Here's some solid BMSN due diligence (DD) in my opinion that I have summarized to hopefully help investors to understand why I feel as confident in BMSN as I do.
http://www.regenbiopharma.com/ Regen BioPharma, Inc., a subsidiary of Bio-Matrix Scientific Group, Inc. (OTCBB: BMSN), is a biotechnology company focused on identifying undervalued regenerative medicine applications in the stem cell space and rapidly advancing these technologies through pre-clinical and Phase I/ II clinical trials.
Regen BioPharma Unveils Plan for Value Optimization of Nascent Stem Cell Patents http://finance.yahoo.com/news/bio-matrix-subsidiary-first-class-123000403.html Month 1-2: Assembly of Team. Completed Regen intends to assemble a team of world-class leaders in the spheres of Technology, Intellectual Property assessment, valuation and Clinical development. Regen will seek to compile a team of Physician-Scientists with experience in the area of clinical trials for regenerative medicine/stem cell products, Regulatory experts who have successfully taken products through the FDA and corresponding agencies internationally, and Biotech Entrepreneurs who have track records of excellence in business formation and value optimization.
Month 1-4: In-licensing of Intellectual Property. Completed The Company having already assessed over 20,000 issued patents and having compiled a shortlist of 30 targets; Regen will seek to execute licensing deals on an initial core of 3 technologies. Regen focuses on issued patents that have already passed preclinical studies but are not under clinical development.
Month 3-6: Interaction with Regulatory Agencies. CompletedRegen intends to develop data packages for each of the technologies and initiate interaction with Regulatory Agencies such as the FDA for initiation of trials.
Month 6-18: Clinical Implementation. Partly CompletedRegen intends to launch clinical trials with world-leading institutions to obtain human safety data and "signal" of therapeutic efficacy.
Month 18-24: Exit. Currently in ProcessIt is intended that technologies "incubated" by Regen will be spun off either as separate companies, or sold to Large Pharma companies seeking to enhance their therapeutic pipeline.
"At present there exists a wealth of intellectual property that is 'collecting dust' in the corridors of Academia. Given the field of regenerative medicine and stem cell therapy is so young, and the business models are fuzzy at best in terms of valuation, we see this space as a unique opportunity for acceleration of clinical development/value optimization," said Bio-Matrix Chairman & CEO David Koos about its Regen BioPharma. "Valuations for stem cell companies that have passed the threshold of clinical safety, with signals of efficacy are astronomical. The $1.8 billion Mesoblast-Cephalon deal, as well as recent financings of private companies with as little as 3 patient data such as Promethera ($31 million) or Allocure with 16 patients ($23 million), is testimony to the extremely high valuations that are characteristic of this space."
BMSN Hires J. Christopher Mizer as President and Chief Operating Officer of its Regen BioPharma subsidiary http://finance.yahoo.com/news/bio-matrix-scientific-group-inc-123000923.html Mr. Mizer is the founder of Vivaris, Ltd., a private investment partnership focused on life science and healthcare opportunities, and co-founder of ChinaBio Capital Partners. He was formerly an investment banker with Key Capital Markets and a consultant with Ernst and Young. He holds a Master of Science degree in biology and an M.B.A. from Case Western Reserve University.
http://www.chinabiollc.com/ We have organized more than 20 conferences in China, the U.S. and Europe, and have generated more than $450M in funding for our participants and clients.
http://www.vivarisltd.com/ We seek companies located across the U.S. with sales between $5.0 million to $50.0 million and an EBITDA of $0.5 million to $10.0 million. We prefer companies that are historically profitable and well managed with well-defined markets, a strong reputation for quality, and a commitment to customer service.
Bio-Matrix' Regen BioPharma Unit Establishes Scientific Advisory Board and Research Relationship With Clinartis in Anticipation of Beginning Clinical Development Stem Cell Studies http://finance.yahoo.com/news/bio-matrix-regen-biopharma-unit-123000524.html • World renowned experts to accelerate development of stem cell therapeutics • Regen anticipates new relationship with Clinartis to fast track clinical studies
Bio-Matrix Scientific Group (BMSN) (BMSN) announced today that its Regen BioPharma unit has appointed three internationally renowned regenerative medicine experts to its Scientific Advisory Board (SAB). The new SAB members appointed are David White, M.D., PhD; Wei-Ping Min, M.D., PhD and Vlad Bogin, M.D.
Regen BioPharma has also entered into a Letter of Intent with Clinartis LLC, a global contract research organization (CRO). Clinartis is a full service global CRO serving pharmaceutical, biotech and medical device companies to support Phase I - IV drug and device clinical trials in the US and Europe.
The SAB and Clinartis will assist the Company in its acquisition of intellectual property related to stem cells, translation of the intellectual property into treatments, and optimizing the value of these new therapies.
http://www.clinartis.com/News.asp Clinartis has entered into a Letter of Intent with Regen BioPharma, a biotechnology company focused on the development translational medicine platforms for the rapid commercialization of stem cell therapies.
