Home > Boards > US OTC > Cannabis >

Skye Bioscience Inc. (SKYE)

Add SKYE Price Alert      Hide Sticky   Hide Intro
Moderator: Southern Gal
Search This Board: 
Last Post: 7/27/2021 10:44:25 AM - Followers: 128 - Board type: Free - Posts Today: 0


Our lead candidate, THCVHS, a proprietary prodrug of tetrahydrocannabinol (THC), is a topical formulation under development for the treatment of glaucoma and ocular hypertension (OHT).

Previous US government studies in humans discovered that THC was able to reduce intraocular pressure (IOP), which is in part responsible for the crush-like injury to the cells of the optic nerve that can eventually result in blindness. Additional preclinical studies have shown the potential for THC to also provide neuroprotective benefit, which may be especially important to patients with glaucoma who are experiencing disease progression with normal IOP levels.

One of the major drawbacks of previous studies of the use of THC for glaucoma was that they relied on inhalation or ingestion of THC. These systemic routes of drug administration cause negative side effects like psychotropic effects and potentially decreasing blood pressure , which resulted in the American Academy of Opthamology determining that the adverse effects of systemic cannabis administration/consumption outweighed its therapeutic benefit.

At Skye Bioscience, we chemically modify THC to create a unique synthetic molecule with the intent to safely realize the known positive effects of THC. Our molecule enables enhanced local delivery in the eye, reduced systemic side effects, and the potential for neuroprotection for the treatment of ocular diseases.

THCVHS for the treatment of glaucoma

Glaucoma is a group of eye diseases that can cause vision loss and blindness by damaging a nerve in the back of the eye called the optic nerve. Damage to the optic nerve is caused by increased intraocular pressure (IOP) due to improper drainage and/or overproduction of fluid in the eye.

According to the American Academy of Ophthalmology, glaucoma affects over 75million people worldwide and is the leading cause of blindness in adults aged 60 and older.

Current therapies can lower IOP but progressive tolerance requires switching or combining drugs. They do NOT provide neuroprotective capabilities.


In preclinical studies, Skye’s THCVHS demonstrated the potential to significantly reduce intraocular pressure (IOP) – exceeding the capabilities of leading commercialized drugs in the current glaucoma market.

Additionally, it has been demonstrated:

  • Skye’s THCVHS formulation enables it to better enter various compartments of the eye vs natural THC
    Its formulation lowers IOP better than leading current prescribed drugs in animal models
    THCVHS or its metabolite (THC) is not detectable in the plasma or brain tissue after topical administration to the eye
    THC in an ex vivo model demonstrated lowering of IOP and the reduction of biomarkers related to fibrosis, inflammation, and vasodilation, supporting a multimodal mechanism of action.

CBDVHS is a proprietary analog of cannabidiol (CBD) that has demonstrated biological activity that is both pharmacologically and therapeutically distinct from CBD in various preclinical modelsPreliminary data suggest potential analgesic, anti-inflammatory, anti-fibrotic, anti-infective and anti-seizure activity of CBDVHS opening the door to multiple therapeutic applications. We are actively conducting additional preclinical studies to help determine and prioritize a well we defined development plan for CBDVHS.



Our Mission

We develop novel and proprietary classes of synthetic molecules through the modification of naturally derived systems.

Our Vision

Shifting the solutions paradigm on a effective treatment of diseases through the development of novel neuroprotective solutions.

Our Values

Science First
The foundation of Skye Bioscience.

Revolutionary Solutions
Solving unmet needs of diseases with limited treatment offerings.

Commercial differentiated applications to provide therapeutic benefits.

Impact driven
Change makers. Platform solutions that can extend beyond a single disease.


Punt Dhillon


Mr. Dhillon was the co-founder, CEO, and director of OncoSec Medical Inc., a leading biopharmaceutical company developing cancer immunotherapies for the treatment of solid tumors.

+Read More

Tu Diep,MSc

Senior Vice President, Development 

Mr. Diep brings more than 15 years of scientific and clinical research experience to Skye Bioscience. Prior to joining Skye, Mr. Diep was at Protox Therapeutics Inc.

