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"CBD-Rich Cannabis Offers ‘Potential Benefits’ For People With Autism Spectrum Disorder, Scientific Review Finds":
March 26, 2025
https://www.marijuanamoment.net/cbd-rich-cannabis-offers-potential-benefits-for-people-with-autism-spectrum-disorder-scientific-review-finds/
Here is the actual study...
"Efficacy and Safety of Cannabinoids for Autism Spectrum Disorder: An Updated Systematic Review":
Published: March 17, 2025 Peer-Reviewed
https://www.cureus.com/articles/347254-efficacy-and-safety-of-cannabinoids-for-autism-spectrum-disorder-an-updated-systematic-review#!/
"PA Supreme Court Approves OTC Supplements & CBD Oil for Workers’ Compensation":
March 20, 2025
This is a game changing decision requiring insurance carriers, third-party administrators and self-insured employers to pay for a broad array of non-prescription items including over-the-counter medications, dietary supplements, non-FDA approved analgesics, and CBD Oil.
Fourth Quarter 2024 Financial Review
Consolidated net revenue for the fourth quarter ended December 31, 2024, was $12.7 million, compared to $15.9 million in the fourth quarter of 2023. Revenue increased modestly on a quarter-over-quarter basis versus Q3 2024 revenue of $12.6 million.
Quarterly revenue trend for 2024:
Q1
Q2
Q3
Q4
U.S. $ millions
2024
2024
2024
2024
Total revenue
$ 12.1
$ 12.3
$ 12.6
$ 12.7
In the fourth quarter, some retailers were negatively impacted by state regulations restricting the sale of certain CBD products, despite meeting federal requirements. However, e-commerce revenue increased quarter-over-quarter following the launch of the Company's new e-commerce platform.
Gross Profit in Q4 2024 was $5.1 million, or 40.2% of revenue, compared to Gross Profit of $8.9 million, or 56.0% of revenue, in Q4 2023. The reduction in gross margin reflected holiday promotional investments, temporary shipping inefficiencies, and reduced fixed cost absorption on lower-than-expected revenue. The Company models gross margin to return above 50% in 2025.
Total selling, general, and administrative ("SG&A") expenses in the quarter were $10.6 million, a 43% improvement from $18.6 million in Q4 2023. Stringent expense controls were implemented during the year to better align with current revenue levels.
Net loss for the fourth quarter of 2024 was $3.4 million, or ($0.02) per share basic and diluted, compared to a net loss of $8.5 million, or ($0.06) per share basic and diluted, for the fourth quarter of 2023.
Excluding depreciation, amortization and other non-cash items, Charlotte's Web reported positive Adjusted EBITDA1 for the fourth quarter of 2024 of $0.3 million, a $6.8 million improvement compared to negative Adjusted EBITDA of $6.5 million in the fourth quarter of 2023.
Fiscal Year 2024 Financial Review
On a year-over-year basis, consolidated net revenue for the twelve months ended December 31, 2024, was $49.7 million, a decrease of 21.4% from $63.2 million in 2023. Revenue was negatively impacted by inflationary impacts on consumer spending and reduced retailer shelf allocations to the CBD category. The Company adopted a new e-commerce platform mid-year that has resulted in improving marketing, customer management, and sales volumes.
Gross profit for the year ended December 31, 2024, was $21.3 million, compared to $35.6 million for the year ended December 31, 2023. Gross profit was negatively impacted by a $4.1 million increase in inventory provision for 2024 due to the revaluation of aged hemp based on current market conditions. The increase was partially offset by lower inventory expenses and other variable costs associated with lower revenue in 2024. Gross profit before inventory provision was $25.4 million, or 51.1%, and $36.6 million, or 58.0%, in 2024 and 2023, respectively.
Total SG&A expense for 2024 was $53.3 million, compared to $75.6 million in the prior year. The $22.4 million or 29.6% decrease resulted from multiple actions taken in 2024 to reduce operating expenses and better align SG&A against the lower revenue levels, including workforce and insurance program adjustments, contract reviews and negotiations, and software optimizations. Additionally, in 2024, the Company amended its MLB Promotional Rights Agreement, resulting in a decrease in amortization and media expense related to MLB assets of approximately $4.9 million compared to 2023.
An operating loss of $32 million in 2024 improved 21.2% from an operating loss of $40.6 million in 2023. Net loss for 2024 was $29.8 million, or $(0.19) per share, basic and diluted, compared to a net loss of $23.8 million, or $(0.16) per share, basic and diluted, in 2023. The lower net loss in 2023 was due to a combined net gain of $20.0 million in that year in the fair value of the Company's debt derivative and from its investment in DeFloria.
