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Re: iwfal post# 188241

Friday, 03/06/2015 2:47:35 PM

Friday, March 06, 2015 2:47:35 PM

Post# of 251617

My question was if anyone has a scenario where a top line result release (only) at the interim somehow caused a substantial bias at the final.

If it did happen, the chances are pretty high that we wouldn’t know about it. There are many more trials with interim looks than there are trials that get published in a peer-reviewed journal and examined with a fine-tooth comb.

“The efficient-market hypothesis may be
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