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Calmare Therapuetics Incorporated.,  (OTCQX: CTTC)

MAYO CLINIC News on Calmare (November, 2014)  




Only machine of its kind in SC appears to get results for patients in pain

Helen Adams | | May 18, 2017


Retired teacher Douglas Foxworth was suffering from pain so severe that it felt like his feet were on fire. The cause was unknown — it’s called idiopathic peripheral neuropathy. When the Sumter man heard about a new pain treatment at MUSC Health called scrambler therapy, he jumped at the chance to try it.

“That morning when I went in, I was practically in tears. When they asked how my pain was, I said a nine, pushing a ‘ten’ out of ten,” Foxworth said.

He became one of the first patients in South Carolina to try scrambler therapy. The scrambler device, by Calmare, has been cleared by the Food and Drug Administration. Nurse Julie Watson described how it works. “The scrambler therapy device uses transcutaneous electrical stimulation to replace maladaptive pain information with ‘non-painful’ or ‘normal’ messages. It does this by traveling along the same pathways to the brain.” 

In other words, as its name suggests, scrambler uses electrical stimulation on the skin to scramble what nerves are trying to tell the brain. Each treatment lasts between a half-hour and 45 minutes. Foxworth had 12 sessions over a 2 1/2-week period. “The first day when they put those electrodes on, about 10 or 15 minutes after, the pain level went down,” he said. “It didn’t last, but the pain level went down to where it was tolerable.”

By the end of the 12th session, the difference was dramatic. “I still have some pain, but I’m no longer on pain medication. The pain is very mild,” Foxworth said. “I consider that this was effective to eliminate probably 90 percent of my pain.”

Palliative care specialist Pat Coyne, who introduced scrambler therapy at MUSC Health, said about 80 percent of the patients who try it feel a substantial difference. He first heard about scrambler therapy while he was working at Virginia Commonwealth University. “We did three research studies,” he said. “We went into the research trying to prove it didn’t work, and everyone kept saying they felt better.”

The skepticism Coyne initially felt resonates with MUSC Health palliative care doctor John Gibson. “Our team has been very happy with the results we have seen,” Gibson said. “I think the biggest point of skepticism for everyone who sees scrambler is that no one really understands how it works. There are theories that make sense, but no one has proven how it works.”

Scrambler therapy was invented by an Italian professor, Coyne said. It has been around for almost two decades, but wasn’t introduced in the U.S. until around 2010. The device requires careful monitoring. “With the electrodes, it senses the nerve firing. The electricity comes in wave forms and pulses. You adjust those based on when the patient tells you the pain is going away,” Coyne said. 

His research team wasn’t alone in finding scrambler therapy was effective. An article in the journal Supportive Care in Cancer said 19 out of 20 reports on scrambler therapy came up with positive results.

It’s a nuanced treatment, Coyne said. “A nurse is going to be sitting at the bedside and adjusting the dials. It will be different each time, and the leads will change because the pain typically gets smaller with each treatment. Really, what it’s trying to do is, when the nerves fire, it’s firing against them. So the pulsation never makes it to the brain and you don’t feel pain. And in doing so, we know it changes the way calcium is absorbed. Nerves that fire a lot actually are sometimes calcium deprived. You’re trying to reset the nerves to normal.”

Coyne said research shows patients who had scrambler therapy showed improvements in their natural pain-fighting reserves. “They get depleted when they’re fighting pain all the time. We found their endorphins changed.”

During a training period at MUSC Health, patients could volunteer to try scrambler therapy. It’s now in use in MUSC Hollings Cancer Center, covered by Medicare, Medicaid, and some insurance providers. “Starting off, we’re going to focus on the cancer population, but it’s going to be open to anyone who has this nerve pain,” Coyne said.

Watson, who has treated patients with the scrambler, said cancer treatments can cause neuropathic pain and sensation problems. “They may be able to stay on their treatments longer or at doses they may not have been able to previously tolerate. This treatment can be life-changing for some by enhancing quality of life and allowing them to do activities they may not have previously been able to do,” Watson said. 

