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biomaven0

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biomaven0

Re: iwfal post# 204583

Saturday, 09/24/2016 2:40:27 PM

Saturday, September 24, 2016 2:40:27 PM

Post# of 253160
There is definitely a link between drug-induced liver injury and daily dose.

See this link - about 80% of DILI occurs with daily doses of 50mg or more, and the real danger comes with lipophilic drugs with doses in excess of 100 mg.

http://www.gwicu.com/Assets/Articles/Drug%20Induced%20Liver%20Injury.pdf

My recollection is that all the drugs first approved but then withdrawn for liver tox had significant daily doses.





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