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MannKind Corp. (MNKD)

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Last Post: 2/17/2018 7:33:20 PM - Followers: 403 - Board type: Free - Posts Today: 0


Many Afrezza users have reported rapid drops in A1c

Yeah, but in the only clinical trials that compared Afrezza to rapid acting insulins, Afrezza did no such thing.

Straight from the label:

Absolute HgA1c reduction:
Afrezza : 0.21
Rapid I : 0.40

% of patients reducing by 7% or more:
Affreza: 13.8%
Rapid I: 27.1%

And there is your problem. Tweets do not counter clinical trial data.

Afrezza avoids the needle, for sure.But is it better?

It has a faster/narrower spike. BUT, to take advantage of this, the user need to know how to use it.

Perhaps a few users have got it down, and do better. But that does not work for the masses.

MNKD really needs to figure out how to work with the new electronic glucose monitors to solve this issue.        

 p.s. Reading the Mannkind report at FDA.GOV provides plenty of clues why Afrezza is a failure.        

About MannKind Corporation

MannKind Corporation (Nasdaq: MNKD) is a biopharmaceutical company focused on the discovery, development and commercialization of therapeutic products for patients.

AFREZZA® (pronounced uh-FREZZ-uh) is a rapid-acting inhaled insulin indicated to improve glycemic control in adults with diabetes. AFREZZA was approved by the FDA in 2014. MannKind has a global licensing agreement with Sanofi for the development and commercialization of AFREZZA. Sanofi is responsible for global commercial, regulatory and development activities and. MannKind manufactures AFREZZA at its manufacturing facility in Danbury, CT.

AFREZZA utilizes our proprietary Technosphere® formulation technology , which is based on a class of organic molecules that are designed to self-assemble into small particles onto which drug molecules can be loaded.  We believe Technosphere represents a versatile drug delivery platform that may allow pulmonary administration of certain drugs that currently require administration by injection, such as GLP-1. Pulmonary administration provides convenience for the patient and we believe a major advantage of drugs inhaled as Technosphere formulations is that they have been shown to be absorbed very rapidly into the arterial circulation, essentially mimicking intra-arterial administration. MannKind is also developing other inhalation technologies, including an innovative line of patient-focused, breath-activated, dry powder inhalers and inhalation profiling to characterize patient inhalation.

- See more at:


Alfred E. Mann, Founder (Deceased)

Alfred E. Mann had been one of MNKD's directors since April 1999, Chairman of the Board since December 2001 and  Executive Chairman since January 2015. He also served as our Chief Executive Officer from October 2003 until January 2015.  Mr. Mann has founded and largely funded 14 companies in his career.  Nine were acquired at an overall total of almost $8 billion, and three companies became public.  In addition to MannKind, he is currently involved with:

• Bioness, which develops and manufactures systems to address neural deficits and to restore controlled function of paralyzed limbs;
• Second Sight, which is developing a visual prosthesis to restore sight to the blind; 
• IncuMed, which is developing novel percutaneous seals for various applications; 
• PerQFlo, which is developing drug delivery systems; and
• RoundTrip, which is developing location and identification technology.

In 1993, Mr. Mann founded and served as Chairman and Chief Executive Officer of MiniMed Inc. until August 2001 when it was acquired by Medtronic, Inc.  Medtronic MiniMed develops, manufactures and distributes microinfusion systems and continuous glucose monitoring systems that have revolutionized the treatment of Type 1 diabetes.  Mr. Mann founded and funded Medical Research Group (MRG), a developer of an artificial pancreas.  MRG was also acquired by Medtronic in 2001.  Mr. Mann also founded and served as the Chairman of the Board and Chief Executive Officer of Advanced Bionics Corporation from its founding in 1993 until it was acquired by Boston Scientific Corporation in 2004.  Advanced Bionics developed neurostimulation devices for various neural deficits, including cochlear stimulators.  Previously, Mr. Mann founded and was Chairman of the Board and CEO of Pacesetter Systems, Inc., which developed, manufactured and distributed cardiac pacemakers, from 1972 until 1985 when it was acquired by Siemens, AG.  From 1985 to September 1992, Mr. Mann continued to serve as Chairman and CEO of the successor company, Siemens-Pacesetter, Inc., Pacesetter is now the Cardiac Rhythm Management unit of St. Jude Medical.  Prior to 1972, he was President of Spectrolab, an electro-optical and aerospace systems company, and Heliotek, a semiconductor and electro-optical components manufacturer.  Mr. Mann founded these companies in 1956 and 1960, respectively, sold them to Textron Inc. in 1960 and continued to lead them until 1972, when he left for Pacesetter.  They are now part of the Boeing Company.
Mr. Mann founded and endowed, and from 1985 until 2006 served as Chairman of the Board of Trustees of The Alfred Mann Foundation, a nonprofit research organization devoted to development of advanced medical products in a variety of fields.  Mr. Mann is currently Chairman of the Board of Trustees of the Alfred Mann Institutes at the University of Southern California, Purdue University, and The Technion Institute (Israel), all of these medical research foundations founded and endowed principally by Mr. Mann.  He also serves as a Trustee for the University of Southern California, as a member of the Board of Overseers of the Keck USC School of Medicine, and as the Chairman of the Southern California Biomedical Council, a nonprofit association dedicated to the fostering of the bio-medical industry in the Los Angeles Metropolitan area.  Alfred Mann also serves as a Director of the Nevada Cancer Institute.
Mr. Mann holds B.A. and M.S. degrees in physics from the University of California, Los Angeles and honorary doctorate degrees from the University of Southern California, The Johns Hopkins University, Western University and the Technion Institute (Israel).  Mr. Mann is also a member of the National Academy of Engineering.