Excluding depreciation, amortization, and interest, the EBITDA1 loss for 2024 was $17.6 million, as compared to an EBITDA loss of $6.3 million for 2023. 2024 included a higher inventory provision than 2023, which included the combined net gain of $20.0 million in fair value of the Company's debt derivative and from its investment in DeFloria. Excluding these items, the Adjusted EBITDA1 loss was $12.6 million for 2024, as compared to the Adjusted EBITDA loss of $22.7 million for 2023.
Balance Sheet and Cash Flow
Net cash used for operations in the fourth quarter of 2024 was $1.8 million. Net cash used for operations in the year ended December 31, 2024, was $21.2 million, including cash paid to MLB for license and media rights assets of $5 million. Capital expenditures of $3.9 million were primarily used for the in-house production of topical and gummy projects.
The Company's cash and working capital as of December 31, 2024, were $22.6 million and $31.1 million, respectively, compared to $47.8 million and $54.5 million as of December 31, 2023, respectively.
"With reduced cash burn, having cash reserves exceeding $22 million provides the runway for 2025 growth and beyond," said Mrs. Lind. "In-house production will increase in 2025, and continued expense discipline is key to stabilizing our financial position."
Consolidated Financial Statements and Management's Discussion and Analysis
The Company's audited consolidated financial statements and accompanying notes for the three and twelve-month periods ended December 31, 2024, and 2023, and related management's discussion and analysis of financial condition and results of operations ("MD&A"), are reported in the Company's 10-K filing on the Securities and Exchange Commission website at www.sec.gov and on SEDAR+ at www.sedarplus.ca and will be available on the Investor Relations section of the Company's website at https://investors.charlottesweb.com.
Item 2.02 Results of Operations and Financial Condition.
On March 19, 2025, Charlotte’s Web Holdings, Inc. (the “Company”) issued an earnings release announcing its financial results for the quarter and year ended December 31, 2024. A copy of the earnings release is furnished herewith as Exhibit 99.1 and incorporated in this Item 2.02 by reference.
I found some YouTube videos from Ajna Biosciences and Charlotte's Web about DeFloria. The first one is from this week. The rest are older but contain much more info...
"DeFloria: A Novel Treatment Option for Autism Spectrum Disorder":
Mar 10, 2025
.08 CENTS!! my apologies for missing it by 2 cents. My call was .10 2+ years ago. Told ya, never marry a stock especially a POS like this.
Good stuff Yoda! I wonder who the thumbs downer could be?
New article on DeFloria today..."Rising High: Exclusive talk with botanical drug JV DeFloria":
Mar. 13, 2025
https://markets.businessinsider.com/news/stocks/rising-high-exclusive-talk-with-botanical-drug-jv-defloria-1034475275
$CWBHF+$TLRY= "Strategic Partners" in Canada...
"Health Canada Consults on Pathway for Health Products Containing CBD":
March 10, 2025
Health Canada recently announced that it is exploring a regulatory pathway that would allow products containing cannabidiol (“CBD”) to be purchased without a prescription.
# Patent # Patent Title Score
1. 3157865 HEMP PLANT NAMED 'EM15B2A170'
2. 3155121 HEMP PLANT NAMED 'AF14B15-21'
3. 3169446 HEMP PLANT NAMED 'KIRSCHE'
4. 3169404 HEMP PLANT NAMED 'LINDOREA'
5. 3101952 HEMP PLANT NAMED 'CW1AS1'
Oh Canada!..."Health Canada has released a new consultation document looking at the potential regulatory path for CBD to be regulated as a natural health product. Feedback must be submitted by June 5, 2025."
March 7, 2025
https://stratcann.com/news/health-canada-seeks-more-feedback-on-cbd-as-a-natural-health-product-and-cbd-for-pets/
"Towards a pathway for health products containing cannabidiol: Natural health products containing cannabidiol":
https://www.canada.ca/en/health-canada/programs/consultation-towards-pathway-products-containing-cannabidiol/natural-health-products.html
"Towards a pathway for health products containing cannabidiol: Veterinary drugs containing cannabidiol for animal use":
https://www.canada.ca/en/health-canada/programs/consultation-towards-pathway-products-containing-cannabidiol/veterinary-drugs-animal-use.html
And a reminder..."FDA Solicits Public Comments on Use of Cannabis-Derived Products in Veterinary Medicine":
January 15, 2025
The comment period for this RFI opens on January 16, and will be open for 90 days, ending on April 16, 2025.
Here are some excerpts from an interesting new article...
