Biotech Values

[biomaven0]

I think this GERD indication is very difficult, and it will be hard to get a trial design that works. One of the complications is rebound when you take people off PPI's. The other is that I'll bet that a lot of people with so-called partial responses to PPI's also have another underlying problem - maybe gall bladder disease, abdominal migraines, IBS or any of the other myriad conditions that can cause abdominal pain and discomfort.

(Not relevant to their trials, but I'd also bet that a lot of these partial responders to PPI's would become complete responders if they doubled up their PPI dose and went to BID).

Peter