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Yeah you can get a few but given how many flop, I think your better off in other sectors. I've gotten a few but overall, cost me plenty. Not worth it IMO. Most are just a place where scientists get to work and play at shareholders expenses. One big hobby cub that usually amount to chasing dead rabbits. Good luck
Would not disagree with your comment, but, I have had some very successful plays that have made up, in spades, for the losers. NBIO went from .04 to .28. Now back to .08 and I am bidding for shares. BIVI could be another mover. Success in Phase2 trials can really move the pps up big time. We shall see. HAWK
Your better off going to the casino than playing small cap bio stocks. Most are dillutive and fails. Just my take.
I have several small/micro cap BIOs. They are all down and no bad news that I can find. I believe the sector is out of favor while money flows into AI and chip technology. Phase2 trials, if there is any success, will push PPS up. Just my take. HAWK
$BIVI News: BioVie Presents Protocol Design of Upcoming SUNRISE-PD Phase 2 Trial of Bezisterim in Patients with Early Parkinson’s Disease at ATMRD 2024
SUNRISE-PD to evaluate the effect of bezisterim (NE3107) on motor and non-motor symptoms in ~60 patients with Parkinson’s disease who are naïve to carbidopa/levodopa
Additional presentation at congress highlighted data from earlier Phase 2a trial of bezisterim in Parkinson’s disease that helped inform SUNRISE-PD trial design
CARSON CITY, Nev., June 25, 2024 (GLOBE NEWSWIRE) -- BioVie Inc., (NASDAQ: BIVI) (“BioVie” or the “Company”) a clinical-stage company developing innovative drug therapies for the treatment of neurological and neurodegenerative disorders and advanced liver disease, today announced data from two presentations at the Advanced Therapeutics in Movement and Related Disorders Congress® (ATMRD Congress) held June 21-25, 2024 in Washington, D.C.
Presentations include a first look at the protocol design of the upcoming SUNRISE-PD Phase 2 trial of bezisterim (NE3107) in patients with early Parkinson’s disease along with an encore presentation of detailed results from the Company’s Phase 2a trial of bezisterim adjunctive to carbidopa/levodopa (C/L) in patients with Parkinson’s disease.
"Promising preclinical data suggest bezisterim may address unmet needs in Parkinson's disease. Existing treatments offer variable success, and disease progression leads to worsening motor function, dyskinesias, and significant disability,” said Cuong Do, BioVie’s President and CEO. “Bezisterim's unique mechanism of action – targeting inflammation and insulin resistance – holds promise for mitigating these issues based on data from earlier-phase trials. SUNRISE-PD will allow us to further investigate bezisterim's safety and efficacy in a larger patient population who have minimal prior exposure to levodopa, with the goal of developing a treatment that can significantly improve the lives of people with Parkinson's disease."
Protocol Design of SUNRISE-PD: A Phase 2, Placebo-Controlled Study of Bezisterim in Early Parkinson’s Disease
The presentation Assessment of Bezisterim (NE3107) in Patients with Early Parkinson’s Disease: A Phase 2, Placebo-Controlled Study outlined the study protocol of the Company’s upcoming SUNRISE-PD Phase 2 trial evaluating bezisterim in patients with Parkinson’s disease who have had minimal exposure to C/L treatment but in need of symptomatic therapy for motor symptoms.
SUNRISE-PD will be a Phase 2, multicenter, randomized, double-blind, placebo-controlled trial with a hybrid decentralized design that will last 20 weeks from the initial screening phase to the safety follow up. During the 12-week double-blind phase, around 60 patients will be randomized 1:1 to receive either bezisterim 20 mg or placebo twice-daily.
