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Come on, covid is over... I agree with the others that the asset is gone, we're left with an empty shell.
We have to assume that Humanigen has a license to use lenz, since Taran bought the IP...or, we just need to see the merger or business combination between Taran and Humanigen. I think that Humanigen has every intention to use lenz for covid, or Durrant would have simply bought out Humanigen.
HI JAY, HOPE ALL IS WELL ... SIMLE QUESTION: DOES HGEN STILL OWN OR HAVE RIGHTS TO LENZ??? _____ IF NOT, WHAT THEN? ... CORPORATE SHELLS CAN RE-EVOLVE INTO PROSPERING ENTITIES BUT MUST HAVE THE BONES TO BUILD UPON, THANX ....
Yes, I think that WAS the Big Pharma/Government objective, to keep us dependent on them.
But, too much evidence is surfacing that the mRNA vaccines (maybe even the adenovirus ones), are causing excess deaths. And I hope that Durrant is going to capitalize on the British Parliament's intent to put a stop to that, and the MHRA may finally approve lenz for covid.
Yes and no, ben. Durrant has gotten FDA approval of many drugs throughout his career, including several that proved to be blockbusters. So I think that demonstrates that he is actually an expert at knowing "what it takes to get a drug approved."
But that also means that regulators can't bullshit him. Yet, that is what they are trying to do. So Durrant knows what he has to do now.
The thing I like about Novavax is that they got regulatory approval from countries all around the world, before trying to get FDA approval in the US. The CEO they had was smart enough to do that, but fell short of managing operations afterwards. So they have a new CEO, and he seems better at managing operations. And I hope they end up partnering with Humanigen, and use lenz as a vaccine enhancement.
But we need lenz approved by a regulator, and I think the UK will finally be the regulator that approves lenz? Why? Because they have to.
My focus lately has been been on the UK's response to reality. I've been showing videos that graphically demonstrate that reality (for my reference, I'm talking about post numbers 42034 and 42035). Still, there is enough video evidence that I've been permitted to show that Humanigen's/Taran's lenz should be used in place of the mRNA vaccines. The proof is incontrovertible.
Not only are doctors/embalmers seeing novel presentations of the deadly blood clots they are finding post-mortem, actuaries and researchers are substantiating the physical evidence with statistical evidence. They are demonstrating multiple findings, such as significant excess deaths, in those patients who had mRNA vaccines.
In Durrant's post (which I still can't find) about Taran's objectives going forward, he didn't specifically mention covid. I hope, however, that's because Humanigen may continue that effort after they recall their loaned shares, and therefore have the funds to proceed.
Big Pharma did not want anything that would actually treat Covid to come out. It was always about the Vaccine and will always be about the Vaccines.
Let's just get it back to $18 dollars again and there would be no complaints from me! LOL :))))
Management gets the blame because they don't understand what it takes to get a drug approved. They couldn't get it over the finish line. That is their job. That is what they get paid for, drug approval. A coach can have the best team in the world but if they don't win a championship, the coach and team is subpar. And that is this management, subpar
Hey Jay, I must have missed this somewhere in the last couple of years. Could you please link or paste where this comes from?
prevents the virus from infecting the intended receptor cells.
This is what management did.
"Effect of CRP<150 mg/L on SWOV and secondary endpoints in
LIVE-AIR
In participants with baseline CRP <150 mg/L, lenzilumab
improved the likelihood of SWOV compared with placebo
(HR: 2.54; 95% CI 1.46 to 4.41; nominal p=0.0009; table 2a,
figure 2B). Separation of the survival curves appeared earlier
than in the overall population and followed a similar pattern
as the overall population thereafter (figure 2B). The number
needed to treat (NNT) was nine for this group compared with
17 for the overall population (table 2A). SWOV, in response to
lenzilumab treatment, was similar to placebo in participants with
CRP ≥150 mg/L at baseline (table 2A and figure 2C). The NNT
for this group was 37 (table 2A)"
https://thorax.bmj.com/content/thoraxjnl/early/2022/07/05/thoraxjnl-2022-218744.full.pdf
How can you look at those results, and NOT blame the FDA for withholding our EUA? That shows stellar performance of lenzilumab, captured brilliantly by the LIVE-AIR trial investigators.