"How the FDA lets chemicals pour into America’s food supply":
March 7, 2025
There are at least 950 substances in our food that are not permitted in Europe, according to one expert’s estimate, and chemicals linked to health concerns show up in hundreds of products that line the shelves of American supermarkets.
The FDA website lists 19 post-market determinations since 2010 that substances were not “generally recognized as safe.” Four involve chemical constituents of one mushroom and the mushroom itself. Others include an anabolic steroid, caffeinated alcoholic beverages, cannabidiol (CBD), Ginkgo biloba, melatonin, and partially hydrogenated oils.
Meanwhile, trichloroethylene, banned by the Environmental Protection Agency in December as “an extremely toxic chemical known to cause liver cancer, kidney cancer, and non-Hodgkin’s lymphoma,” is still allowed under FDA rules for use as a solvent in the production of foods.
FDA spokesperson Enrico Dinges said the agency will work with new leadership at HHS “to safeguard the food supply through pre-market and post-market safety evaluations of chemicals in the food supply.
More than a decade ago, Pew Charitable Trusts estimated that there were about 10,000 additives allowed in food in the United States — and that the FDA had not reviewed the safety of about 3,000 of them.
KFF Health News asked nine of the largest food manufacturers — The Coca-Cola Co., Conagra Brands, General Mills, Kellanova (successor to Kellogg), The Kraft Heinz Co., Mondelez International, Nestlé, PepsiCo, and Unilever — for the number of ingredients, if any, that go unnamed on their product labels and the names of those ingredients deemed safe without involvement by the FDA, and substances used in their products in the United States but not in Europe, and vice versa.
None provided answers to those questions.
For advice on whether ingredients are GRAS, companies may convene panels of specialists. The FDA has noted that panel members could be paid by the companies commissioning the review, but, in guidance to industry, it says “such compensation is not itself an unacceptable conflict."
Could be boom time soon. Check this stuff out...The guy nominated to be the new head of the FDA is Dr. Marty Makary. The news has kinda painted him as anti-cannabis so far. However...he has also publicly acknowledged the therapeutic properties of cannabis. So...for starters here is a quote I found from him in a book review on Amazon...
"The CBD Skincare Solution: The Power of Cannabidiol for Healthy Skin":
"An eye-opening book about how the anti-inflammatory effects of CBD can play an important role in skin health and in improving lives."Marty Makary, MD, John Hopkins physician and New York Times bestselling author of The Price We Pay
“FDA promised that they’re going to answer our citizen petition by July … if you have people in charge who are thinking about a much more holistic approach, they’re much more likely to balance the pharmaceutical industry’s interest and the supplement industry’s interest in a way that we think the law was intended,” Mister said. “The previous administration sat on the CBD issue for over 5 years, and didn’t do anything except conclude that they can’t regulate it,” concurred Israelsen.
CRN asked for clearer and more consistent application of the statute which prohibits ingredients from dietary supplements due to past drug research.
Hearings to examine the nomination of Martin Makary, of Virginia, to be Commissioner of Food and Drugs, Department of Health and Human Services. Thursday, Mar 06, 2025 10:00 AM
Agree💯! Ajna does have plans to do a transaction at some point and this is a direct comment made to me by people entrenched in all this. Aside from the JV with CW, (IF) Defloria pans out, who do you think has first call on the fulfillment side for AJA 001? Out year issue but very compelling nonetheless.
I realize most disagree and I understand why but CW has enormous potential that goes beyond Defloria.
JMHO 😎
Good to hear. Yes, DeFloria is interesting. I should have said Ajna or DeFloria instead of CW when I mentioned Jazz looking for acquisitions. CW is just in on the joint venture. Fwiw though, Orrin Devinsky is the same Lead Scientist behind the development of both Epidiolex and DeFloria(AJA001). I see Ajna and DeFloria have new 2025 investor decks posted. They're very detailed. The psychedelics look interesting too. CW still has the 2024 investor deck posted, but maybe we'll see a new one after the next report which I think may show CW's newer supplements selling well. Maybe one day Ajna will have an IPO and CW holders can have some shares for our long term support...
Ajna
https://ajnabiosciences.com/wp-content/uploads/2025/02/Investor_Deck_2025_Public_PDF_web.pdf
DeFloria
https://foundersuite.com/public_pitch_decks/0b0d6e7a-bfa5-4f27-a77c-9bdfb57a673b
CW
https://s22.q4cdn.com/636117063/files/doc_presentations/2024/Jun/28/cweb-2024-investor-presentation.pdf
Good to see epidiolex doing well. I know someone who takes it. Very effective in this case and very expensive.
