Revance Therapeutics Inc (RVNC)

[Emannow]

Yes, I asked the question, “could you explain why there is no communication with Wall Street on your company “.

They simply did not answer any questions!

[go seek]

…did not take any questions. Did you ask a question? I think they did not want to ‘get into the weeds’ in this shareholder meeting. Just my guess. As you know, we were told that there were no questions. Best to you.

[Emannow]

I listened to the Shareholders call! Angus Russell ran the call and did not take any questions! Why would Russell answer questions about his many bad decisions! Angus has absolutely no idea what he is doing in aesthetics! The guy is clueless which is why the SP is down 90% and 95% of the corporate staff has been let go so they can pay their electric bill! Angus Russell should be removed!

[biotech_researcher]

Bad decision. There is a lot going on, and they didn’t what to share?

[go seek]

Alert… they just did the vote. No discussion of company operations. Nada…

[alertmeipp]

Annual meeting - anyone attended or listened to the call? Any notes? TIA

[go seek]

Not sure why…
IMO it is impossible to determine the whys and wherefores of price actions or trends thereto… The market is not efficient. Bottomline it is fear vs greed and uncertainty vs clarity. Revance has exceptional products in very large and growing markets. Over time, as confidence and sales in these products grow… uncertainty will abate and the stock price should rise.

[Emannow]

Not sure why whoever is shorting RVNC is working so hard! 54% of trades yesterday and 56% of trades today were shorts. Seems someone or some entity is determined at all costs to keep the SP down.

[Emannow]

Starting to see injectors offering Daxi at a Fair Price! This will grow sales!!

[go seek]

You are cordially invited to attend the Annual Meeting of Stockholders of REVANCE THERAPEUTICS, INC. The meeting will be held virtually on Wednesday, May 1, 2024 at 10:00 a.m. Central Time via live audio-only webcast at www.virtualshareholdermeeting.com/RVNC2024 .

[mouton29]

You are harping on the low end of the range, 30 percent, when he is reporting 30 to 100 percent increases. That’s like focusing on the Revance reported results and saying they report 0 percent increase, when they in fact report a range corresponding to something like 0 to 2x with a median of 1x.

I do take your point that other steps could be taken to optimize results and it doesn’t seem like Revance provides a lot of guidance or effort there, so that there’s a fair bit of experimentation and in some cases floundering by some injectors.

[iwfal]

That's not bad and does it really vary materially from the Revance results, given the reduced dose and he is reporting results between 30% and 100% longer.

Sure, agree '30% longer' is in line with 'reduced dose'. But the point stands that the 'feeling too heavy', which was why he reduced the dose doesn't. It seems pretty likely to indicate better optimization is possible. And 30% longer vs, say 65% longer... matters significantly when trying to get word-of-mouth to work. Eg 30% is likely only a little above the noise floor for an individual patient (eg session to session variability), whereas 65% is likely way above it.

[mouton29]

only mildly increase in duration

What he said was, at the 1.65 x dose,

it lasted significantly longer than Botox and what we saw at that 1.65 to 1 is at least 30% longer duration and as much as double the duration in that range.

That's not bad and does it really vary materially from the Revance results, given the reduced dose and he is reporting results between 30% and 100% longer. We don't know what median that translates to but clearly it's north of 30% and likely somewhere in the 50% range. And likely he is reporting the injector evaluation, not the Revance better of the injector and patient evaluation (which significantly skews the median upward).

[biotech_researcher]

It might be that the millennials steer this more than the baby boomers now

[iwfal]

Interesting in that he’s playing with dose, but weirdly unclear on *how* he’s playing w dose (eg further dilution or just less volume injected). My guess is that in order to really unlock Daxxy benefits (longer lasting, cheaper, few AE) you need to play with at least 2 of 3 things: injection pattern, dilution and dose per injection. And he’s only doing one, hence his fairly limited endorsement (too much is too heavy, only mildly increase in duration).

