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nice surge in buying here
getting a good feeling about this week guys, GLTA
I can’t wait either Stockman I’m hoping for some BIG news coming up real soon, us longs deserve it already! $LXRP$
Just registered for the webinar, CANT WAIT! Hopefully the company starts disseminating news in advance of the meeting this week
Oral lipid-based drug delivery systems – an overview
http://www.sciencedirect.com/science/article/pii/S2211383513000919
Watch LXRP Participate in discussion panel 2017
Panel - Investing in the Picks and Shovels of the Industry (2017)
http://cannanet.tv/view/105
Crash Fatality Rates After Recreational Marijuana Legalization
https://www.ncbi.nlm.nih.gov/pubmed/28640679
CannaTech 2017 - Oral Bio-availability: Cannabinoid Delivery System - Doron Friedman
Lexaria presentation at the recent CSE conference...
Chris Bunka presentation
Phil Aislie (University of BC) presentation
Chris can't fit in everything he wants to say. Guy is going to explode if he doesn't get all the news out of his system soon. Here's hoping for the latter! :)
Looks like a big bullish Hammer Candlestick on the chart today along with above-average volume.
Monday should be very interesting!
Coupla nutsacks left in the 30s and we're back in the game
Looking for a good close. Maybe some covering being done today?
If we can close above .38 we can hold the uptrend on the weekly chart
Added on the dip.
CDEL in dump mode again, Nov 1st can't come soon enough
Great find!!!! WOW.
Aurora + Hempco+ Lexaria
Aurora is buying an interest in Hempco which has a licensing agreement with Lexaria.
https://technical420.com/cannabis-article/aurora-cannabis-one-step-away-becoming-cbd-leader
LXRP to Hold Web-Meeting on November 1
- Web-meeting scheduled for November 1, 2017, at 4:15 p.m. ET
- 19 patents filed encompassing 44 countries
- Patents cover broad range of lipophilic bio-actives including cannabinoids, vitamins and other pharma
- Patented lipophilic delivery system proven to improve bio-absorption
The medical effectiveness of cannabinoids is no longer in question, and the cannabinoid market proliferates ever faster as more people realize the therapeutic benefits. However, the human gastrointestinal tract just doesn’t absorb cannabinoids effectively, and much of what is ingested is subsequently excreted by the body, causing onset times and efficacy to vary wildly.
With 19 patent applications filed internationally covering 44 countries, Lexaria Bioscience Corp. (CSE: LXX) (OTCQB: LXRP) has already been issued patents in the U.S. and Australia for the delivery of all non-psychoactive cannabinoids, immediately adding value and validation to the underlying science. Lexaria’s technology is a novel drug delivery platform believed to be applicable across a wide range of different drug types and vitamins, as well as cannabinoids. Lexaria’s lipophilic enhancement technology has been proven to increase both absorption and bioavailability of payload molecules, and the applications and implications are immense.
To clearly communicate this opportunity, Lexaria will host a web-meeting on November 1, 2017, at 4:15 p.m. ET. Lexaria will deliver all the latest news, and, as stated in its newsletter, the company is “expecting to have a LOT to talk about – don’t miss this!” The meeting is open to everyone, but pre-registration is required.
REGISTER here for this important event: https://events.genndi.com/register/169105139238467429/ce8311a9b6
The newsletter also emphasized the fact that Lexaria’s “technology is a delivery platform believed to be applicable to many different types of drugs, vitamins and other substances. It is the applicability of our tech in delivering a substance more efficiently that provides its most substantive value…” To expedite its value proposition, Lexaria has already instructed its attorneys to accelerate examinations of its multiple patent applications wherever possible.
Keeping with strategy, Lexaria is working on several parallel paths toward development of new products and new applications for its technology and seeking new technologies that complement its lipophilic delivery platform. Broad ranging applications will further feed Lexaria’s low-cost, high-margin license and royalty business model of revenue generation. The company’s first licensee is gaining considerable market traction utilizing and paying for its technology, and, with multiple royalty agreements already in the works, Lexaria should easily continue to expand its licensing network. Lexaria has no debt and maintains a healthy cash balance. The company believes it has sufficient cash to follow through with all of the expected R&D and product development, as well as to fund general corporate needs through to the end of 2018.
Lexaria’s novel lipophilic enhancement technology has implications across a wide swath of consumer and pharmaceutical delivery protocols. The global impact of Lexaria’s patented delivery system has barely begun, and it could quickly reverberate to the bottom line.
