Avid Bioservices Inc (CDMO)

[biopharm]

Luhrs and Parseghian...interesting duo and just so happened to notice that Parseghian has recent work with 11 authors and one of them at Peregrine ... hmmmmmm...

Pfizer and Allergan and ??? coming soon after Peregrine ? ... but then we have Zhou from Nant Bioscience owned by Patrick Soon-Shiong and hell... maybe they need a few big backers in order to afford to get a stake in Peregrine Pharmaceuticals

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Missag Hagop Parseghian

https://www.linkedin.com/in/mhparseghian

Founding Partner / Chief Scientific Officer at Rubicon Biotechnology

Orange County, California Area
Biotechnology

Current
Rubicon Biotechnology, Cell and Molecular Biotechnology Consultant

Previous
Stonsa Biopharm, Avid Bioservices, Peregrine Pharmaceuticals, Inc.

Education
UC Irvine

211
connections



Publications
What is the role of histone H1 heterogeneity? A functional model emerges from a 50 year mystery.
AIMS Biophysics
November 16, 2015

High efficacy vasopermeability drug candidates identified by screening in an ex ovo chorioallantoic membrane model(Link)
Scientific Reports
October 29, 2015

11 authors, including:

1)Desmond Pink
Research Scientist at Innovascreen Inc

2)Keith Luhrs
Research Investigator at Allergan

3)LONGEN ZHOU
Head, Preclinical Development at NantBioScience

4)Wendy Schulte

5)Christian Frosch
Owner & Founder at BioBroker IT&Life Sciences

6)Udo Haberl

7)Van Nguyen
Research Scientist at Peregrine Pharmaceuticals

8)Aparna Illa Roy
City of Hope

9)John D. Lewis

10)Andries Zijlstra
Assistant Professor at Vanderbilt University Medical Center in the field of cancer metastasis and translational biology

11)Missag Hagop Parseghian
Founding Partner / Chief Scientific Officer at

...
...
...

https://www.linkedin.com/in/mhparseghian

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2004

Due to its net positive charge histone H1 readily associates with liposomes containing acidic phospholipids, such as phosphatidylserine (PS).

http://pubs.acs.org/doi/abs/10.1021/bi049758b?journalCode=bichaw

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2014

Histones induce phosphatidylserine exposure and a
procoagulant phenotype in human red blood cells

http://www.pfizerpro.com.co/sites/g/files/g10017511/f/publicaciones/102014%20V12I10-%20Histones%20induce%20phosphatidylserine%20exposure%20and%20a%20proagulant%20phenotype%20in%20human%20red%20blood%20cells.pdf

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2015

ApoFlamma® PS Series

ApoFlamma® PS series is for researchers and scientists who wish to decrease cost and increase efficiency in apoptosis detection. ApoFlamma® PS series is an apoptosis detection probe that binds to phosphatidylserine. Phosphatidylserine (PS) is a phospholipid component, which usually resides in the inner leaflet of the cellular membrane. When a cell is undergoing apoptosis, PS becomes exposed to the surface of the cell. We have found a unique peptide sequence that specifically recognizes PS on the cell surface. Coupled with BioActs’ superior Flamma® Fluor Fluorescent dyes, this peptide-dye complex effectively recognizes and binds to PS on cellular surfaces to accurately indicate apoptotic cells.

http://www.chematech-mdt.com/index.php?page=fluorescent-probes

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2015 AACR .... hmmm, Van Nguyen in a couple of the abstracts below and now, we certainly can say Allergan is a collaboration of Peregrines and who is buying Allergan ?? hmmmmm...

Abstract Number: 274

Presentation Title: Bavituximab modulates tumor microenvironment and activates CD8+ tumor infiltrating lymphocytes in a patient-derived 3D ex vivo system of lung cancer
Presentation Time: Sunday, April 19, 2015, 1:00 PM - 5:00 PM Eastern Daylight Time
Location: Section 13
Poster Board Number: 2
Author Block: Soner Altiok1, Melanie Mediavilla-Valera2, Jenny Kreahling2, David Noyes2, Tiffany N. Razabdouski2, Nikoletta L. Kallinteris3, Joseph Shan3, Scott Antonia2. 1Nilogen Oncosystems, Tampa, FL; 2Moffitt Cancer Center, Tampa, FL; 3Peregrine Pharmaceuticals, Inc, Tustin, CA

Abstract Number: 252

Presentation Title: Antibody-mediated phosphatidylserine blockade significantly enhances the efficacy of immune checkpoint blockades in K1735 and B16 mouse melanoma models
Presentation Time: Sunday, April 19, 2015, 1:00 PM - 5:00 PM Eastern Daylight Time
Location: Section 12
Poster Board Number: 10
Author Block: Bruce Freimark1, Jian Gong1, Dan Ye2, Rolf Brekken2, Shen Yin1, Jeff Hutchins1, Van Nguyen1, Chris Hughes3, Xianming Huang2. 1Peregrine Pharmaceuticals, Inc, Tustin, CA; 2UT Southwestern Medical Center, Dallas, TX; 3University of California, Irvine, Irvine, CA

Abstract Number: 4289

Presentation Title: Targeting of phosphatidylserine by monoclonal antibodies enhances the activity of immune checkpoint inhibitors in breast tumors
Presentation Time: Tuesday, April 21, 2015, 1:00 PM - 5:00 PM Eastern Daylight Time
Location: Section 24
Poster Board Number: 19
Author Block: Jian Gong, Shen Yin, Van Nguyen, Jeff Hutchins, Bruce D. Freimark. Peregrine Pharmaceuticals, Inc., Tustin, CA

http://ir.peregrineinc.com/releasedetail.cfm?ReleaseID=906405

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I'll have to end this post here because there are too many off-shoots with all these names... like Aparna Roy, whom is ex-Peregrine and now at City of Hope .. with ties also to Patrick Soon-Shiong...

https://www.linkedin.com/in/aparna-illa-roy-aa17855



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Allergan is known for its specialty in eye care and Peregrines pipeline could help them out, in addition to expanding into other oncology areas where they are not well known at all.

http://investorshub.advfn.com/boards/read_msg.aspx?message_id=91787866&txt2find=allergan

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One of the concerns though is right after Peregrine announced the passing of Dr. Philip Thorpe, there was the patent agent "Brigitte Phan" on the top of his PAV list so I still say she

1) was working with Dr. Thorpe / Peregrine on some patents ... but that doesn't make sense because she is at Allergan... or

2) She knew of his patents or pending patents and were asked to review them possibly? The entire anti-PS platform patent portfolio is soo broad and the first thing "ANY" company will do to verify this is check with a patent attorney to review the existing patents to see if there are any loop holes...etc ... for other MOA for other drugs..etc ? just my guess

Now that alone didn't make me think of anything much ... till that first time seeing "Lisa Ortega" on that list with Gerald Finken and Jeanette Bleecker -- >> Lisa Ortega is at Allergan as well

To top all that off... we have Luhrs and Parseghian leaving Peregrine and landing at Allergan.

..just too many coincidences there all wrapped up into one.

Remember... I'm not saying any of these names I toss out have an agenda-- but there is a solid connection. Check every name on this list... its where it all started: Lisa Ortega at the very top works for Allergan and job title: CSM Planning & Systems Manager ... now check every name below hers (of course we have Finken and Bleecker) but every name is a CSM employee. The connection certainly seems to go back and forth with BMS / CSM / Allergan ... thats where the Federal Authorities should have an aswer at some point.

http://mygcsg.com/community/members/?s=CSM