“We treated a patient with chemo-induced neuropathy, and he wanted to work out and jump rope as he once did. Before he completed his treatments, his numbness had improved so much in his feet that he began jumping rope, which he had not been able to do for several years. Having a non-invasive, non-pharmacological alternative such as scrambler therapy that has shown proven benefit for neuropathic pain is a tremendous stride here at MUSC Health.”

Gibson, the palliative care physician, said it’s important to look for new ways of treating pain. “Unfortunately, and despite years of effort, the health system does not do a great job of treating pain, particularly neuropathic pain, which is really what scrambler is targeted toward,” he said.

“The mainstay of treatment currently is drugs, all of which come with a number of side effects. In many instances, these medicines do not adequately control the pain or cannot be tolerated by the patient. Among these medications are the opioids, which pose possible risks to the patient, and as everyone now has seen commonly on the news, opioids come with a heavy burden on our public health," Gibson said.

Neuropathic pain, particularly chemotherapy-induced neuropathy, is typically a chronic form of pain. "There is very little evidence that opioids are effective in chronic pain, and there are significant issues with tolerance to these medicines which often leads patients to higher and higher doses of the medicine, usually with more side effects," Gibson said. "Scrambler offers the potential to significantly reduce the patient’s pain with basically no side effects and no ongoing need to take pills. Without the pills, many of the societal burdens of pain medicines will be reduced as well.”

Coyne envisions having several scrambler devices at MUSC Health in the future. With scrambler therapy, he said, “The numbness goes away, which no one’s ever found a way to fix. Some meds take away the pain, but the numbness stays.”

To be treated with scrambler therapy at MUSC Health, patients must have a referral from a doctor. Watson said common conditions treated include chemo-induced neuropathy, diabetic neuropathy, phantom limb pain, failed back syndrome, trigeminal neuralgia, postherpetic neuralgia and chronic regional pain syndrome.

Before scrambler therapy, Foxworth, the teacher from Sumter, was taking the pain reliever gabapentin. He’s not anymore, but knows his pain may flare up again. “More than likely it will reoccur. When that happens, I’ll go back for what they call a booster treatment. I’m very pleased with what scrambler therapy has done for me."]b\[


Berkeley, California Neurology Practice Adds Calmare(R) Pain Management Therapy

Dr. Selena Ellis to Treat Chronic Neuropathic Pain with Non-Invasive and Non-Addictive Technology

BERKELEY, CA - (NewMediaWire) - June 13, 2017 - Dr. Selena Ellis ( is proud to announce her medical practice will be the first neurology practice in the western United States to offer Calmare® therapy, an effective non-opioid treatment for neuropathic pain. Dr. Ellis's medical practice treats chronic pain in patients suffering from trigeminal neuralgia, peripheral neuropathy, complex regional pain syndrome (CRPS), headaches and migraines. After an in-depth evaluation process which included the successful treatment of her patients with chronic neuropathic pain, Dr. Ellis has recently added this very promising therapy, also known as "Scrambler Therapy".

Calmare® is a FDA-cleared device that provides a non-invasive therapy for the treatment of chronic neuropathic pain. Calmare® therapy has also been successful in achieving chronic pain relief for patients suffering from failed surgical back syndrome and multiple neuropathies including chemotherapy-induced peripheral neuropathy (CIPN).

Significantly, there have been no reports of adverse side effects associated with this therapeutic modality.

The Calmare® technology employs electrostimulation with a low electrical current directed at the central nervous system and delivered through applied electrodes on the patient's skin surrounding the pain area. Sixteen electrical impulse algorithms are programmed to specifically target the body's sensory fiber pathway (which transmits slower and chronic pain signals). These electrical signals help "re-program" the brain's receipt of the pain signal. In many patients, these signals provide longer-lasting pain relief than those that "blocking" the pain signal, such as with transcutaneous electrical nerve stimulation (TENS).


