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Bio-Path Holdings Inc. (BPTH)

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Last Post: 1/22/2017 10:18:21 PM - Followers: 37 - Board type: Free - Posts Today: 0

Bio-path Holdings Inc.

Company Description:

Bio-Path is engaged in the business of financing and commercializing novel cancer therapeutics acquired from MD Anderson Cancer Center. Their first Antisense drug BP-1001 has completed a combination (with LDAC) safety phase  8 cohort for treatment of AML. No toxicity was seen. 5 out of 6 patients acheived at least partial remission. 50% had total remission! The company has completed the review by the FDA for this drug to begin phase II. The patient dosing has begun at trials which will occur at up to 8 sites or more, including MD Anderson, Baylor and University of Kansas.


Bio-Path Holdings is focused on antisense drugs which work at a cellular level to interrupt protein production by the diseased cell. The lead drug is BP1001 targeting the Grb-2 protein. Several years ago Gilead attempted to produce viable antisense drugs unsuccessfully because of high toxicity caused by their cationic (positively charged) liposome delivery system. Bio Path Holdings' delivery system is a small molecule neutral liposome system. Through the 8 cohort of phase 1 (treating different types of leukemia) there has been absolutely no toxicity. Testing performed by Bio Path demonstrates an uptake of the drug at a cellular level. The pErk results demonstrate not only a 50+% knockdown of the target protein but shows the pathway was shut down validating our delivery system. With the completion of the combination safety trials with LDAC and FDA approval, phase 2 has begun and is accepting patients.  This trial will occur at several sites. The purpose of phase 2 will be to test the effectiveness of the drug. The company may explore FDA accelerated status after testing is complete on 19 additional patients which is expected to occur in mid 2017. A CML combination drug safety study for BP1001 is also expected to be completed by mid 2017.
 
Bio-Path Holdings will also begin phase 1 testing of their antisense drug BP1001 on certain types of breast cancer which the date have been resistant to treatment.  Additionally, BPTH is initiating development of a second drug BP1002 targeting Bcl-2 for Follicular Lymphoma. An IND for BP1002 is projected for early 2017.

The company has entered into a sponsored research agreement with the University of Texas Southwestern Medical Center to evaluate BPTH's pipeline for efficacy in down-regulating the immune response using systemic lupus erythematosus (SLE) as a model. Bio-Path has entered into a sponsored research agreement with Thomas Jefferson University to investigate DNAbilize™ antisense DNA technology for the development of a brain cancer immunotherapy that works by activating the patient’s own immune system to fight their cancer. Also, BPTH has entered into a sponsored research agreement with MD Anderson to evaluate the ability of its pipeline to modulate pancreatic cancer.


http://www.biopathholdings.com


While antisense drugs fell out of favor following Gilead's failed efforts there is now renewed interest.  Ionis established partnerships with Biogen Idec and GlaxoSmithKline for their antisense technology. If Bio-Path holdings proves the validity of their delivery system, I would expect similar partnerships.

This link to the company website describes their novel delivery technology:


http://biopathholdings.com/technology/


The company was founded on the technology from M.D. Anderson Cancer Center at the University of Texas in Houston. M.D. Anderson was the largest shareholder. After raising an additional 10 million dollars the company has $11+ million in cash. These funds should allow the company to start phase II testing of their antisense drug BP1001 on leukemia and begin phase I testing for breast cancer. The company has an "at the market" credit facility in place with Cantor Fitzgerald to raise another $25 million.

 
Bio-Path Holdings do not manufacture their drug but uses contractors. Once the efficacy of BP1001 is established, I would anticipate a manufacturing partnership will occur. The CEO says the company has now ramped up their structure as they are a phase 2 developmental company.
 
BPTH is traded on the NASDAQ.

Here is the link to the recent peer paper prepared by their experts:

http://www.biopathholdings.com/pdf/PeerExpertOpinion20150107.pdf

Analyst target price: Maxim $2, Rodman & Renshaw $5

Zacks rates it a 4 which equals sell.
                        
