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seventhwave

10/12/17 8:57 PM

#124382 RE: F1ash #124378

Could Missling be using Part C as his secret (early) Phase 3 by taking Ariana feedback and confirming Ariana projections on the "current 32?"

ie. at a minimum, he should be able to escalate dosage on the "ongoing 25" to 50mg in case they were below it and didn't optimally respond, to then determine if observed effect matches Ariana's projections.

ie. on top of the "ongoing 25", Missling has the discretion to use Ariana's screening to pick his "new 7" and confirm if ALL of them "super-respond."

He will have almost 12 months of observations on them by now.
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powerwalker

10/12/17 9:21 PM

#124385 RE: F1ash #124378

F1ash, you are correct about the misunderstanding of the timelines. THat is why I refer back to initial entry of the last group.

Actually, the first participants to finish the "new 104 week trial" will occur in December 2017/January 2018 as the first dosing occurred in December 2014 ... or is there a two/three month gap on the "new" trial from the "first" trial?