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Idera Pharmaceuticals, Inc. (IDRA)

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Last Post: 9/15/2020 6:46:10 PM - Followers: 133 - Board type: Free - Posts Today: 0



The Company has created DNA-based compounds that in preclinical studies act as antagonists of TLR7 and TLR9, such as IMO-3100, or as antagonists of TLRs 7, 8, and 9, such as IMO-8400. The Company is developing IMO-3100, an antagonist of TLR7 and TLR9, for the treatment of psoriasis. It has selected IMO-8400, an antagonist of TLRs 7, 8, and 9, for development in the treatment of autoimmune diseases, with lupus as the initial disease indication. IMO-2055, a TLR9 agonist, is its lead drug candidate for the treatment of cancer. Clinical trials of IMO-2055 completed by the Company or by Merck KGaA include four Phase I clinical trials, of which two were in healthy subjects and two were in refractory cancer patients, and one Phase II clinical trial. The Phase II clinical trial was a monotherapy trial of IMO-2055 in patients with metastatic or recurrent clear cell renal cancer.


In preclinical animal models, the Company TLR7, 8, and 9 agonists have shown adjuvant activity when combined with various types of antigens. It has designed and created a new class of molecules to inhibit gene expression. These gene silencing oligonucleotides, which it refer to as GSOs, are nucleic acid-based and represent a novel approach to selectively, silence gene expression. It is actively engaged in preclinical research with its GSOs that is designed to explore their potential as research reagents and therapeutic agents. In addition to the Company’s clinical programs in autoimmune and inflammatory diseases and in cancer, it has identified TLR drug candidates for applications in the treatment of infectious diseases, respiratory diseases and hematological malignancies, and TLR3 agonists for use as vaccine adjuvants.


IMO-2125, a synthetic DNA-based TLR9 agonist, is its lead candidate for the treatment of chronic hepatitis C virus (HCV), infection. The Company conducted two Phase I clinical trials of IMO-2125 in patients with chronic HCV infection, one in patients with HCV who had not responded to prior treatment and one in combination with ribavirin, an antiviral medication approved for use in combination with interferon-alpha in the treatment of HCV infection, in treatment-naive patients with genotype 1 chronic HCV infection. In addition to the use of TLR9 agonists in oncology applications, it selected IMO-4200 as a lead TLR7 and TLR8 agonist candidate for the treatment of hematological cancers. Its TLR9 agonists are designed to induce immune responses that could be useful in restoring immune system balance. IMO-2134 is its lead TLR9 agonist for asthma and allergies. In addition to use of TLR7, 8, and 9 agonists as vaccine adjuvants, it also has created TLR3 agonists for potential use as vaccine adjuvants.


The Company competes with Dynavax Technologies Corporation, GlaxoSmithKline plc., Pfizer, Inc., VentiRx Pharmaceuticals., Novartis, Dynavax Technologies Corporation, VaxInnate, Inc., Intercell AG, Cytos Biotechnology AG and Celldex Therapeutics, Inc.

http://www.iderapharma.com/

 


 

