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Rich Pharmaceuticals Inc. (RCHA)

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http://www.richpharmaceuticals.com/ 

http://www.otcmarkets.com/stock/RCHA/profile

 
RCHA Patent for Treatment of Hodgkin’s Lymphoma

http://www.richpharmaceuticals.com/wp-content/uploads/2014/10/Rich-10_13_14-HL-Patent-Ownership-Rights.pdf

Under terms of the agreement, Rich Pharmaceuticals, Inc. will obtain complete ownership and all interest in the indication, patents and intellectual property related to treatment of Hodgkin’s Lymphoma,
utility patent application number 61998397, entitled COMPOSITIONS AND METHODS OF USE OF PHORBOL ESTERS FOR THE TREATMENT OF HODGKIN’S LYMPHOMA.
 

Facts About Hodgkins Lymphoma

Description of Hodgkins Lymphoma. Hodgkins Lymphoma is a cancer of the lymphatic system. Malignant Reed Sternberg cells invade and destroy the architecture of the lymph nodes and infiltrate major organs such as the liver and spleen in more advanced cases (Stages III and IV). Treatment options for Hodgkins Lymphoma are chemotherapy, radiotherapy or chemotherapy plus radiotherapy. More difficult cases may require high dose chemotherapy and stem cell transplant. In addition to the stage of the disease other factors such as age, general health and location of the disease are considered important in treatment decisions. In recent years PET/CT scans have been helpful in determining the extent of Hodgkins disease and assessing how well treatment is working. In some patients Hodgkins may never go away completely and regular treatments are required to control the disease while others experience relapses. Nowadays chemotherapy plus radiotherapy to involved areas is considered as standard treatment for patients with early stage Hodgkins Lymphoma (Stages I and II) and the incidence of survival in the U.S. after 5-years is about 90%. The 5-year survival rate for stage III patients is about 80% while it is 65% for stage IV patients. Due to long term adverse effects such as secondary malignancies causing both morbidity and mortality, the role of radiotherapy has been questioned and other means of treatment are being sought.

Incidence of Hodgkins Lymphoma. This disease is a cancer that is found most frequently in two different age groups (15 to 35 and over 55) and occurs in both sexes although more common in males and individuals with HIV, and in the third decade of life.. The overall incidence of Hodgkins Lymphoma is 2.7 per 100,000 persons and in the U.S. 185,793 individuals were stricken with this disease in 2011. The worldwide estimate for treatment of Hodgkins Lymphoma is estimated to be $1 to 2 billion. The cause of Hodgkins Lymphoma is unknown but factors such as smoking and alcohol have been linked to this disease, and siblings of with parents with Hodgkins have an increased risk (2 to 5X) of developing this disease. The specific factors triggering the conversion of normal lymphocytes to Hodgkins Lymphoma cells is unknown.

Facts about AML

Acute Myelocytic Leukemia (AML)

Acute myelocytic leukemia (AML), also known as acute myelogenous leukemia is the most common acute leukemia type that affects adults. Other names for AML that refer to the same disease are acute myeloid leukemia and acute myeloblastic leukemia. AML is sometimes referred to as acute myelo cancer, acute myelo leukemia and acute myeloid cancer.

What is Acute Myelocytic Leukemia (AML)?

AML is an aggressive form of cancer of the blood and the bone marrow, characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal white blood cells. The myeloid blood stem cells of the bone marrow develop into abnormal, poorly formed myeloblasts and do not become healthy white blood cells.
The incidence of myeloblastic leukemia in the USA is of about 1 case in 100 000 persons per year during the first 20 years of life, with a later increase to around 20 cases in 100 000 persons per year for octogenarians. Myeloid leukemia progresses rapidly and can typically be fatal within weeks or months.

Acute Myelocytic Leukemia (AML) Symptoms

Most signs and symptoms of AML are caused by the decreased ability of the body to fight off infection due to the replacement of normal blood cells with leukemic cells.
The symptoms of myelogenous leukemia are generally vague and non-specific. All or some of the following symptoms may be experienced by the person affected:

• Lethargy, chronic fatigue
• Fever (usually of unknown origin)
• Shortness of breath
• Inexplicable weight loss
• Frequent infections
• Headaches
• Pale skin, skin rash
• Non-specific bone pain
• Easy bruising
• Unusual bleeding such as nose or gum bleeding
• Blood in urine or stools
• Enlarged lymph nodes and/or spleen
• Abdominal fullness

Other symptoms of myelo leukemia include anemia, tumors of leukemic cells in the lung, breast, brain, uterus, ovary, stomach or prostate.

