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Rich Pharmaceuticals Inc. (RCHA)

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Last Post: 9/19/2017 11:05:57 AM - Followers: 317 - Board type: Free - Posts Today: 4





http://www.richpharmaceuticals.com/ 

http://www.otcmarkets.com/stock/RCHA/profile

 
RCHA Patent for Treatment of Hodgkin’s Lymphoma

http://www.richpharmaceuticals.com/wp-content/uploads/2014/10/Rich-10_13_14-HL-Patent-Ownership-Rights.pdf

Under terms of the agreement, Rich Pharmaceuticals, Inc. will obtain complete ownership and all interest in the indication, patents and intellectual property related to treatment of Hodgkin’s Lymphoma,
utility patent application number 61998397, entitled COMPOSITIONS AND METHODS OF USE OF PHORBOL ESTERS FOR THE TREATMENT OF HODGKIN’S LYMPHOMA.
 

Facts About Hodgkins Lymphoma

Description of Hodgkins Lymphoma. Hodgkins Lymphoma is a cancer of the lymphatic system. Malignant Reed Sternberg cells invade and destroy the architecture of the lymph nodes and infiltrate major organs such as the liver and spleen in more advanced cases (Stages III and IV). Treatment options for Hodgkins Lymphoma are chemotherapy, radiotherapy or chemotherapy plus radiotherapy. More difficult cases may require high dose chemotherapy and stem cell transplant. In addition to the stage of the disease other factors such as age, general health and location of the disease are considered important in treatment decisions. In recent years PET/CT scans have been helpful in determining the extent of Hodgkins disease and assessing how well treatment is working. In some patients Hodgkins may never go away completely and regular treatments are required to control the disease while others experience relapses. Nowadays chemotherapy plus radiotherapy to involved areas is considered as standard treatment for patients with early stage Hodgkins Lymphoma (Stages I and II) and the incidence of survival in the U.S. after 5-years is about 90%. The 5-year survival rate for stage III patients is about 80% while it is 65% for stage IV patients. Due to long term adverse effects such as secondary malignancies causing both morbidity and mortality, the role of radiotherapy has been questioned and other means of treatment are being sought.

Incidence of Hodgkins Lymphoma. This disease is a cancer that is found most frequently in two different age groups (15 to 35 and over 55) and occurs in both sexes although more common in males and individuals with HIV, and in the third decade of life.. The overall incidence of Hodgkins Lymphoma is 2.7 per 100,000 persons and in the U.S. 185,793 individuals were stricken with this disease in 2011. The worldwide estimate for treatment of Hodgkins Lymphoma is estimated to be $1 to 2 billion. The cause of Hodgkins Lymphoma is unknown but factors such as smoking and alcohol have been linked to this disease, and siblings of with parents with Hodgkins have an increased risk (2 to 5X) of developing this disease. The specific factors triggering the conversion of normal lymphocytes to Hodgkins Lymphoma cells is unknown.

Facts about AML

Acute Myelocytic Leukemia (AML)

Acute myelocytic leukemia (AML), also known as acute myelogenous leukemia is the most common acute leukemia type that affects adults. Other names for AML that refer to the same disease are acute myeloid leukemia and acute myeloblastic leukemia. AML is sometimes referred to as acute myelo cancer, acute myelo leukemia and acute myeloid cancer.

What is Acute Myelocytic Leukemia (AML)?

AML is an aggressive form of cancer of the blood and the bone marrow, characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal white blood cells. The myeloid blood stem cells of the bone marrow develop into abnormal, poorly formed myeloblasts and do not become healthy white blood cells.
The incidence of myeloblastic leukemia in the USA is of about 1 case in 100 000 persons per year during the first 20 years of life, with a later increase to around 20 cases in 100 000 persons per year for octogenarians. Myeloid leukemia progresses rapidly and can typically be fatal within weeks or months.

Acute Myelocytic Leukemia (AML) Symptoms

Most signs and symptoms of AML are caused by the decreased ability of the body to fight off infection due to the replacement of normal blood cells with leukemic cells.
The symptoms of myelogenous leukemia are generally vague and non-specific. All or some of the following symptoms may be experienced by the person affected:

• Lethargy, chronic fatigue
• Fever (usually of unknown origin)
• Shortness of breath
• Inexplicable weight loss
• Frequent infections
• Headaches
• Pale skin, skin rash
• Non-specific bone pain
• Easy bruising
• Unusual bleeding such as nose or gum bleeding
• Blood in urine or stools
• Enlarged lymph nodes and/or spleen
• Abdominal fullness

Other symptoms of myelo leukemia include anemia, tumors of leukemic cells in the lung, breast, brain, uterus, ovary, stomach or prostate.

