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Re: es1 post# 73469

Tuesday, 04/22/2014 10:43:49 AM

Tuesday, April 22, 2014 10:43:49 AM

Post# of 276399
Big Red was done with SGMO's zinc fingers, NOT ND/Dr Fraser's piggybac. THe GMs were thus done in the EXACT location targeted and completely stable. (see my first post today for an explanation of the genetic variability and why it is not a problem (as has ALREADY been demonstrated with MS.)

THe genetic variation will be in sequence not important in production of normal silk and hence variable in the Large Commercial Worm from which Big Red (and MS *in part*) was developed. A small part of it would be important in the metabolism of the two amino acids used in very exceptionally large amounts in spider silk protein. Just as almost certainly was the case with MS, the variations most favorable for that metabolism will be selected for during the ramp up of the Big Red population (and the new testing equipment will make the selection for that more directed and much more efficient this time),

KBLB has this under very good control and is taking all appropriate steps as evidence by the acquisition and modification of the testing equipment.
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