Rock Creek Pharmaceuticals Inc. (fka RCPIQ)

[NukeJohn]

Anatabloc, NF-kB and Skin Cream....

I stumbled upon this article while researching NF-kB and the effect it has on aging/wrinkles.

http://www.wired.com/medtech/genetics/news/2007/11/genetic_cosmetic

We all know that Anatabloc stops NF-kB transcription at a cellular level via the JAK-STAT pathway. What most people don't understand are the benefits one might observe from this phenomenon. In the article above, the skin of the mice in the study not only stopped aging when NF-kB transcription was turned off ...it actually started looking young again.

excerpts from the above article....

The researchers first discovered a protein that plays a role in skin aging. Then they used a lotion that inhibited the protein in a genetically engineered mouse. After two weeks of treatment with their genetic cosmetic, the skin of older mice displayed the look and genetic profile of younger skin.

"It would be the best wrinkle cream ever, because it would actually work," said Alexander Hoffman, a biochemistry professor at the University of California at San Diego who did not participate in the study.

Chang's team genetically altered mice so that they could reduce the amount of NF-kB in skin cells -- the protein they found that controls various aging processes –- with a simple chemical. Then they applied that chemical, effectively blocking the protein.

"When you block NF-kB when the organism is quite old," Chang said, "you can basically block the genetic program, 'aging.'"

The skin treated with the NF-kB blocking solution became measurably thicker. A series of genetic changes also showed decreased cell aging.

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I hope Star Scientific brings an Anatabloc-based skin cream to market soon (preferably without any "partners"). As I recall from something I read a few months ago on Yahoo, they already have trademarked the name for a skin cream, and someone even posted a picture of the container (but I can't seem to find that).

JMHO,

NJ