 
RCHA Recent News
 

Rich Pharmaceuticals Announces Principal Doctor for Clinical Trials

June 21, 2017

Dr. Numbenjapon specializes in medical oncology, hematology, and stem cell transplantation. He has over 14 years of experience in Hematology and Oncology.

“We are confident that Dr. Numbenjapon is the best and most qualified physician to head our research abroad, and look forward to his guidance as we embark on the next phase of our clinical studies,” said Ben Chang, CEO.

Now that Rich Pharmaceuticals has filed an IND (https://youtu.be/0CCtXc43a0I) with the FDA and re- ceived approval to start phase I/II (https://youtu.be/1WvlzbzKGqE), operations have progressed to the site level at Phramongkutklao Hospital and a full package has been submitted to the hospitals IRB (Review Board). "Rich Pharmaceuticals is pleased to have reached such a milestone and we look forward to patient enrollment at Phramongkutklao Hospital with the help of Dr. Numbenjapon," stated Mr. Chang.
 

Rich Pharmaceuticals Announces Institutional Review Board Submission

June 8, 2017

Beverly Hills, California - Rich Pharmaceuticals, Inc. (OTCPK: RCHA) (“Rich” or the “Company”), a bio- pharmaceutical Company focused on developing and commercializing innovative therapies in oncology an- nounced today that has filed its submission package to the Institutional Review Board (IRB) of Phramongkutklao Hospital in Bangkok, Thailand.

The submission is part of a process that leads to a study for the treatment of Acute Myelocytic Leukemia (AML) in refractory patients in a Phase I/II trial. “We are happy we’ve reached this milestone and we look forward to communicating further developments on this effort and other clinical milestones over time,” said Ben Chang, CEO.

The Company IRB submission was completed on May 31, 2017. An IRB is a group that is formally desig- nated to review and monitor biomedical research involving human patients. This submission is an integral to the Clinical Trial and drug approval process. 
 

Rich Pharmaceuticals Announces Clinical Site in Thailand

May 31, 2017

Beverly Hills, California - Rich Pharmaceuticals, Inc. (OTCPK: RCHA) (“Rich” or the “Company”), a bio- pharmaceutical company focused on developing and commercializing innovative therapies in oncology an- nounced today that it has selected a site and obtained investigator’s interest at Phramongkutklao Hospital in Bangkok, Thailand. Rich has engaged CMIC ASIA-PACIFIC, PTE. LTD. (“CMIC”) to assist in this project and they have already completed a site selection visit at Phramongkutklao Hospital, and the site has been cleared.

Rich and CMIC are preparing submission packages for the Hospital’s Internal Review Board (IRB) and the Thailand Food and Drug Administration (FDA). This package is near completion and the Company plans to submit it shortly. “The Company has purchased product liability insurance, the package is near completion and we hope to submit in the coming days,” said Ben Chang, CEO.

In cooperation with the Hospital, Rich is seeking to conduct a study for the treatment of Acute Myelocytic Leukemia (AML) in refractory patients in a Phase I/II trial. Acute Myelocytic Leukemia is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal white blood cells that build up in the bone marrow and interfere with the production of normal blood cells. AML is the most common acute leukemia affecting adults, and its incidence increases with age. Because the incidence increases with age, it is expected that incidence will rise as population rises. 

 

Our Science

Rich Pharmaceuticals currently is focused on the clinical development of the chemical molecule TPA (12-O-tetradecanoylphorbol-13-acetate) for the treatment of acute myelogenous leukemia (AML). The Company has technical evidence to suggest that it may also be useful to treat other important diseases resulting in it being a widely used drug with major market potential.

TPA

TPA is a naturally occurring molecule that is isolated and purified from croton oil which is obtained from the seeds of Croton tiglium, a leafy shrub native to Southeast Asia. While this has been the major source of TPA for clinical studies conducted by Rich Company scientists recently devised a synthetic route for preparation of the drug which will ensure providing the necessary supply of highly pure drug for clinical use. TPA has characteristics that are unique to this chemical class including a potent ability to accelerate differentiation of the myeloid cell lines, HL-60 and THP-1, as well as mononuclear phagocytes from bone marrow and peripheral blood. The best characterized receptor for TPA is protein kinase C (PKC) which, once activated, induces substrate phosphorylation that propagates signals to the MAPK cascades. The effects of TPA on MAPK pathways may be particularly relevant to the differentiating and pro-apoptotic effects of TPA in certain cells. The capacity of TPA to activate PKC and to induce phenotypic changes characteristic of differentiation and/or apoptosis led investigators to study its effect in AML.