Physicians using Calmare therapy have reported that patients who experience a reduction in pain after their first 45-minute treatment have a high probability of experiencing a significant reduction in chronic pain after completing a ten-treatment regimen. Patients should be weaned off certain medications before starting the therapy to achieve the best result.

Dr. Ellis says, "My practice focuses on providing chronic pain relief to my patients using the most safe, effective and non-addictive therapies available. As a neurologist, I am open to new modalities after conducting a complete evaluation of the patient. After I saw the positive results in some of my patients after using Calmare, I knew I wanted to be the first neurologist to offer the technology in the western US."

About Selena Ellis, MD (

Dr. Ellis attended medical school at the University of Washington in Seattle and completed her neurology residency at the UCLA School of Medicine in 2002. She obtained subspecialty training in electrodiagnosis of neuromuscular disease as Chief Resident and Fellow at the Wadsworth VA/UCLA Department of Neurology.

Dr. Ellis is board-certified in general neurology and electrodiagnostic medicine by the American Board of Psychiatry and Neurology (ABPN) and the American Board of Electrodiagnostic Medicine (AANEM). She was the president and longtime board member of the San Francisco Neurological Society Dr. Ellis had the first medical practice in Northern California with an AANEM-certified electromyogram (EMG) lab, in addition to being the first neurologist in the western US to offer Calmare therapy.

Dr. Ellis treats common neurological disorders such as headache, peripheral neuropathy, trigeminal neuralgia, occipital neuralgia, complex regional pain syndrome, back pain, and sciatica. Other common symptoms treated at her practice include pain syndromes of many types, difficulty with gait or balance, and sensory changes to the arms or legs. Dr. Ellis also has subspecialty training in evaluation and management of problems affecting the peripheral nervous system, including systemic neuropathies, mononeuropathy and radiculopathy.

About Calmare/Scrambler Therapy

Distributed by Competitive Technologies, Inc., the Calmare® (also known as Scrambler therapy) is a U.S. FDA 510(k)-cleared and European CE mark-certified pain therapy medical device for the non-invasive and non-narcotic treatment of chronic neuropathic and oncologic pain. Using a biophysical rather than a biochemical approach, Calmare employs a multi-processor able to simultaneously treat multiple pain areas by applying surface electrodes to the skin surrounding the area in pain. The device creates and relays a non-pain signal which becomes the dominant signal received by the brain and overrides the pain signal to provide relief for the patient. The Calmare device has been used to successfully treat over 10,000 chronic pain patients worldwide. 


