Are you talking about 10mg of dzp or 5mg, prolly just 10mg, so you're cherry picking the 10mg group. For 273 you're not just cherry picking the 50mg group, you're assessing performance of all scores and comparing that to 10mg dzp group. You looking at 57 weeks or 52 weeks on dzp? 273 was on upward trend beyond 52 weeks on all measures (mmse, adcs adl, erp, adas cog). That so with dzp?
Also, In the 273 trial, those patients were getting no benefit and no synergy from dzp b/c the patients had been on dzp long term before trial start date. We know dzp doesn't do jack after 6 mos. So dzp w/superior sigma affinity was probably just blocking 273 from docking onto sigma receptors and not contributing a benefit.