For more information, visit the company’s website at www.LexariaEnergy.com
Nice updates!
Anyone else been able to successfully subscribe to text updates?
I tried texting “Lexaria” to 76000 and got this message back:
Alert & Msg Service: This was NOT a valid keyword, response or command, pls check spelling. To stop receiving messages reply STOP. For help, call 1-866-866-0009
Lexaria sent out the following email blast update a couple days ago. It's posted over at Facebook, if you're not yet in the group...
https://www.facebook.com/groups/1664919466872085/permalink/1668702153160483/
higher lows you know what that means right?
Canadian side short number as of October 15th is showing at 281K, up from 37K. Whoever it was took advantage of low support and dropped it from 59 cents on October 3rd down.
A good 20-25% move if he covered this week.
TURN DOWN THE SUCK, TURN UP THE GOOD
It's coming
Come on guys, lets band together, take advantage of these temporarily discounted shares, and turn this chart!
Slapped for a few, seller is done by looks of it *knocks on wood*. Up time.
Bidding here, expecting a hard turn north soon.
Updated Website
https://www.lexariaenergy.com/
SO - if we don't see that short get covered on next Tuesday, it could potentially mean that the short was not held by our PP guys, correct?
Weren't we supposed to receive shares from this joint venture?
Website still in limbo http://www.ambariicorp.com/
What ever happened to the neutrisci deal?
Thank You Presley!!
https://www.thestar.com/business/2017/10/17/tsx-to-smoke-out-marijuana-stocks-that-violate-us-federal-law.html should push $ into more legit enterprises like LXRP.
Finally we'll get some updates, yes!!
Expecting some hefty PRs prior to the web meeting!
Lexaria Investor Update on November 1st...
https://www.lexariaenergy.com/event/lexaria-investor-update-web-meeting/e
Volume is bananas on the CDN side. WTF. Why the chump dump?
Im buying these low thirty dips, this girl is going to go soon.
I kicked myself last time for not buying in the low thirties...
Another shit the bed day I see, maybe we can change the sheets tomorrow...
New Facebook group for Lexaria investors has gone live...
https://www.facebook.com/groups/1664919466872085/
Great volume on the CAN side today. 332K shares absorbed and price finished up on day.
I have not bought back anything yet, who knowa- I might miss it. I will buy if it drops a few more cents though
Bought the dip, of course :|
Sorry to see the longs suffering once again with this stock. Im glad I made the decision to get out , however, if this should get back to the high 20's to that 30 or 31 cent level I might have to start to accumulate once again- just too solid a company to not take advantage of a selloff of this magnitude imo. Good luck to the longs
Big dumps on the Canadian side continue. It's coming from Eight Capital and Anonymous.
Jamieson Bondarenko was in on the PP earlier this year for 500K shares. Would he be taking a loss for a reason? I know all that shit with CBW and Eight Capital happened after the fact.
Shakeout? forced sell? No idea at moment.
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Lexaria Bioscience Corp. (CSE:LXX; OTCQX:LXRP) has developed and out-licenses its disruptive and cost-effective DehydraTECH™ technology that promotes healthier administration methods, lower overall dosing and higher effectiveness of ingestible drugs and other beneficial molecules.
Lexaria’s DehydraTECHTM delivery technology is protected by a robust suite of patents granted or pending worldwide and is proven effective in multiple international studies in greatly assisting rapidity and quantity of absorption of a range of lipophilic (i.e., fat-soluble), bioactive molecules. By significantly enhancing the performance and experience with oral ingestion, Lexaria’s DehydraTECH delivery technology offers a viable and often healthier alternative to other delivery methods for bioactive substances in widespread use today such as inhalational delivery through smoking.
Lexaria’s patented technology, DehydraTECH™ delivers these important benefits:
Eliminates the strong tastes/odors of lipophilic compounds, without the need for unwanted sugar or sweeteners
Effects are felt within 15-20 min vs. 60-120 min.
Initial testing indirectly evidences DehydraTECH may deliver ingested molecules through the lymphatic system instead of being subject to immediate “first pass” liver exposure, potentially mitigating unwanted side effects and reducing liver biotransformation.
Bio-absorption increases up to 3 – 10X, to equate or exceed that of other routes of administration like inhalational delivery.
