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Idera Pharmaceuticals, Inc. (IDRA)

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Last Post: 6/26/2017 3:50:40 PM - Followers: 159 - Board type: Free - Posts Today: 0

The Company has created DNA-based compounds that in preclinical studies act as antagonists of TLR7 and TLR9, such as IMO-3100, or as antagonists of TLRs 7, 8, and 9, such as IMO-8400. The Company is developing IMO-3100, an antagonist of TLR7 and TLR9, for the treatment of psoriasis. It has selected IMO-8400, an antagonist of TLRs 7, 8, and 9, for development in the treatment of autoimmune diseases, with lupus as the initial disease indication. IMO-2055, a TLR9 agonist, is its lead drug candidate for the treatment of cancer. Clinical trials of IMO-2055 completed by the Company or by Merck KGaA include four Phase I clinical trials, of which two were in healthy subjects and two were in refractory cancer patients, and one Phase II clinical trial. The Phase II clinical trial was a monotherapy trial of IMO-2055 in patients with metastatic or recurrent clear cell renal cancer.

In preclinical animal models, the Company TLR7, 8, and 9 agonists have shown adjuvant activity when combined with various types of antigens. It has designed and created a new class of molecules to inhibit gene expression. These gene silencing oligonucleotides, which it refer to as GSOs, are nucleic acid-based and represent a novel approach to selectively, silence gene expression. It is actively engaged in preclinical research with its GSOs that is designed to explore their potential as research reagents and therapeutic agents. In addition to the Company’s clinical programs in autoimmune and inflammatory diseases and in cancer, it has identified TLR drug candidates for applications in the treatment of infectious diseases, respiratory diseases and hematological malignancies, and TLR3 agonists for use as vaccine adjuvants.

IMO-2125, a synthetic DNA-based TLR9 agonist, is its lead candidate for the treatment of chronic hepatitis C virus (HCV), infection. The Company conducted two Phase I clinical trials of IMO-2125 in patients with chronic HCV infection, one in patients with HCV who had not responded to prior treatment and one in combination with ribavirin, an antiviral medication approved for use in combination with interferon-alpha in the treatment of HCV infection, in treatment-naive patients with genotype 1 chronic HCV infection. In addition to the use of TLR9 agonists in oncology applications, it selected IMO-4200 as a lead TLR7 and TLR8 agonist candidate for the treatment of hematological cancers. Its TLR9 agonists are designed to induce immune responses that could be useful in restoring immune system balance. IMO-2134 is its lead TLR9 agonist for asthma and allergies. In addition to use of TLR7, 8, and 9 agonists as vaccine adjuvants, it also has created TLR3 agonists for potential use as vaccine adjuvants.

The Company competes with Dynavax Technologies Corporation, GlaxoSmithKline plc., Pfizer, Inc., VentiRx Pharmaceuticals., Novartis, Dynavax Technologies Corporation, VaxInnate, Inc., Intercell AG, Cytos Biotechnology AG and Celldex Therapeutics, Inc.