 
RCHA Recent News
 

Rich Pharmaceuticals Announces Principal Doctor for Clinical Trials

June 21, 2017

Dr. Numbenjapon specializes in medical oncology, hematology, and stem cell transplantation. He has over 14 years of experience in Hematology and Oncology.

“We are confident that Dr. Numbenjapon is the best and most qualified physician to head our research abroad, and look forward to his guidance as we embark on the next phase of our clinical studies,” said Ben Chang, CEO.

Now that Rich Pharmaceuticals has filed an IND (https://youtu.be/0CCtXc43a0I) with the FDA and re- ceived approval to start phase I/II (https://youtu.be/1WvlzbzKGqE), operations have progressed to the site level at Phramongkutklao Hospital and a full package has been submitted to the hospitals IRB (Review Board). "Rich Pharmaceuticals is pleased to have reached such a milestone and we look forward to patient enrollment at Phramongkutklao Hospital with the help of Dr. Numbenjapon," stated Mr. Chang.
 

Rich Pharmaceuticals Announces Institutional Review Board Submission

June 8, 2017

Beverly Hills, California - Rich Pharmaceuticals, Inc. (OTCPK: RCHA) (“Rich” or the “Company”), a bio- pharmaceutical Company focused on developing and commercializing innovative therapies in oncology an- nounced today that has filed its submission package to the Institutional Review Board (IRB) of Phramongkutklao Hospital in Bangkok, Thailand.

The submission is part of a process that leads to a study for the treatment of Acute Myelocytic Leukemia (AML) in refractory patients in a Phase I/II trial. “We are happy we’ve reached this milestone and we look forward to communicating further developments on this effort and other clinical milestones over time,” said Ben Chang, CEO.

The Company IRB submission was completed on May 31, 2017. An IRB is a group that is formally desig- nated to review and monitor biomedical research involving human patients. This submission is an integral to the Clinical Trial and drug approval process. 
 

Rich Pharmaceuticals Announces Clinical Site in Thailand

May 31, 2017

Beverly Hills, California - Rich Pharmaceuticals, Inc. (OTCPK: RCHA) (“Rich” or the “Company”), a bio- pharmaceutical company focused on developing and commercializing innovative therapies in oncology an- nounced today that it has selected a site and obtained investigator’s interest at Phramongkutklao Hospital in Bangkok, Thailand. Rich has engaged CMIC ASIA-PACIFIC, PTE. LTD. (“CMIC”) to assist in this project and they have already completed a site selection visit at Phramongkutklao Hospital, and the site has been cleared.

Rich and CMIC are preparing submission packages for the Hospital’s Internal Review Board (IRB) and the Thailand Food and Drug Administration (FDA). This package is near completion and the Company plans to submit it shortly. “The Company has purchased product liability insurance, the package is near completion and we hope to submit in the coming days,” said Ben Chang, CEO.

In cooperation with the Hospital, Rich is seeking to conduct a study for the treatment of Acute Myelocytic Leukemia (AML) in refractory patients in a Phase I/II trial. Acute Myelocytic Leukemia is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal white blood cells that build up in the bone marrow and interfere with the production of normal blood cells. AML is the most common acute leukemia affecting adults, and its incidence increases with age. Because the incidence increases with age, it is expected that incidence will rise as population rises. 

 

Our Science

Rich Pharmaceuticals currently is focused on the clinical development of the chemical molecule TPA (12-O-tetradecanoylphorbol-13-acetate) for the treatment of acute myelogenous leukemia (AML). The Company has technical evidence to suggest that it may also be useful to treat other important diseases resulting in it being a widely used drug with major market potential.

TPA

TPA is a naturally occurring molecule that is isolated and purified from croton oil which is obtained from the seeds of Croton tiglium, a leafy shrub native to Southeast Asia. While this has been the major source of TPA for clinical studies conducted by Rich Company scientists recently devised a synthetic route for preparation of the drug which will ensure providing the necessary supply of highly pure drug for clinical use. TPA has characteristics that are unique to this chemical class including a potent ability to accelerate differentiation of the myeloid cell lines, HL-60 and THP-1, as well as mononuclear phagocytes from bone marrow and peripheral blood. The best characterized receptor for TPA is protein kinase C (PKC) which, once activated, induces substrate phosphorylation that propagates signals to the MAPK cascades. The effects of TPA on MAPK pathways may be particularly relevant to the differentiating and pro-apoptotic effects of TPA in certain cells. The capacity of TPA to activate PKC and to induce phenotypic changes characteristic of differentiation and/or apoptosis led investigators to study its effect in AML.