Difloria is extremely interesting and think they're on to something very good.
I see Jazz Pharma just reported Q4, and Epidiolex is doing very well. Maybe that can be some kind of benchmark for what to expect from AJA001 one day. It's a testament to the effectiveness of CBD...
Epidiolex Net Product Sales: $275 million in Q4 2024, $972 million for the full year, up 15% year-over-year.
Epidiolex, currently the only FDA-approved CBD product to treat certain types of seizures, is expected to reach blockbuster status this year after its sales grew by 15% to $972 million in 2024.
Good stuff Yoda! I realize drfloria entering P2 means plenty left to do but IMO this is a major milestone and good things will follow.
Great to see the continued positive research being done around hemp and CBD.
I've been taking CBD for 10 years. There's no comparable chemical based concoction on the market. Natural wellness products are gaining serious traction. The better CBD players will thrive but the question is who makes it to the other side!
“Charlotte's Web" or the "Company") will report its 2024 fourth quarter and year-end results prior to market open on March 19, 2025.“
https://finance.yahoo.com/news/charlottes-2024-fourth-quarter-earnings-182700022.html
Lots of different stuff below...
"DeFloria Receives Investigational New Drug Application Clearance from FDA for Phase 2 Clinical Trial of AJA001, an Oral Cannabinoid Drug Being Developed for the Treatment of Autism Spectrum Disorder (ASD)":
Feb 24, 2025
https://www.prnewswire.com/news-releases/defloria-receives-investigational-new-drug-application-clearance-from-fda-for-phase-2-clinical-trial-of-aja001-an-oral-cannabinoid-drug-being-developed-for-the-treatment-of-autism-spectrum-disorder-asd-302382573.html
"With RFK Jr. in charge, supplement makers see chance to cash in":
2/21/2025
Last fall, before being named the senior U.S. health official, Robert F. Kennedy Jr. said the Trump administration would liberate Americans from the FDA's "aggressive suppression" of vitamins, dietary supplements, and other substances — ending the federal agency's "war on public health," as he put it.
With Kennedy now in the driver's seat, the industry will likely expect more: It aims to make bolder health claims for its products and even get the government, private insurers, and flexible spending accounts to pay for supplements, essentially putting them on an equal footing with FDA-approved pharmaceuticals.
On Feb. 13, the day Kennedy was sworn in as secretary of Health and Human Services, President Donald Trump issued a "Make America Healthy Again" agenda targeting alleged corruption in health regulatory agencies and instructing them to "ensure the availability of expanded treatment options and the flexibility for health insurance coverage to provide benefits that support beneficial lifestyle changes and disease prevention."
Kennedy has said exercise, dietary supplements, and nutrition, rather than pharmaceutical products, are key to good health. Supplement makers want consumers to be able to use programs like health savings accounts, Medicare, and even benefits from the Supplemental Nutrition Assistance Program, or SNAP, to pay for such items as vitamins, fish oil, protein powders, and probiotics.
The Alliance for Natural Health hopes that in lieu of strict FDA standards, Kennedy will enable companies to make expanded marketing claims based on evidence from non-FDA sources, Verkerk said, such as the National Institutes of Health's nutritional information site, which describes the pros and cons of different supplements.
During the last decade, the global pharmaceutical industry was primarily focused on cannabinoid extraction (mostly cannabidiol – CBD) from dry hemp (Cannabis sativa L.) biomass. Depending on the extraction method used, the first raw cannabinoid extract amounts to an average of under 10 % of total biomass. The remaining share of 90 % is waste. The aim of this research was to determine the usability of industrial hemp waste after the ultrasound extraction in ethanol for energy production via direct combustion and pyrolysis. The biomass of industrial hemp, variety Fortuna, was used in the research. Analyses were carried out by using standard methods for determining the content of proximate and ultimate analyses, Ash content was found to be 15,40 %, coke content was 22,12 %, fixed carbon was 8,12 %, whereas volatile substances were found to be 68,81 %. The obtained HHV was 16,60 MJ kg-1, while LHV was 15,35 MJ kg-1. After the pyrolysis process, the share of produced biochar (50.45 %) and bio-oil (13.70 %) was determined. The composition of biochar was analyzed using the standard methods – moisture content of 2.71 %, ash 29.22 %, and coke 37.06 %. The obtained results confirmed the potential of CBD extraction by-products in terms of high energy value and environmentally friendly raw materials for energy production. It has proven to be an attractive source of energy that has the potential to partially replace raw materials of fossil origin in energy production.
How It Works
1.Credits Are Generated: Projects like reforestation, renewable energy development, and sustainable regenerative farming techniques create carbon credits by eliminating or avoiding emissions.