+Read More

Richard Janney 

Principal Accounting Officer 

Richard has more than 30 years of business experience and served as a Vice President to CFO on multiple companies in a wide range of industries both public and private, domestic and international.

+Read More

Tom Kim,Esq

General Counsel & Director of IP 

Mr. Kim serves as the General Counsel and Director of IP at Emerald Bioscience. He is an experienced biotech executive and corporate attorney, and a registered patent attorney.

+Read More

Karam Takhar 

Vice President, Corporate Development & Investor Relations

Karam Takhar serves as Vice President, Corporate Development & Investor Relations at Skye Bioscience Inc. Prior to joining Skye, Mr. Takhar was at Emerald Health Sciences.

+Read More

Board of Directors

Punit Dhillon


Mr. Dhillon was the co-founder, CEO, and director of OncoSec Medical Inc., a leading biopharmaceutical company developing cancer immunotherapies for the treatment of solid tumors.

+Read More

Jim Heppell,LLB


Mr. Heppell is the co-founder, President and Director of BC Advantage Funds (VCC) Ltd., a venture fund that invests in and builds technology, life science and clean technology companies.

+Read More

Margaret Dalesandro,PhD


Dr. Dalesandro is the President of Brecon Pharma Consulting, a full-service biotech consultancy firm focused on identifying and obtaining critical information early in product development. 

+Read More

Scientific Advisory Board 

Eduardo Muñoz,MD, PhD

Scientific Advisor

Dr. Muñoz is a Professor of Immunology in the Department of Cell Biology, Physiology, and Immunology of the University of Córdoba, Spain.

+Read More

Giovanni Appendino,PhD

Scientific Advisor 

Dr. Pasquale is a Professor of Organic Chemistry, Department of Pharmaceutical Sciences at the University of Eastern Piedmont, Novara, Italy, where his research activities focus on isolation .. 

+Read More

Clinical Advisory Board 

Jeffrey Goldberg,MD, PhD

Ophthalmology Clinical Advisor 

Dr. Goldberg is the Professor and Chair of Ophthalmology and Director of the Spencer Center for Vision Research at the Byers Eye Institute at Stanford University.

+Read More

Louis Pasquale,MD, FARVO

Ophthalmology Clinical Advisor 

Dr. Pasquale is the Professor of Ophthalmology at the Icahn School of Medicine at Mount Sinai in New York City.

+Read More

Robert Ritch,MD

Ophthalmology Clinical Advisor 

Dr. Ritch holds the Shelley and Steven Einhorn Distinguished Chair in Ophthalmology and is Clinical Professor of Ophthalmology at the Mt. Sinai Medical School and Surgeon Director Emeritus.

