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Bio-Path Holdings Inc. (BPTH)

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Last Post: 10/19/2018 3:08:07 PM - Followers: 58 - Board type: Free - Posts Today: 2

Bio-path Holdings Inc.



Company description:

Bio-Path is engaged in the business of financing and commercializing novel cancer therapeutics acquired from MD Anderson Cancer Center. Their first Antisense drug BP-1001, known as Prexigebersen has completed a partial phase II combination trial (with LDAC). The interim results demonstrated 47% of the patients showed early anti-leukemic activity. The company is in the process of amending the dosing protocols for the combination trial and adding a Decitabine cohort.


The Prexigebersen phase II trials for AML are located at MD Anderson, Weill Cornell Medical College Presbyterian Hospital, Baylor, New Jersey Hematology Oncology Associates, West Virginia University and University of Kansas.

Bio-Path Holdings is focused on antisense drugs which work at a cellular level to interrupt protein production by the diseased cell. The lead drug, Prexigebersen is targeting the Grb-2 protein. Several years ago Gilead attempted to produce viable antisense drugs unsuccessfully, because of high toxicity caused by their cationic (positively charged) liposome delivery system. Bio Path Holdings' delivery system is a small molecule neutral liposome system. Through the phase 2 of the combination trial for Prexigebersen there has been absolutely no toxicity. The results of testing performed by Bio Path demonstrates an uptake of the drug at a cellular level. The pErk results demonstrate not only a 50+% knockdown of the target protein but shows the pathway was shut down validating the delivery system. The purpose of phase 2 will be to test the effectiveness of the drug. Interim results are positive. Will the company apply for FDA acclerated status as interim testing is complete on 17 evaluable patients?

A CML combination drug safety study with Sprycel (Dasatinib) for Prexigebersen has begun at MD Anderson but we are awaiting the FDA website comfirmation of same.

Patent protection for manufacturing their neutral lipid delivery system has been granted.

Bio-Path Holdings may also begin in 2018 phase 1 testing of their antisense drug Prexigebersen on certain types of uterine cancer. An IND using Prexigebersen for treatment resistent breast cancer may also occur.  Additionally, BPTH is initiating the development of a second drug BP1002 targeting Bcl-2 for Follicular Lymphoma. An IND for BP1002 is projected to occur in 2018. The third drug BP1003 which targets the Stat-3 protein, is expected to begin IND-enabling studies with a goal to enter first in-human trials in 2019 for treatment of pancreatic tumors.

The company has entered into a sponsored research agreement with the University of Texas Southwestern Medical Center to evaluate BPTH's pipeline for efficacy in down-regulating the immune response using systemic lupus erythematosus (SLE) as a model. Bio-Path has entered into a sponsored research agreement with Thomas Jefferson University to investigate DNAbilize™ antisense DNA technology for the development of a brain cancer immunotherapy that works by activating the patient’s own immune system to fight their cancer. Also, BPTH has entered into a sponsored research agreement with MD Anderson to evaluate the ability of its pipeline to modulate pancreatic cancer.


While antisense drugs fell out of favor following Gilead's failed efforts there was some renewed interest. Ionis established partnerships with Biogen Idec and GlaxoSmithKline for their antisense technology. At the present BPTH has no partnerships with drug manufacturers but if BPTH's delivery system and drugs continue to show promise partnerships are expected.

This link to the company website describes their delivery technology:


The company was founded on the technology from M.D. Anderson Cancer Center at the University of Texas in Houston. M.D. Anderson is the largest insitutional shareholder. After raising additional funds the company has 5+ million in cash.

Bio-Path Holdings does not manufacture their drugs but uses contractors, hence the need for partners.
BPTH is presently traded on the NASDAQ.

Here are links to articles on their drug technology:




Analyst coverage:

