Charlotte's Web Holdings Inc (CWBHF)

[Wolf-man jack]

https://finance.yahoo.com/news/charlottes-2024-first-quarter-earnings-131000187.html

[Wolf-man jack]

Why WE Wonder

[Wolf-man jack]

Not good

[Wolf-man jack]

Thank you 🙏

[Wolf-man jack]

CWBHF either BK or Hostile Takeover by the Bloody Brits Cancer Company YQU Now Understand YQU Understand. Have Mercy Capiche WQLF ahoooooooo

https://investorshub.advfn.com/boards/read_msg.aspx?message_id=174281764

[Gladys Thong]

CWBHF vs CVSI and DJTWW since March28 post



CWBHF: UP 10%

vs MaxwellE favorites:

CVSI: DOWN 10%
DJTWW: DOWN 70%

[Thomas@yahoo]

SOMEONE SUGGESTED I SHARE THE 10k SO ANY POTENTIAL INVESTORS CAN READ THE LENGTHY RISK FACTORS SUMMARY WITH STRUGGLING CHARLOTTES WEB.
https://www.sec.gov/ix?doc=/Archives/edgar/data/1750155/000175015524000027/cweb-20231231.htm

[MADDSTACKER]

Keep posting price going up , thank you

[MADDSTACKER]

How can they when it’s there website , sounds like a bs lawsuit

[Thomas@yahoo]

Charlottes Web fine would exceed $5 Million.
https://hemptoday.net/wp-content/uploads/2024/04/jurdi-v-charlottes-web-inc.pdf

[Thomas@yahoo]

STRUGGLING CBD MAKER CHARLOTTES WEB EAVESDROPPED ON WEBSITE USERS, LAWSUIT ALLEGES.
https://hemptoday.net/struggling-cbd-maker-charlottes-web-eavesdropped-on-website-users-lawsuit-alleges/

[2TimeTrader]

Looks like the price is baked in , if it holds these levels
till fall , could be in for a nice run Nov threw new years...

[MaxwellE]

$.19 is still a little to high for this POS...M

[oilfieldmafia]

Cheap shares huh....

[2TimeTrader]

FDA says medical Marijuana has legitimate Medicinal Purpose... 4 Days ago... https://www.abcactionnews.com/news/national/fda-says-marijuana-has-a-legitimate-medicinal-purpose

[2TimeTrader]

Yea this will.get u cheap shares... Told u.. CBD-Focused Charlotte's Web Narrows Net Loss 75% YoY In Q4, Reports Drop In Revenue https://www.benzinga.com/markets/cannabis/24/03/37871894/cbd-focused-charlottes-web-narrows-net-loss-75-yoy-in-q4-reports-drop-in-revenue

[2TimeTrader]

If Earnings numbers are bad on the 21st this is gonna dip.. Have cash ready to seize the opportunity.... Cheap shares

[GE_Jim]

FYI- https://www.marijuanamoment.net/fda-official-says-agency-is-actively-exploring-cbd-regulations-as-it-continues-to-monitor-kratom/

[2TimeTrader]

Mid summer this should be scraping under 0.10 and shares will be scooped up in blocks... An when big news comes those with bottom positions gonna clean up....

[GE_Jim]

Hey Darth, just trying to catch up some. Back to 1 you say, no reason to respond to this one, save for a more important subject.

[DarthYoda]

The "Autism" trend chart is even more shocking than the earlier chart for ASD, "Autism Spectrum Disorder"...
Does anyone have any politically correct explanations for this chart?...
"Autism"
https://trends.google.com/trends/explore?date=all&geo=US&q=%2Fg%2F121kwpxw&hl=en-US

[Wolf-man jack]

WQLF SAYS: Great News for CV Sciences stock YQU Understand. Have Mercy Ahooooooo

The MLB sponsorship was a Biggly mistake and is going to continue burning cash to the point that the Pps will continue to plunder. BAT should just make an offer to buyout the itsy itsy bitsy spider web company. In my opinion, It seems that there is an intentional manipulation of the company stock in order to lower its market cap for a possible BAT friendly takeover was their plan from the start. BAT would be foolish to pump more monies into this losing game company. Why not just take over the company and merge the other company. That would allow BAT to bring back one of the seven hostile dwarfs. Glad to have you back. My good riddance remark was the key for your return we do Understand YQU Understand. Lollipops 🍭 Have Mercy WQLF Ahooooooo

WOLFMAN JACK SAID;

[DarthYoda]

That ASD trend chart shocked me. It should be on the news.