Bio-Matrix Scientific Group's Regen BioPharma Subsidiary Executes Option Agreement to License Stem Cell Intellectual Property http://finance.yahoo.com/news/bio-matrix-scientific-groups-regen-123000589.html BMSN’s wholly owned subsidiary Regen BioPharma, Inc. has executed an exclusive option agreement which grants Regen BioPharma an option to license Patent #6,821,513 which patents methods of stimulating blood production in patients with deficient stem cells. The patent, as well as data licensed with the patent, covers methods of stimulating the bone marrow to generate new blood cells.
http://www.cellmedicinesociety.org/ As executive director and CEO of the International Cellular Medicine Society (ICMS), Mr. Audley has spearheaded development and implementation of global guidelines for accreditation of stem cell clinics. Under his leadership, the ICMS has grown from a loose association of a handful of physicians to a major international standards organization with over 3500 members from 36 countries. He is a strong advocate for stem cell therapy development and implementation, and is the chief architect of the ICMS accreditation program that is currently evaluating the practices of nearly 20 facilities in a dozen countries.
"Mr. Audley has made a substantial impact in the clinical translation of stem cell therapeutics by establishing standards, accreditations, an Institutional Review Board (IRB), and partnerships with major organizations such as the AABB,"
Thomas E. Ichim, PhD has joined the management team of its Regen BioPharma, Inc. subsidiary as Chief Scientific Officer and Director of Research.
Dr. Ichim is one of the leading authorities in the world on stem cell biology. To date, he has published 82 peer-reviewed articles and is co-editor of the textbook RNA Interference: From Bench to Clinical Translation. ** He is also inventor on over 30 patents and patent applications. ** He currently serves as the CEO of Medistem, Inc. http://medisteminc.com/
** Was formerly chief of scientific development, and is the scientific founder / co-founder of Medvax Pharma, ToleroTech, bioRASI, and OncoMune.
http://www.tolerotech.com/ ToleroTech is an emerging siRNA company focusing on treatment of immune-associated diseases through immunomodulation using gene-specific silencing technologies.
http://biorasi.com/site/ bioRASI accelerates the process of obtaining FDA approvals with a full spectrum of services, including: * Program Optimization * Project Management * Regulatory * Clinical * Data Management & Analysis * Compliance & Audit
http://biorasi.com/oncomune OncoMune develops targeted cancer therapeutics through focusing on a newly-discovered, epigenetic transcription factor called Brother of the Regulator of Imprinted Sites (BORIS). This protein is expressed in all cancers tested to date and coordinates expression of numerous downstream genes that give cancer its properties of immortality, metastasis, and uncontrolled growth.
Bio-Matrix' Regen BioPharma Initiates Pre-Clinical Study in Support of HemaXellerate(TM) Cell Therapy
Company Also Developing Two Solutions for Restoring Blood Production That Lack the Adverse Effects of Current Bone Marrow Stimulating Growth Factors http://finance.yahoo.com/news/bio-matrix-regen-biopharma-initiates-133000984.html BMSN announced today that its wholly owned subsidiary, Regen BioPharma, Inc., has contracted Cascade Life Sciences, Inc. to research the safety and efficacy of Regen's HemaXellerate™ product using mice models for testing.
CASCADE LIFESCIENCES http://www.ohsu.edu/xd/research/techtransfer/startups/2008-ohsu-startup-companies.cfm The inspiration for Cascade Life sciences grew from the work of OHSU’s Shoukhrat Mitalipov, PhD. Dr. Mitalipov’s laboratory at the Oregon National Primate Research Center (ONPRC) was the first to successfully create monkey embryonic stem cells using a technique known as somatic cell nuclear transfer (SCNT). The technique may advance health care research and discovery and help lead to therapeutic stem cell products to combat numerous human diseases.
Cascade Lifesciences is a privately-owned San Diego-based company with a platform of stem cell related technologies that are being advanced to serve the research community and the commercial development of stem cell-based therapeutics.
…The results of Regen's study will provide the safety profile data required for filing of an Investigational New Drug (IND) application for the product with the US Food and Drug Administration . Regen intends to file an IND Application in the fourth quarter of 2012 and conduct Phase I/II clinical trials during 2013 and 2014.
HemaXellerate™ offers the possibility of delivering a population of endothelial cells to restore blood production in patients with hematological conditions. …
…Regen has submitted two provisional patent applications covering the use of different sources of endothelial cells to heal damaged bone marrow. These applications cover: (1) placental cells (61/648898 - Acceleration 0f Hematopoietic Reconstitution by Placental Endothelial and Endothelial Progenitor Cells); and (2) fat cells (61/670791 - Treatment of Hematopoietic Disorders). …
Important for BMSN to trade at the above explained $1.19 per share is for BMSN to maintain being current with their filings on the OTCQB/SEC and if they obtain their FDA Letter. If these things happen, then there are some chances that BMSN ”could” begin heading in that direction over time or even sooner than what some might realize. Still, I like our odds as BMSN shareholders.
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