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Idera Pharmaceuticals, Inc. (IDRA)

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IDRA [NASD]     https://www.otcmarkets.com/stock/IDRA/overview
Idera Pharmaceuticals, Inc.

TRANSFORMING IMMUNITY. RESTORING HOPE.

We’re devoted to redefining the treatment of cancer and rare diseases where serious unmet needs exist.
https://www.iderapharma.com/our-company/
https://www.iderapharma.com/who-we-help/
https://www.iderapharma.com/our-approach/toll-like-receptor-immune-modulation/

Toll-like receptors (TLRs) are a class of proteins that are an important part of the innate immune system.
They alert the body to potential danger by recognizing pieces of bacteria, viruses, or damaged cells.
They essentially act like a smoke alarm, warning the body when trouble is detected.

Our lead investigational agent, tilsotolimod, activates TLR9. In cancer patients with solid tumors,
tilsotolimod is injected directly into a tumor to trigger TLR9 into action and prime a local immune response to help attack the tumor.
This has been demonstrated in pre-clinical models, and our translational studies during early clinical trials have shown rapid immune
activation in the injected tumor along with systemic increases in T cells.

Idera is investigating the combination of tilsotolimod with checkpoint inhibitors and other immune activators with the aim of providing improved outcomes for patients in need.
https://www.iderapharma.com/our-approach/key-publications/
https://www.iderapharma.com/areas-of-focus/oncology/immuno-oncology/
https://www.iderapharma.com/pipeline-programs/

Tilsotolimod (IMO-2125) Program

TUMOR TYPE
TRIAL REGIMEN COLLABORATOR PHASE 1 PHASE 2 PIVOTAL APPROVED
Anti-PD-1 Refractory Advanced Melanoma
ILLUMINATE-301 tilsotolimod +
ipilimumab
       
Microsatellite-Stable Colorectal Cancer
ILLUMINATE-206 tilsotolimod +
ipilimumab/ nivolumab
       
Resistant Solid Tumors
ILLUMINATE-101 tilsotolimod
monotherapy
       
Recurrent/Metastatic Head & Neck Squamous Cell Carcinoma
AbbVie-Sponsored Trial tilsotolimod +
ABBV-368 (OX-40)
       
 

1 Tilsotolimod is an investigational agent which has not been approved by any regulatory authority

https://ir.iderapharma.com/news-releases/news-release-details/idera-pharmaceuticals-announces-corporate-updates

https://www.iderapharma.com/careers/

https://finviz.com/quote.ashx?t=idra&ty=c&ta=1&p=d

[-chart]finviz.com/chart.ashx?t=idra&ty=c&ta=1&p=d&s=l[/chart]
 
 

$IDRA FIVE YR.

 

IDRA [NASD]
Idera Pharmaceuticals, Inc.
Healthcare | Biotechnology | USA
Shs Outstand 41.19M
Shs Float 38.72M    ,   
Short Float 9.57%
52W Range 0.97 - 6.14
 
52W High -81.76%
Insider Own 1.30%
Inst Own 19.70%
Book/sh 1.03
Cash/sh 0.84
Employees 32
Debt/Eq 0.00   no short term either





The Company has created DNA-based compounds that in preclinical studies act as antagonists of TLR7 and TLR9,
such as IMO-3100, or as antagonists of TLRs 7, 8, and 9, such as IMO-8400.
The Company is developing IMO-3100, an antagonist of TLR7 and TLR9, for the treatment of psoriasis.
It has selected IMO-8400, an antagonist of TLRs 7, 8, and 9, for development in the treatment of autoimmune diseases, with lupus as the initial disease indication.
IMO-2055, a TLR9 agonist, is its lead drug candidate for the treatment of cancer. Clinical trials of IMO-2055 completed by the Company
or by Merck KGaA include four Phase I clinical trials, of which two were in healthy subjects and two were in refractory cancer patients, and one Phase II clinical trial.
The Phase II clinical trial was a monotherapy trial of IMO-2055 in patients with metastatic or recurrent clear cell renal cancer.


