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“Increased statistical power of EEG/ERP biomarkers to help minimize trial size and cost • Streamlined regulatory process for trials leveraging the EEG/ERP biomarkers”
https://erpbiomarkers.org/
Seems to me this kind of consortium would help call the bluff of a company trying to stretch out its so called failures. Spending 2+ years in a co sortium figuring out specific disease characteristics and measuring metrics is advancing medicine not delaying. All this bei g said Im beginning to believe the Schizophrenia trial could advance to a new stage rather quickly with these new qualifying biomarker tools.
This company is a complete fraud or a grand slam, cant be both or any where in the middle imo and partnerships like this only add to the strength and integrity if you ask me. This is leading, not following the herd off the cliff thinking. Im sure all companies involved are keeping a close eye on trial design and results of our Schizophrenia trial. Our trials keep getting stronger and stronger with time.
Anyone have the new institutional holding numbers due out yesterday?
TIA
MM’s are working overtime to extract shares without raising the price. Whats it going to take to get this stock into “fair” territory. We are still at the bottom of our range with copper being all the new rage and gold over $2300.
I guess the big boyz have to get theirs first. Nice sleeper stock
Amazing isnt it, 52 week low sitting on the next safe and effective SOC for Alzheimer’s. Gods watching!
It will be very interesting to see who is left holding the bag of shares after this rebalancing of the Russel 2000. There is no other way to get shares in large amounts outside of buying them on the open market.
We will see if Harald Hampel joined the right #WINNING! Team after all. First to market isnt always the best.
Thanks for the reminder Chris.’Quite the ensemble that is being comprised here at little ol Anavex. Many recent Senior roles throwing away their careers by joining a pre revenue biotech at a mere $3.69 a share in a washed up, over committed, near failing hair brained Ceo led company…or do they know something we dont know? Is it that Dr. Missling wasnt “investor” hunting at all these “financial” and scientific conferences but rather “head” hunting? Im sure the that companies cultures become bloated, toxic, stagnant etc so maybe joining a young agile biotech with promising data at becoming the next SOC for many CNS diseases has its appeal?
All I know is Im staying parked regardless of the financial wizards doling out free saving advice, save it!
Appears on the surface that shares are getting harder and harder to shake out. .20 - .75 cent moves. Time to let it rain.
Nice idea Nidan just dont hold your breath. Sorry for the late reply as I didnt see your reply.
Historically did these filings support their findings with full genomic data from a trial in a different disease that correlates 70%? Not saying this would multiply by 10 fold. Like Cresentmotor said, he could of just been overstating the monumental task to prove a point.
Thanks for shedding light cresentmotor. I would only add that I believe they would also be adding genomic findings from the PDD trial as he has mentioned more than once that there is a 70% correlation between the two diseases.
Much heavy lifting and after further thought it was probably this MAA filing that was what put our prior Fda exec. Dr. Fadirian out to pasture. The poor man has carried many filings for us for years on top of his 27 (?) years at the Fda and probably didnt have the umph to sit through the arduous task of putting it all together.
Jhmo
“ managing biometrics activities for 4 oncology compounds' clinical development (model-based strategical designs in drug development,”
This caught my eye from her previous experience. Dr. Missling has repeatedly mentioned we are retracing the road cancer medicines have taken whereas utilizing the bodies own defense mechanism to rid the body upstream of the disease instead of micromanaging treating a symptom(s) of the disease.
Great insight and revolutionary if you ask me.
Im pretty sure I heard him mention it in the conference. His dialect is pretty heavy but I will re listen to it again for a third time and see.
Well said Hosai. Unlike many here Dr. Missling is staying the course, keeping the company funded, and in the “applying for regulatory approval stage” ( paraphrased). This is huge, a 1 million page document with many modules for EMA regulatory approval is a monumental task for a small company. The good part is it sounds like much of it overlaps from agency to agency. This bodes well coupling it with the “phase 4 open label AD trial which is not needed but is helpful in showing safety” ( paraphrased) finishing in July. All good news and yet the price drops.
I cant wait for Dr. Missling to drop the MOAB on the world.
Cheers
Tred
Well, in light of all the trial data to date that has been presented so often that even I can recite it with clarity and ease. Efficacy is as efficacy is as efficacy is….! Its not about the efficacy here, its about approval and REVENUE! If Kun Jin’s presence doesnt give you and others pause as to your disbief thannothing is going to convince you that Anavex has a safe, oral, novel drug for Alzheimer’s that blows away the SOC and worth everybit of 20 billion dollars upon approval.
All that being said, YES there is a conspiracy to suppress the price when the above stands true and we sit at $3.69! Algorithms, spoofing, HFT, weighted indexes, options, naked shorting dark pools, lawsuits, and yes, delay tactics from “Dr’s” on the take. So many ways to hammer a small company until someone gets a wiff of revenue generation.
Woe to you Pharisees and Sagisees, you see and still you do not believe!
What are the chances that one of the “peer reviewers” is communicating to “friends” that the paper is close to completion and looks very promising? Just sayin as BP’s tentacles run deep in research grants. More than one way to cause a delay in bring a novel drug to market.