Nice Braveheart speech. Management should have never gone it alone. They were greedy and hurt shareholders. They failed in their fiduciary responsibility. They must be horrible doctors if this is how they view fulfilling oaths
The disgrace belongs to people like us, for failing to demand accountability from our government, who focuses on "government of the people," and never has to worry about that governance being exercised "by the people, and for the people." All discretionary authority should be rescinded from government agencies.
But, in our case, management didn't intend to treat covid, when they took over the company, which was almost 3 years before covid arrived. When the disease hit, management had no choice but to put lenzilumab into the fight. They were right to do so. They are doctors bound by an Hippocratic Oath.
"I shall work with my profession to improve the quality of medical care and to improve the public health, but I shall not let any lesser public or professional consideration interfere with my primary commitment to provide the best and most appropriate care available to each of my patients."
Lenzilumab is the only therapeutic that binds GM-CSF and prevents the virus from infecting the intended receptor cells. And as importantly, it imbues an appropriate immune response to prevent future infections. Even now, our MOA offers the most effective solution to fight covid.
Where would the world be right now, if the FDA had approved our EUA application in May of 2021?
https://ir.humanigen.com/English/news/news-details/2021/-Humanigen-Submits-Application-to-FDA-for-Emergency-Use-Authorization-for-Lenzilumab-in-COVID-19/default.aspx
Instead, where are we now? We have covid deaths ranging from 7M - 20M, by some estimates. AND, we have no safe and effective TRUE vaccine, nor do we have a safe and effective therapeutic, both of which we would likely have, if lenz was approved. This is no time to still our voices, and surrender. Preventable deaths are occurring every single day.
And this is why Humanigen's management is a disgrace. They should have never tried to challenge the system. They were too pigheaded. I am not saying I agree with the big pharma game, but big pharma controls the rules and Humanigen screwed all of the shareholders by trying to buck the system
Big Pharma provides 65% of FDA funding, and 86% of MHRA funding.
This is according to Dr. Aseem Malhotra, as he claimed in an interview with Tucker. If this is true, how can a small biotech like Humanigen, even with a mega-blockbuster drug, which lenzilumab is, ever get Regulatory approval?
See minute mark 23:50 of the video linked below.
Andrew Bridgen, MP, requests meeting with Scotland Yard, "...regarding, "Very serious criminal offences to name but a few, Misconduct in Public Office, Misfeasence in Public Office, Gross Negligent Manslaughter, Corporate Manslaughter, Fraud, Murder, Manslaughter and Grievous Bodily Harm,.." and more, regarding the Coronavirus pandemic and vaccination program.
https://www.linkedin.com/posts/andrewpearce_andrew-bridgen-mp-abridgen-on-x-activity-7171096018267131904-dnT4
This is of significant relevance to Humanigen, as an appropriate Regulatory response would include the authorization and approval of lenzilumab to treat covid prophylactically as a vaccine adjuvant, and therapeutically.
The safety and efficacy of lenz has resulted in meeting the primary endpoint in the company-sponsored LIIVE-AIR trial, and the results have been peer-reviewed by both Lancet and Thorax.
https://www.humanigen.com/
Novel presentations of blood clots, including long white fibrous strands of blood clots, are being discovered in the bodies of patients who had multiple mRNA vaccinations. They have also resulted in covid spike proteins located in organs such as the brain and heart. as shown in the following videos.
LOL :) That was pretty good, and you almost made me choke on my coffee. LOL You are right in that we at least have the hat! :))
I think the only rabbit out of the hat trick was pulled by Durrant taking everything that had value in HGEN for $2milly and leaving shareholders with an empty hat haha!
At least we still have the hat, maybe someone will put something in it worth a dime or two a share in future….
Edit "...6.9M American,,," should have read 6.9M worldwide deaths. Americans accounted for 1.123M of the total deaths as of one year ago.
https://coronavirus.jhu.edu/map.html
Unfortunately, this is what I am seeing too. I am an eternal optimist, but I just don't see how this is good for HGEN shareholders???
Like Yourself I am hoping someone can buy the shell and get us relisted again and that maybe we can get a nice run to .05 to .10 cents if we're lucky?
At least we are chapter11 and the stock will survive. The shell should be worth something in the future here especially being debt free after the bankruptcy is discharged.