In preclinical animal models, the Company TLR7, 8, and 9 agonists have shown adjuvant activity when combined with various types of antigens.
It has designed and created a new class of molecules to inhibit gene expression. These gene silencing oligonucleotides, which it refer to as GSOs,
are nucleic acid-based and represent a novel approach to selectively, silence gene expression.
It is actively engaged in preclinical research with its GSOs that is designed to explore their potential as research reagents and therapeutic agents.
In addition to the Company’s clinical programs in autoimmune and inflammatory diseases and in cancer,
it has identified TLR drug candidates for applications in the treatment of infectious diseases, respiratory diseases and hematological malignancies,
and TLR3 agonists for use as vaccine adjuvants.


IMO-2125, a synthetic DNA-based TLR9 agonist, is its lead candidate for the treatment of chronic hepatitis C virus (HCV), infection.
The Company conducted two Phase I clinical trials of IMO-2125 in patients with chronic HCV infection,
one in patients with HCV who had not responded to prior treatment and one in combination with ribavirin,
an antiviral medication approved for use in combination with interferon-alpha in the treatment of HCV infection, in treatment-naive patients with genotype 1 chronic HCV infection.
In addition to the use of TLR9 agonists in oncology applications, it selected IMO-4200 as a lead TLR7 and TLR8 agonist candidate for the treatment of hematological cancers.
Its TLR9 agonists are designed to induce immune responses that could be useful in restoring immune system balance. IMO-2134 is its lead TLR9 agonist for asthma and allergies.
In addition to use of TLR7, 8, and 9 agonists as vaccine adjuvants, it also has created TLR3 agonists for potential use as vaccine adjuvants.


The Company competes with Dynavax Technologies Corporation,
GlaxoSmithKline plc.,
Pfizer, Inc.,
VentiRx Pharmaceuticals.,
Novartis,
Dynavax Technologies Corporation,
VaxInnate, Inc.,
Intercell AG,
Cytos Biotechnology AG and
Celldex Therapeutics, Inc.

http://www.iderapharma.com/








 

