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MannKind Corp. (MNKD)

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Last Post: 8/18/2017 10:47:55 PM - Followers: 381 - Board type: Free - Posts Today: 29


Many Afrezza users have reported rapid drops in A1c

Yeah, but in the only clinical trials that compared Afrezza to rapid acting insulins, Afrezza did no such thing.

Straight from the label:

Absolute HgA1c reduction:
Afrezza : 0.21
Rapid I : 0.40

% of patients reducing by 7% or more:
Affreza: 13.8%
Rapid I: 27.1%

And there is your problem. Tweets do not counter clinical trial data.

Afrezza avoids the needle, for sure.But is it better?

It has a faster/narrower spike. BUT, to take advantage of this, the user need to know how to use it.

Perhaps a few users have got it down, and do better. But that does not work for the masses.

MNKD really needs to figure out how to work with the new electronic glucose monitors to solve this issue.        

 p.s. Reading the Mannkind report at FDA.GOV provides plenty of clues why Afrezza is a failure.        

About MannKind Corporation

MannKind Corporation (Nasdaq: MNKD) is a biopharmaceutical company focused on the discovery, development and commercialization of therapeutic products for patients.

AFREZZA® (pronounced uh-FREZZ-uh) is a rapid-acting inhaled insulin indicated to improve glycemic control in adults with diabetes. AFREZZA was approved by the FDA in 2014. MannKind has a global licensing agreement with Sanofi for the development and commercialization of AFREZZA. Sanofi is responsible for global commercial, regulatory and development activities and. MannKind manufactures AFREZZA at its manufacturing facility in Danbury, CT.

AFREZZA utilizes our proprietary Technosphere® formulation technology , which is based on a class of organic molecules that are designed to self-assemble into small particles onto which drug molecules can be loaded.  We believe Technosphere represents a versatile drug delivery platform that may allow pulmonary administration of certain drugs that currently require administration by injection, such as GLP-1. Pulmonary administration provides convenience for the patient and we believe a major advantage of drugs inhaled as Technosphere formulations is that they have been shown to be absorbed very rapidly into the arterial circulation, essentially mimicking intra-arterial administration. MannKind is also developing other inhalation technologies, including an innovative line of patient-focused, breath-activated, dry powder inhalers and inhalation profiling to characterize patient inhalation.

- See more at:


Alfred E. Mann, Founder (Deceased)

Alfred E. Mann had been one of MNKD's directors since April 1999, Chairman of the Board since December 2001 and  Executive Chairman since January 2015. He also served as our Chief Executive Officer from October 2003 until January 2015.  Mr. Mann has founded and largely funded 14 companies in his career.  Nine were acquired at an overall total of almost $8 billion, and three companies became public.  In addition to MannKind, he is currently involved with:

• Bioness, which develops and manufactures systems to address neural deficits and to restore controlled function of paralyzed limbs;
• Second Sight, which is developing a visual prosthesis to restore sight to the blind; 
• IncuMed, which is developing novel percutaneous seals for various applications; 
• PerQFlo, which is developing drug delivery systems; and
• RoundTrip, which is developing location and identification technology.

In 1993, Mr. Mann founded and served as Chairman and Chief Executive Officer of MiniMed Inc. until August 2001 when it was acquired by Medtronic, Inc.  Medtronic MiniMed develops, manufactures and distributes microinfusion systems and continuous glucose monitoring systems that have revolutionized the treatment of Type 1 diabetes.  Mr. Mann founded and funded Medical Research Group (MRG), a developer of an artificial pancreas.  MRG was also acquired by Medtronic in 2001.  Mr. Mann also founded and served as the Chairman of the Board and Chief Executive Officer of Advanced Bionics Corporation from its founding in 1993 until it was acquired by Boston Scientific Corporation in 2004.  Advanced Bionics developed neurostimulation devices for various neural deficits, including cochlear stimulators.  Previously, Mr. Mann founded and was Chairman of the Board and CEO of Pacesetter Systems, Inc., which developed, manufactured and distributed cardiac pacemakers, from 1972 until 1985 when it was acquired by Siemens, AG.  From 1985 to September 1992, Mr. Mann continued to serve as Chairman and CEO of the successor company, Siemens-Pacesetter, Inc., Pacesetter is now the Cardiac Rhythm Management unit of St. Jude Medical.  Prior to 1972, he was President of Spectrolab, an electro-optical and aerospace systems company, and Heliotek, a semiconductor and electro-optical components manufacturer.  Mr. Mann founded these companies in 1956 and 1960, respectively, sold them to Textron Inc. in 1960 and continued to lead them until 1972, when he left for Pacesetter.  They are now part of the Boeing Company.
Mr. Mann founded and endowed, and from 1985 until 2006 served as Chairman of the Board of Trustees of The Alfred Mann Foundation, a nonprofit research organization devoted to development of advanced medical products in a variety of fields.  Mr. Mann is currently Chairman of the Board of Trustees of the Alfred Mann Institutes at the University of Southern California, Purdue University, and The Technion Institute (Israel), all of these medical research foundations founded and endowed principally by Mr. Mann.  He also serves as a Trustee for the University of Southern California, as a member of the Board of Overseers of the Keck USC School of Medicine, and as the Chairman of the Southern California Biomedical Council, a nonprofit association dedicated to the fostering of the bio-medical industry in the Los Angeles Metropolitan area.  Alfred Mann also serves as a Director of the Nevada Cancer Institute.
Mr. Mann holds B.A. and M.S. degrees in physics from the University of California, Los Angeles and honorary doctorate degrees from the University of Southern California, The Johns Hopkins University, Western University and the Technion Institute (Israel).  Mr. Mann is also a member of the National Academy of Engineering.