What Justifies the Use of TPA to Treat AML?

Acute myelogenous leukemia (AML) is an aggressive disease that requires urgent and intensive therapy. Patients diagnosed with AML are, on average, between 64 and 68 years of age. Patients over 60 treated with standard chemotherapy are cured of their disease less that 20 percent of the time. In addition, patients who develop AML after an antecedent hematologic disorder or prior leukemogenic chemotherapy/radiation have similarly poor outcomes as do patients whose disease is associated with specific cytogenetic and clinical features. Most patients diagnosed with AML have a poor prognosis. For patients with relapsed disease, no standard non-transplant therapy has demonstrated the capacity for cure and AML is often fatal.

In view of the above facts, it is obvious that new approaches to therapy are needed. The clinical studies completed and those currently in progress with TPA report feasibility and potential efficacy of this drug in patients with relapsed/refractory myeloid malignancies.


 
WuXi PharmaTech, Inc. trades on the NYSE in the area of $40.00 per share under the ticker of WX with a $2.8 Billion Market Cap:

http://finance.yahoo.com/q/ks?s=WX+Key+Statistics
http://finance.yahoo.com/q?s=wx&ql=1
http://www.wuxiapptec.com/

 
"We believe RP-323 has best-in-class potential and holds significant promise for patients suffering from AML and MDS," said Ben Chang, Rich Pharmaceuticals' Chief Executive Officer.  Mr. Chang further stated, "We are especially excited to have a partner in the manufacture of RP-323 of the high caliber of Wuxi Apptec.  We expect to pursue the approval of the IND promptly and to be in clinical studies in the very near term."
Courtesy of Sibware: 
http://investorshub.advfn.com/boards/read_msg.aspx?message_id=110569310 
 
RCHA RP-323:Potential Market=$1 to 2 Billion/Year US.$5 Billion Worldwide. 

Business Overview 

The Company is developing RP-323 (formerly called PD-616) for the treatment of Acute Myelogenous Leukemia (AML), and to cause elevation of white blood cells
(WBC) in patients depleted of these elements due to various conditions.
 

Clinical Studies in Acute Myelocytic Leukemia 

Based on the known properties of RP-323, it was first administered in a pilot study in China, either alone or in combination with standard drugs and caused temporary remission of AML in some patients’ refractory to standard therapy. Several patients recovered sufficiently with RP-323 treatment to return to their normal occupations, symptom-free. 
Interest in these findings led to a Phase I investigator-sponsored trial in 35 patients by a leading oncologist at a leading cancer hospital in New Jersey, the University of Medicine and Dentistry of New Jersey (UMDNJ). 

Market Opportunities 

AML 

It is estimated that 40,000 people in the US have AML and an additional 14,000 are diagnosed annually with a yearly death rate of over 10,000.
Based on this incidence,
the potential market for RP-323 for the treatment of AML is approximately $1 to 2 billion peak sales annually in the US and more than $5 billion worldwide.
 

RCHA Key DD Posts:
 
Key RCHA & WX:NYSE Relationship
http://investorshub.advfn.com/boards/read_msg.aspx?message_id=110555124
 
Respectfully, again, key with the Authorized Shares
http://investorshub.advfn.com/boards/read_msg.aspx?message_id=110551465
 
RCHA NEWS
 
http://finance.yahoo.com/q/h?s=RCHA+Headlines
http://www.richpharmaceuticals.com/category/news/
 
RCHA SEC FILINGS
https://www.sec.gov/cgi-bin/browse-edgar?action=getcompany&CIK=0001504389&owner=exclude&count=40
 
http://www.richpharmaceuticals.com/contact-us/

Contact Us
9595 Wilshire Boulevard, Ste. 900
Beverly Hills, CA 90045

P: 424.230.7001
F: 424.230.7003

E: info@richpharmaceuticals.com
 

 

