Yes, KOL's like Dr Cortez are beginning to make the case that using ponatinib in a front-line setting may prevent mutations from developing in the first place. He mentions this possibility in an interview he gave at ASCO (starts around the 9:30 mark) https://accesscmldrugs.wordpress.com/2012/10/14/dr-jorge-cortes-explains-latest-on-existing-and-emerging-treatments/