Replies to post #26533 on NorthWest Biotherapeutics Inc (NWBO)

[flipper44]

RK, thanks for adding the Q&A transcript portion.

This was a very important exchange IMO. I keep in mind that LP is aware of ongoing results.

Linda, do you have any comments to make on duration of effect....? -- Larry (Smith?)

....And, you know, in terms of duration of DCVax Direct, I mean, the patients haven't even finished the treatment regimen yet. In the pre-clinical animal studies, which is worth mentioning, those animal studies, where you saw the eradication of the tumor, umm and it went to zero. We treated several different cancer types and multiple groups of animals and between 80 - 100 percent of animals in the various groups cleared all of the tumors from their body - both the ones that were injected, and the ones that were not injected. And to Larry's question about duration, the other piece of important information about immune memory was that those mice were re-injected again, with the same tumor cells that had established the tumors in the first place; and, they were re-injected 60 days later. Which, if you are familiar with mice, you know that's a long time in a life a mouse. Sixty days is a long time. And, none of the tumors established a second time, indicating immune memory. So, memory is one of the. And you are all familiar with that, you get your tetanus shot once every 10 years, right, you get your vaccines, and you have memory in between. So if you can mount an immune response effectively in the first place, we are hopeful, but we'll have to see, that we'll see immune memory in people, similar to what we saw in the animal studies. -- Linda Powers