2.Credits Are Verified: To ensure the project’s credibility, verification bodies confirm that the claimed reductions are real, measurable, and longterm.
3.Credits Are Traded: Buyers, typically companies looking to offset their emissions, purchase the credits, supporting the funding of these projects.
Challenges in the Current System
1.Complex Verification: Proving the effectiveness of carbon-reduction projects often requires sophisticated monitoring systems, making entry daunting for smaller participants.
2.High Costs: Smaller players, including smallholder farmers or grassroots projects, struggle with the financial burden involved in generating and navigating carbon credits.
3.Transparency Issues: Some markets lack clarity on where funds go and how environmental benefits are quantified, raising concerns about accountability.
Why Hemp? Why Now?
Hemp has long been praised for its environmental benefits, but its potential as a powerful carbon-sequestration crop is only beginning to be realized. Unlike many other crops, industrial hemp not only removes CO2 but also regenerates the soil, making it an ideal candidate for nature-based carbon credits.
Hemp’s Unique Advantages
1.Rapid Growth: Industrial hemp is one of the fastest-growing plants, capable of absorbing significant quantities of CO2 during its short growth cycle.
2.Versatile Applications: Beyond its environmental benefits, hemp can be used to produce textiles, construction materials, biochar, and more, creating additional economic opportunities.
3.Sustainability: Unlike some carbon-offset solutions, hemp farming leaves the land enriched, making it a regenerative approach to climate action.
"Cannabidiol reshapes the gut microbiome to promote endurance exercise in mice":
18 February 2025
Abstract
Cannabidiol (CBD), a nonpsychoactive compound from Cannabis, has various bioactive functions in humans and animals. Evidence suggests that CBD promotes muscle injury recovery in athletes, but whether and how CBD improves endurance performance remains unclear. Here we investigated the effects of CBD treatment on exercise performance in mice and assessed whether this effect involves the gut microbiome. CBD administration significantly increased treadmill running performance in mice, accompanied by an increase in oxidative myofiber composition. CBD also increased mitochondrial biogenesis and the expression of associated genes such as PGC-1a, phosphorylated CREB and AMPK in muscle tissue. Interestingly, CBD altered the composition of the gut microbiome, and antibiotic treatment reduced the muscle endurance-enhancing effects of CBD and mitochondrial biogenesis. We isolated Bifidobacterium animalis, a microbe increased by CBD administration, and named it KBP-1. Treatment with B. animalis KBP-1 in mice resulted in improved running performance. Whole-genome analysis revealed that B. animalis KBP-1 presented high expression of genes involved in branched-chain amino acid biosynthesis, expression of branched-chain amino acid release pumps and metabolism of lactic acid. In summary, our study identified CBD and B. animalis KBP-1 as potential endurance exercise-promoting agents.
"Nanoemulsions with cannabidiol reduced autistic-like behaviors and reversed decreased hippocampus viable cells and cerebral cortex neuronal death in a prenatal valproic acid rat model":
07 Feb 2025
Prenatal exposure to VPA increased anxiety and grooming time, and reduced exploratory activity, sociability, and the social preference index in the animals. Furthermore, VPA-exposed animals exhibited elevated neuronal death and a reduction in viable cells in the hippocampus. In conclusion, CBD nanoemulsion treatment reversed autistic-like behaviors, potentially by protecting against hippocampal neuronal death.
You can induce Alzheimer's Disease in Rats by injecting them with Aluminum. You can protect them from the Aluminum, and thus the Alzheimer's as well, with Cannabis Oil...
"The therapeutic effect of the oily extract of Cannabis sp. in Aluminum Chloride-Induced Alzheimer's Disease in Rats":
May 14, 2024
Results: Reduction of more than 80% in cell death in the dentate gyrus region of the hippocampus in animals treated with cannabis extract. Furthermore, a reduction in total protein levels by approximately 20% and an increase (15%) in antioxidant enzymes in relation to the positive control were also observed in the serum. Conclusion: The use of the oily extract of Cannabis sp. in a 2:1 ratio of delta-9-tetrahydrocannabinol (THC): Cannabidiol (CBD) effectively reduced hippocampal neuron deaths from amyloidosis induced in chronic aluminum chloride intoxication.
We concluded that the oils have a protective effect and might be used with proposals for neurological and antioxidant impairment avoidance caused by Al intoxications.
Using a randomized crossover design, the study evaluated the impact of a standardized high-fat meal compared to fasting on the oral bioavailability of CBD. Consumption of a high-fat meal significantly increases the bioavailability of CBD.