[DarthYoda]

OMG...ASD...https://trends.google.com/trends/explore?date=all&geo=US&q=%2Fm%2F02p3f5&hl=en-US

[DarthYoda]

"Could an NLRP3 inhibitor be the one drug to conquer common diseases?":
February 17, 2020
https://cen.acs.org/pharmaceuticals/drug-discovery/Could-an-NLRP3-inhibitor-be-the-one-drug-to-conquer-common-diseases/98/i7

[DarthYoda]

CBD's range of powers should make more sense now...
"Pharma Looks to Inflammasome Inhibitors as All-Around Therapies":
Apr 1, 2021
Many major biopharmaceutical companies are developing or acquiring drugs that target the NLRP3 inflammasome, a large intracellular complex that researchers say can spark inflammation and stoke diseases of lifestyle and aging.


https://www.the-scientist.com/pharma-looks-to-inflammasome-inhibitors-as-all-around-therapies-68582
"...finding drugs to selectively stop NLRP3 will be difficult."
https://cen.acs.org/pharmaceuticals/drug-discovery/Could-an-NLRP3-inhibitor-be-the-one-drug-to-conquer-common-diseases/98/i7
"...we emphasize the capacity of cannabidiol to suppress inflammation by blocking the NLRP3 signaling pathway..."
https://link.springer.com/article/10.1007/s00011-023-01831-y

[Fangster]

CW still advertising on Fox News tonight. Been seeing the commercials in the mornings but first time in prime time.

I like it!!!

[DarthYoda]

Hmmm...Pericarditis...https://trends.google.com/trends/explore?date=all&geo=US&q=%2Fm%2F032snl&hl=en-US

[DarthYoda]

Recreate+MLB+PLL website looking good...
https://recreateyou.com/mlb
https://recreateyou.com/pll

[DarthYoda]

"Farmers, businesses push back on Florida Republicans' efforts to restrict THC products"
Feb 16, 2024
https://www.orlandoweekly.com/cannabis/farmers-businesses-push-back-on-florida-republicans-efforts-to-restrict-thc-products-36201768

[DarthYoda]

Same goes for ASD..."Multiple inflammasome complexes are activated in autistic spectrum disorders":
2016 Mar 12

Abstract
Background: Inflammasomes are multimeric protein platforms involved in the regulation of inflammatory responses whose activity results in the production of proinflammatory cytokines. Because neuroinflammation is observed in autistic spectrum disorders (ASD), a neurologic condition of childhood resulting in a complex behavioural impairment, we analyzed the inflammasomes activity in ASD. Additionally we verified whether alterations of the gastrointestinal (GI) barriers might play a role in inflammasomes activation.

Methods: The activity of the inflammasomes, the concentration of the inflammasomes-derived proinflammatory cytokines interleukin (IL)-1ß and IL-18, and serum parameters of GI damage were analyzed in 25 ASD children, 23 healthy siblings (HS) and 30 unrelated age-matched healthy controls (HC).

Results: A significant upregulation of the AIM2 and the NLRP3 inflammasomes and an increased production of IL-1ß and IL-18 that was associated with a consistent reduction of IL-33, an anti inflammation cytokine were observed in ASD alone. Notably, in a possible immune-mediated attempt to dampen inflammation, IL-37, a suppressor of innate inflammatory responses, was significantly augmented in these same children. Finally, intestinal fatty acid binding protein (IFABP), an index of altered GI permeability, was significantly increased in serum of ASD and HS.

Conclusions: These results show that the inflammasomes are activated in ASD and shed light on the molecular mechanisms responsible for ASD-associated neuroinflammation. The observation that GI alterations could be present as well in ASD offers a possible link between such alterations and neuroinflammation. Therapeutic strategies targeting inflammasome activation could be useful in ASD.

https://pubmed.ncbi.nlm.nih.gov/26979869/

[DarthYoda]

"Inflammasomes"...Looks like we're on to something here...CBD/Hemp extract has shown promise for all of these conditions as well...
"...Inflammasome Activation Is Pathogenic in Multiple Neurological Diseases":
Feb. 14, 2024

This article provides increasing evidence that activation of several types of inflammasomes and extracellular ASC specks contribute to the development and progression of multiple neurological diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), epilepsy, traumatic brain injury (TBI), and stroke.