+Read More
Current Price
Bid Ask Day's Range
  • 1D
  • 1M
  • 2M
  • 3M
  • 6M
  • 1Y
  • 2Y
  • 3Y
  • 5Y
#6208   why the volume surge? And the bump up? Chefboy69 07/27/21 10:44:24 AM
#6207   Skye Bioscience Appoints Biotech Executive Praveen Tyle, Ph.D. Southern Gal 07/26/21 08:39:06 AM
#6206   And? jlee3 07/21/21 11:36:00 PM
#6205   https://www.youtube.com/watch?v=QX5UI4q4P6Y Southern Gal 07/21/21 02:08:55 PM
#6204   https://d1io3yog0oux5.cloudfront.net/_5adeb041b362f0c3b02efb74eca84ff2/skyebiosc Southern Gal 07/18/21 10:40:43 AM
#6203   #SKYE: WHAT DO WE HAVE HERE...:-)? $0.17 captainscotty 07/10/21 07:29:34 AM
#6201   Great time to buy imo Fishazo 06/09/21 05:30:59 PM
#6200   I am hoping for this to go back jamcneel 06/04/21 11:04:58 AM
#6199   Skye good informative video bobbleheadtwin 06/03/21 05:43:27 AM
#6198   This News was Awesome looking Foward... https://finance.yahoo.com/news/skye-bios N.C.LUCKY(7) 06/02/21 11:24:53 PM
#6197   Undervalued... In the whole time I have N.C.LUCKY(7) 06/02/21 11:19:29 PM
#6196   I got an "alert" two days ago from Blue Man 06/02/21 10:11:06 PM
#6195   why the sudden upswing? are there any news Chefboy69 06/02/21 09:42:30 PM
#6193   NMUS->EMBI->SKYE-> Moon let's goo!!!! Jdanger 2 06/02/21 02:18:47 PM
#6192   NEW 52 WEEK HIGH bobbleheadtwin 06/02/21 01:44:09 PM
#6191   JUST BEAUTIFUL Southern Gal 06/02/21 10:09:36 AM
#6190   The 1 analysts offering 12-month price forecasts for Dutchpaul1 06/01/21 09:48:43 AM
#6189   Today’s upgrade from Stockinvest: Southern Gal 05/29/21 09:56:26 AM
#6188   Closed up 26.4% on 4,200,000 shares Southern Gal 05/28/21 04:01:22 PM
#6187   Something is up. Bring the news Scout72 05/28/21 03:48:18 PM
#6186   Volume and movement Southern Gal 05/28/21 03:36:47 PM
#6185   NICE CLOSE TODAY FOR SKYE.. GOOD VOLUME ALSO.. N.C.LUCKY(7) 05/18/21 05:04:40 PM
#6184   BOOM....If we can get some new eyeballs on frozenspokes 05/17/21 09:08:15 AM
#6183   I feel you... Dutch Paul... Market makers N.C.LUCKY(7) 05/14/21 02:54:22 PM
#6182   Sell higher, you cunts! Dutchpaul1 05/12/21 03:04:11 PM
#6181   Great opportunity to add to your position more N.C.LUCKY(7) 05/10/21 12:14:32 AM
#6180   0.1240 NICE CLOSE FOR SKYE TODAY... Consolidating beautifully... N.C.LUCKY(7) 04/29/21 04:36:12 PM
#6179   Nothing we can do... SKYE did this 0.03 N.C.LUCKY(7) 04/26/21 04:56:08 PM
#6178   we need some action! Dutchpaul1 04/26/21 01:58:34 PM
#6177   This has been floating around several boards I've justs0medude 04/21/21 01:00:18 PM
#6176   CNN CANNABIS STOCKS ARE HOT... THE BULL RUN N.C.LUCKY(7) 04/20/21 08:25:00 PM
#6175   Senate majority leader say Marijuana decriminalize by 4/20/2022... https://www.c N.C.LUCKY(7) 04/20/21 08:23:43 PM
#6174   TECHNICAL analysis for SKYE 100% Buy for 4/20... N.C.LUCKY(7) 04/20/21 08:21:30 PM
#6173   Sequire Conference today: 1. IOP data to frozenspokes 04/20/21 04:27:05 PM
#6172   Give a little pasta towards 0,13 Dutchpaul1 04/16/21 02:12:51 PM
#6170   Cannabis Market can be Brutal in the Summer.. N.C.LUCKY(7) 04/13/21 10:17:19 PM
#6169   Head of Regulatory Affairs and Quality Assurance position frozenspokes 04/12/21 06:04:16 PM
#6168   0,19 Dutchpaul1 04/11/21 02:57:24 PM
#6167   Indicators have SKYE As a Strong Buy... https://www.barchart.com/stocks/quotes/S N.C.LUCKY(7) 04/09/21 11:27:36 PM
#6164   April 8, 2021 01:09 PM ET (BZ Newswire) Scout72 04/08/21 01:23:58 PM
#6163   Ready for the launch? Dutchpaul1 04/07/21 11:37:07 AM
#6161   hey thank you. I still own GWPRF Chefboy69 04/05/21 11:07:03 PM
#6160   Good to see you here.. I Remember you N.C.LUCKY(7) 04/05/21 11:01:06 PM
#6159   this will RUN as soon as news hits. Chefboy69 04/05/21 02:22:29 PM
#6158   Schumer says bill to legalize marijuana Federally will N.C.LUCKY(7) 03/31/21 04:39:25 PM
#6157   WAKE UP OVER HERE... QUIT NAPPING ON THE N.C.LUCKY(7) 03/31/21 03:00:10 PM
#6154   Many people are aware that almost the entire Dutchpaul1 03/25/21 07:51:42 PM
Consent Preferences