Ronald Consiglio 

Ronald J. Consiglio has been one of our directors since October 2003. Since 1999, Mr. Consiglio has been the managing director of Synergy Trading, a securities-trading partnership. From 1999 to 2001, Mr. Consiglio was Executive Vice President and Chief Financial Officer of Trading Edge, Inc., a national automated bond-trading firm. From January 1993 to 1998 Mr. Consiglio served as Chief Executive Officer of Angeles Mortgage Investment Trust, a publicly traded Real Estate Investment Trust. His prior experience includes serving as Senior Vice President and Chief Financial Officer of Cantor Fitzgerald & Co. and as a member of its board of directors. Mr. Consiglio has served as a member of the board of trustees for the Metropolitan West Funds since 2003. Mr. Consiglio is a certified public accountant and holds a bachelor’s degree in accounting from California State University at Northridge  A good forum for discussion on Mankind

MannKind Corporation, a development stage company, engages in the discovery, development, and commercialization of therapeutic products for the treatment of diabetes and cancer. Its lead investigational product candidate, the Technosphere Insulin System, is in phase III clinical trials in the United States, Europe, and Latin America for the treatment of diabetes. This dry powder therapy consists of Technosphere particles onto which insulin molecules are loaded. These loaded particles are then aerosolized and inhaled into the deep lung using its proprietary MedTone inhaler. The company is also developing therapies for the treatment of solid tumor cancers. The lead product candidate in this program, MKC1106-PP, which is in phase I clinical trial is intended for the treatment of various solid-tumor cancers, including ovarian, colorectal, pancreatic, renal, breast, and prostate carcinomas and melanoma. MannKind was founded in 1991 and is headquartered in Valencia, CA.;;