Objectives and Endpoints:
Objective Endpoint
Primary
Evaluate the efficacy of bezisterim in the treatment of motor symptoms of PD Change in MDS-UPDRS Part III score at week 12 (centralized ratings)
Secondary
Evaluate the impact of bezisterim on non-motor symptoms of PD and on overall symptoms of PD as assessed by the clinician
Change in the MDS-UPDRS Part I and Part II scores at week 12
Percent of subjects with any improvement as measured by the CGI-I at week 12
Percent of subjects with any improvement as measured by the CGI-S at week 1
Exploratory
Assess the effects of bezisterim treatment on other aspects of PD Change in MDS-UPDRS combined and sub-domain scores
Evaluate the effect of bezisterim on Patient Reported Outcomes
Change in PDQ-39 response
Change in PDSS score
Evaluate the effect of bezisterim on discontinuation events for worsening of PD
Proportion of subjects discontinuing from the study due to worsening of PD
Time to discontinuation due to worsening of PD
Assess the effect of bezisterim on epigenetics associated with biological age and alpha synuclein gene methylation Change in DNA methylation up to week 12
Assess the effect of bezisterim on plasma biomarkers of inflammation and pharmacodynamics Change in plasma biomarkers of inflammation up to week 12
Assess the effect of bezisterim on circulating biomarkers and correlations between biomarkers and clinical endpoint changes Change and percent change from baseline in pre-specified exploratory biomarkers and the correlation between biomarkers and clinical endpoints at week 12
Assess population PK and E-R relationships for efficacy and safety of bezisterim PK and E-R assessments for efficacy and safety where data permit
Safety
Assess the safety and tolerability of bezisterim
Treatment-emergent adverse events
Vital signs
Electrocardiograms
Clinical laboratory values
Physical exam
C-SSRS
PD = Parkinson’s disease; MDS-UPDRS = Disorder Society Unified Parkinson’s Disease Rating Scale; CGI-I = Clinical Global Impression-Improvement; CGI-S = Clinical Global Severity Scale; PDQ-39 = Parkinson’s Disease Questionnaire-39; PDSS = Parkinson’s Disease Sleep Scale; PK = pharmacokinetics; E-R = exposure response; C-SSRS = Columbia-Suicide-Severity Rating Scale
As part of the trial, patients may participate either completely from their home or at a clinical site. At-home participants will be visited by study nurses who will complete study assessments with the assistance of a neurologist who will attend the visit remotely by video. If the results of the study are positive, then participants may be eligible to enter a longer-term, open-label safety study at a future date.
Phase 2a Data Reinforce Potential of Bezisterim to Improve Motor and Non-Motor Symptoms of Parkinson’s Disease
An encore presentation, Improvement of Motor and Non-Motor Symptoms with Bezisterim (NE3107) Adjunctive to Carbidopa/Levodopa in Patients with Parkinson’s Disease: A Phase 2a, Placebo-Controlled Study, suggested improvements in both motor and non-motor symptoms with bezisterim adjunctive to C/L. These findings were presented last month at the XXIX World Congress on Parkinson’s Disease and Related Disorders hosted by the International Association of Parkinsonism and Related Disorders (IAPRD) in Lisbon, Portugal.
"The data from this comprehensive analysis of our Phase 2a trial strengthen the potential of bezisterim as an add-on therapy to levodopa for managing specific non-motor symptoms in Parkinson's disease, particularly sleep/fatigue and restless legs,” said Joseph Palumbo, BioVie’s Chief Medical Officer. “These findings built upon prior evidence of bezisterim's impact on motor symptoms and helped inform the direction of our Parkinson’s disease program. We believe that our body of evidence to-date positions bezisterim well for further evaluation in our larger, late-stage SUNRISE-2 trial."
Patients treated with bezisterim and C/L experienced superior improvements on the Disorder Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) Part III at 2- and 3-hour marks when compared to placebo. In patients younger than 70 years old (~50% of the total patient population) the advantage for bezisterim-treated patients was -4.7 points. Furthermore, 30% of bezisterim-treated patients experienced improvement in their ability to move, having Part III scores prior to their first morning dose of C/L that were equal to or better than Part III scores associated with their being in the “ON” state after C/L treatment at the start of the study, whereas none of the placebo patients had the similarly improved morning Part III scores. The difference was statistically significant (p=0.02).
Bezisterim-treated patients experienced a significant improvement of -2.4 points for the sleep/fatigue domain of the Non-Motor Symptom Scale (NMSS) in Parkinson’s disease, whereas placebo patients experienced a worsening of +1.0 points (p=0.0159). Sleep/fatigue domain improvements correlated with motor score improvements (r=0.51; p=0.0259). More patients on bezisterim had improvements in the NMSS sleep/fatigue domain, while more patients on placebo worsened.