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IDRA News: Idera Announces FDA Orphan Drug Designation for IMO-2125 for the Treatment of Melanoma 06/22/2017 04:30:00 PM
IDRA News: Statement of Changes in Beneficial Ownership (4) 06/09/2017 04:18:18 PM
IDRA News: Statement of Changes in Beneficial Ownership (4) 06/09/2017 04:18:18 PM
IDRA News: Statement of Changes in Beneficial Ownership (4) 06/09/2017 04:17:52 PM
IDRA News: Statement of Changes in Beneficial Ownership (4) 06/09/2017 04:17:25 PM
#2935   Started trading this again after a while away rivervalley 06/26/17 03:50:40 PM
#2934   Wouldn't be surprised to see it touch the Cbdpotential 06/26/17 10:55:11 AM
#2933   Yep, looks like it is just playing with Citrati 06/26/17 10:41:08 AM
#2932   Obviously ;-) hehe Nice buying opportunity today (now) imo Hope Cbdpotential 06/26/17 10:37:20 AM
#2931   I feel as a business only strategy. That chriswolff 06/26/17 06:02:21 AM
#2930   2 hours ago Motley Fool quoted another article Citrati 06/24/17 01:31:34 PM
#2929   Shorts very active Friday, caught by surprise with the gipper 06/24/17 08:18:08 AM
#2928   Surprised this isn't flying. Mms? docprep 06/23/17 02:23:46 PM
#2927   Congrats Those with impatience and/or little dd will be Citrati 06/23/17 12:45:47 AM
#2926   I've been adding recently And a bit frustrating watching Cbdpotential 06/22/17 10:56:50 PM
#2925   Key phrase is "we are increasingly encouraged with jaybe 06/22/17 09:40:45 PM
#2924   Idera Announces FDA Orphan Drug Designation for IMO-2125 Cbdpotential 06/22/17 08:49:11 PM
#2923   Nice! Cbdpotential 06/22/17 08:48:28 PM
#2922   Orphan Drug Designation. Nice 15% pop after hours... Stockdoggy 06/22/17 06:24:25 PM
#2921   No chart? attilathehunt 06/20/17 03:30:14 PM
#2920   Several happy chart indicators. Citrati 06/20/17 03:28:26 PM
#2919   Come on IDRA make this the bottom. Citrati 06/15/17 11:25:35 PM
#2918   It may be bottoming, but it doesn't seem Cre8tivmynd 06/13/17 01:46:25 PM
#2917   So far today price tested our recent low Citrati 06/12/17 11:07:26 AM
#2916   Actually, IMO, the chart looks to be bottoming Citrati 06/07/17 06:36:29 PM
#2915   It's not looking promising. Cre8tivmynd 06/07/17 02:02:00 PM
#2914   There is day 2 for price above the 4ema. Citrati 06/02/17 11:12:20 PM
#2913   Good call rocket. attilathehunt 06/02/17 02:18:53 PM
#2912   Added 1.73 $IDRA , Greece ;-) Cbdpotential 06/02/17 01:52:24 PM
#2911   Couldn't help but buy a slug at 1.57 rocketeer357 05/31/17 12:52:54 AM
#2910   You would think we are about there, but Citrati 05/30/17 03:23:56 PM
#2909   Geez...@ $1.57, How oversold does this need to go?? Cre8tivmynd 05/30/17 02:47:49 PM
#2908   I don't think that is an unreasonable target. Citrati 05/19/17 11:33:57 PM
#2907   Need some volume! Cbdpotential 05/15/17 08:40:55 PM
#2906   3$+ by eoy Imo Cbdpotential 05/15/17 07:49:20 PM
#2905   Check out all the changes in tutes recently.. Citrati 05/12/17 04:27:33 PM
#2904   GREEN ! $IDRA Get ready folks ;) Cbdpotential 05/10/17 09:21:50 PM
#2903   How about that. After 9 red days a Citrati 05/10/17 10:06:37 AM
#2902   Not yet. 3rd day outside the lower bb Citrati 05/09/17 09:51:00 AM
#2901   Will be interesting to see if IDRA has Citrati 05/07/17 08:44:10 PM
#2900   Just increased my pos by 25% at 1,9, Radar_Mi 05/05/17 12:48:50 PM
#2899   You know it just might be. The amount Citrati 05/05/17 10:34:47 AM
#2898   Shake out before the ever so massive breakout. THEPK5 05/04/17 12:55:25 PM
#2897   Shake out before the break out! THEPK5 05/04/17 11:26:09 AM
#2896   Excerpt from post on another site. Citrati 05/04/17 10:36:57 AM
#2895   I am no savant, but as near as Citrati 05/03/17 09:39:05 PM
#2894   Haha, you jump right to the bottom target Citrati 05/03/17 03:33:39 PM
#2893   1.65? Cbdpotential 05/03/17 03:07:13 PM
#2892   What is your target on that trigger(s)? If you Cbdpotential 05/03/17 03:06:39 PM
#2891   Congrats. Save some powder in case we test closer Citrati 05/02/17 08:38:05 PM
#2890   Adding some trading shares back 2.2's Cbdpotential 05/02/17 11:11:40 AM
#2889   Annual SH meeting. Citrati 04/28/17 05:46:32 PM
#2888   Your comments are helpful. Thanks... Stockdoggy 04/27/17 06:58:32 AM
#2887   Pillar actually, sold 437,829 Monday and 890,593 on Citrati 04/26/17 07:08:06 PM
#2886   Very good response and I do agree, in Farmmarket1 04/26/17 06:29:20 PM