What Justifies the Use of TPA to Treat AML?

Acute myelogenous leukemia (AML) is an aggressive disease that requires urgent and intensive therapy. Patients diagnosed with AML are, on average, between 64 and 68 years of age. Patients over 60 treated with standard chemotherapy are cured of their disease less that 20 percent of the time. In addition, patients who develop AML after an antecedent hematologic disorder or prior leukemogenic chemotherapy/radiation have similarly poor outcomes as do patients whose disease is associated with specific cytogenetic and clinical features. Most patients diagnosed with AML have a poor prognosis. For patients with relapsed disease, no standard non-transplant therapy has demonstrated the capacity for cure and AML is often fatal.

In view of the above facts, it is obvious that new approaches to therapy are needed. The clinical studies completed and those currently in progress with TPA report feasibility and potential efficacy of this drug in patients with relapsed/refractory myeloid malignancies.


 
WuXi PharmaTech, Inc. trades on the NYSE in the area of $40.00 per share under the ticker of WX with a $2.8 Billion Market Cap:

http://finance.yahoo.com/q/ks?s=WX+Key+Statistics
http://finance.yahoo.com/q?s=wx&ql=1
http://www.wuxiapptec.com/

 
"We believe RP-323 has best-in-class potential and holds significant promise for patients suffering from AML and MDS," said Ben Chang, Rich Pharmaceuticals' Chief Executive Officer.  Mr. Chang further stated, "We are especially excited to have a partner in the manufacture of RP-323 of the high caliber of Wuxi Apptec.  We expect to pursue the approval of the IND promptly and to be in clinical studies in the very near term."
Courtesy of Sibware: 
http://investorshub.advfn.com/boards/read_msg.aspx?message_id=110569310 
 
RCHA RP-323:Potential Market=$1 to 2 Billion/Year US.$5 Billion Worldwide. 

Business Overview 

The Company is developing RP-323 (formerly called PD-616) for the treatment of Acute Myelogenous Leukemia (AML), and to cause elevation of white blood cells
(WBC) in patients depleted of these elements due to various conditions.
 

Clinical Studies in Acute Myelocytic Leukemia 

Based on the known properties of RP-323, it was first administered in a pilot study in China, either alone or in combination with standard drugs and caused temporary remission of AML in some patients’ refractory to standard therapy. Several patients recovered sufficiently with RP-323 treatment to return to their normal occupations, symptom-free. 
Interest in these findings led to a Phase I investigator-sponsored trial in 35 patients by a leading oncologist at a leading cancer hospital in New Jersey, the University of Medicine and Dentistry of New Jersey (UMDNJ). 

Market Opportunities 

AML 

It is estimated that 40,000 people in the US have AML and an additional 14,000 are diagnosed annually with a yearly death rate of over 10,000.
Based on this incidence,
the potential market for RP-323 for the treatment of AML is approximately $1 to 2 billion peak sales annually in the US and more than $5 billion worldwide.
 

RCHA Key DD Posts:
 
Key RCHA & WX:NYSE Relationship
http://investorshub.advfn.com/boards/read_msg.aspx?message_id=110555124
 
Respectfully, again, key with the Authorized Shares
http://investorshub.advfn.com/boards/read_msg.aspx?message_id=110551465
 
RCHA NEWS
 
http://finance.yahoo.com/q/h?s=RCHA+Headlines
http://www.richpharmaceuticals.com/category/news/
 
RCHA SEC FILINGS
https://www.sec.gov/cgi-bin/browse-edgar?action=getcompany&CIK=0001504389&owner=exclude&count=40
 
http://www.richpharmaceuticals.com/contact-us/

Contact Us
9595 Wilshire Boulevard, Ste. 900
Beverly Hills, CA 90045

P: 424.230.7001
F: 424.230.7003

E: info@richpharmaceuticals.com
 

 

