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Last Post: 11/10/2017 12:49:40 PM - Followers: 8 - Board type: Free - Posts Today: 0

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Over the last three decades, intraoral dosage forms have been evolving as an acceptable and in some cases as the preferred, alternative to conventional tablets and capsules. Among them, Oral sprays are the fastest, most effective and comfortable way to take medicines, nutrients, minerals and vitamins. They have been acquiring important position in the market by overcoming previously encountered administration problems and contributing to extension of patent life.

Oral sprays have the unique property of rapidly releasing the drug in the oral cavity, thus obviating the requirement of water during administration. Therefore, these dosage forms have lured the market for a certain section of the patient population which includes dysphagic, bed ridden, and psychic, geriatric patients. This article focuses on the transmucosal view , spray formulation aspects , advances made so far in the field oral sprays and patented technologies.



Abstract: Nitroglycerin (glyceryl trinitrate, CAS 55-63-0, NTG) administered with an oral spray may be more effective in relieving anginal pain than sublingual tablets especially when the patient’s mouth is dry. In this study, the effect of a NTG oral spray (Myocor Spray) on exercise-induced angina was compared with that of a sublingual tablet in relation to the oral dryness. In 17 patients with effort angina, graded bicycle exercise was performed twice at an interval of one week.

Exercise was discontinued upon the onset of moderate anginal pain. Immediately after exercise, the oral dryness was evaluated by touching the tip of the tongue with a blotting paper for a moment. Then, 0.3 mg of NTG was administered by either a squirt of spray or a sublingual tablet in a randomized crossover fashion. Exercise results were reproducible between two exercise tests. According to the extent of the wet area of the blotting paper, the subjects were divided into two groups.

In 7 patients of the wet group, the remission times of chest pain and ST segment depression were not significantly different by the formulation of NTG. In 10 patients of the dry group, however, both chest pain and ST depression more rapidly recovered with use of the oral spray (p < 0.05 and p < 0.05, respectively). These results strongly suggest that the NTG oral spray is superior to the sublingual tablet in relieving anginal attacks, when the oral wetness is decreased.{3ef37769-ee40-419f-a8f1-c8cb87298698}&p=CRPGF&i=93426&v=stock-chart&vs=636447329625438624
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#85   I think we see 60s and 70s again... I Need Money 11/10/17 12:49:40 PM
#84   I’m not touching this thing unless it GE dawood 11/10/17 12:40:12 PM
#83   Agree. Time to look for reentry on pullback... I Need Money 11/10/17 09:57:14 AM
#82   I had to get out. Pump seemed done. dawood 11/10/17 09:54:39 AM
#81   From sleep to energy, X-Sprays proprietary CBD infused Camelot 11/10/17 04:08:03 AM
#80   I got that notification and loaded at .61... I Need Money 11/10/17 03:00:49 AM
#79 Camelot 11/09/17 11:32:23 PM
#78   Fun fun Now i keep getn txt messages TaperT2 11/09/17 08:33:51 PM
#77   Looks like some coward just had to sell Camelot 11/09/17 04:06:42 PM
#76   Closing green again. Going to close very strong. Camelot 11/09/17 03:17:41 PM
#75   Head back down Lion33 11/09/17 03:15:11 PM
#74   No pullbacks. Only minor dips due to some profit Camelot 11/09/17 02:41:05 PM
#73   Pullback into the weekend. Reload tomorrow afternoon.... I Need Money 11/09/17 01:52:53 PM
#72   It is running back up. I can see it Camelot 11/09/17 01:29:36 PM
#71   Little bit of profit taking is all it Camelot 11/09/17 12:46:36 PM
#70   Just a minor dip. Take advantage of it. It Camelot 11/09/17 11:02:33 AM
#69   Soon to be under $1 Lion33 11/09/17 10:54:15 AM
#68   Damn. She’s crashing dawood 11/09/17 10:44:41 AM
#67   CRPGF has been a monster the last two TheOtcStockGuy 11/09/17 09:41:35 AM
#66   stock is a beast. Camelot 11/08/17 07:51:23 PM
#65   Damn. Kind a quiet in here. This thing dawood 11/08/17 07:35:17 PM
#64   I saw the latest news. Future is huge here. Camelot 11/08/17 03:50:50 PM
#63   I wonder who are clowns selling when it Camelot 11/08/17 01:36:06 PM
#62   Booom!!!!! Stockteacher80 11/08/17 01:18:55 PM
#61   Looking good here my dollar entry was perfect Stockteacher80 11/08/17 01:18:38 PM
#60   Minor dip here. Won't last. There is a very good Camelot 11/08/17 12:44:10 PM
#59   $2 is almost here. I am loving this incredible Camelot 11/08/17 12:24:01 PM
#58   I would say you are correct! TradeUptrendz 11/08/17 11:42:38 AM
#57   CRPGF 1.60 on the ask! LETS GOOOOOOOOOOO TradeUptrendz 11/08/17 11:41:47 AM
#56   $2 is written all over the wall now. Camelot 11/08/17 11:21:06 AM
#55   Might have to update that $1.20 trend target... @WolfofWeedST 11/08/17 11:21:05 AM
#54   Not many shares left to be had. This is Camelot 11/08/17 11:01:43 AM
#53   you may want to load this up. Camelot 11/08/17 10:08:28 AM
#52   Thanks, any chance you think we see $2 TheOtcStockGuy 11/08/17 09:50:17 AM
#51   Good call on 140 dawood 11/08/17 09:47:55 AM
#50   CRPGF nice news out this morning. The company TheOtcStockGuy 11/08/17 08:17:57 AM
#49   CRPGF The way this has been trading I TheOtcStockGuy 11/08/17 07:24:02 AM
#48   Cbds are the future and $Mj stocks waking simmons420 11/08/17 06:13:10 AM
#47   Limited float. Hardly any shares left to be had. Camelot 11/07/17 01:44:35 PM
#46   Stock is a beast. It is going well past Camelot 11/07/17 01:44:06 PM
#45   Cruising! Its gotta have a pullback at I Need Money 11/07/17 12:03:02 PM
#44   This stock is a ANIMAL TradeUptrendz 11/07/17 10:37:05 AM
#43   crpgf has been a great swing the last TheOtcStockGuy 11/07/17 10:17:52 AM
#42   I like this little unknown gem. If this dawood 11/07/17 09:56:14 AM
#41   All stocks need stock awarnes. All companies use. simmons420 11/07/17 05:10:04 AM
#40   Waiting for the sell off then the place stockmoneybaby 11/06/17 06:50:32 PM
#39   10000% agree the $Mj sector waking up. $Crpgf simmons420 11/06/17 06:06:09 PM
#38   CRPGF Gearing up for another push here! TradeUptrendz 11/06/17 03:02:16 PM
#37   CRPGF $1.03s almost gone. L2 looks pretty thin TheOtcStockGuy 11/06/17 10:13:27 AM
#36   The trend is ur friend @WolfofWeedST 11/06/17 10:09:13 AM