O........When the rep from Allergan used to come to my office to promote Restasis,(a dilute solution of cyclosporin,(which is an antimetabolite/antiinflammatory drug )his message was that it it had to be used for 3 months for the patient to see a significant effect. When the rep returned and was informed by me that I and the patient were disappointed, he replied that the patient needs to continue for another 3-6 months and will have a good result....... Although DES is a widespread, bothersome problem, I eventually discontinued using this ineffective drug.......I guess that from Allergan's point of view they made enough revenue from the patient with this expensive drug, to register a success with the balance sheet, even though it was a failure with the patient.