Avid Bioservices Inc (CDMO)

[vinmantoo]

How do you separate out the effect of the adjunctive hormonal therapy from the actual chemo/radiation given for the breast or prostate cancer?

It is easy. Radiation and chemo (docetaxel, doxirubicin, bleomycin etc) are drugs that can effect all cells, but they are especially toxic to dividing cells. That is what makes them have potentially or even likely ot have a negative effect on IO combinations since IOs trigger cell division. Anti-hormonal based treatments (tamoxifen, Xtandi ) or antibodies that target specific receptors on cancer cells shouldn't affect T-cells or macrophages stumulate by IO effectors. Got it?