NDT Pharmaceuticals Inc. (NDTP)

Patent number: 5922350

Abstract: Dehydrated liposomes are prepared by drying liposome preparations under reduced pressure in the presence of one or more protective sugars, e.g., the disaccharides

trehalose and sucrose. Preferably, the protective sugars are present at both the inside and outside surfaces of the liposome membranes. Freezing of the liposome preparation

prior to dehydration is optional. Alternatively, the protective sugar can be omitted if: (1) the liposomes are of the type which have multiple lipid layers; (2) the dehydration is done

without prior freezing; and (3) the dehydration is performed to an end point which results in sufficient water being left in the preparation (e.g., at least 12 moles water/mole lipid)

so that the integrity of a substantial portion of the multiple lipid layers is retained upon rehydration.

Type: Grant

Filed: June 16, 1997

Date of Patent: July 13, 1999

Assignee: The Liposome Company, Inc.

Inventors: Andrew S. Janoff, Pieter R. Cullis, Marcel B. Bally, Michael W. Fountain, Richard S. Ginsberg, Michael J. Hope, Thomas D. Madden, Hugh P. Schieren, Regina L. Jablonski

Lipid matrix carriers for use in drug delivery systems

Patent number: 4610868

Abstract: Lipid matrix carriers are described which provide for the sustained release of bioactive agents in vivo or in vitro. The properties

of the lipid matrix carriers of the present

invention include high entrapment efficiencies; release of entrapped compounds in their active form; biodegradability and avoidance of

vascular occlusion in vivo; and avoidance

of sequestration of the bioactive agent in the liver and spleen.

Type: Grant

Filed: March 20, 1984

Date of Patent: September 9, 1986

Assignee: The Liposome Company, Inc.

Inventors: Michael W. Fountain, Steven J. Weiss, John J. Kearns, Alan L. Weiner, Mircea C. Popescu

Lipid vesicles prepared in a monophase

Patent number: 4588578

Abstract: A process for the preparation in a monophasic solvent system of a new type of lipid vesicles, called monophasic lipid vesicles

(MPVs). MPVs can be made to

encapsulate one or more bioactive agents. MPVs are stable during storage and can be used in vivo in the treatment of disease.

Type: Grant

Filed: August 8, 1983

Date of Patent: May 13, 1986

Assignee: The Liposome Company, Inc.