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Thank you for digging....which caused me to dig further.
It would seem that my former answer still stands because that is the way it was set up.
I will now try to explain as it was explained to me.
One may set up a cup program to mimic a trial....collect all the data.
Doctors wanted the CUP program......PVCT provided.
But what use is that data? It could not be used for any PII or PIII or for the FDA.
But you will be incurring the cost of a trial......millions......money they did not have when they started the CUP.
PVCT decided to set up the CUP to let the doctors treat the patients without the expense of running it as a trial. The decision was made to run it that way because of the risk, cost, and liability vs the benefit.
Since that is the way it is set up it, it becomes an expensive and time consuming effort to change the program to collect that data.....basically the cost of setting up a PIII. Back then they did not have the money to do that and because a CUP is more laxed an not as controlled the data becomes expensive PR use only. If you want trial data....run a trial.
Sometimes when I ask for info I get a minimum amount because they do not understand the context of what I am asking.
The above post is in reply to a post lifted off another board.
Nice resource. You can see the history of the shell they reversed into when starting the company.
Half a CC per cubic cm tumor with max dose around 15CC as it stands now but they may titer that up since safety is not an issue.
Biggest limitation is tumor burden.....only so much tumor you can ablate and not damage kidneys and liver with dying tissue. In those cases you would limit the dosage and wait for the body to eliminate necrotic tissue before retreating other tumors. To make that clear, they may titer up the dosage for the tumor with consideration to the volume of tumors being treated in a session. It is the volume size of the tumor(s) being ablated that limits everything.
I agree.
There is no evidence anywhere that PVCT paid for or had others pay for this article.
Yawn.........ZZZZZZZZZZZZZZZZZZZZZZ
I told you....it doesn't matter.
Doesn't matter if it drops another twenty cents. You guys that trade on short terms miss the clues. But it is a very good chance for you to buy.
It hit $6 because a group from Toronto was buying it back and forth between their branches and at the top they opened the gate and let all the momentum sheep in. They then closed the gate and shorted it massively. They timed it to coincide with the corporation change. It was the perfect bear raid.
Read the fine print
Six month extension
But company says deal should be done in a few weeks
Everybody set your Bears traps!
China gives them wiggle room
Six month extension but Pvct says they hope to finish deal in a few weeks
The added time is in case the fda changes sonething
Six month extension shows they are serious
Also stated that the new Moffitt data adds a factor in the deal.
So I guess I was right in stating that they would extend after the other ran out.
You should learn to listen
That being said...more upfront money!!!
Oh the HORROR.....wait a minute....we are up 2%.
BTW....I just got word that a rat chewed through a cable and knocked out a whole pod at the NYSE.
I am firmly saying that.
Pete and members of big Pharma are in Zurich now through this weekend....including Sinopharm?
Look for extension when they get back....next Tuesday or Wednesday.
No....they will not issue that. But in fact they will probably announce an extension in a few days.
email Pete and ask
Because you do what the FDA recommends.
Studying the poster
I've been studying the poster
Pv-10 only administered once
Immunotherapies administered every three days
Interesting
What was left out of the study is injecting Pv-10 as monotherapy every three days...as a true comparison...why
did they not do that?...lol
Not in the slightest
Gulfbreeze, Ovidius, buccaneer1961, 236T568, robofat
Those are the moderators
A post on yahoo with my rebuttal:
danzimbabwe • 53 minutes ago
CTD & Trust"Intelligence" Pumpers Trying To Steal The Earle A. Chiles Research Institute's Thunder
And are trying to pass it off as PVCTs. Try again liars.
Just because their titles had similar key words in them and one was well received (EACRIs) and the other wasn't (Moffitts), doesn't mean they're both the same.
My rebuttal:
I don't think they were trying to steal anything.
They are trying to make a point.
The poster that Moffitt will publish will show that Pv-10 is the primer/stimulator being sought in those discussions.....that was the reason they attended SITC.
How effective we will all get to see soon.
It will show that the best attack against cancer is a combination of checkpoint inhibitors and immune system stimulators. Pv-10 as an tumor ablation agent is the first step...the fact that it does not damage the antigens nor the apc cells allows the immune system to finally recognize the cancer (after it has already destroyed the injected tumor in most cases). Follow that treatment with checkpoint inhibitors and you have a very powerful cancer treatment. What you end up with is a giant leap forward.