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PostSubject
#19889   Very wise advice! PepsiMan 09/19/17 11:05:57 AM
#19888   lol is why I dont like chasing stocks, RammageRaul 09/19/17 11:03:39 AM
#19887   One thing I like about $RCHA currently is PepsiMan 09/19/17 10:53:45 AM
#19886   Good Morning $RCHA PepsiMan 09/19/17 09:21:15 AM
#19885   It's been nothing upward at all since mid august... masahirox 09/18/17 11:05:46 PM
#19884   Alright! Like your honesty. Quick trade and your out. Depending Jacque_Strap 09/18/17 08:44:55 PM
#19883   Good one haha. I'm just telling it like Axeman 09/18/17 06:19:27 PM
#19882   Tomorrow is another day. Always seem to want to pop, Jacque_Strap 09/18/17 04:14:53 PM
#19881   I'll be kind I'll give you to Thurs. One Jacque_Strap 09/18/17 04:11:05 PM
#19880   RCHA looking good Jacque still 26 milly 0n beer$$money 09/18/17 02:49:41 PM
#19879   I would say with the OS increasing daily Axeman 09/18/17 02:28:02 PM
#19878   Define soon? So I can hold you to it.. Jacque_Strap 09/18/17 02:22:17 PM
#19877   That'll be gone soon Axeman 09/18/17 02:18:16 PM
#19876   Level Ii update 26 million bid @.0005. Jacque_Strap 09/18/17 02:01:32 PM
#19875   Thanks bro Linnear4242 09/18/17 12:32:39 PM
#19874   It’s nothing, read the filing.. RocknRoll 09/18/17 12:19:56 PM
#19873   Is that good bro? Linnear4242 09/18/17 12:19:08 PM
#19872   Change of accounting firms with no disagreements except RocknRoll 09/18/17 12:17:51 PM
#19871   Another 8k out today Linnear4242 09/18/17 11:52:05 AM
#19870   IMHO and this is not to try to PepsiMan 09/18/17 10:26:04 AM
#19869   Looking good people, Holding and wait for lift off!! X-ray07 09/18/17 10:15:23 AM
#19868   I hope you do sell the teens :) X-ray07 09/18/17 10:14:39 AM
#19867   Yea but does this go .002 and beyond?? masahirox 09/18/17 10:13:19 AM
#19866   reversal coming 5 was bottom chart way oversold RammageRaul 09/18/17 10:11:47 AM
#19865   As you are I am trying to be PepsiMan 09/18/17 10:04:12 AM
#19864   GM Pepsi... 7s hitting masahirox 09/18/17 09:56:50 AM
#19863   Good morning $RCHA. PepsiMan 09/18/17 09:40:22 AM
#19862   I have not checked that site in sometime. PepsiMan 09/17/17 11:16:44 PM
#19861   If you look on stockscores.com and RCHA has Linnear4242 09/17/17 01:10:19 PM
#19860   Good analysis I agree. Axeman 09/16/17 02:05:04 PM
#19859   Personally I am not worried a bit about PepsiMan 09/16/17 02:01:11 PM
#19858   I know it's tough to pick an average Axeman 09/16/17 12:50:04 PM
#19857   We're moving on up. On the "Breakout Boards." Now if Jacque_Strap 09/16/17 12:17:45 PM
#19856   Still holding 5 mil at .00115.... looking to masahirox 09/16/17 11:51:07 AM
#19855   $RCHA`` Held up well today all things considered PepsiMan 09/16/17 12:28:04 AM
#19854   Thanks for your valued imput there RocknRoll. PepsiMan 09/16/17 12:24:07 AM
#19853   My guess is 0001 AstnMartin 09/15/17 11:19:05 PM
#19852   At open there was 16m+- on bid and RocknRoll 09/15/17 06:43:44 PM
#19851   no t-trades today after market Hmmm RammageRaul 09/15/17 06:21:28 PM
#19850   Maybe we can kidnap Ben and hold him Jacque_Strap 09/15/17 06:17:29 PM
#19849   Good eye J-Strap , I did see the chico hombre2 09/15/17 06:00:16 PM
#19848   "Uncle Bendover" could be setting us all up.. Jacque_Strap 09/15/17 05:41:05 PM
#19846   Maybe next week?!?!? AKsquared 09/15/17 04:25:51 PM
#19845   Your guess is as good as ours. Axeman 09/15/17 04:18:04 PM
#19844   whose the wise guy selling 250 @.0005 chico hombre2 09/15/17 04:12:48 PM
#19843   OK RCHA a nice day of trading to beer$$money 09/15/17 04:01:38 PM
#19842   When is the next FDA update due here? ROBOTICTRADER 09/15/17 03:46:24 PM
#19841   RammageRaul 09/15/17 03:39:24 PM
#19840   Next support .0003 resistance .0008, back in full chico hombre2 09/15/17 03:21:22 PM
#19839   RCHA settin up Bombshot 09/15/17 02:49:54 PM
PostSubject