Rock Creek Pharmaceuticals Inc. (fka RCPIQ)

[NukeJohn]

NF-kB and Inflammation

What is NF-kB and what does it do?

http://en.wikipedia.org/wiki/NF-%CE%BAB

excerpts....

NF-kB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-kB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-kB has also been implicated in processes of synaptic plasticity and memory.

Because NF-kB controls many genes involved in inflammation, it is not surprising that NF-kB is found to be chronically active in many inflammatory diseases, such as inflammatory bowel disease, arthritis, sepsis, gastritis, asthma, atherosclerosis[52] and others.

Here is a video on CBS affiliate WNEM that discusses some of the results observed in a clinical trial of Anatabloc (which inhibits the transcription of NF-kB). Pay close attention to the list of diseases at the 2 minute mark that Anatabloc could help.

Take a few minutes to read the links below, and you'll understand why stopping the transcription of NF-kB (which Anatabloc does), is such a game changer.

Aging and NF-kB
http://www.aginganddisease.org/AD-2011-Robbins.pdf

MS and NF-kB
http://www.ncbi.nlm.nih.gov/pubmed/19128210

http://doctorstevesbanjo.com/nfkappab-inhibition-therapeutic-objective-multiple-sclerosis-treatment/

Mice with MS and no Anatabloc

Mice with MS and Anatabloc

Melanoma and NF-kB
http://www.translational-medicine.com/content/10/1/53

Diabetes and NF-kB
http://www.ncbi.nlm.nih.gov/pubmed/19815941

Asthma and NF-kB
http://www.ncbi.nlm.nih.gov/pubmed/18950657

Autism and NF-kB
http://www.medicalnewstoday.com/opinions/92639/

Cancer and Chronic Inflammation associated with NF-kB
http://naturalsupplementsresearch.org/assets/applets/Inflammation_and_cancer-_how_hot_is_the_link.pdf

excerpts...

Although inflammation has long been known as a localized protective reaction of tissue to irritation, injury, or infection, characterized by pain, redness, swelling, and sometimes loss of function, there has been a new realization about its role in a wide variety of diseases, including cancer. While acute inflammation is a part of the defense response, chronic inflammation can lead to cancer, diabetes, cardiovascular, pulmonary, and neurological diseases. Several pro-inflammatory gene products have been identified that mediate a critical role in suppression of apoptosis, proliferation, angiogenesis, invasion, and metastasis. Among these gene products are TNF and members of its superfamily, IL-1a, IL-1b, IL-6, IL-8, IL-18, chemokines, MMP-9, VEGF, COX-2, and 5-LOX. The expression of all these genes are mainly regulated by the transcription factor NF-kB, which is constitutively active in most tumors and is induced by carcinogens (such as cigarette smoke), tumor promoters, carcinogenic viral proteins (HIV-tat, HIV-nef, HIV-vpr, KHSV, EBV-LMP1, HTLV1-tax, HPV, HCV, and HBV), chemotherapeutic agents, and g-irradiation. These observations imply that antiinflammatory agents that suppress NF-kB or NF-kB-regulated products should have a potential in both the prevention and treatment of cancer. The current review describes in detail the critical link between inflammation and cancer.

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These are just a few of the human ailments that seem to have the errant transcription of NF-kB (chronic low grade inflammation) as a root cause. If you want to see others simply pick a human ailment and google it with NF-kB to see if researchers have found any connection.


Everyone should read the articles linked above and think of the implications now that Anatabine has been proven to stop the transcription of NF-kB.

JMHO,

NJ