I would absolutely love to see a rabbit pulled out of the hat here, and Jay somehow be right! I would love that more than anything else, but it looks like Taran got the Gold and while we got the Shaft. LOL
Dr Durant: Following an amazing eight-year, hugely intense journey at Humanigen, we recently closed the acquisition of the Humanigen assets and placing them in Taran, a Delaware C-corporation, with UK and Australian wholly-owned subsidiaries.
Where have you been, OneDay? What I saw yesterday was hardly a sign of short covering.
"The short sale volume percent (not short interest) for stock ticker HGENQ is 99.74% on Mar 08, 2024. The short sale volume is 190,171. The total volume is 190,671."
http://shortvolumes.com/?t=hgenq
Maybe some brokerage was caught charging a client short interest, without having secured a locate.
Thank you, JA3. I am of Irish, German, and Welsh descent, myself. I was glad to see a male choir from Wales perform on Britain's Got Talent last year. I thought BGT judge Amanda Holden was simply going to melt, just listening to them. I definitely could have blended right in with those guys, without buying a new wardrobe. I wonder if I had family in that group, LOL! I just felt right at home with them.
All the volume since delisting is the shorts covering ??
Taran got the assets, we have worthless stock that can barely be given away lol!
Maybe this will be a shell that gets pumped and dumped for a run with claims of getting into Artificial Intelligence or something.
It’s a post by Cameron:
Following an amazing eight-year, hugely intense journey at Humanigen, we recently closed the acquisition of the Humanigen assets and placing them in Taran, a Delaware C-corporation, with UK and Australian wholly-owned subsidiaries.
Taran is focused on helping bring life-saving medicines to patients, including lenzilumab ("LENZ") and ifabtotuzumab ("IFAB") in various leukemias, Graft vs. Host Disease and cancer, with possibilities in multiple other areas of high unmet medical need.
Taran is the Welsh word for "thunder". My wife bred a beautiful male Welsh cob foal, who was born during a thunderstorm and named him Taran.
The choice of Taran for the new company name honors her memory, as well as the beauty, pride and strength of the Welsh people and language and the physical and mythical power of thunder as an unstoppable force.
"Moderna pays US government $400M 'catch-up payment' under new COVID-19 vaccine license
By Eric SagonowskyFeb 24, 2023"
https://www.fiercepharma.com/pharma/moderna-pays-us-government-400m-catch-payment-under-new-covid-19-vaccine-license
Wut da problem is?
Good to see you, JA3. Your link just took me a Linked-In sign in page. I don't have a Linked-In account.
Just FYI: Wegovy approved in U.S. for heart benefits, which may expand insurance coverage https://www.cnbc.com/2024/03/08/novo-nordisks-wegovy-wins-fda-approval-for-heart-health-benefits-in-move-that-could-expand-insurance-coverage.html?__source=iosappshare%7Ccom.apple.UIKit.activity.CopyToPasteboard
Sincerely I hope you are right obviously, but I just can’t see it going through that way, that’s only from what I have seen with other bankruptcy plays, but who knows…Kalibios and Humanigen have surprised me before.
It made sense to me, as I said in a previous post, to transfer the IP rights to Taran to safeguard the IP in the event that the bankruptcy court judge converted the case to CH7, in which case the IP would have been included in the sale.
Did Humanigen have entitlement to sells revenue earned by our Korean partner, simply because we owned the IP? No.
Nor would Taran have entitlement to sells revenue earned by Humanigen.
We just haven't see the details yet regarding licensing, or a possible merger. What we DO know is that Taran did not submit a tender offer to buy Humanigen, which is the only way Taran could claim sells revenue. But again, as Asset Purchase Agreement is not a buy-out.
Let's say HGENQ has to start over from scratch. As this appears to be the case. What one entity or person would benefit the most from its future success?
I hope you are right, truly do. Just would be super astonished.
How would it be Humanigen’s revenue stream? It belongs to Durrant and Taran, there may be some measly payouts down the road that could make this worth a couple of cents but it would still have to regain currency for that to matter.
If Lenz was going to be HGEN’s revenue stream why spend 2 million dollars to take it to Tarant? Sorry Jay that doesn’t make sense to me.
Well, first of all, I don't see a revenue stream for Taran. It will be Humanigen's revenue. And did you see Durrant resign as Humanigen's CEO? I didn't.