Ronald Consiglio 

Ronald J. Consiglio has been one of our directors since October 2003. Since 1999, Mr. Consiglio has been the managing director of Synergy Trading, a securities-trading partnership. From 1999 to 2001, Mr. Consiglio was Executive Vice President and Chief Financial Officer of Trading Edge, Inc., a national automated bond-trading firm. From January 1993 to 1998 Mr. Consiglio served as Chief Executive Officer of Angeles Mortgage Investment Trust, a publicly traded Real Estate Investment Trust. His prior experience includes serving as Senior Vice President and Chief Financial Officer of Cantor Fitzgerald & Co. and as a member of its board of directors. Mr. Consiglio has served as a member of the board of trustees for the Metropolitan West Funds since 2003. Mr. Consiglio is a certified public accountant and holds a bachelor’s degree in accounting from California State University at Northridge  A good forum for discussion on Mankind

MannKind Corporation, a development stage company, engages in the discovery, development, and commercialization of therapeutic products for the treatment of diabetes and cancer. Its lead investigational product candidate, the Technosphere Insulin System, is in phase III clinical trials in the United States, Europe, and Latin America for the treatment of diabetes. This dry powder therapy consists of Technosphere particles onto which insulin molecules are loaded. These loaded particles are then aerosolized and inhaled into the deep lung using its proprietary MedTone inhaler. The company is also developing therapies for the treatment of solid tumor cancers. The lead product candidate in this program, MKC1106-PP, which is in phase I clinical trial is intended for the treatment of various solid-tumor cancers, including ovarian, colorectal, pancreatic, renal, breast, and prostate carcinomas and melanoma. MannKind was founded in 1991 and is headquartered in Valencia, CA.;;