 
 
 
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#2398   Hugely beneficial. Sincerely appreciate you and the Clinter04 01/22/17 10:18:21 PM
#2397   SJSTOCKSHARK post to you talked of this media BULLDOZER1 01/22/17 07:32:14 PM
#2396   Clint, The key for PPS increases in the SJSTOCKSHARK 01/22/17 04:46:21 PM
#2395   Thanks bulldozer! I'll be patient, I was Clinter04 01/22/17 03:11:34 PM
#2394   I'm sure most of us here have been BULLDOZER1 01/22/17 03:09:21 PM
#2393   I'm newer to this stock and added a Clinter04 01/22/17 01:45:09 PM
#2392   Thank you for your comment too simple. Glad BULLDOZER1 01/22/17 12:51:10 PM
#2391   Thank you Dozer for sharing. I hope that too simple 01/22/17 10:21:46 AM
#2390   Thanks Shark, Sorry to hear about your brother. BULLDOZER1 01/21/17 08:26:38 PM
#2389   Sorry to hear about your mom. Just got BULLDOZER1 01/21/17 06:43:32 PM
#2388   Dozer, I lost my younger brother to colon SJSTOCKSHARK 01/21/17 06:42:06 PM
#2387   I am very glad to hear it worked dmoffat 01/21/17 05:31:38 PM
#2386   Until a few days ago I haven't posted BULLDOZER1 01/21/17 05:01:46 PM
#2385   I hope your sources are wrong. I've been BULLDOZER1 01/21/17 09:45:39 AM
#2384   I am hearing, from some reliable and usually iloveu2 01/21/17 08:53:35 AM
#2383   No need to go in circles, straight line BULLDOZER1 01/20/17 07:49:12 PM
#2382   GP, Thanks for the advice. SJSTOCKSHARK 01/20/17 07:23:16 PM
#2381   SJ, MY 2C WORTH: Consider taking a profit Gpheart2016 01/20/17 05:59:36 PM
#2380   GP, I believe you are correct. There is SJSTOCKSHARK 01/20/17 05:23:29 PM
#2379   Good timing SJ. Your basis for the Roth Gpheart2016 01/20/17 01:27:08 PM
#2378   When you head south far enough you end iloveu2 01/20/17 12:36:07 AM
#2377   GP, I moved the other half into my SJSTOCKSHARK 01/19/17 09:06:03 PM
#2376   I was looking to add here in the BPTH2008 01/19/17 07:28:46 PM
#2375   Unless they are lying to us about the Pat Torney 01/19/17 06:30:42 PM
#2374   I note that BPTH shares outstanding has increased Gpheart2016 01/19/17 03:43:56 PM
#2373   Good time to be loading these up, I BULLDOZER1 01/19/17 03:41:04 PM
#2372   Unfortunately my 80s prediction was correct but where iloveu2 01/19/17 02:59:36 PM
#2371   GP bought this stock to low to short tyroneweaver 01/19/17 01:34:55 PM
#2370   Can anyone explain without fancy SEC postings what Clinter04 01/19/17 01:31:47 PM
#2369   Can anyone explain without fancy SEC postings what Clinter04 01/19/17 01:28:29 PM
#2368   I bought a little bit more in the wordlender 01/19/17 01:22:12 PM
#2367   Welcome back, now bend over and grab your ankles.....shorty. Gpheart2016 01/19/17 12:49:55 PM
#2366   SJ, looks like you paid too much. Gpheart2016 01/19/17 12:48:10 PM
#2365   tyrones back. Care to refute me now tyroneweaver 01/19/17 12:17:18 PM
#2364   Caddy, Thank you for your advice which is SJSTOCKSHARK 01/18/17 11:45:00 PM
#2363   I don't think you need rehab. You just cadillac107 01/18/17 10:45:43 PM
#2362   Maybe in the mid 80s iloveu2 01/18/17 10:26:30 PM
#2361   GP, I need rehab. I bought another 7600 SJSTOCKSHARK 01/18/17 10:16:12 PM
#2360   Not me, I am done buying . Have too simple 01/18/17 06:34:49 PM
#2359   The ask price is under $1; is anyone buying? Gpheart2016 01/18/17 11:23:41 AM
#2358   SJ, you sold some wine? I Gpheart2016 01/15/17 07:40:08 PM
#2357   GP, I have not moved into my Roth SJSTOCKSHARK 01/14/17 07:02:56 PM
#2356   Last week the "shorts" sold 77,593 shares per Gpheart2016 01/14/17 03:30:30 PM
#2355   Dilution coming. Is the real reason the stock SJSTOCKSHARK 01/12/17 12:05:30 PM
#2354   You may be right! Outside of the psychological BPTH2008 01/11/17 11:38:42 PM
#2353   I wouldn't even buy at a $1.00 right iloveu2 01/11/17 08:23:49 PM
#2352   The. Buyers did not step in, even at Gpheart2016 01/11/17 04:36:06 PM
#2351   And unfortunately there is is at $1.00. iloveu2 01/11/17 12:30:12 PM
#2350   It means the recent stock registration is accepted SJSTOCKSHARK 01/10/17 01:35:19 PM
#2349   What does this mean? Can anyone please explain? allbetson 01/10/17 09:54:40 AM
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