CW is tariff-proof. Their Canadian products are made with Canadian grown hemp and their American products are made with American grown hemp. Both use their patented hemp genetics...
At the end of the third quarter, Charlotte's Web gummies were launched in Canada. These gummies are crafted using Charlotte's Web's proprietary hemp genetics, cultivated in the pristine northern Okanagan Valley of British Columbia, Canada, and feature full-spectrum CBD hemp extract combined with functional botanical supplements, designed to provide synergistic support for targeted wellness benefits. The gummies are produced in accordance with Health Canada Processing and under a license by Aphria Inc., a subsidiary of Tilray Brands, Inc. ("Tilray") (Nasdaq: TLRY; TSX: TLRY). They are being distributed through cannabis retailers in select provinces and on the Tilray Medical website. The launch of gummies follows the earlier availability of Charlotte's Web hemp extract oil tinctures and topicals in Canada, expanding Canadian access to trusted, high-quality CBD products.
"New Peer-reviewed Study Again Confirms Childhood Vaccines Are Likely Responsible for Nearly 80% of the Autism Cases in US":
29 January 2025
https://www.globalresearch.ca/childhood-vaccines-responsible-80-autism-cases-us/5878382
Here is the actual study of 47,155 children...
"Vaccination and Neurodevelopmental Disorders: A Study of Nine-Year-Old Children Enrolled in Medicaid":
01/23/2025
Children with just one vaccination visit were 1.7 times more likely to have been diagnosed with ASD than the unvaccinated (95% CI: 1.21, 2.35) whereas those with 11 or more visits were 4.4 times more likely to have been diagnosed with ASD than those with no visit for vaccination (95% CI: 2.85, 6.84).
SEN. MULLIN: "1-in-36. If that's not a pandemic, then what is? It used to be 1-in-10,000 have autism. Can any of you guys with a straight face say that we shouldn't look at every aspect to what we're putting in our kids, be it from the food to the vaccines?"
SEN. MULLIN: "1-in-36. If that's not a pandemic, then what is? It used to be 1-in-10,000 have autism. Can any of you guys with a straight face say that we shouldn't look at every aspect to what we're putting in our kids, be it from the food to the vaccines?" pic.twitter.com/lzgGQF9IlQ
— Chief Nerd (@TheChiefNerd) January 30, 2025
I vaguely remember posting about heavy metals, hemp, batteries, CBD, etc a long time ago, but there does now seem to be even more connections worth investigating. What condition does RFK say some vaccines can cause? Autism. What does RFK say one of the biggest problems are with vaccines? Heavy metals. What does RFK suggest people with Autism try? Chelation to remove heavy metals...
http://www.autismpolicyblog.com/2024/10/rfk-jr-and-chelation.html?m=1
What protects against heavy metals toxicity? CBD. What can improve life and symptoms for people with Autism? CBD. There seem to be profound connections between CBD, heavy metals, and Autism. Thankfully, these connections are being investigated. Hopefully, this research can lead to Ajna001 being fast tracked by FDA for Autism treatment.
"Exposure to heavy metals may increase risk of autism":
https://www.medicalnewstoday.com/articles/317754
"Association of autism with toxic metals: A systematic review of case-control studies":
2022 Jan
The findings from this review demonstrate that high levels of toxic metals are associated with ASD, therefore, critical care is necessary to reduce body burden of these metals in children with ASD as a major therapeutic strategy.
Gee, who could the thumbs downer be 🤣.
I'd be watching AJNA very close. The JV through Deforia with CW will be opening a few eyes. Good things going on there!
DeFloria-"A Novel Botanical Drug for Autism":
IND Filing Q1 2025 & Phase 2 Entrance Q2 2025
https://foundersuite.com/public_pitch_decks/cc7fb59a-333b-4d4d-9f8f-e0d3c732c2a0
https://defloria.bio/
"Charlotte’s Web Founder Aims For FDA Approval Of Autism Spectrum Disorder Drug":
Jan 24, 2025
As a botanical drug candidate, the road to approval is less linear. “A lot of people don't even realize that the FDA has a different regulatory regime for botanical drugs,” Stanley says. “And only four botanical drugs have been approved. And none of those are oral system. Three of them are topical and one of them coats the GI tract, so they're not absorbed by the body.”
They have the right team for the job. Dr. Orrin Devinski, who was the lead principal investigator for Epidiolex, is Ajna's chief medical officer and oversees the clinical trial design. Epidiolex is the only non-synthetic cannabis drug to get through the FDA approval process. Devinski is also director at the Comprehensive Epilepsy Center at NYU Langone.
