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baltimorebullet
John K, thanks . I also have an AD close relative sad story. I am male age 82 , my identical twin brother recently passed away from AD regression ...,he may have just given up after his ("what's the use") frustration. This REALLY is about how our time gets used. W/S is finding more clever ways to leapfrog or deal with the diversion "TIME USE" thing. To WS ...TIME IS $$$$. Just ignore it, create new ways to change time reality...." make up artificial ways to shuffle the deck" . We each ONLY get one deck of cards to play with, when your deck runs out , your clock stops.
A. I. can be a very positive tool for dealing with TIME, and how time gets used. IMO, WS uses of AI need to be cautiously understood . If AI can be used to accelerate the rate at which technical problems get solved then GREAT. How time gets used is key. We do not want any of our time wasted on dry holes.
Sure, whatever you say.
We need to get real and to recognize the potential of this new tool suite to generate fact based RWE-RWD which is reproduceable and (REAL WORLD) .
https://www.openpr.com/news/3473833/cognision-partners-with-anavex-for-phase-2-study-of-anavex-3-71.
Obviously the FDA is clueless on root cause(s) for CNS diseases after decades of beating the Amyloid dead horse they have back off...and now HOPE...is the plan.
This new partnership presents an opportunity to drive-evaluate for RWD-RWE and other hard CNS CAUSAL evidence. Begin finally to understand the key variables in the CNS (Central Nervous System). The FDA , "Problem solvers" have been shooting in a DARK ROOM w/ no real tools nor any evidence of the (ANY) analytical tool suite required to (AT LEAST) consistently reproduce results.
As Dr. W. Edwards Deming has famously said (50 years ago) , " The first step in solving a problem is recognizing that one exists". Unless and UNTIL the people in charge at FDA (or alternate regulatory bodies) agree they would not recognize a CNS SOLUTION (Even if they found it in their OATMEAL ) then they are kidding the world w/all their BS trials VAPORWARE logic.
The only starting point is w/ RWE-RWD and tools that are capable of building -supporting legitimate analytical methods and tools that are consistent and reproducible, 50+ years w/no clues is long enough. RWE and RWD will present a path to CNS (systems) certainty.
Ponken...
A helpful, well informed assessment. Thanks.
AB-E-NORMAL day so far? No AVXL premarket trading/sales (+/-) Volume or nasty back & forth? HUH. ? So What?
How to prove CNS diseases failure root causes?
As someone who spent many years/decades engineering/testing and developing semiconductor devices I am amazed to see the basics in what REALLY causes-contributes-accelerates human CNS (systems) failure is not well understood-or proven.
https://www.sciencedirect.com/science/article/abs/pii/S0026271417304985
Up until the mid 60's semiconductor devices were a lab novelty w/so many problems which prevented full commercial volume and uses (stability-reliability being the biggest BLACK hole) . Imagine our world today w/o microprocessors or integrated ckts or even reliable diodes. There would be no WW communication systems or electronics wonders had the basic early failure physics mechanisms not been understood. (BTW those failure physics still exist in nature but we have since engineered ways to fix/prevent/control them through solid manufacturing controls) .
All of the basic failure mechanisms were wrung out by smart-hard working people at Bell Labs and in a few other places (MIT) WW once the mechanisms were proven. I find it curious that CNS medical systems are stuck w/no basic tool suite to work on/engineer the CNS issues after decades. WE are still beating Amyloid Plaques after 50+ years and getting no where.
The biggest breakthroughs in semiconductor physics happened when Dr. Connie Zerdt (sp?) at Bell labs introduced accelerated failure tools. No such tool suite exists in CNS tool box (yet) . Research in CNS failure mechanisms has consequently not figured out how to accelerate (speed up ) CNS brain failures in a lab. Consequently we/they wait years to study efficacy w/very little other than time, as a control. Find a way to accelerate CNS micro failures & root causes.
Find a way to accelerate brain shrinkage (if that is an important metric) . By doing accelerated testing we will easily get better (more predictable results) faster. The rate of progress in CNS root cause analysis is mid-evil...THX FDA. When key failure micro variables are understood then accelerated test modes will prove the root causes very quickly and then results will jump off the page. Bottom line, accelerated failure models/concepts are bullet proof.
As long as the current (time driven) investigation methods are used no high confidence processes (accelerated failure models) can be developed and no solutions will be produced. BTW, in semiconductor research we discovered that Ionic Contaminants, poor designs and sloppy manufacturing practices resulted in unstable devices w/high failure rates. These failure mechanisms also exist today all BP unless they are measured and controlled.
power walker[quote]1) The members of the Board know the plan and the strategy going forward; you nor anyone on this board knows that.
2) The Board members have seen the full results of all the trials. They agree in principle with 1).
3) They are well aware of TGD's short-comings. His management of 1) and 2) over-rides that concern.
4) Tom Skarpelos is not afraid to pull the plug on a floundering CEO (see Missling's predecessor, Cameron Durrant). He is still in Dr. Missling's corner.
5) Naysayers' success of scaring posters to sell 10K, 50K or 100K over a week's time, is a win for lower prices and its benefactors and indicates a drug's failure. Only, the world's drug agencies will decide a drug's pass or fail. IMO, 2-73 will pass![/quote]
Excellent post. Thank you , I needed that on this darker then normal day.
georgejji
Any thoughts on when and how these phony suites get dispositioned? TIA
https://ih.advfn.com/stock-market/NASDAQ/anavex-life-sciences-AVXL/stock-news/93662788/the-gross-law-firm-reminds-shareholders-of-a-lea
What quick and effective tools does AVXL staff have to counteract-prevent this daily SP beatdown ? Urgently request that tool suite be put to use. NOW.
Yes, today, Monday, April 15, 2024,
the stock market will be open.
Tomorrow, Tuesday, April 16, 2024, the stock market will be open.
4.4300
+0.13
(+3.14%)
Pre-Market: 8:51 AM EDT
4.4700
+0.17
(+4.07%)
Pre-Market: 8:45 AM EDT
Is WS open today as stated on goggle?
Xena
test...
PSA: Conclusion: Owning Anavex stock and getting older is not for sissies. Some days it seems like you can do one OR the other.
As an old friend of mine (W. Edwards Deming) would often say..."The first step in solving a problem is recognizing that one exists."
As an old friend of mine (W. Edwards Deming) would often say..."The first step in solving a problem is recognizing that one exists." .IMO, Dr. M. is very capable of doing what is needed to be done ... BUT, he just does not see what we(and others) see.
IMO, Dr. M sees AVXL as a leadership technology-scientific organization which is performing incredible positive technical work (he is right), continuously proving the science and the Med-truth. IMO, from his perspective, he is absolutely correct about that . AVXL is a world class CNS leadership highest technology firm. Sadly , the WS-BP world has a different set of metrics-values and time lines. One would think that after 50+ years of following-chasing the wrong thing w/FDA controls dictating good news vs not good news a better set of metrics would have evolved for defining value in CNS diseases. A lot of very smart people (WS-BP-other) have allowed themselves to get rat holed and are not able to see(recognize& value) AVXL as a solution. It is very sad but IMO, we are on the right train but it is seeen as not moving yet????.
"A little good news Today"?
We are sooooo fxng due...TURN IT UP ....
...TCLW...
https://www.anavex.com/_files/ugd/850d88_80ed72201c1f4173a87f87a09470aa46.pdf
Very impressive new package from AVXL staff...looks strong...WELL DONE
Boopka...You are EXACTLY CORRECT.
Talon38