surgery the consideration of pros/cons is taken, however, the potential for healing with the use of regenerative therapies is a fast growing option that works in many cases.
Anavex 2-73 has a diversity of positive effects in poorly functioning neurons... very well put! I like to call it an anti-inflammatory for the brain with multiple benefits. I do very much enjoy your detailed science explanations, but I also love the simplicity of a one liner that pretty much covers it all.