Bezisterim-treated patients experienced an improvement of -0.89 on the urge to move legs/restlessness in legs whereas placebo patients experienced a worsening of +0.99 (p=0.0321).
About Bezisterim
Bezisterim (NE3107) is an orally bioavailable, BBB-permeable, insulin-sensitizer that is also anti-inflammatory. In addition, it is not immunosuppressive and has a low risk of drug-to-drug interaction. Bezisterim has the potential to reduce symptoms of long COVID, including fatigue and cognitive dysfunction. Persistently circulating viral spike proteins are believed to trigger TLR-4 driven activation of NFkB and the subsequent expression of inflammatory cytokines (IL-6, TNF, IFNg). Bezisterim has been shown to modulate the activation of NFkB and thus modulate inflammation.
Bezisterim is being investigated for Alzheimer’s disease (AD) and Parkinson’s disease (PD). BioVie has conducted and reported efficacy data on its Phase 3 randomized, double-blind, placebo-controlled, parallel-group, multicenter study to evaluate bezisterim in patients who have mild-to-moderate AD (NCT04669028). Results of a Phase 2 investigator-initiated trial (NCT05227820) showing bezisterim-treated patients experienced improved cognition and biomarker levels were presented at the Clinical Trials on Alzheimer’s Disease (CTAD) annual conference in December 2022. An estimated six million Americans suffer from AD. A Phase 2 study of bezisterim in PD (NCT05083260) has been completed, and data presented at the AD/PD™ 2023 International Conference on Alzheimer’s and Parkinson’s Diseases and related neurological disorders in Gothenburg, Sweden in March 2023 showed significant improvements in “morning on” symptoms and clinically meaningful improvement in motor control in patients treated with a combination of bezisterim and levodopa vs. patients treated with levodopa alone, and no drug-related adverse events.
About BioVie Inc.
BioVie Inc. (NASDAQ: BIVI) is a clinical-stage company developing innovative drug therapies for the treatment of neurological and neurodegenerative disorders and advanced liver disease. In neurodegenerative disease, the Company’s drug candidate bezisterim inhibits inflammatory activation of ERK and NFkB (e.g., TNF signaling) that leads to neuroinflammation and insulin resistance, but not their homeostatic functions (e.g., insulin signaling and neuron growth and survival). Both are drivers of AD and PD. In liver disease, the Company’s Orphan drug candidate BIV201 (continuous infusion terlipressin), with U.S. Food and Drug Administration (“FDA”) Fast Track status, is being evaluated and discussed with guidance received from the FDA regarding the design of Phase 3 clinical testing of BIV201 for the treatment of ascites due to chronic liver cirrhosis. The active agent is approved in the U.S. and in about 40 countries for related complications of advanced liver cirrhosis. For more information, visit http://www.bioviepharma.com.
Forward-Looking StatementsThis press release contains forward-looking statements, which may be identified by words such as "expect," "look forward to," "anticipate" "intend," "plan," "believe," "seek," "estimate," "will," "project" or words of similar meaning. . Although BioVie Inc. believes such forward-looking statements are based on reasonable assumptions, it can give no assurance that its expectations will be attained. Actual results may vary materially from those expressed or implied by the statements herein due to the Company's ability to successfully raise sufficient capital on reasonable terms or at all, available cash on hand and contractual and statutory limitations that could impair our ability to pay future dividends, our ability to complete our pre-clinical or clinical studies and to obtain approval for our product candidates, our ability to successfully defend potential future litigation, changes in local or national economic conditions as well as various additional risks, many of which are now unknown and generally out of the Company's control, and which are detailed from time to time in reports filed by the Company with the SEC, including quarterly reports on Form 10-Q, reports on Form 8-K and annual reports on Form 10-K. BioVie Inc. does not undertake any duty to update any statements contained herein (including any forward-looking statements), except as required by law.
