Patent number: 5922350
Abstract: Dehydrated liposomes are prepared by drying liposome preparations under reduced pressure in the presence of one or more protective sugars, e.g., the disaccharides
trehalose and sucrose. Preferably, the protective sugars are present at both the inside and outside surfaces of the liposome membranes. Freezing of the liposome preparation
prior to dehydration is optional. Alternatively, the protective sugar can be omitted if: (1) the liposomes are of the type which have multiple lipid layers; (2) the dehydration is done
without prior freezing; and (3) the dehydration is performed to an end point which results in sufficient water being left in the preparation (e.g., at least 12 moles water/mole lipid)
so that the integrity of a substantial portion of the multiple lipid layers is retained upon rehydration.
Type: Grant
Filed: June 16, 1997
Date of Patent: July 13, 1999
Assignee: The Liposome Company, Inc.
Inventors: Andrew S. Janoff, Pieter R. Cullis, Marcel B. Bally, Michael W. Fountain, Richard S. Ginsberg, Michael J. Hope, Thomas D. Madden, Hugh P. Schieren, Regina L. Jablonski
Patent number: 4610868
Abstract: Lipid matrix carriers are described which provide for the sustained release of bioactive agents in vivo or in vitro. The properties
of the lipid matrix carriers of the present
invention include high entrapment efficiencies; release of entrapped compounds in their active form; biodegradability and avoidance of
vascular occlusion in vivo; and avoidance
of sequestration of the bioactive agent in the liver and spleen.
Type: Grant
Filed: March 20, 1984
Date of Patent: September 9, 1986
Assignee: The Liposome Company, Inc.
Inventors: Michael W. Fountain, Steven J. Weiss, John J. Kearns, Alan L. Weiner, Mircea C. Popescu
Patent number: 4588578
Abstract: A process for the preparation in a monophasic solvent system of a new type of lipid vesicles, called monophasic lipid vesicles
(MPVs). MPVs can be made to
encapsulate one or more bioactive agents. MPVs are stable during storage and can be used in vivo in the treatment of disease.
Type: Grant
Filed: August 8, 1983
Date of Patent: May 13, 1986
Assignee: The Liposome Company, Inc.
Inventors: Michael W. Fountain, Steven J. Weiss, Mircea C. Popescu
Patent number: 4522803
Abstract: A new and substantially improved type of lipid vesicle, called stable plurilamellar vesicles (SPLVs), are described, as well as the
process for making the same. SPLVs
are stable during storage and can be used in vivo for the sustained release of compounds and in the treatment of disease.
Type: Grant
Filed: March 24, 1983
Date of Patent: June 11, 1985
Assignee: The Liposome Company, Inc.
Inventors: Robert P. Lenk, Michael W. Fountain, Andrew S. Janoff, Marc J. Ostro, Micrea C. Popescu
Related Univ of Penn Patents that might be involved with the formation of NDT Pharmaceutcal Inc
Application number: US06/591,576; Inventor: Michael W. Fountain: Steven J. Weiss: John J. ... Liposome Co Inc; Original Assignee:
Liposome Co Inc; Priority date (The priority date is ... US20100098773A1 (en) *, 2008-09-26, 2010-04-22, The Trustees Of The
University Of Pennsylvania, Polymer ... Non-Patent Citations (7) ...
Earlier Historical Info The R/M Custodial Letter that first allerted us to what was R/M with MILV
Oct. 24, 2019

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