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IDRA News: Idera Pharmaceuticals to Present Tilsotolimod Data at ESMO Virtual Congress 2020 09/15/2020 07:18:10 AM
IDRA News: Statement of Changes in Beneficial Ownership (4) 09/04/2020 07:04:00 PM
IDRA News: Statement of Changes in Beneficial Ownership (4) 09/04/2020 07:02:35 PM
IDRA News: Current Report Filing (8-k) 09/03/2020 08:37:42 AM
IDRA News: Prospectus Filed Pursuant to Rule 424(b)(5) (424b5) 09/03/2020 08:26:37 AM
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#3294   Just In: $IDRA Idera Pharmaceuticals to Present Tilsotolimod whytestocks 09/15/20 06:46:10 PM
#3293   Nothing happening here except stock options being given paperman 07/27/20 11:13:37 AM
#3292   Agree dinogreeves 07/22/20 02:13:41 PM
#3291   We need something positive to happen here paperman 07/22/20 02:06:05 PM
#3290   No, just waiting on news. dinogreeves 07/20/20 07:20:16 PM
#3289   Anything new on idra today, looks like it paperman 07/20/20 07:11:00 PM
#3288   Well, looks like it's going to pop Monday paperman 07/18/20 06:49:45 PM
#3287   I owned IDRA some time ago (in part nsomniyak 07/18/20 03:19:51 PM
#3286   That is very true, it is all about dinogreeves 07/18/20 03:17:36 PM
#3285   Baker Brothers do indeed have a very good nsomniyak 07/18/20 03:12:36 PM
#3284   Whenever you see them on biotech almost a dinogreeves 07/18/20 11:28:55 AM
#3283   Thank you, I think I'll wait for paperman 07/18/20 10:47:32 AM
#3282   The Baker Brothers are very highly regarded hedge The Canes 07/18/20 09:35:52 AM
#3281   What does that mean? paperman 07/18/20 08:36:52 AM
#3280   Ah!!!! I see, baker brothers own this dinogreeves 07/17/20 06:23:26 PM
#3279   If they have news next week then no, dinogreeves 07/17/20 05:56:56 PM
#3278   Is too late to buy? paperman 07/17/20 05:54:59 PM
#3277   Looks like IDRA could reach DVA*X market cap dinogreeves 07/17/20 05:54:45 PM
#3276   Over one million volume, something tells me data dinogreeves 07/17/20 05:33:35 PM
#3275   You were right over $3.00 post market...only took The Canes 07/17/20 04:20:28 PM
#3274   * * $IDRA Video Chart 06-02-2020 * * ClayTrader 06/02/20 05:53:08 PM
#3273   3+Dollars very soon!! percival77 04/22/20 09:55:54 AM
#3272   Insiders and institutions must know something,,they are loading percival77 04/21/20 09:40:31 PM
#3271   Actually PMs on IDRA board percival77 04/21/20 09:34:31 PM
#3270   Stock is up from 80 Cents!! percival77 04/21/20 09:31:16 PM
#3268   $IDRA target price percival77 04/20/20 01:46:45 PM
#3267   Apparently after closing hours on a short trading jahyde 04/11/20 05:41:39 PM
#3266   Insider Short swing realized. Smh jahyde 04/10/20 10:06:05 AM
#3265   Likewise why I added a position too rocknroll350 03/03/20 09:20:52 AM
#3264   whyte I notice that the Baker Brothers own 4.6 gandalf50 02/20/20 02:26:54 PM
#3263   * * $IDRA Video Chart 12-23-2019 * * ClayTrader 12/23/19 05:30:18 PM
#3262   News: $IDRA Idera Pharmaceuticals Announces Private Placement Up whytestocks 12/23/19 12:19:16 PM
#3261   Haven't posted here in a while but I rivervalley 10/26/19 02:03:32 PM
#3260   News: $IDRA Idera Pharmaceuticals Announces Initiation of the whytestocks 09/30/19 12:50:28 PM
#3259   News: $IDRA Idera Pharmaceuticals Announces Immuno-Oncology Clinical Rese whytestocks 09/04/19 11:51:10 AM
#3258   In 1500 shares @ 2.27. This turd Black sunshine 08/23/19 09:45:24 PM
#3257   * * $IDRA Video Chart 05-06-2019 * * ClayTrader 05/06/19 06:00:03 PM
#3256   * * $IDRA Video Chart 05-03-2019 * * ClayTrader 05/03/19 05:52:08 PM
#3255   Fun fun! 420man 03/13/19 08:23:31 AM
#3254   This was one of my cannabinoid plays Had Cbdpotential 01/25/19 03:54:47 PM
#3253   * * $IDRA Video Chart 08-15-18 * * ClayTrader 08/15/18 05:16:54 PM
#3252   * * $IDRA Video Chart 08-14-18 * * ClayTrader 08/14/18 05:28:50 PM
#3251   * * $IDRA Video Chart 08-09-18 * * ClayTrader 08/09/18 05:37:40 PM
#3250   This is a Great time for News with dwh 07/29/18 09:05:16 PM
#3249   Guess everyone saw the AH 1-8 r/s that Citrati 07/27/18 11:19:53 PM
#3248   Citrati, what do you think of IDRA at LGviolet 07/24/18 03:53:34 PM
#3247   If anyone still cares. Citrati 07/24/18 12:12:23 PM
#3246   * * $IDRA Video Chart 07-18-18 * * ClayTrader 07/18/18 05:31:28 PM
#3245   i was wrong...BIG TROUBLE here noretreat 07/18/18 12:32:37 PM
#3244   Anyone know what is happening here? snoyzflake 07/18/18 12:04:22 PM
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