CytoSorbents Corporation (CTSO)

[Paulness]

Could this be related to Ebola treatments?

Very few references to capillary leakage, except when related to Dengue infections.

Hemorrhagic fever is the byproduct of EBOLA.

The overproduction of cytokines by the immune system, often called “cytokine storm”, is a hallmark of many life-threatening illnesses seen in the ICU such as severe sepsis and septic shock
A cytokine storm can be toxic, causing direct cell death, massive capillary leakage, severe inflammation, and a cascade of events that can ultimately lead to shock and multiple organ failure
At the heart of the Cytosorb® technology is a biocompatible, highly porous polymer designed to capture and absorb cytokines in the ~10-50 kDa “cytokine sweet spot” where most cytokines reside
The goal is to reduce toxic cytokine levels to prevent or mitigate organ failure and immune suppression, and to seal the capillary leak, thereby improving clinical outcome
Key-learning issues during this lecture:
Recognize the role of uncontrolled immune response for clinical changes of vascular tone, hemodynamic changes, capillary permeability, organ dysfunction