Annovis Bio Inc (ANVS)

[conix]

Annovis Bio (ANVS) loses nearly half after presenting Alzheimer's drug data at AAIC 2021

Jul. 29, 2021

By: Mamta Mayani, SA News Editor

Annovis Bio (NYSE:ANVS) plunges 49.3% premarket after announcing new clinical efficacy and biomarker data of its drug ANVS401 at the 2021 Alzheimer's Association International Conference (AAIC).

ANVS401 reverses the toxic cascade, starting with lowering the levels of neurotoxic proteins, improving the health of the axon, reduced inflammation and improving cognition and motor function.

In addition, data from 14 Alzheimer's disease (AD) patients show that from baseline to 25 days in the Posiphen, dubbed ANVS401-treated group, ADAS-Cog11 improved by 4.4 points, a statistically significant improvement of 30% (p<0.05).

Posiphen-treated group compared to placebo at baseline and 25 days showed an improvement of 3.3 points, or 22% (p=0.13).

Posiphen-treated group showed trends of improvement in all four ADAS-Cog tests compared to placebo.

In Parkinson's disease (PD) patients, Posiphen-treated group showed trends of improvement in all four parts of UPDRS test compared to placebo.

In WAIS coding test, ANVS401-treated AD patients show a 6.6 point and PD patients a 6.1 point improvement in coding.
However, changes in MMSE scores are not statistically significant compared to placebo.

50% and 30% of AD and PD patients (N=10) encountered adverse events. Most AEs were due to the spinal fluid extraction that resulted in headaches and back aches.

[conix]

Feuerstein Strikes Again

l=d&Volume=1&ChartType=CandleStick&Stockscores=1&ChartWidth=830&ChartHeight=500&LogScale=None&Band=None&avgType1=SMA&movAvg1=50&avgType2=SMA&movAvg2=100&Indicator1=RSI&Indicator2=BBW&Indicator3=AccDist&Indicator4=MACD&endDate=&CompareWith=&entryPrice=&stopLossPrice=&candles=redgreen[/chart]

[The_Wade]

It's Adam Feuerstein & Stat News out with a short FUD report.

I got out of this one around 100, but happy to be able to get back in when this settles down, which will probably take a while to recover.

I like the MOA of this one & Maria is awesome.

There was no chance of hitting stat sig with 14 patients. The FUD guys love to hammer on that one.

[McMagyar]

This could be an over reaction to Anavex news, that anavex prevents ad..
I think Annovis and Anavex will be a mighty fine combo someday..

20% of people will not respond to Anavex...
How many millions will need more than restoration to recover in three years?


Millions upon millions..

Liked it at $7
Loved it at $30
Excited about $50
Saw it going to $100

Beautiful things still to come..
Clinical data released this fall should be very exciting..

We have to find a way to speed up clinical trials and access to drugs that may stop death sentence diseases.. other than cancer..

[McMagyar]

Is this concern over
Not statistically significant?

The group w
Of patients was small.. very small..
Concern over bad reactions?
They were taking spinal samples from old people.. ouch..perhaps They won’t need to do that in later trials.

Great run.. they have lots of cash..
I am Still anticipating great news from addional studies with more participants this fall.

I like the leadership
And the drug

[FooBarAndGrill]

LOL. Yeah, no.

[McMagyar]

What’s up? July 28 presentation..
Everything seems positive..

[ven69]

Keep sticking with it

[Marvy]

I just stick with ANVS and SAVA

[Marvy]

Wow...more insider buying at $100

[Marvy]

It did for a split second...maybe this week we will break and sustain $100

[Marvy]

Come on ANVS break $the mental $100

[Cbdpotential]

https://pubmed.ncbi.nlm.nih.gov/34110944/

[Marvy]

Anyone think they'll do a forward split at some point (might be a good thing?)

[Marvy]

What a after hours...I guess orphan drug designation could come between now and next month and P3 study could begin relatively soon

[conix]

Moving on up...Glad I held on.

[Marvy]

Could happen sooner than I thought

[Marvy]

Could challenge its 52 week high by end of Summer.

[conix]

Nice consolidation after huge move.

[noretreat]

agree

[Marvy]

This will be a major stock one day

[Marvy]

What a buy someone just did

[conix]

ANVS has been sweet. With the right news, these biotechs will run as hard as a meme stock

[McMagyar]

For new owners of annovis..
Our CEO has sold Companies before
and is well aware of the value of partnerships.

The float is only 4-5 million shares so there is the possibility that a multiple of
That number is SHORT in the market place.

It will be difficult for institutional buyers not to own a piece of such an increddible drug..

[McMagyar]

New Confirmatory clinical news will be occurring over the next few months..imo

Still well undervalued..imo

[McMagyar]

Thx for posting

[tootalljones]

Clay did a good video here. Especially at around the 51 second mark where he does that arrow thing. It is a big red arrow, for a reason. The price over the next several weeks or month and a half will try to close the gap. I do not think it will close it but still, that is so far down there.

