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Yup LP did good! Awesome job with the Sawston deal. Glad she had that up her sleeve, all longs must be comfortable with future deals she has planned. Dr.Liau got the science covered, LP has the business covered we are in great shape. Can't wait till we start flying....gonna be fun! Especially when we start Direct trials, Big game changer!
https://www.nasdaq.com/article/bristolmyers-squibb-says-cancer-drug-combination-fails-latestage-trial-20181126-01014
we have 93 patients with 36 plus months of OS, bms, merck, celg, etc... should be knocking on LP's door soon. LP has grown on me with her resilience, faith, in the science. Dr.Liau has never faltered in her observation that 25% of Gbm patients could have 5 plus years of survival with DC-Vax. I truly believe that we have closer to 35% OS of 36 months in DC-Vax treatment arm once unblinded. LP & LL deserve all the validation this trial will bring and more.
for the record I think jon is correct with his math, we had 108 alive and 83 PFS as of 2/2017, given event rates slowing down to one or less per month since then, would not be surprising to have 92 alive as of 11/2018 since 93 have made it to 36 months plus of OS as of 11/2018. Maybe Rk can weigh in on this? In any event 93 making it to 36 months is what is important.
Thank you! jon
2017 data 23.1 months 89.3% 46.2% 25.4%
2018 data 23.1 months 89.3% 46.4% 28.2%
Well looks like we had 84 alive for 36 months at 2017 and we had 93 alive at 36 months 2018. Chances are if you make to 36 months you have a good chance of making it to 88months... go figure.
tilt, seeing as how we had 83 PFS patients as of 02/07/17 and we have 93 patients still alive as of 11/18/18 , I can see how you or another reasonable person would come to that conclusion. The cat has been out of the bag for a long time the shorts are in denial for good reason they are trying to do damage control but they just keep on digging the hole deeper for themselves.
nice post congrats Dr.Liau, I'd go out tonight but I haven't a stitch to wear
anyone call for a drunk plumber? methinks not!
Mr.AF is a toad and JC is a weasel...pop!
senti, prayers and blessings for your husband's healthy recovery. So glad he is okay! Thanks for your updates!
hi biosect, yeah all cause the guy shared that he liked brownies to Les.... LOL doesn't everybody like brownies? sounds like he was a brownie loser trying to take advantage of an old nice guy like Les. Glad the judge was not bias. Hope Chardan has to cough up all the shares they have shorted.
Yeah LP needs to talk to Elon and get him to invest in NWBO. We just need one tweet from him. Her and Les are ancient, would be nice if they got some young blood working the website, social media campaign. Elon just torched the shorts with one tweet. Have him help us. Just tweet him LP!
Like,ROFLMAO funniest post of the decade for NWBO.
TF, Dr.Liau
Thanks follower, GREAT ARTICLE! 110% believe Dr.Liau when she states DC-Vax L will provide 25% of Ngbm patients over 5 years OS. She is actually being very conservative, I think it looks closer to 40% once we unblind. Thank GOD for Dr.Liaus of the world. Shorters were positive the vaccine was going to fail 5 years ago and still the trial is proving them wrong. It would of stopped long ago if we didn't have over 100 survivors 3/17, now possibly over 80 survivors 8/18. FACTS don't LIE. Shorters gonna have face reality soon.
Thanks Cherry, for keeping it authentic. So tired of the BS on trial failure. Truth is we don't know but it sure looks like a success! We should be at least 2 Billion MC given data read out within next several months. We have a phase III trial with phenomenal blinded results and most likely 200 million shares shorted stock... Time is on our side... Our patients are living WAY LONGER than anyone woulda thought. They want us to unblind as to not let our OS mature cause the tail is gonna give them whiplash!
doingmybest, yes it does seem methylated/total resection with DC-Vax are the bulk of the survivors.
yes doingmybest, exactly Dr.Liau said everyone is living longer, DC-Vax helps everyone M+, M- and looks like we can be closer to 40% living longer past 3 years. Our long tail is HUGE! Once they add a CI they can maybe get up to 60% or greater take out the radiation we got better white cell counts, everyone will be living longer. Everyone that is on DC-Vax.
meirluc, nice post! quite mind blowing those numbers. Approximately 30% of the ITT population (n?=?100) showed particularly extended survival, with a KM derived mOS estimate of 40.5 months. This is not fully explained by known prognostic factors, as only some of these patients had positive prognostic factors: only 29% were younger than 50 years of age, 65.9% had methylated MGMT, 71% had a complete resection, and only 8% of these patients had all three positive prognostic factors. These patients will be the subject of extensive further analyses and research. This was as 3/17? updated numbers as of 8/18 will show continued long tail as those living past 36 months have KM derived mOS of 88 months!
Thanks andrew, nice article.
senti, yeah have to wear the helmet the rest of your life! Good grief talk about total lack of quality of life. Plus DC-Vax more cost effective after last treatment you are done. Very exciting we have reached 36 months in August, rate of progression should be down to nothing now... smooth sailing to 88 months...WooHOO!
Thanks Lykiri, interesting publication.
Thank you senti, great reminder why we are waiting on 36 months from surgery data, leads to 88.2 months life expectancy for NGBM patients. WOW! over 7 YEARS OS! Thanks for all your DD and keeping it honest.