Those are the facts....no spinning.....there will be no need to pump or shake Pom poms.
The poster, once published, will say it all.
Dan, you can try to say bad things about this but it will do you no good.
The pIII trial starts, liver soon, a combo human trial will follow. Sinopharm along with all other big Pharmas were there at the SITC. The MOU will be extended. Your side has lost now....though it may take you a bit to understand that fact. Soon you will have to switch sides or move on. Being short in the stock has now become extremely dangerous. Good luck to you now. Less
After Sinopharm saw the Moffitt poster I can assure you they will continue with the deal and will wait for the liver protocols. Anyone that is worried about that has no real reason to. Wait for that poster and see.
Moderators
Do not erase
Again
Moffitt poster will be out
I heard from docs at SITC
Every big pharma there spent lots of time with Moffitt
For gooooooooooooooood reason
The first one has not expired....what do you want?
Ok...I see your point. If you go back and look.....they typically spend almost as much every quarter. Getting PIII ready, liver sites ready, CRO's.....it adds up. But....the average cost of getting a drug to market runs between one and five billion.
http://www.forbes.com/sites/matthewherper/2013/08/11/how-the-staggering-cost-of-inventing-new-drugs-is-shaping-the-future-of-medicine/
Now if you factor that 70% of the cost of testing is in PIII then one could expect to spend at least 700 million for PIII. However, PVCT expects to spend less than 20 million over two years. I don't see the problem.
I think everybody here understands the fundamentals. Of course they have a loss.....they are not selling a product yet. Nice try....but you knew that.
Why did they stop trading for a bit today?
The only power that can do that is the nyse
They got everybodys attention today
It was a wake up and pay attention... This is really important stuff
It was considered very material
They saw it
I saw it
The blog sees it
Trust intelligence sees it
Wake up!
In case you didn't get it
We now have the long sought primer for ALL immunotherapies
We own the patent for all the combo's with Pv-10
NYSE thought that was important enough to stop trading
We possess the fuse that makes their drugs go boom.
And there is only one fuse
And they don't get to light it without our permission
Not much melanoma in China
There is a lot of liver cancer
What has got your goat?
Things get done when they get done
No one promised a deal during the mou time period
The mou is basically a public statement that says we are going to see if we can cut a deal
The mou has provision for an extension
Should it have said this is a one year mou?
Would that have calmed people down?
Lol
Look ....I told you PIII first then there is time to finish up liver protocols
What's the hurry? Are they going to run out of money?....nope!
I know what's bugging everybody.....the perception that a China deal will raise the stock price up and you are impatient to look at your computer screen and smile. I get that.
In my opinion....any delay will be just a few weeks.
Do you think the China deal is the most important thing to be concerned about?
If you do then you haven't got a grasp on the big picture.
I have waited over a year for this moffitt data. It's bigger than China deal.
It's what is going to move big Pharma.
Sit back and watch the experts digest the data this weekend.
Then you might understand why I look at the China deal and yawn and go "yea,that's going to happen" but look at this! My my my!
St Luke's has been ready to go for awhile
I think enrollment will start soon
Chill out
China just around the corner
China
Pete says liver protocols needed to close the China deal.
I meant PIII protocols filed....but you knew that.
So PIII can now begin.
Geesh? LMAO.....Phase III filed!
Warming up for the CC.
I want to see how fast shorts can cover...no bad news on the radar...
I got my popcorn and coke!
Inglorious Bastards is on.
Lets use logic.
It cannot be bad data from Moffitt......they already said data was good.
Delisting?.....the clock was reset and NYSE sends a notice first which has to be published. They don't halt on notices. They didn't run out of money.
Nope.....nothing bad left......which means to me it must be damn good. I hope so. I need to kick another short on the fire....I need more popcorn popped.
Beats me.....many things about due.
You are correct.
Now its time to go the other direction.
No. It will not be flat.
Remember this order
PIII protocols need filing
PIII begins soon thereafter
then there will be time to finish up liver protocols (needed for China deal...the good China deal)
They can extend the MOU to give them time to get those protocols
Thats all very important and exciting stuff......but to me the real kicker is the Moffitt abstract. Somebody(s) commissioned that study and now we have indication of who. That who will be the first one to step up for end game. I have been waiting over a year for that initial peek.
Whether you all realize it or not....the first step in the end game has happened.