Cynthia Laird at 510-644-2282 for Dr. Selena Ellis or


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CTTC News: Additional Proxy Soliciting Materials - Non-management (definitive) (dfan14a) 02/20/2018 09:47:57 AM
CTTC News: Current Report Filing (8-k) 02/20/2018 06:33:20 AM
CTTC News: Additional Proxy Soliciting Materials (definitive) (defa14a) 02/20/2018 06:32:58 AM
CTTC News: Current Report Filing (8-k) 02/16/2018 05:16:41 PM
CTTC News: Additional Proxy Soliciting Materials - Non-management (definitive) (dfan14a) 02/16/2018 12:06:26 PM
News News Alert: Additional Proxy Soliciting Materials - Non-management (definitive) (dfan14a) 02/20/2018 09:47:57 AM
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#14766   And if 12 mil isn't paid? Onya 02/21/18 07:27:24 AM
#14765   $12,000,000.00 plus Judgement. GEOMC andy55q 02/21/18 07:20:32 AM
#14764   So all this talk about fraud and who Onya 02/21/18 07:10:19 AM
#14763   " empty shell of a company..." -- ain't parkourstar 02/20/18 11:16:55 PM
#14762   Sounds like you know something about smoking....too bad Couch 02/20/18 07:19:41 PM
#14761   Does Mir have a file with (compromising) documents, mog1962 02/20/18 04:38:41 PM
#14760   Does Mir have a file with (compromising) documents, mog1962 02/20/18 03:53:52 PM
#14759   I hope the SEC and the Dept. of Prudent Capitalist 02/20/18 03:44:58 PM
#14758   Conrad Mir is highlighting his criminal behavior with conix 02/20/18 03:24:51 PM
#14757   What is frightening to me is that Mir/Brennan mog1962 02/20/18 02:38:01 PM
#14756   WOW! I love this Yarbro! Talk conix 02/20/18 02:14:11 PM
#14755   It is hard to believe that this affair mog1962 02/20/18 01:26:15 PM
#14754   WOW It gets nastier as time goes by................ mog1962 02/18/18 07:56:34 PM
#14753   You just gotta laugh: parkourstar 02/18/18 07:34:19 PM
#14752   It deals with the issue of dates but mog1962 02/17/18 08:28:17 PM
#14751   I got my materials today and.............. mog1962 02/17/18 08:24:14 PM
#14750   Great stuff. At least we have Conrad Prudent Capitalist 02/16/18 03:51:32 PM
#14749   they are asking us to vote "Yes" to Prudent Capitalist 02/16/18 03:08:38 PM
#14748   Prudent I believe this has been posted previously, but mog1962 02/16/18 03:02:32 PM
#14747   Conix: I still hold significant shares here, Prudent Capitalist 02/16/18 02:34:20 PM
#14746   and now we get more government filings and mog1962 02/16/18 02:01:55 PM
#14745   while it reads like a carefully researched journal mog1962 02/16/18 01:55:20 PM
#14744   About time for what? There's still two lawsuits, parkourstar 02/15/18 12:00:43 PM
#14743   A single case from last year by someone parkourstar 02/15/18 11:56:24 AM
#14742   Can someone explain why we are now seeing mog1962 02/14/18 02:10:32 PM
#14741   Powderbum In response to your seeking one share in mog1962 02/14/18 12:41:47 PM
#14740   Message to the BOD. Please give me one powderbum 02/14/18 10:29:23 AM
#14739 powderbum 02/14/18 02:05:44 AM
#14738   any thoughts about the new filing by Bard today? mog1962 02/13/18 02:27:37 PM
#14737   The only game plan so far was to mog1962 02/12/18 11:45:45 AM
#14736   Great news! andy55q 02/11/18 06:35:10 PM
#14735   New research: powderbum 02/11/18 06:30:15 PM
#14734   Since the attachments referenced by Cutler are not mog1962 02/10/18 05:16:33 PM
#14733   By the way what happened when the gang mog1962 02/10/18 03:38:57 PM
#14732   Looks like lots of heads rolled!!! conix 02/10/18 01:11:26 PM
#14731   In-the-mean-time. CITY of HOPE is now offering Calmare. powderbum 02/10/18 11:25:53 AM
#14730   BOD is out! powderbum 02/10/18 11:22:35 AM
#14729   Latest filing 2/9/2018?? Onya 02/09/18 04:55:20 PM
#14728   Looks like the judge isn't going to be parkourstar 02/08/18 10:04:09 AM
#14727   CTTC are not taking calls or returning emails Onya 02/08/18 01:41:38 AM
#14726   Nope, maybe next week !! andy55q 02/07/18 12:15:44 PM
#14725   So do we have Mir's head yet? Onya 02/07/18 07:05:43 AM
#14724   No--just waiting for the guillotine and Mir's head. conix 02/01/18 09:22:10 AM
#14723   Has everyone capitulated or just grown bored? mog1962 01/31/18 06:46:45 PM
#14722   Mir has gotten a part in the upcoming conix 01/24/18 03:19:58 PM
#14721   Mueller investigation is looking at CM !! andy55q 01/23/18 10:42:44 AM
#14720   He has history with Russia !!! andy55q 01/23/18 10:04:26 AM
#14719   CEO Conrad Mir posts on this board? conix 01/23/18 09:16:14 AM
#14718   CM is the former poster VC !! andy55q 01/23/18 08:12:24 AM
#14717   Conrad Mir is a "mole"? Is that conix 01/22/18 08:09:06 AM