[CYDYWinning]

Agree I’m not going to lie sold some today but I’m playing with only house money now. I may increase my position but in the short term I’m looking at SLS for their phase 3 data peak on June 3rd.

[ombay1]

CEO live tomorrow. There are links to sign up in the press release on their website. Don't know if it will move the stock price, but after the past couple of days, I'll take anything.

Thu, 20 May 2021
BERWYN, PA., May 20, 2021 -- Annovis Bio Inc. (NYSE American: ANVS), a clinical-stage drug platform company addressing Alzheimer’s disease (AD), Parkinson’s disease (PD) and other neurodegenerative diseases, today announced CEO Maria L. Maccecchini , Ph.D., will participate in the Alzheimer Disease Panel, presented by Maxim Group LLC and hosted by M-Vest, on Wednesday May 26th, 2021 at 11:00 a.m. ET.

[CYDYWinning]

Any news on the next thing that will make this pop !?

[McMagyar]

Yes very good news!
Few shares..
enough clinical
Money to get through phase 3..

[ClayTrader]

* * $ANVS Video Chart 05-24-2021 * *

Link to Video - click here to watch the technical chart video

[MZlu]

It allows for a quicker approval process as the patients should be easier to recruit for phase 3 (inclusion criteria are more defined for Down Syndrom patients. Besides, they are a rather large population).

Annovis will also very probably get Orphan Drug designation.

[tootalljones]

can somebody elaborate or post info to explain the company's strategy for the capital raise and their targeting of AD in down syndrome.

[CYDYWinning]

Price predictions?

[crudeoil24]

Company will have an extra $50M cash later this week.

[crudeoil24]

Hedge funds, University endowment funds, pension plans, and mutual funds and other tutes loading shares.

The OS will increase by 1M. I see the super low trading float still at around 4M or even less. ANVS will move up with ease.

Plus an announcement of big Pharma that may do a joint venture, creating huge upside value!!!!!

[crudeoil24]

The offering will close in 72 hours. > May 26, 2021 > Annovis Bio Priced 1M Share Public Offering @$50/Share
6:42 pm ET May 23, 2021 (Benzinga) Print
Annovis Bio (NYSE: ANVS) today announced the pricing of its underwritten public offering of 1,000,000 shares of its common stock at a public offering price of $50.00 per share, for gross proceeds of $50,000,000, before deducting underwriting discounts, commissions and offering expenses. All of the shares of common stock are being offered by the Company.

The offering is expected to close on May 26, 2021, subject to satisfaction of customary closing conditions.

ThinkEquity, a division of Fordham Financial Management, Inc., is acting as sole book-running manager for the offering and Maxim Group LLC is acting as co-manager for the offering.

The Company intends to use the net proceeds from the offering primarily for general corporate purposes, including working capital, research and development, capital expenditures and the completion of our planned Phase 3 clinical trial for ANVS401 in AD in persons with Down Syndrome

[CYDYWinning]

This is good news correct ?

Seems like we could soar tmw

[stockwhat]

The offering is only 1 million shares at $50

[CYDYWinning]

Offering is out? Isn’t it like 50 for 1 million shares ?

[TraderNeoMtl]

it depends on the offering, it could deep to 40s where I ll be reloading again :)

[CYDYWinning]

https://seekingalpha.com/article/4430722-annovis-bio-positive-alzheimers-data-strengthens-bullish-thesis

[CYDYWinning]

Price target for Monday ?
I hit the sell on some but have plenty left

[CYDYWinning]

Personally we close above 100

[stockwhat]

What’s the predictions for Monday?

[McMagyar]

The beauty of Anavex is there is no
Competition. Every disease starts with cellular imbalance.. so cellular homeostasis is the Alpha drug.

However ,
Annovis does have an incredible drug
That saves nerves.. I believe the combination of the two
Can save many many people.

Some disagree..

I would like to see some preclinical work in transgenic mouse models

[tootalljones]

McM what are your thoughts (or anybodys) on this post. I am a little behind in this sector.

Bourbon_on_my_cornflakes Friday, 05/21/21 06:49:11 PM
Re: None 0
Post #
311006
of 311051
WHAT IS THE P-VALUE THE FDA REQUIRES??????

"the ANVS401-treated group compared to the placebo group at 25 days showed an improvement of 3.3 points, or 22% (p= 0.13)."

ISN'T P-VAL OF 0.05 OR LESS NORMALLY REQUIRED BY THE FDA??????

MAYBE SOME WALNUTS WOULD HELP?????

Not a threat to AVXL?

[McMagyar]

Great company..
Ceo has already started and sold one biopharm..

Will always keep the shorts and longs guessing..

Is it for sale or isn’t it?


Haha.. good luck to longs!!!!!

[tootalljones]

just kidding McMagyar, but now there are eyeballs on this thing, for good or ill.