I know my metals talk has nothing to do with the company's current business plan, but it does look like I was onto something...Because of the battery and electric vehicle boom Nickel is actually the metal for which phytomining is being researched the most...The new research below is exactly what should be done with hemp. It may turn out to be the best candidate for the job...
"US scientists engineer plant to harvest precious minerals, improve soil, create biofuel":
1/28/2025
“Our idea” Dhankher said as per the UMass Amherst release, “is to determine which genes and proteins are responsible for Alyssum’s nickel hyperaccumulation, then re-engineer Camelina so that it, too, can hyperaccumulate nickel. We also want to determine which soil amendments will optimize the engineered Camelina’s ability to pull even more nickel from the soil.”
Some species can absorb extreme amounts of nickel from soils. Such “phytomining” could help provide batteries essential for the renewable revolution.
Of the 350,000 known plant species, just 750 are “hyperaccumulators” that readily absorb sky-high amounts of metals and incorporate them into their tissues.
“Starting in 2025, the Mi’kmaq Nation, [Upland Grassroots], [University of Virginia], the Connecticut Agricultural Experiment Station and Central Aroostook Soil and Water Conservation District will use a four-year, $1.6 million EPA grant to continue hemp planting at [the former] Loring [Air Force Base] and testing potential ways to extract PFAS [per- and polyfluoroalkyl substances] from harvested hemp.”
On January 16, Gustafson introduced bill SF 188, which aims to pressure food manufacturers to reduce their use and levels of phthalate chemicals — plasticizers used to make plastics more flexible and durable — in their products.
Hey good to see you Fangster. I agree about the food. There are a lot of issues in this sector. All are government dependent unfortunately. There is no free market. There is no sense in how they approach food, drugs, dietary supplements, even without cannabis. So much needs to be fixed. However, next week on Feb 5th there will be a banking hearing so maybe that is a start...
https://www.marijuanamoment.net/marijuana-businesses-tell-gop-senate-committee-about-struggles-accessing-financial-services-ahead-of-debanking-hearing/
Oh, and FWIW, hemp plants CAN pull soluble precious metals like Gold and Palladium out of the ground. It's called phytomining, but there hasn't been much effort to research it thoroughly to see how well it could work after things like selective breeding for enhanced metals absorption...
"Phytoextraction of palladium and gold from Broken Hill gossan" :
2015
A second trial used Cannabis sativa (Hemp) due to recorded metal tolerance of this species. Pots were re-seeded with C. sativa. Hemp germinated and grew well relative to B. juncea. Potassium cyanide solution (50 mL of 8 g L-1) was applied to each pot at the point of maximum biomass to induce the solubility of precious metals and therefore to induce hyperaccumulation. Significant metal concentration values after KCN treatment were as follows: Copper (6,726 µg g-1) > nickel (184 µg g-1) > palladium (62 µg g-1) > gold (9 µg g-1). Following established criteria values, copper, palladium, and gold hyperaccumulation was observed. The mean metal concentrations of copper, nickel, and palladium from Hemp grown in soil B were greater compared to Hemp grown in soil A and control plants (p < 0.05). However, gold concentration between Hemp A and Hemp B was not different significantly (p > 0.05).
DY, very interesting posts. It's long past the point for the FDA and whatever other alphabet agency come clean and address the real health hazards of fast and processed foods.
It really should NOT take scientific studies to confirm these issues. The ballooning health care crisis overwhelming society tells the story. Just look at individuals over 30 that live chemically infused foods vs. those that don't. In most cases, it clear who's eating what.
"100% of Fast Food Samples Tested Positive for Heavy Metals, Lead, and Cadmium":
October 12, 2023
Summary
-100% of the fast food samples tested contained alarming levels of cadmium.The levels of cadmium were between 74%-1158% higher than what the EPA allows in drinking water.
-Cadmium is highly carcinogenic and can cause toxic reactions even at low levels.
-In-and-Out french fries had 1,158% higher levels of cadmium than what the EPA allows in drinking water.
-Jack-in-the-Box french fries had 970% higher levels of cadmium than what the EPA allows in drinking water.
-100% of the 42 fast food samples tested had trace amounts or higher of lead.
-Even low levels of lead in blood have been shown to negatively affect a child’s intelligence, ability to pay attention, and academic achievement.
-A Sonic Drive-in cheeseburger had the highest amount of lead, 912% higher than what the EPA allows in drinking water.
-Arsenic was also detected in 17% of the fast food samples.
-The highest level of arsenic was found in Panda Express’s orange chicken and white rice at 362% higher than EPA levels allowed in drinking water.
