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Nope we write the script, always steps ahead you!
lol! It’s a bit like the Irish joke about asking directions - if that’s where you want to go, I wouldn’t have started here.
Or sideways!
Read my reply to Xena's post.
Yes Anavex did not met all endpoints as defined at the time of their Dec 22 fumbled topline presentation, when Anavex claimed they were met. That was always clear and is now established by Missling himself recently admitting that ADL was not significant.
Since then alternative ways of presenting the data from the P2b/3 have been used and may indeed be approvable. The EMA submission if/when finalised, submitted and validated may then in turn lead to approval. That outcome will not be known for another year or so.
Spend sometime thinking about it. It could help you become a better biotech investor or just in general investing in public listed companies based required information disclosures.
Only if as an investor in a public company you can rely on public information that the company is responsible for updating, such as that on clinicaltrials.gov and in their presentations.
It was and is lying to state all endpoints were met. A strange thing to say, when also at the same time saying they did't have all the data in until last minute. It was clear all along to experienced biotech investors that ADL was not stat sig.
It is rare I sell and even rarer that buy $AVXL. Each time aiming to improve my risk/reward and all the time being way in profit from selling at every irrational price spike with zero FOMO concerns. If something absolutely great should happen, I can always buy in with lower risk, but for a for smaller gain. I have no need to increase risk without a higher chance of a return.
What anyone might or might not do inspired by anything I post, is their own issue. I am not an investment advisor to anyone here. I don't care whether folks posting here owns $AVXL or not.
I never look in the rear mirror and think if only, cause its a useless waste of energy. I do however try to learn from my mistakes and of course the wonderful insights posted here.
Probably tomorrow will be worse. But but but there is an 85% WGT chance so what could possibly go wrong?
Bought some at the unpredicted LOD. I reckon the other side of index rebalancing will make that bit of dry power dryer.
Bas, you may use this advise and shared it with BSIG or was that just Sparky's thing?
Usually the saying goes, no news is good news. I guess it is becoming, old news is good news! We certainly don't want more new news at this rate.
I have found the same works with the Flying Spaghetti Monster - it is rocking my world, I think but I don't really know and it doesn't matter that much for anything anyway. Do you think maybe the FDA will listen to The Flying Spaghetti Monster? - who knows maybe, cool in'it!
Presumably you believe that is the reason you have not become hugely rich yet?
Must been bas deploying more dry powder.
And we know who it wasn't.
Oh oh! Did Missling speak again somewhere?
You have said that so many times.
You would have to ask that of the folks here who felt sure Hampel would bring Anavex with him into a partnership with Easai.
“why would Anavex want to partner with Eisai”
Why would Eisai do that with Hampel knowing better, when there is Anavex?
Press release: BioArctic and Eisai sign research evaluation agreement regarding a potential new treatment combining BioArctic’s proprietary BrainTransporter™ technology with an undisclosed Alzheimer drug candidat. https://t.co/BBnMqt4FFT
— BioArcticAB (@bioarcticab) April 20, 2024
Or just more absolute nonsense from you...
Maybe even delusions too.
Yes automated analysis of MRI volumetric scan images are validated, but not equally reliable for all parts of the brain. I doubt a comparison between human expert and automated image analysis would fall out to the advantage of a manual expert approach. It would also be a very expensive test to establish given that those experts are likely spending their time and efforts in the clinic where needed and as they should.
I might be adding too, but not in any FOMO hurry 😉
Yes and if those volumetric results correlates to other biomarkers and clinical outcomes, as Missling indicates, it should change the outlook.
As always I want the opportunity to scrutinise the information before getting too excited.
That is correct.
The P2b/3 MRI brain region volumetric biomarker top level results Anavex have published so far are encouraging and I'm looking forward to more detail on that, the data overall and correlations between all the various measures, when presented or published hopefully soon'ish.
Meanwhile, this recent paper and table 1 gives some insights into the reliability of automatically establishing volumetrics across different brain regions by comparing two such software applications, one of which is FDA certified: Reliability of automated brain volumetric analysis: A test by comparing NeuroQuant and volBrain software
Fortunately we have you to remember to add that - well done! You can have a biscuit.
That’s fine.
The point is to weigh up as an investor individual appetite for risk, because risk there is in being caught up in FOMO!
Indeed Missling is the FOMO master and it is becoming clearer from every presentation he makes. He has clearly snared, possibly beyond means, some here. Is his straight face really straight? Could be with some non-zero chance worth a well considered can afford to lose dip.
Ohsay is as original as ever and obviously talented, I just don’t know at what.
Yeah they are not paying me or providing the script these days.
Aliens and cowboys is another possibility.
Who is manipulating the manipulators?
Easy to call a $AVXL bottom, there is a new one every trading day and especially on days where Missling speaks.
Or just deploy more of the endless reserves of ever more dry powder?
That’s like saying just approve it without the approval process be cause the CHMP has accepted that the application is worthy of going through the approval process.
If that makes sense to you then it explains a few things about the WGT mind.
You haven’t responded in reasoned way to the reasoned explanations that you have received.
I don’t exclude that no MAA will be filed, but more a question of when. To me it is more likely Anavex could fail to respond satisfactorily to clock stop 1 requests, simply because the P2b/3 results are not good enough once scrutinised by CHMP.