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Bio-Path Holdings Inc. (BPTH)

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Last Post: 6/26/2017 1:02:45 PM - Followers: 38 - Board type: Free - Posts Today: 2

Bio-path Holdings Inc.

Company Description:

Bio-Path is engaged in the business of financing and commercializing novel cancer therapeutics acquired from MD Anderson Cancer Center. Their first Antisense drug BP-1001 has completed a combination (with LDAC) safety phase  8 cohort for treatment of AML. No toxicity was seen. 5 out of 6 patients acheived at least partial remission. 50% had total remission! The company has completed the review by the FDA for this drug to begin phase II. The patient dosing has begun at trials which will occur at up to 10 sites or more, including MD Anderson, Baylor, New Jersey Hematology Oncolo
gy Associates, West Virginia University and University of Kansas.

Bio-Path Holdings is focused on antisense drugs which work at a cellular level to interrupt protein production by the diseased cell. The lead drug is BP1001 targeting the Grb-2 protein. Several years ago Gilead attempted to produce viable antisense drugs unsuccessfully because of high toxicity caused by their cationic (positively charged) liposome delivery system. Bio Path Holdings' delivery system is a small molecule neutral liposome system. Through the 8 cohort of phase 1 (treating different types of leukemia) there has been absolutely no toxicity. Testing performed by Bio Path demonstrates an uptake of the drug at a cellular level. The pErk results demonstrate not only a 50+% knockdown of the target protein but shows the pathway was shut down validating our delivery system. With the completion of the combination safety trials with LDAC and FDA approval, phase 2 has begun and is accepting patients.  This trial will occur at several sites. The purpose of phase 2 will be to test the effectiveness of the drug. The company may explore FDA accelerated status after testing is complete on 19 additional patients which is expected to occur in mid 2017. A CML combination drug safety study for BP1001 is also expected to be completed by mid 2017.
Bio-Path Holdings will also begin phase 1 testing of their antisense drug BP1001 on certain types of breast cancer which the date have been resistant to treatment.  Additionally, BPTH is initiating development of a second drug BP1002 targeting Bcl-2 for Follicular Lymphoma. An IND for BP1002 is projected for early 2017.

The company has entered into a sponsored research agreement with the University of Texas Southwestern Medical Center to evaluate BPTH's pipeline for efficacy in down-regulating the immune response using systemic lupus erythematosus (SLE) as a model. Bio-Path has entered into a sponsored research agreement with Thomas Jefferson University to investigate DNAbilize™ antisense DNA technology for the development of a brain cancer immunotherapy that works by activating the patient’s own immune system to fight their cancer. Also, BPTH has entered into a sponsored research agreement with MD Anderson to evaluate the ability of its pipeline to modulate pancreatic cancer.

While antisense drugs fell out of favor following Gilead's failed efforts there is now renewed interest.  Ionis established partnerships with Biogen Idec and GlaxoSmithKline for their antisense technology. If Bio-Path holdings proves the validity of their delivery system, I would expect similar partnerships.

This link to the company website describes their novel delivery technology:

The company was founded on the technology from M.D. Anderson Cancer Center at the University of Texas in Houston. M.D. Anderson was the largest shareholder. After raising an additional 10 million dollars the company has $11+ million in cash. These funds should allow the company to start phase II testing of their antisense drug BP1001 on leukemia and begin phase I testing for breast cancer. The company has an "at the market" credit facility in place with Cantor Fitzgerald to raise another $25 million.

Bio-Path Holdings do not manufacture their drug but uses contractors. Once the efficacy of BP1001 is established, I would anticipate a manufacturing partnership will occur. The CEO says the company has now ramped up their structure as they are a phase 2 developmental company.
BPTH is traded on the NASDAQ.

Here is the link to the peer paper prepared by their experts:!/4292/presentation/2610

Analyst target price: Maxim $2, Rodman & Renshaw $5, HC Wainwright a buy with a $5.00 target.

Zack's upgraded rating now equals 2 or buy.