The in-process structural change has not diminished Humanigen's capacity to execute their business plan. I'm not worried at all. In act, I'm excited to see how all the pieces will fit together.
The bankruptcy judge did not share your pessimistic view.
I wish i felt the same. I’ve seen no evidence or reason to think Taran is going to magically share revenue with former LENZ owner Humanigen. Crushing blow to folks holding bankrupt stock from HGEN. Cameron appears to have moved on completely. What is giving you hope or feeling that HGEN stock has future value?
It's a very exciting time for us, Jim!
Following an amazing eight-year, hugely intense journey at Humanigen, recently closed on acquiring the Humanigen assets and placing them in Taran, a Delaware C-corporation, with UK and Australian wholly-owned subsidiaries.
Taran is focused on helping bring life-saving medicines to patients, including lenzilumab ("LENZ") and ifabtotuzumab ("IFAB") in various leukemias, Graft vs. Host Disease and cancer, with possibilities in multiple other areas of high unmet medical need.
In regards to my oft-wondered-about covid pneumonia reinfection rate in lenz-treated patients, which I think could be an absolute game-changer for Humanigen's lenzilumab, I learned last night that I may again have to re-phrase my question, and likely have to ask more than just one question. But just to get started, let me ask the following.
In patients diagnosed with covid pneumonia, and treated with lenzilumab, what is the recurrence rate of those patients presenting with SARS-CoV-2 nucleocapsid proteins after treatment? (I'll have to pin this post to remember how to ask that question).
As my question was originally phrased, I didn't know better than to exclude subsequent presentations of covid found in spike proteins. The studies I reviewed last night demonstrate that covid in the spike proteins has no relation to how well lenz prevents future infections. Rather, as I read the studies I will link, covid found in spike proteins is mRNA vaccine-induced. So lenz-treated patients who subsequently present with covid spike proteins, have no bearing on the efficacy of lenz.
Attached is an autopsy report of a 76 year old man, which was used as a case study. The patient had no history of covid, but the pathologist found covid spike proteins leading to the heart and brain. It's a fascinating study which, along with a different, un-related discussion concerning San Vincente in the Darian Pass, kept me up all night reviewing.
The presentation gets off to what might be perceived as a slow start, but don't fast forward past the 11 minute mark, of the 28 minute video.
AND THE FDA AND NIH BEAT GOES ON: Eli Lilly says FDA delays approval of Alzheimer's drug in surprise move https://www.cnbc.com/2024/03/08/eli-lilly-alzheimers-drug-fda-approval-delayed.html?__source=iosappshare%7Ccom.apple.UIKit.activity.CopyToPasteboard
Interesting niche. But I don't see anything about production turnaround, and it appears that their CAR-T is designed to enhance mitigation of CCR-9. I think Gracell's 24 hour turnaround for CAR-T is a much better, even revolutionary, alternative, which I hope that lenz is a part of making that happen.
I see that they also provide CRISPR services. I think that lenz was developed with that gene-editing technology. But even so, I'm not comfortable with it, generally. And I see that GenScript also provides mRNA solutions, and I am becoming increasingly wary of that.
Lots and lots of potential with those technologies, but way too much opportunity for abuse of those capabilities.
https://www.genscript.com/?src=google&utm_source=google&utm_medium=cpc&utm_campaign=GenScript-ECPC_NA&jiraid=12194&gad_source=1&gclid=EAIaIQobChMIzsnPnL_ihAMVGy7UAR2UUQsxEAAYASAAEgJy3vD_BwE
Do you have a minute? Do you have 51 minutes?
I had never heard of Sharyl Attkisson, or her "Full Measure" weekly broadcast program, but I was fortunate enough to have just finished watching her program on "The Covid Clots," and I highly recommend that you watch it. It so happens that I am scheduled for an exam by my vascular surgeon on Friday, because it has been a year since he did the angioplasty/atherectomy on my leg artery. And I'm curious to see if he is familiar with the information I just learned about covid clots.
You brought this issue up last month, Jim
February 14, 2024
Isn't HGEN bankrupt? how do HGEN share holders have any chance at success? I was under impression that assets would be sold off and HGEN stock worth nothing now.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=173844576
and I gave you my thoughts on this subject at that time
02/14/24
Hi, Jim,
Welcome to the room, and to Ihub.