Cadmium
The highest level of cadmium was found in fast food french fries. This is presumably because potatoes are grown in the ground and absorb more heavy metals in the growth process. In-and-Out had 1,158% higher levels than what the EPA allows in drinking water, and Jack-in-the-Box had cadmium levels 970% higher than what the EPA allows in drinking water. According to a March 2023 paper by Wang et al. “Cadmium (Cd) is a highly carcinogenic metal, which can cause toxic reactions even at low concentrations. Long-term ingestion of high-dose Cd can cause serious health problems (Ankit et al., 2021).
The paper further explains how cadmium may be polluting food. “Application of sewage sludge, farmyard manure, or some commercial fertilizers may also increase Cd levels in the soil (Bigalke et al., 2017, Kubier et al.,)” The paper also points to reasons “such as dumping of domestic or industrial wastewater (Rao & Kashifuddin, 2016), and misuse of phosphate fertilizer.”
This preprint research paper shows hemp/CBD protects against Lead toxicity and another paper shows it even protects against Copper toxicity too. Maybe it's ability to modulate a wide variety of metals will become more important in the future. Maybe Hemp can pull Gold, Silver, Platinum, Palladium out of the ground...
"Evaluation of the protective effect of cannabidiol in lead toxicity in mice":
12 Feb, 2024
Conclusion
This study showed that CBD has a protective effect against Pb toxicity. This finding indicates that CBD could be used as a food additive or supportive treatment for alleviating the toxic effects of Pb at risked population groups.
"In conclusion, hemp seed supplementation showed significant (P < 0.05) improved results against copper toxicity. Thus, it could be recommended as an animal feed ingredient for its therapeutic role."
Interesting circle of life...heavy metal content(Cadmium) in soil modulates cannabinoid content in hemp and then the hemp's cannabinoid content (CBD specifically) modulates heavy metals, and their toxicity, in humans...
"Study: CBD Protects Against Some of the Toxic Effects of Cadmium":
Jan 21,2025
https://themarijuanaherald.com/2025/01/study-cbd-protects-against-some-of-the-toxic-effects-of-cadmium/
Here is the actual paper..."Investigation of Cannabidiol's Protective Effects on Cadmium-Induced Toxicity in Mice":
2025 Feb
https://pubmed.ncbi.nlm.nih.gov/39832793/
"Cadmium in Food and Foodwares":
https://www.fda.gov/food/environmental-contaminants-food/cadmium-food-and-foodwares
"Dietary exposure to cadmium from six common foods in the United States":
June 2, 2023
https://www.sciencedirect.com/science/article/pii/S0278691523002752
"Cannabidiol Protects (human)Dopaminergic Neuronal Cells from Cadmium":
2019 Nov
https://pmc.ncbi.nlm.nih.gov/articles/PMC6888634/
"Protective effect of cannabidiol against cadmium hepatotoxicity in rats":
2013 Oct
https://pubmed.ncbi.nlm.nih.gov/23993482/
"Identification of MYB genes reveals their potential functions in cadmium stress response and the regulation of cannabinoid biosynthesis in hemp":
8 March 2022
"Industrial hemp (Cannabis sativa L.) is an important fiber crop used to remediate soils contaminated with heavy metals. Studies have shown that exogenous Cd(Cadmium) stress can affect the production of secondary metabolites in industrial hemp plants."
https://www.sciencedirect.com/science/article/abs/pii/S0926669022000905
How about CBD analysts John Smith/ (Pinocchio) also recommending TCNNF and Ayrwf besides cwbhf 😆🤣
WQLF SAYS CWBHF Sucks 10 Pennies and falling YQU DO Understand YQU Understand. Have Mercy WQLF Ahooooooo
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=17552012
☝️
WQLF SAYS: ALL 34 SKU’s Removed. Oh My My Have Mercy WQLF Ahooooooo
https://data.food.gov.uk/cbd-products/products-list?page=1&row-limit=10&search=Charlotte+s+Web
Wolfman Jack Says: Oh My My You Understand. Ahooooooo
WQLF SAYS: It just dawned on me that JD mentioned Cannabis in the call. I believe the company is going to merge with or acquire a Cannabis
Company. Your thoughts?
“We will continue to participate in the contraction and consolidation of both the CANNABIS and HEMP industries and will evaluate both inbound and outbound M&A opportunities that have strategic value and help scale our company profitably.”
WQLF SAYS;
“Charlotte's Web" or the "Company"), the market laggard in cannabidiol (CBD) hemp extract wellness products, stands in firm opposition to the new regulations in California that restrict the sale of many ingestible full-spectrum hemp CBD products that meet federal requirements.”
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=175135284
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