[go seek]

New Daxxi Provider and what sets Daxi apart from other neuromodulators…
https://www.instagram.com/reel/C4qvLGJRcGf/?igsh=MTMzMmQ3MnFtNjRreA==

[edcoolidge]

Many of the practices offering Daxxify do heavily market that it is vegan. It's a strong selling point and Revance should definitely lean into it. However I think the use of the word "safe" or any allusion to these types of incidents is a very bad idea.

[edcoolidge]

Where are all the "market is never wrong" folks today. 🤣

[go seek]

Daxxi Dosage Experience
https://www.instagram.com/reel/C5ygX2BRxYx/?igsh=eXY4dnVnMDg4NGV5

[Monksdream]

RVNC under $5

[vinmantoo]

I know that the infections in this report was due to contaminated needles and using microneedling - but as this spreads throughout the industry, one can throw in the slogan - "If you want the best and the safest , you can trust DAXXY"

All's fair in love and business.

[rock mountain]

First reported transmission of HIV-AIDS as a result of beauty treatment! In Morbidity and Mortality Weekly Report April 25. 2024 (73(16):372) the CDC reports on the first reported transmission of HIV-AIDS as a result of micro-needling. As this raises concern, I hope that RVNC again reiterates the point that DAXXI does not contain human blood by-products, whereas BOTOX does contain stabalizers derived from human blood. I know that the infections in this report was due to contaminated needles and using microneedling - but as this spreads throughout the industry, one can throw in the slogan - "If you want the best and the safest , you can trust DAXXY"

[biotech_researcher]

As you whine and pout, RVNC gains traction. The KOL coverage here was great..

[vinmantoo]

And then there’s Vinman who thinks he’s much smarter than both Milton Friedman and Jay Powell put together. Guess what Vinman. - you are nowhere close.

Maybe if you win the Nobel prize for economics and get a pointed as chairman of the fed, your economic “wisdom“ might be worth listening to.

Hey Ian, what put the bug up your butt? I never claimed to be an economist. You made some claims about interest rates and inflation that were false so I corrected them. I even posted links showing the FED hasn't raised interest rates since last year and has been taking about cutting rates at some point this year. I am sorry if you can't acknowledge you were wrong and don't like being corrected so lash out.

[vinmantoo]

Don’t get me started on Alzheimer’s disease. Roy “sicced” Vinman on me when I expressed my views to a new poster questioning four biotech stocks. Essentially, there are dozens of phase 3 trials, all of which have failed. that attacked amyloid Beta or tau plaques.

Hey Ian, what put the bug up your butt? Nobody got me to go after you. You made some comments about Alzheimers that I disagreed with and talked about why, and why that amyloid plaque idea might be wrong. I am sorry you don't like differing opinions or being so lash out.

[edcoolidge]

The feeling is mutual iwfal. Ian is clearly a liar since he just outright lied about what Dew posted on the other board. I didn't think you were stupid but your inability to understand the difference has me second guessing that. You were also naive about double dose Jeuveau.

[iwfal]

You are a liar and a loser Ian.

Honestly I find both you and Ian are of frustratingly little utility (albeit *some* utility). In both cases you hurt yourself by claiming those who disagree with you are ‘stupid’ or ‘evil’ or … . Which is annoyingly boring.

The worst sin on an investment board is being boring.

[edcoolidge]

You are a liar and a loser Ian. I've known that for a while but now everyone can see it. You're even more unhinged than CosmeticMD, who at least is motivated by kickbacks from Galderma. What's your motive? You seem to be angry at Dew because you lost money.

[IanFromSI]

I was referring to a different post on the biotech values thread which is much closer to what I posted on this thread than the post that you found.


If all the readers of this thread were experienced financial analysts with expertise in biotech, I wouldn’t bother making a single post here. I suspect many of the readers are lurkers with very little biotech expertise and not much investment experience. Those people deserve to get a balanced set of views. If they only read posts from the perma-bulls, they will not get a realistic impression of the risks involved.

Don’t get me started on Alzheimer’s disease. Roy “sicced” Vinman on me when I expressed my views to a new poster questioning four biotech stocks. Essentially, there are dozens of phase 3 trials, all of which have failed. that attacked amyloid Beta or tau plaques. The Aduhelm fiasco was the only time the FDA approved an Alzheimer’s disease treatment. Biogen withdrew it after no healthcare agency would pay the bill nor would doctors prescribe it.