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MNKD News: Annual Statement of Changes in Beneficial Ownership (5) 02/14/2018 06:24:47 PM
MNKD News: Amended Statement of Ownership (sc 13g/a) 02/14/2018 08:58:40 AM
MNKD News: David Kendall Joins MannKind as Chief Medical Officer 02/06/2018 08:00:00 AM
MNKD News: Current Report Filing (8-k) 01/19/2018 06:53:47 AM
MNKD News: MannKind Corporation to Present at NobleCon14 - Noble Capital Markets’ Fourteenth Annual Investor Conference 01/16/2018 09:00:00 AM
PlusOneCoin Top Posts
#27507   $MNKD Daily and Weekly Chart http://stockchar $Pistol Pete$ 02/14/18 12:06:05 PM
#27521  Sticky Note From the MNKD proboards -->> TTIME 02/14/18 02:49:38 PM
#23743  Sticky Note $MNKD MannKind and Biomm Enter Into Distribution Agreement $Pistol Pete$ 06/01/17 01:49:35 AM
#23541  Sticky Note Buffalo teacher a key advocate in breakthrough diabetes drug Phaeton 05/19/17 12:07:29 PM
#27581   Day 2, 3, 4, who cares? The question XenaLives 02/17/18 07:33:20 PM
#27574  Restored A "typo" is is miss spelling or the XenaLives 02/16/18 07:21:57 PM
#27573   Again, you are using a typo to deflect SidVicious 02/16/18 07:10:44 PM
#27572   Typo. My bad. I did look at his SidVicious 02/16/18 07:09:31 PM
#27571   Lol TTIME 02/16/18 05:54:37 PM
#27570   Maybe if you used the correct name in XenaLives 02/16/18 04:29:33 PM
#27569   Um... Perhaps you should double check the name XenaLives 02/16/18 04:28:58 PM
#27563   Figure it out for yourself,shorts are gonna be TTIME 02/16/18 01:22:25 PM
#27562   Ok, so direct me to what he's done SidVicious 02/16/18 12:27:48 PM
#27561   That's your opinion...not mine TTIME 02/16/18 12:25:09 PM
#27560   I have. And your response tells me your SidVicious 02/16/18 11:54:00 AM
#27559   Do your DD..I'm real comfortable with holding MNKD TTIME 02/16/18 11:35:25 AM
#27558   Out of curiosity, what ground breaking things did SidVicious 02/16/18 11:18:28 AM
#27557   Out of curiosity, what ground breaking things did SidVicious 02/16/18 11:17:39 AM
#27556  Restored None like Dr. Kendall TTIME 02/16/18 11:16:28 AM
#27554   Maybe they feel like I do,that this is TTIME 02/16/18 10:54:42 AM
#27553   Kind of a lopsided cup and handle going XenaLives 02/16/18 10:47:42 AM
#27552 TTIME 02/16/18 08:56:38 AM
#27550   Lol.... sure you want it to go up. Phaeton 02/15/18 08:44:07 PM
#27549   Lol...... Yep you know it. Milk it Phaeton 02/15/18 08:40:39 PM
#27548   Long term investors with MNKD and Afezza know Denise Chanterelle 02/15/18 08:20:26 PM
#27547   Why we had a very bearish sign today terragord7 02/15/18 06:04:34 PM
#27546   LOL...Not at leg up coming imo TTIME 02/15/18 05:00:15 PM
#27545   What's happening guys? Are we losing all our money? Unoqualunque 02/15/18 03:46:49 PM
#27544   But it sort of depends on who owns what... XenaLives 02/15/18 03:16:46 PM
#27543   Max pain is $3 if I'm not mistaken. bidrite 02/15/18 03:02:51 PM
#27542   This weekly options stuff is really messy, isn't it? XenaLives 02/15/18 02:59:07 PM
#27541   You'll see...this is gonna go alot higher in TTIME 02/15/18 02:57:47 PM
#27540   OMG, why is this tanking? I thought this SidVicious 02/15/18 02:48:23 PM
#27539   Conferences and presentations never have helped the stock. SidVicious 02/15/18 02:06:33 PM
#27538   Do not understand optimism conference stock crashes terragord7 02/15/18 12:29:01 PM
#27537   Well stock not doing well now terragord7 02/15/18 12:23:27 PM
#27536   I am pretty sure shorts here don't care Profit 02/15/18 11:33:40 AM
#27530 MNKD $$ TTIME 02/15/18 10:41:17 AM
#27528   Appears that Dr. Kendall likes to move around. SidVicious 02/15/18 10:20:41 AM
#27527   I thought that Ace was Afrezza and it Profit 02/15/18 09:10:33 AM
#27526   Have a feeling the CEO is holding a TTIME 02/15/18 08:47:28 AM
#27525   Have to agree Friend. Anybody going to Phaeton 02/15/18 03:39:39 AM
#27524   * * $MNKD Video Chart 02-14-18 * * ClayTrader 02/14/18 04:23:50 PM
#27523   Good post friend!! martind18 02/14/18 03:14:53 PM
#27522   New Sheriff in town and I think that Hypi 02/14/18 02:54:34 PM
#27521   From the MNKD proboards -->> TTIME 02/14/18 02:49:38 PM
#27520   They have a decent short position, so I'm Don Quixote 02/14/18 02:25:54 PM
#27519 TTIME 02/14/18 02:03:40 PM
#27518   Ok, so the answer is no. SidVicious 02/14/18 01:45:38 PM
#27512   I see a Epic move imo TTIME 02/14/18 01:18:55 PM
#27509   SO you think $MNKD will experience a bigger SidVicious 02/14/18 12:18:07 PM
#27508   Good,that will contribute to the Motha of all TTIME 02/14/18 12:08:42 PM
#27507   $MNKD Daily and Weekly Chart http://stockchar $Pistol Pete$ 02/14/18 12:06:05 PM
#27506   MNKD ceo said yesterday... "The first day with TTIME 02/14/18 12:05:09 PM