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News: RespireRx Pharmaceuticals Inc. (OTCMKTS:RSPI) Short Interest Down 73.1% in April.
RespireRx Pharmaceuticals Short Interest Data
Change Vs. Previous Month: 73.07%
Short Interest Ratio / Days to Cover: 0.0
Last Record Date: April 15, 2024
Outstanding Shares: 774,680,000 shares
Percentage of Shares Shorted: 0.00%
https://mayfieldrecorder.com/2024/04/25/respirerx-pharmaceuticals-inc-otcmktsrspi-short-interest-down-73-1-in-april.html
https://www.marketbeat.com/stocks/OTCMKTS/RSPI/short-interest/
I'm only guessing and speculating here but... I think that BP would be using inside information on how the 3rd stage tests are going and if it looks like they will come out of tat stage with more good news. Then BP would probably pounce on it. BP would probably assume that NIH is involved and the drug market is looking for an answer to the addiction issue that plagues the world. They would want in knowing that the process should move quickly.
Yes. I think BP is watching this with great interest. This has moved along quickly and they wont fall a sleep at the wheel and miss what's next for this company without having a hand in it. I feel it will drop without warning and be one of those OTC companies that runs off the chart before most people can even get near it.
Thanks thought it was quite witty...lol.Nice buying today.
Ace LoL i love it
RSPI 🟢💚🚀
Nice to see RSPI close up today
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RespireRx Pharmaceuticals Inc. and its subsidiaries and business units are discovering and developing medicines for the treatment of psychiatric and neurological disorders, with a focus on treatments that address conditions affecting millions of people, but for which there are few or poor treatment options, including epilepsy, pain, attention deficit hyperactivity disorder (“ADHD”), recovery from spinal cord injury (“SCI”), certain neurological orphan diseases and obstructive sleep apnea (“OSA”). The RespireRx Group is developing a pipeline of new and repurposed drug products based on our broad patent portfolios for two drug platforms: (i) neuromodulators, which include GABAkines and AMPAkines, proprietary chemical entities that positively modulate (positive allosteric modulators or “PAMs”) GABAA receptors and AMPA-type glutamate receptors, respectively, and (ii) pharmaceutical cannabinoids, which include dronabinol, a synthetic compound that acts upon the nervous system’s endogenous cannabinoid receptors and
The RespireRx Group holds exclusive licenses and owns patents and patent applications or rights thereto for certain families of chemical compounds that claim the chemical structures and their uses in the treatment of a variety of disorders, as well as claims for novel uses of known drugs.
EndeavourRx: Neuromodulators
GABAkines. Under a License Agreement with the University of Wisconsin-Milwaukee Research Foundation, Inc. (“UWMRF”) and on behalf of its EndeavourRx business unit, RespireRx has licensed rights to certain selectively acting GABAkines because of their ability to selectively amplify inhibitory neurotransmission at a highly specific subset of GABAA receptors, thus producing a unique efficacy profile with reduced side effects. Preclinical studies have documented their efficacy in a broad array of animal models of interrelated neurological and psychiatric disorders including epilepsy, pain, anxiety, and depression in the absence of or with greatly reduced propensity to produce sedation, motor-impairment, tolerance, dependence and abuse. EndeavourRx currently is focusing on developing KRM-II-81 for the treatment of epilepsy and pain.
KRM-II-81 has displayed a high degree of anti-convulsant activity in a broad range of preclinical studies, including in treatment resistant and pharmaco-resistant models. Not only was KRM-II-81 highly effective in these models, but pharmaco-resistance or tolerance did not develop to its anti-convulsant properties. These latter results are particularly important because pharmaco-resistance occurs when medications that once controlled seizures lose efficacy as a result of chronic use and it is a principal reason some epileptic patients require brain surgery to control their seizures. In support of its potential clinical efficacy, translational studies have demonstrated the ability of KRM-II-81 to dramatically reduce epileptiform electrical activity when administered in situ to brain slices excised from treatment resistant epileptic patients undergoing surgery.
In addition, KRM-II-81 has displayed a high degree of analgesic activity in a broad range of preclinical studies. In intact animal models of pain, the analgesic efficacy of KRM-II-81 was comparable to or greater than commonly used analgesics. At the same time, KRM-II-81 did not display side effects such as sedation and motor impairment, but even more importantly, it did not produce tolerance, dependence, respiratory depression or behavioral changes indicative of abuse liability, which are produced by opioid narcotics and are at the heart of the opioid epidemic.
AMPAkines. Through an extensive translational research effort from the cellular level through Phase 2 clinical trials, RespireRx has developed a family of novel, low impact AMPAkines, including CX717, CX1739 and CX1942 that may have clinical application in the treatment of CNS-driven neurobehavioral and cognitive disorders, spinal cord injury, neurological diseases, and certain orphan indications. Our lead clinical compounds, CX717 and CX1739, have successfully completed multiple Phase 1 safety trials. Both compounds have also completed Phase 2 proof of concept trials demonstrating target engagement, by antagonizing the ability of opioids to induce respiratory depression.
AMPAkines have demonstrated positive activity in animal models of ADHD, results that have been extended translationally into statistically significant improvement of symptoms observed in a Phase 2 human clinical trial of CX717 in adult patients with ADHD. Statistically significant therapeutic effects were observed within one week. We believe AMPAkines may represent a novel, non-stimulant treatment for ADHD with a more rapid onset of action than alternative non-stimulants, such as Straterra® (atomoxetine), and without the drawbacks of amphetamine-type stimulants.
In a series of important studies funded by grants from the National Institutes of Health and published in a number of peer reviewed articles, Dr. David Fuller (University of Florida), a long-time RespireRx collaborator, has demonstrated the ability of CX1739 and CX717, RespireRx’s lead AMPAkines, to improve motor nerve activity and muscle function in a number of animal models of spinal cord injury (SCI).
| Form Type | Received | Period End Date | Report |
|---|---|---|---|
| 8-K | 09/06/2024 | 08/30/2024 | PDFRTFHTMLXLS |
| 8-K | 08/02/2024 | 07/29/2024 | PDFRTFHTMLXLS |
| 8-K | 07/08/2024 | 07/02/2024 | PDFRTFHTMLXLS |
| 8-K | 05/29/2024 | 05/29/2024 | PDFRTFHTMLXLS |
| 8-K | 04/16/2024 | 04/10/2024 | PDFRTFHTMLXLS |
| NT 10-K | 04/01/2024 | 12/31/2023 | PDFRTFHTMLXLS |
| 8-K | 02/02/2024 | 01/30/2024 | PDFRTFHTMLXLS |
| 8-K | 01/22/2024 | 01/18/2024 | PDFRTFHTMLXLS |
| 8-K | 12/11/2023 | 12/06/2023 | PDFRTFHTMLXLS |
| 10-Q | 11/17/2023 | 09/30/2023 | PDFRTFHTMLXLS |
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