For Investor Relations Inquiries:
Contact: Bruce Mackle Managing Director LifeSci Advisors, LLC bmackle@lifesciadvisors.com
For Media Inquires
Melyssa Weible
Managing Partner, Elixir Health Public Relations
Ph: +1 201-723-5705
mweible@elixirhealthpr.com
https://www.globenewswire.com/newsroom/ti?nf=OTE2ODc0NSM2MzQxMzEyIzUwMDA3OTY2Ng==
https://ml.globenewswire.com/media/YTliMmFlOTUtMzBmYy00MDkyLWIzY2EtMjE2ODY0MTQ0NDQ5LTUwMDA3OTY2Ng==/tiny/BioVie-Inc-.png
Source: BioVie, Inc.
Success with Phase2 trials will boost the pps to new highs. imho. HAWK
BioVie and Mobilicom Interviews to Air on the RedChip Small Stocks, Big Money(TM) Show on Bloomberg TV
ORLANDO, FL / ACCESSWIRE / June 21, 2024 / RedChip Companies will air interviews with BioVie, Inc. (Nasdaq:BIVI) and Mobilicom Ltd. (Nasdaq:MOB) on the RedChip Small Stocks, Big Money™ show, a sponsored program on Bloomberg TV, this Saturday, June 22, at 7 p.m. Eastern Time (ET). Bloomberg TV is available in an estimated 73 million homes across the U.S.
Access the interviews in their entirety at:
BioVie: https://www.redchip.com/assets/access/bivi_access
Mobilicom: https://www.redchip.com/assets/access/mob_access
In an exclusive interview, Cuong Do, President and CEO of BioVie, who will share insight into the Company's pipeline of late-stage clinical programs targeting unmet medical needs in neurodegeneration and liver disease. BioVie's lead asset, bezisterim (formerly NE3107), has demonstrated the ability to modulate TNFa production, leading to significant clinical improvements. Patients treated with bezisterim experienced reduced inflammation and insulin resistance, improved motor control and "morning on" symptoms in Parkinson's disease (PD), enhanced cognition and function, and better brain imaging scans in Alzheimer's disease (AD), as well as reduced DNA methylation levels. The Company's strategic priorities include launching a Phase 2b trial for Parkinson's in Fall 2024, initiating a Phase 3 trial for Alzheimer's in mid-2025 with a new once-daily formulation of bezisterim, continuing partnering discussions for bezisterim's geographic rights, and commencing an ascites Phase 3 trial upon identifying a suitable partner.
Oren Elkayam, Founder and CEO of Mobilicom, appears on the RedChip Small Stocks, Big Money™ show on Bloomberg TV to provide a corporate update. Mobilicom presents a strong investment opportunity with its comprehensive and proprietary technology suite. The company's products, including SkyHopper Datalinks, Ground Control Systems, Mobile Mesh Networking, the ICE Cybersecurity Suite, and CONTROLiT cloud management, form the core 'brain' of drones, providing control, guidance, and cybersecurity. Mobilicom's intellectual property, comprising trade secrets and 34 patent claims across two patent families, underscores its innovation leadership. With a global footprint, the company has secured over 50 customers in 18 countries and achieved 50 "design wins," indicating significant market penetration and long-term revenue potential. Mobilicom generated 43% revenue growth with 59% gross margin in 2023, and ended the year with a strong cash balance of $8.4 million. Combined with a narrowing monthly burn rate, this affords Mobilicom a long cash runway to implement its strategic plans, capture market share, and ramp revenues.
About BioVie Inc.
BioVie Inc. (NASDAQ: BIVI) is a clinical-stage company developing innovative drug therapies for the treatment of neurological and neurodegenerative disorders and advanced liver disease. In neurodegenerative disease, the Company's drug candidate bezisterim inhibits inflammatory activation of ERK and NF?B (e.g., TNF signaling) that leads to neuroinflammation and insulin resistance, but not their homeostatic functions (e.g., insulin signaling and neuron growth and survival). Both are drivers of AD and PD. In liver disease, the Company's Orphan drug candidate BIV201 (continuous infusion terlipressin), with U.S. Food and Drug Administration ("FDA") Fast Track status, is being evaluated and discussed with guidance received from the FDA regarding the design of Phase 3 clinical testing of BIV201 for the treatment of ascites due to chronic liver cirrhosis. The active agent is approved in the U.S. and in about 40 countries for related complications of advanced liver cirrhosis. For more information, visit www.bioviepharma.com.