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#2766   I wonder who is selling now that the SJSTOCKSHARK 06/26/17 01:02:45 PM
#2765   Gp are you the big buyer @ $.37? SJSTOCKSHARK 06/26/17 12:09:49 PM
#2764   Yes, the stock will drop! iloveu2 06/23/17 06:20:46 PM
#2763   SJ, I agree. I would add shares if Gpheart2016 06/23/17 05:45:41 PM
#2762   Simple, 19 already enrolled would indicated BPTH is SJSTOCKSHARK 06/23/17 04:43:26 PM
#2761   SJ, totall agree. I would love to see too simple 06/23/17 02:49:24 PM
#2760   GP if we hit $.35 again I will SJSTOCKSHARK 06/23/17 02:29:46 PM
#2759   Great, I love secrets. How soon will this Gpheart2016 06/23/17 01:48:17 PM
#2758   After we are delisted from the Russell index Teeds 06/23/17 01:44:22 PM
#2757   It looks like we failed breaking the .45 Gpheart2016 06/23/17 01:12:17 PM
#2756   What a joke....Man... Barto 06/23/17 12:25:46 PM
#2755   Works that way for me too! dmoffat 06/22/17 09:15:05 PM
#2754   Moffat, Now I am certain we heading down SJSTOCKSHARK 06/22/17 04:02:44 PM
#2753   Moffat, My guess would be down since I SJSTOCKSHARK 06/22/17 03:46:04 PM
#2752   Humpty Dumpty is sitting on the wall, which dmoffat 06/22/17 02:16:03 PM
#2751   The shorts are still piling on. Yesterday's short Gpheart2016 06/22/17 10:40:36 AM
#2750   This is as much information as I've seen Brettj 06/21/17 02:24:10 PM
#2749   I don't know if shorts are covering but Gpheart2016 06/21/17 01:54:46 PM
#2748   Does anyone know the date that we might dmoffat 06/21/17 01:08:55 PM
#2747   The volume has returned and the price is SJSTOCKSHARK 06/21/17 12:48:50 PM
#2746   GP, So far today volume is down. SJSTOCKSHARK 06/21/17 10:39:43 AM
#2745   GP, It is good news. Now if we SJSTOCKSHARK 06/20/17 10:36:51 AM
#2744   Hey check out the release dated 6/20/17. Gpheart2016 06/20/17 09:47:57 AM
#2743   Anybody care to share their understanding of the BPTH2008 06/19/17 08:44:06 PM
#2742   Good thought SJS ! Never thought of that. too simple 06/17/17 04:34:21 PM
#2741   Soon we will see if the Russell short SJSTOCKSHARK 06/17/17 03:19:08 AM
#2740   I am in complete agreement with iloveu2. They PStates 06/16/17 05:23:28 PM
#2739   I really want this stock to go up iloveu2 06/16/17 10:21:41 AM
#2738   Deleted from the Russell means the Russell index SJSTOCKSHARK 06/14/17 06:45:38 PM
#2737   Are they not currently in a number of Barto 06/14/17 09:27:59 AM
#2736   Please give us one! I am all iloveu2 06/14/17 06:20:16 AM
#2735   Let's be positive now iloveu2! And actually there Teeds 06/14/17 12:59:18 AM
#2734   There is not one reason right now this iloveu2 06/14/17 12:30:45 AM
#2733   So what's it mean when the Russell has batmen 06/13/17 07:14:48 PM
#2732   SJ, I bought back in at .38-.39. I Gpheart2016 06/13/17 07:05:45 PM
#2731   As expected the preliminary Russell lists delete BPTH. SJSTOCKSHARK 06/13/17 01:32:42 AM
#2730   I think I will stay in Europe as SJSTOCKSHARK 06/13/17 01:06:18 AM
#2729   After hours trading has pushed price up as Gpheart2016 06/12/17 08:36:13 PM
#2728   On the 6th of June, I stated I Barto 06/12/17 08:18:44 PM
#2727   I think this stock is turning around. High Gpheart2016 06/12/17 08:18:26 PM
#2726   On June 6th, I said we are going Barto 06/12/17 08:17:02 PM
#2725   I believe that's the 52 week high for volume! BPTH2008 06/12/17 07:19:27 PM
#2724   Over 2 million in volume! Can't be all The Carp 06/12/17 06:46:16 PM
#2723   That is a lot of volume for there dmoffat 06/12/17 05:38:00 PM
#2722   GP, I am out of the country on SJSTOCKSHARK 06/08/17 10:47:33 PM
#2721   After reading the statement more carefully I can Gpheart2016 06/08/17 06:28:22 PM
#2720   I hope you are right. Gpheart2016 06/08/17 10:19:22 AM
#2719   I wasn't sure if they are making it dmoffat 06/08/17 10:07:16 AM
#2718   It sounds like they are making it more Gpheart2016 06/08/17 10:01:48 AM
#2717   What are they getting ready to do with dmoffat 06/08/17 08:25:46 AM