Many neurological conditions involve an underlying chronic inflammasome-mediated inflammatory process that worsens the trajectory of these conditions.
Beyond NLRP3, evidence suggests that other inflammasomes, including but not restricted to NLRP1, NLRC4, and AIM2, and their downstream effectors contribute to neuropathology in AD, PD, ALS, MS, stroke, epilepsy, and TBI.

https://markets.businessinsider.com/news/stocks/zyversa-therapeutics-highlights-review-article-substantiating-that-inflammasome-activation-is-pathogenic-in-multiple-neurological-diseases-1033066259

[DarthYoda]

Re: Social benefit projects...I was happy with what these guys were doing with Realm of Caring and thought they would do more together. Maybe the FDA would pick on them for it now. I don't know, but I do think CW should do all, most, or at least some of their social benefit work through RoC. It made more sense IMO.

[DarthYoda]

Well, whaddya know. FDA grants orphan drug status for a CBD formulation to protect from a very popular "vaccine" side effect, based on the NLRP3 inflammasome I posted about a couple weeks ago..."Cannabidiol Formulation Granted Orphan Drug Designation for Pericarditis":
February 15, 2024

The Food and Drug Administration (FDA) has granted Orphan Drug designation to CardiolRx™ (cannabidiol oral solution) for the treatment of recurrent pericarditis. The NLRP3 inflammasome is known to play a key role in the inflammation and fibrosis associated with pericarditis.

https://www.empr.com/home/news/drugs-in-the-pipeline/cannabidiol-formulation-granted-orphan-drug-designation-for-pericarditis/
"The NLRP3 inflammasome: a vital player in inflammation and mediating the anti-inflammatory effect of CBD":
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=173751754

[Wolf-man jack]

🐺 WISE WOLF SAYS 🐺

Get ready to push the button for the 10 cents coming soon 🔜 Possibly next week…. Have Mercy WQLF Ahooooooo

[Wolf-man jack]

AP 17 SAID;

https://investorshub.advfn.com/boards/read_msg.aspx?message_id=171562405

https://investorshub.advfn.com/boards/read_msg.aspx?message_id=173860431

[Wolf-man jack]

🐺 WOLF SAYS; It appears that there is now a “Hail Mary” attempt to pump this stock back up. Will this succeed? We shall see real soon You Understand. Have Mercy WQLF Ahooooooo

Dr. Joong J Fang Said; It appears that it is Getting closer to a buyout by the CANCER STICK company. They must be waiting for the price of the stock to fall to the single digits. The environment is ripe for this LOW CAP Stock to be easily taken over. IMO

[DarthYoda]

"Why to consider botanical drug INDs?":

Dietary supplements:
-Cannot make medical claims: dietary supplements are restricted from making medical claims, limiting their market positioning.
-Low market barrier and high competition
-High product development cost leading to low-profit margin
What a botanical drug IND provides:
-A botanical drug IND allows you to make distinct medical claims, creating a market barrier
-Botanical drugs are not required to show specific active ingredients.
-Botanical drugs can be developed from a single plant or a blend of multiple plants, providing flexibility in product development.
-No need to describe the mechanism of action
-The success rate is significantly higher when developing known safe and effective botanical products compared to synthesizing or purifying new chemical molecules.
-The concept of botanical drugs primarily exists within the FDA regulatory framework and is specific to the process of regulatory filing and approval. Once botanical products receive approval as prescription drugs and enter the market, there is no perceived difference from chemical drugs.

https://www.botanicaldrug.org/service

[DarthYoda]

"Botanical Drug Development Guidance for Industry":
https://www.fda.gov/media/93113/download

[DarthYoda]

https://www.fda.gov/about-fda/center-drug-evaluation-and-research-cder/frequently-asked-questions-botanical-drug-product-development

[DarthYoda]

Fwiw, I was happy to see the CEO of Ben and Jerry's in the picture at all as I sent the company an email suggesting they work with Ben and Jerry's years ago. I meant something more like a business venture though and not just another board member as I think this company has had way too many execs and board members passing through already. They need permanent long term people who are dedicated to the bigger long term goals. Hopefully, something bigger can come out of them working together. I saw he took no shares when he joined the Board, which is different than usual...
https://www.otcmarkets.com/filing/html?id=17247304&guid=5Qd-kKhdNG6Vvhh

[DarthYoda]