About Mobilicom
Mobilicom is a leading provider of cybersecure robust solutions for the rapidly growing defense and commercial drones and robotics market. Mobilicom's large portfolio of field-proven technologies includes cybersecurity, software, hardware, and professional services that power, connect, guide, and secure drones and robotics. Through deployments across the globe with over 50 customers, including the world's largest drone manufacturers, Mobilicom's end-to-end solutions are used in mission-critical functions.
For investors, please use https://ir.mobilicom.com/
For company, please use www.mobilicom.com
About RedChip Companies
RedChip Companies, an Inc. 5000 company, is an international investor relations, media, and research firm focused on microcap and small-cap companies. For 32 years, RedChip has delivered concrete, measurable results for its clients. Our newsletter, Small Stocks, Big Money™, is delivered online weekly to 60,000 investors. RedChip has developed the most comprehensive service platform in the industry for microcap and small-cap companies. These services include the following: a worldwide distribution network for its stock research; retail and institutional roadshows in major U.S. cities; outbound marketing to stock brokers, RIAs, institutions, and family offices; a digital media investor relations platform that has generated millions of unique investor views; investor webinars and group calls; a television show, Small Stocks, Big Money™, which airs weekly on Bloomberg US; TV commercials in local and national markets; corporate and product videos; website design; and traditional investor relation services, which include press release writing, development of investor presentations, quarterly conference call script writing, strategic consulting, capital raising, and more.
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View the original press release on accesswire.com
Well apparently this is another small cap bio dead dog. Rip...Sheesh..
Getting perky for turn upside!
BIVI is waking up... Possible turn around on a swing trade or investment.
BIVI.....Picked up .5250's on Thursday.....Due for a bounce.
It ran alright ... ran right down to that $1 offering price.
Impressive Trial Updates
Brave soul...I wouldn't sell till maybe after the conference March 8-9...maybe the 7th...this stock is wound up pretty tight...seems to have lots more upside than down side...
BioVie’s NE3107 Demonstrates Potential Improvements in Motor and Non-motor Symptoms for Parkinson’s Disease Patients and May Be Realigning Physiological Processes for Alzheimer’s Patients in Data to be Presented at the International Conference on Alzheimer’s and Parkinson’s Diseases 2024
https://finance.yahoo.com/news/biovie-ne3107-demonstrates-potential-improvements-130000143.html
BioVie Shares Double After Positive Data for Parkinson's Disease Treatment
BioVie shares doubled to $2.89 in premarket trading Friday after the company said its Phase 2A study of NE3107 suggested improvements in non-motor symptoms in patients with Parkinson's disease.
The company said these findings complement previously reported improvement in motor symptoms in patients treated with NE3107 and demonstrate potential intrinsic, levodopa-enhancing activity of NE3107 that is consistent with data from animal models.
NE3107-treated patients experienced a significant improvement for the sleep/fatigue domain of the Non-Motor Symptom Scale in Parkinson's disease, whereas placebo patients experienced a worsening.
Sleep/fatigue domain improvements correlated with motor score improvements. More patients on NE3107 had improvements in the NMSS sleep/fatigue domain, while more patients on placebo worsened.
https://www.google.com/amp/s/www.marketwatch.com/amp/story/biovie-shares-double-after-positive-data-for-parkinson-s-disease-treatment-6fca8fee
If it is true they can continue the study and add more patients at compliant clinical sites then that is one good reason to buy - after all they have a strong signal already. And of course Ascites...that is bigger than most seem to think.
BIVI seems like a good buy after that sharp drop! I've watched this stock do the same before. After news a huge drop, then a big run! Is there a good reason not to buy BIVI below $2?
https://finance.yahoo.com/news/biovie-bivi-falls-61-despite-152000388.html
BioVie (BIVI) Falls 61% Despite Upbeat Alzheimer's Study Data
re. 'single entity?'
Only if the individual sites were all under a single umbrella, which I don't know.
Longer answer: We're talking about this clinical trial.