Lexaria’s DehydraTECH™ is designed specifically for formulating and delivering lipophilic (i.e. fat-soluble) drug payloads. It is patented or patent-pending for use with a broad range of bioactive molecules, including but not limited to:
Lexaria Bioscience Corp. (“Lexaria”) has formed the Lexaria Nicotine Corp. as its exclusive worldwide nicotine business unit. More than 89% of all nicotine that is consumed worldwide is delivered through smoking cigarettes. Approximately 6,000,000 deaths per year around the world are attributed primarily to the delivery of nicotine through the act of smoking according to the Centers for Disease Control and Prevention. Of note: “…it is primarily the toxins and carcinogens in tobacco smoke – not the nicotine – that cause illness and death.” (U.K. National Institute for Health and Care Excellence [NICE]). As many as 69% of U.S. adult smokers want to quit smoking and 43% of US adult smokers have attempted to quit in any twelve-month period. Lexaria postulates that delivery of nicotine to satisfy current demand, utilizing our patented DehydraTECH technology in common food and consumer product formats, could shift demand away from smoking cigarettes. However, ingestion of nicotine is challenging because it is poorly tolerated by the human gastrointestinal system and then significantly metabolized by the liver, thereby diminishing its overall effectiveness through edibles. Lexaria’s DehydraTECH technology offers a means to formulate ingestible product formats of nicotine and/or its analogs with higher bioavailability performance possibilities due to the benefits of our technology.
Lexaria is developing a patent suite with supporting intellectual property in the pharmaceutical sector that will supply significant long-term strategic growth potential. Lexaria Pharmaceutical Corp. is the 100%-owned subsidiary that has obtained exclusive worldwide rights to Lexaria’s patent portfolio related to pharmaceutical applications. Currently within this business unit resides the IP for Non-Steroidal Anti-Inflammatories (NSAIDs), Vitamins, hormone treatments utilizing estrogen or testosterone, phosphodiesterase inhibitors (PDE5). Additional molecules of interest could be added to this unit over time.
According to Statista.com, the global pharma industry was worth $1,105 billion in 2016, and the US pharma industry alone spent over $71 billion in 2017 on R&D: a larger R&D expenditure than the entire gross revenues of many other business sectors.. Lexaria Pharmaceutical Corp. is implementing a strategy of reinforcing its IP-suite to sufficient degree to begin partnering within this dynamic industry.
The Lexaria Hemp Co. holds exclusive global rights to the Lexaria patent portfolio related to hemp-based applications. Lexaria’s DehydraTECH technology is designed to deliver functional ingredients within hemp in oral product formats with significantly enhanced palatability, speed of effectiveness and potency as a viable and healthier alternative to conventional inhalational (i.e. smoking or vaping) administration practices. Extensively evaluated through invivo, invitro, and human clinical studies, one of the most extensive databases in the world has been collected by Lexaria related to hemp-based ingredients empowered with our DehydraTECH technology. In 2018, the World Anti Doping Agency (WADA) for the first time ever exempted cannabidiol from hemp from its list of restricted substances on its International Standards Prohibited List of substances.
Lexaria CanPharm Corp, a Canadian corporation, owns exclusive global rights to Lexaria’s intellectual property as it is applied to psychotropic bioactive molecules that act upon human CB1 and CB2 receptors in those areas of the world where it is permissible to do so. Substances that act upon these receptors and systems in the human body that affect pain, inflammation, anxiety and depression, and have also been shown to have utility against cancer and neurodegenerative conditions. Lexaria’s ground-breaking 2018 research that proved many-fold improvements in delivering an active ingredient across the blood-brain-barrier could have disruptive potential within this business sector as well as all others where Lexaria is active.
The safety and effectiveness of Lexaria’s DehydraTECH™ technology has been studied in a series of controlled and well designed in vitro and in vivo human focus studies, examining factors such as total bioabsorption directly and indirectly through surrogate biomarkers, time to onset of effectiveness, flavor appeal and quality of effectiveness. Studies to-date have focused on cannabinoid applications where Lexaria is most advanced commercially, although research is underway for the other bioactive compounds named in Lexaria’s patent portfolio and described under Commercial Applications.
