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Re: JohnWayne post# 209228

Saturday, 02/18/2017 11:17:34 PM

Saturday, February 18, 2017 11:17:34 PM

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That ignored independent study testing 4 different assays from MRK/BMY/AZN/Roche on same samples presented last year. Concordance among MRK/BMY/AZN assays based on TC was very high, about 90%, but significantly fewer positives by Roche assay, only about 60%. Concordance among all 4 assays based on IC was less than based on TC, but Roche isn't alone compared to the other 3 unlike based on TC. Thus at least it needs caution to generalize clinical trial results based on PD-L1 expression from Roche to the other 3.

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