If Durrant had filed a Chapter 7 bankruptcy, shareholders would have been wiped out.
But Durrant filed a reorganization bankruptcy under Chapter 11, which allows for the share structure to remain intact.
Here are a couple of articles about our previous bankruptcy, when the company was known as Kalobios, before restructuring.
https://moxreports.com/kbio-infinity-squeeze/
https://www.globenewswire.com/news-release/2017/07/27/1063782/0/en/KaloBios-To-Change-Company-Name-To-Humanigen-Inc.html
I'm looking for management to recall their loaned shares once again, and to cause yet another massive short squeeze.
https://investorshub.advfn.com/boards/replies.aspx?msg=173844576
What right does Taran have to recall the loaned shares? Did they loan any of those shares? What clinical trial relationships does Taran have with Humanigen's partners, working on bringing lenz to market for CMML, or aGvHD, or Covid, or for any of Sanofi's oncology or asthma indications? Taran's CEO Durrant could make Humanigen's CEO Durrant sign a licensing agreement, which he may have done already, if that would alleviate your concern.
But, Taran did not buy Humanigen. I think Humanigen remains on track with all of their on-going work, and the pending results of all that work are what shareholders have to look forward to accomplishing. If you think I'm missing something, maybe I am, in which case please inform me of what that is.
Doesn’t Taran own Lenz now? What value is there and assets in bankrupt Humanigen?
Is the Sanofi spin-off of their healthcare division designed to partner with Humanigen on the asthma market, and more?
According to Humanigen's Featured Presentation, "...historical clinical results could provide basis for global partnering discussions."
asthma mentioned on five slides in the chart deck
https://ir.humanigen.com/English/events-and-presentations/default.aspx
Does Sanofi think that lenz could do better than their Regeneron partner, using Dupixent? Or is Sanofi looking to expand their supply chain?
https://investor.regeneron.com/news-releases/news-release-details/dupixentr-dupilumab-fda-approved-first-and-only-treatment
There are worse problems to have than trying to figure out what will be the most valuable entity for Humanigen shareholders 🙂. You make some good points and I can understand your enthusiasm, which I share, for our success in Australia.
But, if the loaned shares are recalled, chances are it will be with news, and Humanigen's value could skyrocket well beyond the value of their subsidiaries or Taran, if that news is related to covid prevention/treatment authorization. And in that regard, I now see news from the UK Ministers accusing the Health Secretary, "...of withholding data that could link the Covid vaccine to excess deaths, and criticised a “wall of silence” on the topic.
A cross-party group has written to Victoria Atkins to sound alarm about the “growing public and professional concerns” at the UK’s rates of excess deaths since 2020."
https://www.yahoo.com/news/health-secretary-urged-release-data-181513423.html
I'm disappointed that the UK regulators did not act independently and much earlier to approve lenz for covid. So I'm glad to see pressure building on them in this regard. I think a study of lenz patients could actually show "decreased deaths" and negligible (or at least show a statistically significant lower level) of covid pneumonia reinfections.
I see the value in subsidiaries(specifically, the Australian one )as more immediate and substantive compared to the IP with Taran . As it is only holdi ( IP and inventory). The only potential revenue for Taran will be licensing fees from future sales from the subsidiaries of Humanigen .. This structure essentially separates the IP company from the operating. Entities . This was also necessary for providing the DIP financing . Taran does not have access to the rights that the Australian company has and data on clinical trials for a potential biologic submission as it was excluded from the sale to Taran .
You can never be sure how a bankruptcy court judge is going to rule, even with guys like Barliant (?) helping the company through the process. I appeared once in a corporate bankruptcy case, where the issue concerned naked shorting. The company was being naked shorted tens of millions of shares everyday, even though they were on the Failure-to-Deliver (FTD) list. The judge told me that he thought I (shareholders) had a case. But he couldn't see how naked shorting negatively impacted the issuer. I was dumb-founded, and I mean literally.
So, I can see how transferring intellectual property rights to Taran could have been a safeguard, pending how the judge ruled.