I am aware of the very real effect of full spectrum hemp extract on Autism and I think that should be one of the best and most widespread uses for it. I am still waiting for an autistic spectrum relative's federal legal situation(drug tests) to finish up after many years so they can try it for the first time. I think it could be a life changer for them. My pessimism here comes only from the business side, not the science side at all.
I also am not a fan of corporate America's version of "social equity". "Get woke, go broke" is a well known saying now for a reason. I'd like to see CW drop the B corp designation, donate to an appropriate charity when it makes sense, and stop giving away money, products, and company IP based on sexual preference and skin color. Corporate wokeness is just racism and bigotry and was supposed to be illegal in America. I grew up in a genuinely multicutural way, in one of the most multicultural neighborhoods in America, with friends and girlfriends of all races, so the fake woke shit is just nails on a chalk board to me. Gay people are not victims who deserve free money just because they are gay and it's not ok to give away shareholder IP to farmers just because they are Black farmers and not White or Asian farmers.
I honestly can't believe I've found my self explaining this stuff to adults who run million or billion dollar corporations in 2024, but here we are, that's our country now, a confused cult. I never expected Big Tobacco to be involved here, and am surprised I stuck around after they showed up. However, if they can stick to CW's original mission, I am all for their redemption. This company's social goals were originally supposed to be about disabled children and adults who lacked access to the plant. That is a mission I can respect. Those people really do need the products and support. I wont be lead astray like the kids today though into cheering for a social philosophy that I know is the exact opposite direction of where the country was headed 15-25 years ago, when we were much more on the right track. I want to see the original mission succeed and will criticize deviation from that, especially when it is morally bankrupt and detrimental to shareholders.

[Fangster]

Good stuff! For those that understand partnership structuring, they should like this disclosure. Sure, the preferred is first in line but a ton of potential upside to the common interests otherwise.

I read the technical stuff you post albeit the science is above me but I get what I need from it. Lots white papers turning up on the medicinal side of CBD. I’m not suggesting defloia will be the next best thing but pharma grade botanicals are going to be an explosive sector. Question is when it starts.

[Fangster]

I get the pessimism on the stock. However, AJNA -001 is going to put eyes on CW this year and maybe sooner than later.

[DarthYoda]

???...

Select symbol
Canada
CWEB:TORTSX
United States
CWBHF:QXEOTCQX International
Germany
6CW:FRAFrankfurt Stock Exchange
6CW:DEUGerman Composite
6CW:DUSDusseldorf Stock Exchange
6CW:BERBerlin Stock Exchange
6CW:MUNMunich Stock Exchange
6CW:STUStuttgart Stock Exchange

https://markets.ft.com/data/equities/tearsheet/summary?s=6CW:BER

[2TimeTrader]

I'm gonna wait till mid July August if this goes under 0.10 I'm gonna load up.. News looming of DEA rescheduling, and FDA news of regulations for CBD and Hemp... An Banking still be addressed... All excellent catalysts and After November Presidential elections Cannabis sector really heats up... Patience will pay.. Good luck everyone...

[DarthYoda]

https://defloria.bio/

On April 6, 2023, the Company announced the formation of DeFloria LLC, a Delaware limited liability company (“DeFloria”) with AJNA BioSciences PBC (“AJNA”), and a subsidiary of British American Tobacco PLC (LSE: BATS and NYSE: BTI) (“BAT”). BAT holds a 100% equity interest in the preferred units of DeFloria and the Company and AJNA each hold 50% of the joint venture’s voting common units. The Company’s contribution to the joint venture was a license permitting the use of certain proprietary hemp intellectual properties, including clinical and consumer data.

Effective February 12, 2024, the Company and DeFloria entered into a Master Services Agreement (“Services Agreement”) pursuant to which the Company will be compensated for the provision of certain services to DeFloria. The services include assistance with Standard Operating Procedures (SOPs), product testing, stability testing, lab liaison, sampling of product, sample submission, data review, Out of Specification (OOS) evaluation, BMCS, document creation, documentation transition project, BR review, spec/RF creation, clinical trials advisory, OOS and risk mitigation testing.

https://www.otcmarkets.com/filing/html?id=17276969&guid=8dd-keHwt05eJth

[DarthYoda]

New 8-K...not sure why the big drop...
https://www.otcmarkets.com/filing/html?id=17276969&guid=8dd-keHwt05eJth

[DarthYoda]

Couldn't resist...
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=173852245
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=173852354

[Wolf-man jack]

WOLF SAYS; In Reality you only had two choice You Understand. You could have had a V-8 or CVSI Undervalued CVSI stock. In the past the itsy itsy bitsy spider 🕷️ web company had an eight and ten fold advantage in Pps over CVSI. It has now been cut to 2.5 times the price per share of CWBHF over CVSI. Soon they will be at an equilibrium as soon as CWBHF Q-4/2023 10-K dismal returns are expected and released next month. Have Mercy WQLF oooooohA 🐺

🤓 SAID;

Well, this company has destroyed my long term interest in seeing hemp become a legitimate thriving industry. I wont be posting here anymore and am moving on…

WOLFMAN JACK SAYS; Good Riddance. Have Mercy Ahooooooo