Pre-Clinical Research into Lexaria’s DehydraTECH™
An in vitro absorption study was performed to assess unidirectional CBD permeability using a human epi-intestinal tissue model with various formulations in the presence of simulated intestinal fluid. The study was designed to, as closely as possible, mimic intestinal absorption as it would occur in a live subject. Samples of Lexaria’s commercially available CBD-fortified ViPova™ black tea were administered in the model compared with concentration-matched CBD control preparations that lacked Lexaria’s patented formulation and process enhancements. The study showed as much as a 499% improvement, on average, in intestinal tissue permeability with the ViPova™ black tea formulation relative to a concentration-matched CBD control preparation without any Lexaria technology enhancements. The study also showed a 325% improvement, on average, in intestinal tissue permeability comparing the ViPova™ black tea preparation to a concentration-matched CBD control preparation that utilized Lexaria`s dehydration synthesis processing methodology but lacked its fatty acid ingredient incorporation, demonstrating the power of the Lexaria technology as a whole (see Figure 1).
Following this study, a series of independent, well designed, well controlled human focus studies were undertaken corroborating Lexaria’s in vitro performance findings. A study in healthy volunteers (n=6) suggested as much as a 5-10X increase in CBD absorption, which was assessed indirectly through measurement of the increase in salivary nitric oxide as a directly proportional surrogate biomarker, with onset of action in as little as 15-30 minutes. In all cases, the maximum increased level of salivary nitric oxide remained evident at the 60-minute end period of this particular test. Further testing is required to determine the full duration of elevated nitric oxide levels.
Thereafter, a blinded human focus study was conducted to evaluate the performance of THC-infused chocolates formulated using Lexaria’s DehydraTECH™ technology. This study compared the performance of the THC-infused chocolates powered by Lexaria’s technology to concentration matched THC-infused chocolates formulated using a commercial dextrin absorption enhancer. The subjects (n=12) that participated in this study indicated a clear preference on taste and overall effectiveness with the chocolates formulated using Lexaria’s technology, and onset of effectiveness was again observed very quickly, in as little as 15-20 minutes.
Lexaria Bioscience Corp’s disruptive new patented technology DehydraTECH™ is available to be licensed.
DehydraTECH can be used to improve existing products or to create new products. It is suitable for use with a wide range of consumer product formats including:
DehydraTECH is designed to be effective in delivering most fat-soluble molecules through the human gastrointestinal system and has also demonstrated affinity for transdermal applications and even effectiveness in crossing the blood-brain-barrier once within blood plasma. Lexaria has, or is conducting, in vitro, in vivo and human clinical testing, including pharmacokinetic data gathering, for the delivery of API’s through ingestible means. Test data has consistently pointed to reduced time required to enter the bloodstream, increased absorption rate, and reported improvements in taste and smell of edible products.
Contact us today to speak about your licensing needs at ablanchard@lexariabioscience.com
Terms and rights associated with our licensing opportunities are discussed on an individual basis.
Lexaria’s typical approach to working with a new prospective licensee is to effect confidentiality terms and then collaborate with the license prospect under a non-binding letter of intent to evaluate the feasibility and applicability of the Lexaria DehydraTECH technology for the license prospect`s needs. Following this, if the license prospect is satisfied with the performance enhancements delivered by the DehydraTECH technology, Lexaria then seeks to transition to a definitive fee bearing agreement structure between it and the new licensee.
We will license our technology in any of the more than 40 countries around the world where the DehydraTECH is patented or patent-pending. Licensees can feel confident that Lexaria’s extensive IP portfolio – constantly expanding – will help to provide a competitive edge and protection against inferior methodologies or older, outdated technology.
If your company works in a different but related field, please contact us if you’d like to conduct research on applicability for your specific application.
Licensees should also always remember that DehydraTECH costs less than a penny per serving to implement – sometimes a bare fraction of a penny. Licensees may experience an increase in market share or an increase in pricing power as a result of offering their customers superior delivery characteristics. Customers are loyal to the improved performance of DehydraTECH based products.
DehydraTECH is one of the world’s ONLY delivery technologies that does not require the addition of chemicals or intimidating, complex ingredients requiring disclosure on a food label. DehydraTECH works with commons GRAS ingredients that can be organic, gluten-free, and dairy free.
If your company works in a different but related field, please contact us if you’d like to conduct research on applicability for your specific application.
Masks taste/odor
Eliminates the strong tastes/odors of lipophilic compounds, without the need for unwanted sugar or sweeteners.
Reduces time of onset
Effects are felt within 15-20 min vs. 60-120 min.
Increases bio-absorption
Increases bio-absorption by 2 – 10x, to equate or exceed that of other routes of administration like inhalational delivery.
Avoids first-pass liver metabolism
Testing has evidenced that DehydraTECH may deliver molecules through the lymphatic system instead of being subject to immediate “first pass” liver exposure, potentially mitigating unwanted side effects. More recent testing in animals even demonstrated an ability to cross the blood-brain-barrier to a degree previously thought not possible.