Beyond that, in my opinion, it has made a lot of sense to use Dale's entities as we have, broadly, as what I call our financing arm. I hope, going forward, that we continue to segregate our financing and operational activities, in the manner that we have. But I have to think that the value of Humanigen's shares is a reflection of the value of our intellectual property, and I expect that issue will be addressed as you mentioned, either by way of exclusive licensing, or with a potential merger through subsidiaries of Humanigen and Taran.
"COVID-19 remains a danger, especially to older people and those with underlying medical conditions. There are still more than 20,000 hospitalizations and more than 2,000 deaths each week due to the coronavirus, according to the CDC. And people 65 and older have the highest hospitalization and death rates."
https://www.yahoo.com/news/older-us-adults-another-covid-191550624.html
No, thanks. I'll have lenz, please.
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Humanigen, Inc. is a clinical-stage biopharmaceutical company developing its portfolio of next-generation cell and gene therapies for the treatment of cancers via its novel, GM-CSF neutralization and gene-knockout platforms. As a leader in GM-CSF pathway science, we believe that we have the ability to transform CAR-T therapy and a broad range of other T-cell engaging therapies, including both autologous and allogeneic cell transplantation. There is a direct correlation between the efficacy of CAR-T therapy and the incidence of life-threatening toxicities (referred to as the efficacy/toxicity linkage). We believe that our GM-CSF neutralization and gene-editing platform technologies have the potential to reduce the inflammatory cascade associated with serious and potentially life-threatening CAR-T therapy-related side effects while preserving and potentially improving the efficacy of the CAR-T therapy itself, thereby breaking the efficacy/toxicity linkage. Clinical correlative analysis and pre-clinical in vivo evidence points to GM-CSF as the key initiator of the inflammatory cascade resulting in CAR-T therapy’s side-effects. Pre-clinical in vivo data on the neutralization of GM-CSF using antibody or gene KO indicates that it is not required for CAR-T cell activity. Our strategy is to continue to pioneer the use of GM-CSF neutralization and GM-CSF gene knockout technologies to improve efficacy and prevent or significantly reduce the serious side-effects associated with CAR-T therapy.
We believe that our GM-CSF pathway science, assets and expertise create two technology platforms to usher in next-generation CAR-T therapies. Lenzilumab, our proprietary Humaneered® anti-GM-CSF immunotherapy, has the potential to be used in combination with any FDA-approved or development stage CAR-T therapy, as well as in combination with other cell therapies such as HSCT, to make these treatments safer and more effective. In addition, our GM-CSF knockout gene-editing platform has the potential to create next-generation CAR-T therapies that may inherently avoid any efficacy/toxicity linkage, thereby potentially preserving the benefits of the CAR-T therapy while altogether avoiding its serious and potentially life-threatening side-effects.
The company’s immediate focus is combining FDA-approved and development stage CAR-T therapies with lenzilumab, the company’s proprietary Humaneered® anti-human-GM-CSF immunotherapy, which is its lead product candidate. A clinical collaboration with Kite, a Gilead Company, was recently announced to evaluate the use of lenzilumab with Yescarta®, axicabtagene ciloleucel, in a multicenter clinical trial in adults with relapsed or refractory large B-cell lymphoma. The company is also focused on creating next-generation combinatory gene-edited CAR-T therapies using strategies to improve efficacy while employing GM-CSF gene knockout technologies to control toxicity. The company is also developing its own portfolio of proprietary first-in-class EphA3-CAR-T for various solid cancers and EMR1-CAR-T for various eosinophilic disorders. The company is also exploring the effectiveness of its GM-CSF neutralization technologies (either through the use of lenzilumab as a neutralizing antibody or through GM-CSF gene knockout) in combination with other CAR-T, T cell engaging, and immunotherapy treatments to break the efficacy/toxicity linkage including the prevention and/or treatment graft-versus-host disease (GvHD) in patients undergoing allogeneic HSCT. The company has established several partnerships with leading institutions to advance its innovative cell and gene therapy pipeline.
June 15, 2020
Phase 3 Study to Evaluate Efficacy and Safety of Lenzilumab in Hospitalized Patients With COVID-19 Pneumonia
https://clinicaltrials.gov/ct2/show/NCT04351152
Anti-GM-CSF antibodies expected to show better effect in Covid-19 than cytokine-specific targets
July 27, 2020
https://discoverysedge.mayo.edu/2021/06/22/cancer-to-covid-19/
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