Money dammit!!! All we want is more and more MONEY!! Arent you aware its not about patients getting better or approval just give the hungry market more gratification through profits!!
All sarcasm of course but true unfortunately.
“If they are committed then I think the medical staff can order whatever meds they want, no?”
As long as they dont delay the trial from those damn covid requirements. They probably still have the i patients walking round with masks.
Ohh just the thought!
Good assessment of the conference Skitahoe. I agree with it and might add that they are not waiting for approval before thinking a out commercialization. I find it in stark contrast of many negative posters here the fact that a company who is so crooked in producing illusionary trials data has spent much of their last 3-4 presentations highlighting the commercialization aspect “ ahead” of approval. He even mentioned utilizing Amazon this time around , which I had envisioned some months ago, as a reliable source for delivery. This drug, its partnership (s), and its access to market is going to revolutionize the way medicine is practiced in the not too distant future.
Along those lines too he is very upbeat about the Fda and their new endpoint acceptance qualification for AD. Couldnt happen at a better time, for a better drug, for a top notch company.
I say pound sand to all those who are looking for tree branches high enough with ropes in their hands. I also had a vision/reflection of a time long ago when another person was trying to share something revolutionary with the world. He also went to another group instead of the first group for acceptance and still, the powers to be were overly concerned about their wealth, status, and power so much so they had Him killed. The more things change the more they stay the same.
Blessings
Tred
He is not talking to anyone on this board CM so your reply is futile. His dog whistle is heard by his followers.
Volume and wealth transfer will trend with our being graced by the posers to be. Trust me, they are lurking.
Todays presentation tells me all I need to know. I hope Dr M launches a surprise here one day soon, he is due some credit.
“ I question the desperate potential buyers of this equity..”
It comes in waves TH, prior to the revealing of the delay in Rett Syndrome approval there was angst in the “back room” I guarantee you even though hey still had/have measures to suppress the stock price in the event of RS approval.
Look at 5 year charts for HARP, ANVS, SAVA, and CDXC. You can throw out the huge greedy HFT trading during covid to “absorb” all the ez money but here, imo, you will see examples of ZERO angst or concern by large pharma in taking over companies with a promising product or pipeline. The HF’s did/are doing a nice and orderly transfer of wealth and control, textbook if you ask me through secondaries. Now look at a 5 year chart for AVXL. No secondaries and until the Rett announcement, which Rett Syndrome fda direction is not dead imo, we were on an uptrend. HF’s are having to work to transfer wealth through AF’s, lawsuits, MB trolls, etc. Are “they” sweating at night in their sleep, no but to only own 30ish % at this point, and no secondaries, is not where they wish to be on the heels of the EMA MAA application and ongoing talks with the FDA. I am positive as can be that “they” will hear/know way before us if there is movement in either agency towards goo news and that will be obvious with the turning of sentiment in the “fair and balanced” market towards our prospects. We should make every headline on Motley (Constant) Fools and the like. This will happen because the “fair and balanced” market does not like to be blindsided by small insignificant non revenue biotechs especially when they are towing the rope SOLO in applying for AD approval. The arrival of certain message board posters with huge number of followers ahead of time will fortell when we are near, the “tab keepers” if you will.
Anyways all this is just my humble opinion and in no way investment advice but Im in it to win it, not here to trade nickels and dimes clutching to every last dollar relying on my daily bank margin or AVXL’s MC as a justification for my “#Winning”.
Oh, and Dr. Missling should keep his salary and get more imo. One approval and he goes from a Zero to hero in the flick of a switch. What he is shouldering is not glamorous or trendy or even desired by the faint of heart. Bringing a successful AD to drug to market in a 14’ klamath boat up next to the 350’ ocean haulers is a monumental task but I want to be waiting at the pier to see the faces of those observing it.
Cheers
Tred
Thanks for the article Talon. I see HARP and others did not fare well until “AI” fou d them and large investments were made in them. In fact, one could say, with such a promising pipeline, why would they (HARP) be sitting at an all time low before investment coming in?
Our shareprice decline reeks of desparation by those wanting to “heavily invest” in our IP and pipeline.
Im feeling that it is of no use to fight the share price current. Dr. Missling and team are doing the best they can to swiftly get us approved as an effective and safe treatment for the largest unmet CNS need in the history of mankind. God be with them.
Tred
“ Big boys own 31% of the company. I would say by the next update on institutional ownership we are at 35%.”
Correct and what is it the “big boyz” like to be at before big news is released? Ive heard somewhere in the neighborhood of 60-70%. How will they achieve this with no secondaries? Maybe the answer layes in how much pressure they can put on the stock causing the smaller funds who haven’t done their homework to capitulate.
This could go to $1.50 and it will have ZERO effect on the science. It will just give me moremof an opportunity to add before approval by the EMA.
Cheers
MM’s always scooping up 200,000 + shares every day at the end and at the low. Hmmm, when does the next insty report come out?
Very nice snapshot of the mineral industry JD. Seems like those speaking about copper talk in the millions of pounds and Rob speaks magnitudes more in the billions of lbs. quite the difference.