Interview with CEO Chris Bunka
https://youtu.be/9bRSWYKIEL8
New Enhanced DehydraTECHTM formulation delivers 8X more CBD into blood and over 19X more CBD into brain tissue than standard industry formulations.
Kelowna, British Columbia – June 4, 2019 – Lexaria Bioscience Corp. (OTCQX: LXRP) (CSE: LXX) (the “Company” or “Lexaria”), a drug delivery platform innovator, has discovered improved performance characteristics of a new version of the DehydraTECHTM delivery platform initially suitable for use in solid oral dosage forms like capsules, tablets and pills for the pharmaceutical, medical, and supplement markets. Lexaria’s innovative use of a naturally sourced formulation enhancement more than doubles DehydraTECH’s absorption performance compared to previous DehydraTECH results demonstrated to-date. The Company has filed new patent applications related to the recent innovations.
BACKGROUND
On March 20, 2019 Lexaria announced it was beginning a series of animal studies with multiple objectives, including evaluating enhanced DehydraTECH formulations that might offer improved performance. Copious data streams have been generated from these tests and continue to be analyzed.
In this arm of animal study, Lexaria tested its DehydraTECH delivery technology with compounds postulated to behave in a synergistic fashion for enhancement of gastro-intestinal absorption, which resulted in significantly enhanced DehydraTECH performance (“Enhanced DehydraTECH”).
Of note, the new Enhanced DehydraTECH and its improved performance is separate and distinct from the nanotech improvement techniques recently announced by the Company.
TEST RESULTS
In each arm of the Lexaria animal studies, 10 male Sprague-Dawley rats were administered an identically sourced CBD at a rate of 25mg per kg of bodyweight. Delivery of CBD into the bloodstream was measured at 2; 4; 6; 8; 12; 15; 30; 45; and 60 minutes after dosing. DehydraTECH-enabled CBD was measurable in animal blood within 2 to 4 minutes after dosing.
On May 15, 2019 the Company reported that DehydraTECH achieved a CBD blood concentration level that was 475% more than a generic industry medium chain triglyceride (“MCT”) coconut-oil formulation 15 minutes after dosing. Today, the Company reports that Enhanced DehydraTECH led to 811% more CBD delivery into blood than generic industry MCT coconut-oil formulations (p=0.00008); and 110% more CBD into blood than DehydraTECH in its traditional format (p=0.02).
Also of note is that both traditional DehydraTECH and Enhanced DehyraTECH delivered maximum blood concentration levels prior to the 60-minute end-of-test, with levels tapering off thereafter. The DehydraTECH technology therefore demonstrates both fast onset and fast offset as tested which is of interest for dose titration purposes when repeated dosing is desired.
CONCLUSION
DehydraTECH’s in its traditional format has been used commercially by the Company since 2014; and by the Company’s technology licensees since 2016. Lexaria has consistently introduced leading innovation for oral cannabis formats such as capsules, beverages and edibles, with a focus on the consumer experience as measured by qualities such as taste, rapidity of onset and offset, and reliability of effect. Unique among the cannabis industry, DehydraTECH has proven itself equally transformative in other sectors such as the nicotine industry where Lexaria has licensed its technology to one of the largest nicotine products companies in the world.
Enhanced DehydraTECH seems particularly adept at delivering previously unreachable quantities of CBD across the blood brain barrier and into brain tissue; more so than even the most advanced nanotech as previously reported utilized in these studies. Since most human receptor cells of the CB1 variety and otherwise that are associated with the psychotropic effects of cannabinoids are located within the brain these findings significantly expand upon the power of Lexaria’s technology to reach the target site of action for these purposes.
With this new innovation, Lexaria is establishing new performance thresholds for drug delivery technology, with tested performance of 8x (blood plasma) and more than 19x (brain tissue) of generic industry formulations. The Company intends to perform further studies to fully characterize Enhanced DehydraTECH and will work throughout 2019 to optimize implementation into the best product applications for use by its licensees.
The animal test results announced to date have led to additional new patent applications based on the positive performance results achieved. The specific nature of enhanced DehydraTECH shall remain undisclosed for proprietary reasons until the new patent filings are published. Although the current tests were limited to CBD absorption, Lexaria expects knowledge from the current innovation to apply equally to tetrahydrocannabinol (THC) as well to enhance formulation innovation for nicotine and various pharmaceutical compounds already named within the Lexaria patent suite.
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