>>Could a combination with other elements get a patent?
Yes, you could get a patent for a non-obvious combo. It wouldn't be a composition of matter patent but could still have some value. But once you are into combos, trials (and the FDA) become tougher.
There has already been one attempt at exploiting one of the marijuana pathways - the doomed anti-obesity drug rimonabant. It does the opposite of what marijuana does (it's a CB1 antagonist) and it did cause weight loss (anti-munchies!), but also caused depression and other psychiatric issues and was taken off the market after initial approval in Europe.
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