Thanks again
Tred
For sure. As investors we should have for sure expected the casin…er uhhh the “fair and balanced” market to welcome a new cutting exge way of Alzheimer’s thinking with open arms, no? Why, a safe oral drug that may prove out to help fix most of our daily “mis fires” up top and with in the whole body would surely go from a penny stock and stair step perfectly ascending up into the 3 -5 billion dollar range by now, no?
If we were Biogen or Esaly and announced we met all endpoints with a safe once a day oral pill that has no SAE’s that has shown RWE and RWD we of course would have skipped a couple of floors on the way up but fair to say at least 5 billion.
What is that skeptics continue to say,
1) Dr. Missling ran a weird new trial design based off some sketchy open label ph 1 adaptive trial? Well, the FDA designed it!
2) Changed the endpoints to fit the trial outcome? Well, where is the beef, bring the lawsuits and follow through! Dr. Kun Jin has been on board and has seen ALL the data since it has been mentioned that “ all endpoints were met”….2-3x!
3) Taking too long? Nope, barely a decade! When and where will he finance? He has and will at his discretion, not some manipulative loan shark bottom barrel middleman for the big pharma that orchestrates and manipulates a take over before approval.
4) nobody believes him? Let us see the peer review and let them be the judge, not a anonymous message board trader looking to capitalize off your fear.
Longs, do yourself a favor and save a whole wave of grief by shutting down your expectations for the next two months. All that is going to happen is winey over exposed traders are going to try to separate you from your shares. If you didnt sell at $10 you surely arent going to sell ahead of an EMA submittal of a MAA application or wait and see what the Fda and Anavex (Dr. Kun Jin) are discussing in light of the new fda documents/position on endpoint change relating to considering a trial a success or not. Seriously, take a 30,60,90 day break
(I did) and if your signed up for Anavex Alerts, you will surely find it nicely sitting in your email inbox when something happens.
Cheers
WGT
Tred
A long slow transfer of wealth has been going on now for 8-10 years. With no secondaries offered, how else would investment funds take sizeable positions PRIOR to revenue or AD approval? “They” never pay premium price for anything so down the price goes putting the squeeze on the companies ability to raise capital and retail. Good thing Dr. Missling is a financial genius and beat them at their own game with having 2-3 access to capital agreements simeoultaneously.
Too much hand holding, either pull back and appreciate the goings on behind the scenes or move on. Even better, join the class action lawsuit to no where lol.
We are way way under the total cost to bring a drug to market let alone an AD drug, and are still under or right on track of the time it take as well (a decade) and have weathered a pandemic. Perspective, perspective, perspective!!
Contrarian investment doesnt seem to fit you and sumby very well. Bringing a novel precision medicine drug platform for CNS to market takes too long and is too risky it appears for you and others. Perhaps BIIB would be a better play as they are most likely entering a price range where they are due for another 20 billion dollar MC increase from some concocted new announcement. Seems a bit safer of an investment regardless of the efficacy of the drug.
Consider this your cheese and crackers to pair with your whine.
“ There seems to be a disparity somewhere? I wonder what it could be?”
Lack of revenue, greed, HFT algorithms, all systematically beating down a pre revenue company sitting on very tight IP for the above circumstances mentioned. This is why BR SS and Vanguard all keep increasing their position QoQ directly or indirectly. Dr. Missling is playing this right and Rett Syndrome is the only hiccup to date.
“ They wouldn't dare let the EU get ahead of them.”
Especially from a company right in their back yard, ie New York City. Well, then again New York isnt what it used to be. It seems to be slipping off the face of the earth actually.
Thank you
Not that I care but how do u see who the one poster that craps 0n your post? They changed something.
Thanks
Yes LTB , you add, Blackrock adds, State street and Fidelity all add. Its amazing how that continues and repeats as we continue to drop.
Good points. Major MM “scooping” going on with no fear. Ragdoll with our data….? Dr. Missling has seen this before with his prior experience Im sure.
Hang on!
“ Wait!!! He has been around for 10 years surely he learned something?!?!?!”
Like Xena has opined many times, compared to what….? Compared to, say, dozens of companies with many hundreds of billions of dollars at their (wasteful) disposal, tens of hundreds thousands of employees combined, and top notch financial CEO gurus leading the way flushing it all down the drain following the herd of bison (mabs) right off the cliff. They even have bought, aggressively overtook, or partnered with 10’s of hundreds of smaller companies and they still squandered hundreds of billions of dollars in investors money, wasted many decadez of time lost with loved ones raising false hope ….!
I digress and apologize for the long winded rant but you really need to put things into context when you bash a small cutting edge biotech who is very fiscally responsible and about to commercialize a platform drug that will substantially cut the rate of suffering for humanity in CNS disease.
Watch the presentation and think through the incremental differences and advancements from the last conference.
Hint: we have on board the prior fda lead biostatistician and things just got easier.
Absolutely!
George is there a link to relisten to the Needham presentation?
Thanks
Tred
Makes one wonder after looking at the trading pattern of CDXC (whom Dr. Frost is connected with) if OPK will do the same in the near future. Transfer of wealth in a very coordinated manner imo.
Time to go UP!!! $1.10 is nice but still dirt cheap.