Now if you look at that trial, you will only find one study location mentioned: The Ohio State University
However, if you look at the history of changes, you'll see the list of locations was deleted by the last change done on November 20, 2023
That's something like, what, 32 sites gone.
Do you think all those clinics were run by a single entity?
Yes, I agree it's not clear. Sorry. The CROs and demographic group are unnamed. I'm guessing the lawyer is filtering those details. Call it Florida/Covid crazy.
FWIW, I don't read a clear explanation just a statement that there were issues. How did 15 clinics fail to follow protocol?
Today's PR clearly explains. See the section 'Data Review and Audit'.
November 29, 2023 PR
How were 80% of patients treated using the wrong protocol or at least no using the approved protocol? How does this happen?
It happens, but also provided a nice trade this am.......
Bulls got slaughtered ouch
@#&%!*........
Didn't wanna cuss.
Freakin' data.
Biovie Webinar:
Date & Time: Dec 7, 2023 03:15 PM Central
Zoom Registration
Peeved, I've never been real big on this one but had hopes without following closely. This latest revelation really puts their credibility on the line
Any thoughts on the blinded data runncoach?
It really looks good imo
Wow. I've never been in this one but that really is potentially about as bad as it gets I would think
This guy with this posting is likely the nature of these 'good clinical practices' irregularities. And before he deletes the post, I've captured the screen.
Actual Twitter Post (while it lasts)
And my copy here.
$BIVI 10-Q issued today.
A section on 'good clinical practices' (GCP) contains the reason for the drop.
Official 10-Q
Good update from the CEO. Long for the next few years, but I think they'll be many trading opportunities here with quite the volatility in that time frame.
The unblinded results might give BIVI a pop, but I would expect a drop too. It's the nature of these plays.
We'll see.
Aha! Official: just found how to embed yt videos
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=39097864
and it works
Sorry. IHUB tries (and fails) to preview naked YT links.
Let's try this.
Can you edit? The video isn't playing.....
Sandbagging? Oh yeah. Expensive lawyers give this advice. lol..
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With no medications approved by the FDA specifically to treat ascites, the prognosis for these patients is very poor. Certain drugs which have been approved for other medical conditions (such as diuretics) combined with a salt restricted diet usually provide symptomatic relief in the initial stages of the disease. But as the ascites worsens their efficacy often diminishes. BioVie is working on a solution to address this critical unmet medical need.
Julie G. Anderson, Director. Anderson most recently served Catheter Connections, Inc. as its Vice President of Marketing until the company was sold last month. Previously she was Senior Director of Marketing for Durata Therapeutics, Inc., playing a key role in helping build the infrastructure and commercialization plan necessary to launch the novel antibiotic Dalvance. The team's efforts led to an acquisition of the company in 2014 by Actavis (now Allergan) in a deal valued at about $675 million. Prior to Durata, Julie worked for Sanofi-Synthelabo, Inc., Bayer Pharmaceuticals, and G.D. Searle in various marketing leadership positions. She originally trained as a nurse and earned a Masters of Management at the J.L. Kellogg Graduate School of Management at Northwestern University. As a critical care nurse, Julie treated patients at risk of death due to complications caused by chronic liver cirrhosis, and deeply understands the unmet medical need targeted by BioVie.
Hari Kumar, Director. Board of Directors as an independent director. In addition, Dr. Kumar purchased common shares of BioVie stock through a private placement. After earning a PhD in immunology in 1984, Dr. Kumar embarked upon a successful career in the biopharmaceutical industry. He held positions of increasing responsibility at Roche Pharma culminating in serving as Global Business Development Director, and in 2007 assumed the role of Chief Business Officer for Amira Pharmaceuticals. He led the sale of Amira to Bristol-Myers Squibb in 2011 for $475 million. He then served as Chief Executive Officer (CEO) for Panmira Pharmaceuticals LLC, which is developing anti-inflammatory compounds, and in 2013 became CEO for Adheron Therapeutics, which Roche Pharma acquired in 2015 for $580 million. Beyond his impressive track record, Dr. Kumar brings deep experience in fibrotic and liver diseases to the Company.
Press Releases: https://finance.yahoo.com/quote/bivi?p=bivi
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