Stonegate Capital target $11-14


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#4126   $BPTH - I am bullish on this play Backstabbed 10/19/18 03:08:07 PM
#4125   Where is Sabby? The last buyers in the SJSTOCKSHARK 10/19/18 10:05:35 AM
#4124   $BPTH - still bottom fishing for shares. Backstabbed 10/18/18 08:55:47 AM
#4123   It’s your typical daily short selling by MMs. Backstabbed 10/15/18 05:24:51 PM
#4122   Back, Too me it looks like shorting games SJSTOCKSHARK 10/15/18 05:17:17 PM
#4121   No, it’s stupid to short on no volume. Backstabbed 10/15/18 01:30:20 PM
#4120   Have the shorters returned? SJSTOCKSHARK 10/15/18 11:37:46 AM
#4119   We are off the circuit breaker list. We SJSTOCKSHARK 10/15/18 10:08:02 AM
#4118   Back, Good we need to get over a SJSTOCKSHARK 10/12/18 06:36:26 PM
#4117   $BPTH still on the short sale circuit breaker list! Backstabbed 10/12/18 11:32:30 AM
#4115   "The Price Restriction remains in effect for the SJSTOCKSHARK 10/12/18 11:26:11 AM
#4114   No it doesn’t Backstabbed 10/12/18 10:41:13 AM
#4113   Was there was "naked" shorting? SJSTOCKSHARK 10/12/18 10:31:29 AM
#4112   Back, That certainly supports the shorting theory. SJSTOCKSHARK 10/11/18 07:25:46 PM
#4111   $BPTH is on the Short Sale Circuit Breaker List! Backstabbed 10/11/18 01:53:52 PM
#4110   Agree, Sabby has history . I saw the too simple 10/11/18 12:19:12 PM
#4109   Simple I am adding a few here at SJSTOCKSHARK 10/11/18 10:46:01 AM
#4108   I agree Word. Welcome Backstabbed ! Hope you too simple 10/11/18 10:02:22 AM
#4107   I’m glad to see new people here. Thanks wordlender 10/11/18 07:19:39 AM
#4106   Dang, just a minor catalyst or some volume, Backstabbed 10/10/18 03:34:23 PM
#4105   Who cares! Seems to be a good I Need Money 10/09/18 04:39:53 PM
#4104   With BPTH major selling has NOT been over craiviolin 10/09/18 04:34:27 PM
#4103   This one is itching to go! Just needs Backstabbed 10/09/18 01:13:10 PM
#4102   Back, I hope you are correct. SJSTOCKSHARK 10/09/18 10:59:24 AM
#4101   Looks like that $0.56 seller from yesterday is Backstabbed 10/09/18 10:41:17 AM
#4100   Are the traders right? SJSTOCKSHARK 10/09/18 10:39:28 AM
#4099   $BPTH - 52 week low $0.528 and 52 Backstabbed 10/08/18 05:07:39 PM
#4098   Back in for a few today. Lets I Need Money 10/08/18 04:47:59 PM
#4097   A nice catalyst from the company will help Backstabbed 10/08/18 12:28:03 PM
#4096   I hope the company has been selling into SJSTOCKSHARK 10/08/18 12:20:57 PM
#4095   BTW... trade the chart. I must have traded Backstabbed 10/05/18 02:52:15 PM
#4094   alright thanks bud. good luck Backstabbed 10/05/18 02:40:40 PM
#4093   Good luck with your wishful thinking.....been there done craiviolin 10/05/18 02:39:41 PM
#4092   $BPTH - I like how it’s holding. Backstabbed 10/05/18 01:46:34 PM
#4091   Today marked the 52 week low at $0.528 Backstabbed 10/05/18 11:39:25 AM
#4090   People sold on fear from recent offerings AH. Backstabbed 10/05/18 11:33:19 AM
#4089   What does this mean? blairsoldman 10/05/18 10:38:29 AM
#4088   As long as momentum is not killed. They Backstabbed 10/04/18 08:56:42 PM
#4087   Backstab, Unfortunately they need the cash...NOW! SJSTOCKSHARK 10/04/18 08:49:14 PM
#4086   Added more today as well. sham1002 10/04/18 04:04:54 PM
#4085   Nice break :) $BPTH r1aviator 10/04/18 01:29:39 PM
#4084   This will run like HSGX soon Backstabbed 10/04/18 01:02:26 PM
#4083   Added to my position Backstabbed 10/04/18 12:44:59 PM
#4082   I like and the price and volume action, wordlender 10/04/18 12:06:03 PM
#4081   Here she goes, lock up your shares for $1.00+ Backstabbed 10/04/18 11:46:33 AM
#4080   Word to the wise! You raise money when Backstabbed 10/04/18 11:02:01 AM
#4079   I hope the company sells stock into this SJSTOCKSHARK 10/04/18 10:53:02 AM
#4078   Twitter Backstabbed 10/04/18 10:51:39 AM
#4077   Backstabber, Welcome aboard. How did you hear about BPTH? SJSTOCKSHARK 10/04/18 10:50:59 AM
#4076   $BPTH - Another promising runner! Looks ready for Backstabbed 10/04/18 10:34:06 AM