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sulaco

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sulaco

Re: vinmantoo post# 268956

Monday, 07/25/2016 3:33:21 PM

Monday, July 25, 2016 3:33:21 PM

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Vin, mechanism of action matters not


when you compare trial arms. You're trying to beat SOC. You don't measure MOA as an outcome. You measure OS or PFS in the control arm (e.g. chemo + adjunctive hormonal therapy, which is standard of care) versus the experimental arm (chemo + adjunctive hormonal therapy + downstream 1.0 anti-XYZers).

You can't isolate the effect of adjunctive hormonal therapy because it's in both trial arms.

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