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MNKD News: Statement of Changes in Beneficial Ownership (4) 08/11/2017 06:19:11 PM
MNKD News: Quarterly Report (10-q) 08/07/2017 04:09:41 PM
MNKD News: Current Report Filing (8-k) 08/07/2017 04:07:56 PM
MNKD News: Current Report Filing (8-k) 08/07/2017 04:07:34 PM
MNKD News: MannKind Corporation Reports 2017 Second Quarter Financial Results 08/07/2017 04:05:00 PM
#24979  Sticky Note MNKD DAILY WEEKLY TREND1 08/18/17 07:48:44 PM
#23743  Sticky Note $MNKD MannKind and Biomm Enter Into Distribution Agreement $Pistol Pete$ 06/01/17 01:49:35 AM
#23541  Sticky Note Buffalo teacher a key advocate in breakthrough diabetes drug Phaeton 05/19/17 12:07:29 PM
#24983   been buying it up! gonna make wealth again harry crumb 08/18/17 10:47:54 PM
#24982   BUY ALL YOU CAN UNDER $2.21 Aloha96707 08/18/17 09:21:26 PM
#24981   Looks good. What a fantastic week! OTC BB King 08/18/17 09:16:04 PM
#24980   Long term MNKD bulls see only a great future. TREND1 08/18/17 07:52:47 PM
#24979   MNKD DAILY WEEKLY TREND1 08/18/17 07:48:44 PM
#24978   Rising Scripts!!!!!! tyfoidhana 08/18/17 07:14:31 PM
#24977   Interesting analysis from seekingalpha's "risingskeptic": nobodysbusiness 08/18/17 06:53:04 PM
#24976   Just think when they announce some + news...then Go4itbigtime 08/18/17 12:53:48 PM
#24975   Surging higher now on volume. Looks like MNKD OTC BB King 08/18/17 12:37:14 PM
#24974   You said something similar a day or two martind18 08/18/17 11:49:58 AM
#24973   are day will come! kugel 08/18/17 11:38:02 AM
#24969   $1.46 HOD and moving higher on a down TREND1 08/18/17 11:26:42 AM
#24968   $1.46 HOD and moving higher on a down OTC BB King 08/18/17 11:23:26 AM
#24967   The same company that raised the target to TREND1 08/18/17 11:15:06 AM
#24966   MNKD needs new high above 1.52 today TREND1 08/18/17 10:41:05 AM
#24965   1 AFREZZA uses 400% more insulin. AFREZZA drop TREND1 08/18/17 10:39:09 AM
#24964   One exclamation so much better!!!!!!!!!!!!!!!!!! tyfoidhana 08/18/17 10:31:41 AM
#24963   Rising scripts! tyfoidhana 08/18/17 10:29:07 AM
#24961   Consider that refills were 300 the week that nobodysbusiness 08/18/17 09:49:36 AM
#24960   Great news! OTC BB King 08/18/17 09:25:04 AM
#24959   If true - should be a class action Aloha96707 08/18/17 09:20:29 AM
#24958   Rising Scripts/////// Rising Refills!!!!!! tyfoidhana 08/18/17 09:08:52 AM
#24957   Script numbers from proboards: nobodysbusiness 08/18/17 08:58:02 AM
#24956 Adv Functional Med WHS 08/18/17 03:48:05 AM
#24955   Understand major lawsuit to be announced against FDA, Hypi 08/18/17 02:50:56 AM
#24954   $MNKD $Pistol Pete$ 08/17/17 10:30:34 PM
#24953   $MNKD Daily and Weekly Charts http://www.stock $Pistol Pete$ 08/17/17 10:29:53 PM
#24952   Still 95% rejection of those who try AFREZZA. TREND1 08/17/17 10:27:39 PM
#24951   $MNKD $Pistol Pete$ 08/17/17 10:24:23 PM
#24950   It did not close in the green. TREND1 08/17/17 05:53:13 PM
#24949   Wouldn't doubt it if it closes in the Go4itbigtime 08/17/17 03:41:06 PM
#24948   Any thing over 1.88 would be a major TREND1 08/17/17 12:23:04 PM
#24947   1.41 bottom for today $2 eod TREND1 08/17/17 12:10:31 PM
#24946   1.41 bottom for today $2 eod stockpro3434 08/17/17 11:52:00 AM
#24945   CCI 10 confirming start of down move TREND1 08/17/17 11:36:30 AM
#24944   So why is this a short covering rally ? TREND1 08/17/17 11:16:15 AM
#24943   Looks like another good day in store here. TREND1 08/17/17 11:14:03 AM
#24942   Wrong, wrong and wrong again :) TREND1 08/17/17 11:12:17 AM
#24941   MNKD DAILY WEEKLY LONG TERM TREND1 08/17/17 11:02:16 AM
#24940   The key is no higher high and the bidrite 08/17/17 09:50:52 AM
#24939   Yes, big premarket volume. Looks like strong continuation today. OTC BB King 08/17/17 09:29:37 AM
#24938   Wrong, wrong and wrong again :) Go4itbigtime 08/17/17 09:26:13 AM
#24937   Looks like another good day in store here. martind18 08/17/17 09:13:13 AM
#24936   Sold yesterday too 65K shares, but that doesnt anotherboat12 08/17/17 08:20:28 AM
#24935 LeAnne Rooks? @Roo WHS 08/17/17 12:04:07 AM
#24934   The key is no higher high and the TREND1 08/16/17 10:17:53 PM
#24933   ***** SOLD MNKD TREND1 08/16/17 07:48:26 PM
#24932   Combination of Maxim, Cantor-Fitgerald, and Aegis boiler nobodysbusiness 08/16/17 06:22:48 PM
#24931   That does not seem likely. Will probably test OTC BB King 08/16/17 06:03:24 PM
#24930   To bad it is a TOP ! TREND1 08/16/17 04:18:43 PM