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02-07-2021
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IDRA News: Idera Pharmaceuticals Shares Positive Results from Investigator-Sponsored Trial in Melanoma Patients at Amsterdam UMC 05/17/2022 04:04:46 AM
IDRA News: Current Report Filing (8-k) 05/05/2022 12:41:29 PM
IDRA News: Idera Pharmaceuticals Reports First Quarter 2022 Financial Results and Provides Corporate Update 05/05/2022 12:15:00 PM
IDRA News: Additional Proxy Soliciting Materials (definitive) (defa14a) 04/29/2022 12:16:04 PM
IDRA News: Statement of Changes in Beneficial Ownership (4) 04/05/2022 01:05:39 PM
PostSubject
#3425   Idera Pharmaceutical (IDRA) mick 05/01/22 04:03:49 PM
#3424   Why isnt this dying dog dead yet? What urge2surge 04/23/22 10:50:06 AM
#3423   Idera Pharmaceutical (IDRA) mick 03/12/22 03:04:58 PM
#3422   Stinky poop pile eh? Big fat nothing burger...lol. urge2surge 02/16/22 05:38:17 PM
#3421   Someone needs to take this dying dog to urge2surge 02/08/22 05:14:47 PM
#3420   Idera Pharmaceutical (IDRA) mick 02/06/22 06:01:22 PM
#3419   Last one out, turn off the lights. Nothing urge2surge 02/05/22 06:23:27 AM
#3418   Lmao..what a dog pile.. A dead dog with urge2surge 02/02/22 11:30:05 AM
#3417   Idera Pharmaceutical (IDRA) mick 01/18/22 02:35:22 PM
#3416   holding $idra mick 01/18/22 02:35:13 PM
#3415   Block of 10,000 traded pre-market at .72 news The Canes 01/18/22 08:36:29 AM
#3414   Recent Trades - Last 10 of 674 mick 01/05/22 01:50:14 PM
#3413   Idera Pharmaceutical (IDRA) mick 01/05/22 01:49:34 PM
#3412   Somebody bought a block of 30,000 at .645 The Canes 01/04/22 09:38:22 AM
#3411   nice thank you fer sharing Idera Pharmaceutical (IDRA) mick 01/04/22 09:26:59 AM
#3410   Picked up a bunch at .53 cents on The Canes 01/04/22 09:22:09 AM
#3409   https://www.otcmarkets.com/stock/IDRA mick 01/02/22 06:18:57 PM
#3408   What's up homeless harry?? Cat got the tongue? urge2surge 12/16/21 05:00:36 PM
#3407   Clean up at card board box Kenny's residence..poop urge2surge 12/14/21 04:52:29 PM
#3406   https://www.otcmarkets.com/stock/IDRA mick 12/11/21 07:27:22 PM
#3405   Sure you do cardboard Kenny. You hang in urge2surge 12/10/21 08:45:06 AM
#3404   You knew? Sure our Lake has a McDonald's The Canes 12/10/21 08:38:45 AM
#3403   So your actually living in a card board urge2surge 12/09/21 09:19:13 PM
#3402   Actually single-wide I live in a gated community The Canes 12/09/21 07:06:46 PM
#3401   Lmfao...some seriously funny shit there. Sounds like your urge2surge 12/09/21 04:28:17 PM
#3400   I posted on 10/25 there would be another The Canes 12/09/21 08:54:49 AM
#3399   Lol...you've been AWOL and you come out after urge2surge 12/08/21 06:44:16 PM
#3398   Young Urgie as I predicted in my post The Canes 12/08/21 03:00:29 PM
#3397   Let's go! MOVE IT ON UP! Insider urge2surge 12/08/21 02:10:53 PM
#3396   Another clean up on all the aisles...lol.. urge2surge 12/03/21 04:35:03 PM
#3395   Nyuck Nyuck..;&) urge2surge 11/22/21 04:54:25 PM
#3394   Yeehaw...it's a great holiday season here! Keep up urge2surge 11/20/21 08:15:50 AM
#3393   Loving the love and hugs here! The easiest urge2surge 11/18/21 04:08:42 PM
#3392   Riflmfao...big time.. urge2surge 11/17/21 04:59:08 PM
#3391   Zero turn crash and burn...nyuk nyuk... urge2surge 11/16/21 07:17:38 PM
#3390   Lmfao..clean up in aisle 9,10, and 12.... Junk! urge2surge 11/16/21 10:49:43 AM
#3389   Idera Pharmaceutical (IDRA) mick 11/07/21 12:32:15 PM
#3388   Another clean up or is this the moment urge2surge 11/03/21 04:29:32 PM
#3387   Clean up in aisle 9... Price check on urge2surge 10/29/21 04:42:26 PM
#3386   Should be a menstruation s company seeing all urge2surge 10/25/21 09:29:37 AM
#3385   It's over your head and I apologize for The Canes 10/25/21 09:15:49 AM
#3384   Not only do you have terrible sentence structure, urge2surge 10/21/21 09:06:41 AM
#3383   The dotard has sunk to new lows! The Canes 10/19/21 07:51:07 PM
#3382   if you want to learn to how to urge2surge 10/19/21 05:21:30 PM
#3381   I've seen pitiful responses but you're the gold The Canes 10/19/21 08:42:48 AM
#3380   What a moron... Just like this company.. urge2surge 10/18/21 09:13:21 AM
#3379   It's not "to stupid" it's "too stupid". Elementary The Canes 10/17/21 08:57:42 PM
#3378   Drop this pig.. urge2surge 10/10/21 06:15:42 PM
#3377   A big steamy dog pile here. 50 cents urge2surge 10/08/21 09:00:48 AM
#3376   Beat this dog down like the dog it is...poc.. urge2surge 09/30/21 11:55:06 AM
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