Enjoy the rest of your weekend.
Ian

[alertmeipp]

IanFromSI, now we all know your motive here. lol.
So stupid

[10nisman]

What was the point of your post, Ian?

Even Roy hinted that he is worried that something is going wrong in revance that he’s not aware of (on the biotech values thread).

What are you talking about? Roy said "If I didn’t have first-hand knowledge of how much better Daxxify is, I would be concerned about my investment." https://investorshub.advfn.com/boards/read_msg.aspx?message_id=174306934

BTW, all investors should be concerned about the things they don't know.

[DewDiligence]

...Roy hinted that he is worried that something is going wrong in revance that he’s not aware of (on the biotech values thread).

I did no such thing. You ought to reread the post in question.

[IanFromSI]

Is this not just another example of atrocious management practises at RVNC?

(re-YY1000 post)

Even Roy hinted that he is worried that something is going wrong in revance that he’s not aware of (on the biotech values thread).

And then there’s Vinman who thinks he’s much smarter than both Milton Friedman and Jay Powell put together. Guess what Vinman. - you are nowhere close.

Maybe if you win the Nobel prize for economics and get a pointed as chairman of the fed, your economic “wisdom“ might be worth listening to.

…. And then bragging about how smart you are taking a loss to offset your capital gains, then, pointing out that you hope to be able to do it again!!!, And suggesting that others adopt us similar strategy. Has it got to be the most asinine investment strategy I have ever heard of.

Are you and Roy that desperate for increased liquidity that you think that posts on iHub might help you out of your fix?

Any competent investor is not going to speculate with cash that he either can't afford to lose, or isn't willing to lose by buying into a company that he strongly believes has the worst management in the world. And as I read the posts on this thread, most of the perma bulls have got an extraordinarily low opinion of Foley.

[alertmeipp]

So you said some injectors are not using Daxxify because they are too busy to try... but isn't the long lasting feature of Daxxify the exact solution they are looking for to make them less busy?

[vinmantoo]

Yes, if every injector used 30% daxxify. But there are about 10 other doctors in their practices that do not seem to use it much, so my guess is if you looked at total toxin purchases for these practices it would be 6-10% Daxxi,

For now and 10% market share is pretty nice given the horrid launch. This share can and likely will increase with time given Daxxify is the best neurotoxin on the market.

[edcoolidge]

"Daxxify is the best neurotoxin and I recommend it to all my patients."

This is, of course, what a doctor is supposed to do. Be knowledgeable and recommend the best option to their patients. Contrast that with what some unscrupulous CosmeticMDs are doing: keeping the best product away from their patients while taking kickbacks from Galderma or Abbvie. We won't see that type of rent seeking behavior in therapeutics.

[YY1000]

KOLs are charging patients 50% to 75% more for Daxi versus Botox and purchasing Daxi for less than Botox.

Correct and I find this puzzling... This seems to be one of the lingering negative effects of the premium price launch strategy.

large multi unit practices make up over 50% of the Botox sales. KOLs write most of the white papers but do very little of the injections.

Big medspa chains are in a different category but with the KOLs, other doctors, PAs, NPs the practices where these doctors work are among the largest dermatologist users of toxins.

[YY1000]

Yes, if every injector used 30% daxxify. But there are about 10 other doctors in their practices that do not seem to use it much, so my guess is if you looked at total toxin purchases for these practices it would be 6-10% Daxxi, with Botox about 30%, Jeuveau about 30% and rest 20% or so (by dollars, which would make Jeuveau the largest in terms of use).

[Emannow]

Thank you for your input and thoughts!

Two important points to consider: (1) if you look at the sales region award winners for RVNC and Allergan, you can see what areas of the country are doing well with Daxi and Botox. RVNC is doing very well in the Northeast and Mid Atlantic as well as a few other areas in the USA as these regions are winning sales awards every year. Allergan is doing well in the Northwest and Southwest USA as these areas are their sales award winners!

