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tony111

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tony111

Re: jq1234 post# 180662

Wednesday, 07/23/2014 7:51:51 PM

Wednesday, July 23, 2014 7:51:51 PM

Post# of 253213
Well in vitro and in vivo animal data both show Her-2 kinase inhibitor is synergistic with herceptin, but it just doesn't work in human trials. However, If you cannot achieve similar serum concentration like seen in the animal data due to tolerability issue, I don't think you can rule out herceptin/her-2 kinase combo inhibition as a viable mechanism for breast cancer.
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