Thanks Doc, great post. Dr.Bosch said over 50 group doing surprisingly well? Lucky we did not unblind early.... clear separation with long term survival
Thanks biosect, you are so right, the combo is going to kick up the survival benefits for everyone. Interesting she said the radiation treatment may turn the cancer cells to cancer stem cells that come back later, so radiation may not be the best treatment option after surgery. She was very careful stating that.
beartrap, it was a good interview, Dr.Liau was very measured in her talk about DC-Vax L as she should be and stressed that the trial is still blinded but obviously she has very long lived patients that if not on the treatment arm would most likely have passed by now given historical data and common sense. She was consistent in her evaluation that DC-VAX will provide 25-30% of patients with long term survival of greater than 3-5 years and that I/O trials have to account for the long tail of survival instead of median survival data, just as Dr.Hoos had stated in his video of "YOU MUST WAIT" This is nothing new and she was just confirming what she has always said without any hype just the pure honest modest decent person that she is. Thanks for all your consistent support and DD.
Perspective is everything and as Dr.Liau says the positive attitude of her patients really count towards quality of life and recovery. Always have hope that was the one thing the oncologist took away from Dr.Liau's mom when she told her she only had 3 months to live when in fact she lived another year that could of been fill with joy instead of preparing for her death. She really wished the oncologist would not have said that to her mom and taken her hope away. Too bad they don't train doctors on the right thing to say to a patients that are terminally ill or at least consult with their family or a therapist before they issue death warrants. Like you could have anywhere from 3 months to years depending on how aggressive your cancer is. Give them at least a range of survival. I mean we have possibly 80 GBM patients that are alive over 3 years in our little trial where median survival should be 12-15 months. We should all be dancing and singing, instead of complaining about the ridiculous SP.
senti thanks great post glad it got a sticky, well deserved.
doingmybest, that's why NWBO is being relentlessly attacked? We are going to kill off a lot of cash cow therapies. Direct is paradigm shift for medicine, we don't use poison, we use our own immune systems as we were always the answer.
doingmybest, why not DC-Vax Direct for ALL tumors operable and inoperable? great post btw thanks.
right on ike, why JR sticky post on our board??? who used their one sticky for that post???
senti, excellent post BUMP! Keep it up! can you sticky your post? actually you may feel honored and special that they are taking up their time to discredit you. They must feel threatened by your DD.
no worries flip, everyone is getting anxious. I appreciate your work, have a good weekend.
flip I am not at all asking for that! I am asking we be patient and wait for 36 months past enrollment/surgery. I was just saying that maybe those 83 PFS patients have still not progressed and that is why Dr.Bosch would like to see as the number of events dwindle to next to nothing as all pass the 36 month survival and are projected to live now to 88 months.
Of course I expect them to unblind in 3 to 6 months from now, I would be perfectly happy if they unblinded today but I can see their reasons for waiting till August/November.
If the therapy really works then there would be no progression of disease so there would be no event rates, progression or death? there is always death but if they are living longer then death is delayed which is what we all want.
that's not what I meant by ZERO, I just meant when we reach 36 months for that last patient enrolled they will have a solid count of survivors at 36 months and that will enable them to project survival to 88 months as per Dr.Bosch..
maybe when event rate hits ZERO and patients get to pass of old age, no progression of disease! Could happen. I hope that is what they are waiting for once 36 months hits they get a pass to 88 months and beyond. This trial is evolving and one must expect the unexpected. LP was being optimistic being this is NGBM so she expected everyone to pass within one to two years? Who knew they would be living so much longer as to Over five years? We may have at least 83 survivors still? Best they don't rush and do the it right! I'm very thankful that LP has stood her ground and is doing what is right for patients in the bigger picture of things. They get to write history and create the first vaccine to possibly cure and prevent GBM cancer and/or all solid tumor cancers with little to no side effects. WOW! worth the three or six months wait.
Great post survivor, they got this! The shorts on the board are just messing with us longs, best not to take the bait. They are so transparent for those of us who see the truth. Be well don't engage with them is my motto otherwise you end up feeling yucky. Who wants to feel yucky??? not me.
yeah senti, what's up with that? He must be getting paid cause nobody spends that much effort on a little biotech with failed trial? Cofer should be able to show reasonable evidence in a court of law possibly using the RICO Act. Have you contacted Mr.Black with all your findings? You should!
Big drum roll please!!! Thanks senti, August will be BIG! BTW do you think Dr.Liau would know about those 22 patients??? Hmmm...BaddaBing!
monen, I disagree, they were incredibly open actually to a fault where LP had no filters and said whatever popped into her head. They they got severely beat up by Mr.AF for everything including their ASCO booth location in vicinity to the restrooms and all that garbage he spews out of his stench of a orifice. They went silent as to not get anymore lawsuits, LG unfortunately is a talker and should be more careful as the case with Chardan? They are not very good communicators that is certain, best they stay quiet as the science speaks for itself. Hopefully they can Hire a CFO and Marketing/Communications Project Leader ASAP when they get funds. Dr.Liau has stated they have a long tail of survivors 25% with survival of greater than 5 years with DC-Vax L thats all I need to know. Thank you and Good Day!
They could hire a college student to be a better communicator than either LP or LG. That would be an excellent use of funds instead of a ASCO booth that is a waste of space as they have no one effective to man it. At least bring some energy to the booth, they seem so tired and lifeless.
Thanks Rk, that makes perfect sense. I agree with you. Great research and reasoning can always count on you to be objective without bias.