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PostSubject
#21727  Sticky Note RCHA and WX connections below: cjstocksup 10/23/17 10:31:51 AM
#20256  Sticky Note RCHA FDA Approval News & Must See Videos… stervc 09/29/17 02:54:06 PM
#20049  Sticky Note RCHA New Auditor = NASDAQ Co. IPO Auditor… stervc 09/25/17 12:13:24 PM
#22593   AKsquared 12/14/17 11:16:11 PM
#22592   not sure, its your news. I needed a Alexxdj1 12/14/17 08:55:47 PM
#22591   Yep, and I was played. Don't want others Sage7243 12/14/17 08:55:41 PM
#22590   Ladies & gentlemen.....it MUST be time! Sage, my dear AKsquared 12/14/17 08:54:41 PM
#22589   Fake News? Sage7243 12/14/17 08:53:57 PM
#22588   Better alert the media. Alexxdj1 12/14/17 08:53:29 PM
#22587   Yep Sage7243 12/14/17 08:37:33 PM
#22586   So youre saying that the clinical trials are Alexxdj1 12/14/17 08:37:09 PM
#22585   This scam sucks...you $$$ away. Stay far away. Sage7243 12/14/17 08:05:44 PM
#22584   It's deja`vu all over again. lol. Scott12 12/14/17 03:29:40 PM
#22583   Every POS in the marker moving but this Pstats 12/14/17 10:23:27 AM
#22582   why do we need volume? there hasn't been Alexxdj1 12/13/17 09:28:24 PM
#22581   Waiting waiting waiting! That is the name wedman 12/13/17 04:08:38 PM
#22580   Same here Pepsi- I'm still expecting big things bz777 12/13/17 04:03:49 PM
#22579   Agreed PepsiMan load , hold for the gold beer$$money 12/13/17 01:08:35 PM
#22578   True my friend. Just waiting to see PepsiMan 12/13/17 12:44:49 PM
#22577   No Dilution going on here, not much volume stoprun 12/13/17 10:29:43 AM
#22576   Too funny !! wedman 12/12/17 09:07:53 PM
#22575   Corona maybe? Werbe 12/12/17 07:15:12 PM
#22574   I got too much Native American in my beer$$money 12/12/17 07:10:08 PM
#22573   I'm a vodka guy. Screwdrivers are my thing:-) Werbe 12/12/17 07:08:21 PM
#22572   I’m loading bourbon and waiting patiently ! wedman 12/12/17 07:03:44 PM
#22571   :-D Funny times. Werbe 12/12/17 07:01:06 PM
#22570   LMAO! No Dilution since early October OS is beer$$money 12/12/17 06:18:12 PM
#22568   Someone is working hard for those 5’s AKsquared 12/12/17 03:33:29 PM
#22567   Agreed. And I am hopeful that is PepsiMan 12/12/17 03:21:54 PM
#22566   I prefer a real move for real reasons !! wedman 12/12/17 03:20:07 PM
#22565   WE had 2 solid runs and 2 spikes PepsiMan 12/12/17 03:18:57 PM
#22564   Big bid support today ! wedman 12/12/17 11:08:42 AM
#22563   Such a good post ! I would wedman 12/12/17 11:04:17 AM
#22562   I will not post directly on the thread. PepsiMan 12/12/17 10:58:59 AM
#22561   Yea that last 8K was a real RCHA beer$$money 12/12/17 09:56:45 AM
#22560   This is nothing but a pump and dump! Pstats 12/12/17 09:47:25 AM
#22559   living in exciting times for sure, deff one Alexxdj1 12/11/17 10:37:15 PM
#22558   Maybe or maybe a signal wedman 12/11/17 03:00:18 PM
#22557   Someone trying to keep the PPS up with stoprun 12/11/17 01:43:17 PM
#22555   RCHA----Agreed. I just noticed I had not PepsiMan 12/11/17 09:43:04 AM
#22554   Good morning!! Let’s see what this week brings AKsquared 12/11/17 09:02:25 AM
#22553   I wish I knew but looking forward to PepsiMan 12/11/17 08:58:27 AM
#22552   Glad I came across this back in August. Alexxdj1 12/10/17 04:00:22 PM
#22551   That is a definite possibility. I still PepsiMan 12/10/17 02:48:43 PM
#22550   I also would not overthink the way this wedman 12/10/17 09:56:30 AM
#22549   I hear ya. Anything is possible but PepsiMan 12/09/17 11:28:04 PM
#22548   probs gonna pick up another half M this Alexxdj1 12/09/17 08:53:51 PM
#22547   Have a wonderful weekend!! I'll be praying to the AKsquared 12/08/17 05:17:32 PM
#22546   $RCHA---Agreed. Have a nice weekend ahead everyone. PepsiMan 12/08/17 04:09:56 PM
#22545   That would be nice for sure GLTA have Linnear4242 12/08/17 04:02:42 PM
#22544   Would LOVE to see her run next week Just AKsquared 12/08/17 03:57:54 PM
#22543   The joy of $RCHA is it sleeps accumulating PepsiMan 12/08/17 02:45:06 PM
#22542   Looks like some steady accumulation today.....someone trying hard AKsquared 12/08/17 02:41:37 PM
PostSubject