(2) KOLs are charging patients 50% to 75% more for Daxi versus Botox and purchasing Daxi for less than Botox. KOLs are all about the $$ and are now a very small % of total sales. National Med Spa chains and large multi unit practices make up over 50% of the Botox sales. KOLs write most of the white papers but do very little of the injections.

If KOLs charge patients a far price for Daxi as compared to the cost, 75% of their patients would pick Daxi. Eventually, competitive pricing for Daxi will impact the prices KOLs charge! Over time, patients will realize and understand the benefits of Daxi at a fair price.

[iwfal]

Worth noting that through about Jan 2024 Dr. Barrett was posting Botox stories. Since late Feb, only Daxxi.

[alertmeipp]

Many here seems to forget that RVNC actually has a very successful rollout of RHA product lines. They screwed up the first Daxxify launch but it does not mean they are incompetent fools. Hopefully, the second attempt will bring successes.

[edcoolidge]

Thanks for sharing! So many Daxxify posts every day on social media. Here are some more just from the last day. Galderma's pathetic unscrupulous CosmeticMD shills are going to need to work overtime to hold back the tide.

[alertmeipp]

>>about 30% of their toxin use is Daxxify

That's very high percentage (I assume 15% for my base case), is it not?

[YY1000]

The info I am getting from my East Coast KOLs is similar to Boraborak's. They tried it on more than half their toxin patients, and about half of those stayed on it, so about 30% of their toxin use is Daxxify. Their schedules are full so they get few new patients, so in terms of within-practice growth there was not much change in Daxxxify units Q4 to Q1, which amounts to small growth as most other toxins were a bit down Q-over-Q. Growth could have come from new physicians in their practices adopting, and they haven't seen that. They don't have a good explanation for that, other than the launch was a failure, and these doctors are too busy to give it another look until they get new information from sources they trust.

I am puzzled at the current share price. Assuming there is not some Valeant-type mess about to be unveiled, it could reflect that analysts and short sellers get negative info from the channel. Also there is a lot of turnover, as stated in many messages. That said, these doctors like their new reps that they've had since January more than the old ones. I made 3 very substantial purchases at 3.30/3.31 on Thursday, and given that they executed within minutes and without much price movement, there must be a lot of non-retail investors willing to sell or short at these prices. FWIW, I have not seen any of my shares being lent to shorts, which is unlike what happened with Valeant (which I bought after it already was 90% down from its highs).

[go seek]

Plastic Surgeon Beverly Hills | Dr. Daniel Barrett
https://www.drdanielbarrett.com/dr-barrett

[Tomdontworry]

Now this is a HUGE deal. Multi millionaire celebrity plastic surgeon pitches Daxi… you would think these people would not only use the product but buy into the stock to own a piece of the pie.

[RVNCfan]

https://www.instagram.com/reel/C6PLozoSc2h/?igsh=cHpqMWFzbzZheG5t

Dr. Daniel Barrett

[go seek]

I am seeing many new ads and practices pitching DAXXIFY…
https://www.instagram.com/reel/C6OQOgEuUYh/?igsh=MWNyeThuNHdqNHY2Yg==

https://www.instagram.com/reel/C6Kdl4ivXld/?igsh=Nm1qeGpkeHE0bnZ5

https://www.instagram.com/reel/C59L4ZqI71W/?igsh=cHoycDEwYXRyMmc=

https://www.instagram.com/reel/C6FJIA0gc_e/?igsh=c3dyMDNkcWlpdGFq

https://www.instagram.com/reel/C6M8U38vltb/?igsh=MXN1c3pveWYycDk1dA==

https://www.instagram.com/reel/C6J8LLKgysU/?igsh=MWM3MXJvZmJ3d2I3dQ==

[PioneerUniverse8]

Daxxi practice locator tool for Miami area is now showing 52 locations compared to 26 just yesterday. Whatever they did to gain traction in Miami seems to be working.

[MrMILL]

Well, thank you for the insight. I didn’t know that! 🤦🏻‍♂️