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Advanced Medical Isotope Corporation (ADMDD)

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Last Post: 10/22/2016 6:02:25 PM - Followers: 454 - Board type: Free - Posts Today: 4


Advanced Medical Isotope Corporation (AMI)

is a late stage development company engaged primarily in the development of brachytherapy devices and medical isotopes for diagnostic and therapeutic applications.  AMI's focus is on transitioning to full operations upon receipt of FDA clearance for its patented Y-90 brachytherapy product, RadioGel


What is Brachytherapy?
Brachytherapy is the use of radiation to destroy cancerous tumors by placing a radiation source inside or next to the treatment area.  According to Global Industry Analysts, by 2016 the U.S. brachytherapy market will reach $2 billion.  It is estimated that the U.S. market represents approximately half of the global market.  AMI believes there are significant opportunities in prostate, breast, liver, pancreatic, head and neck cancers.  The 2013 U.S. estimated new cases according to the American Cancer Society are 240,000 prostate cancer, 235,000 breast cancer and 31,000 liver cancer.

What is RadioGel™?
The Y-90 RadioGel™ device is a brachytherapy device comprising highly insoluble Y-90 particles delivered by needle injection using a water-polymer composite for high-dose treatment of non-resectable solid tumors that cannot be treated effectively by any other means. It is designed for maximum safety: to deliver a high, pure-beta radiation dose to target (tumor) tissue, with comparatively small-to-negligible radiation doses to adjacent normal tissues, and with negligible radiation dose to any major organ or tissue in the body.

Two key design characteristics of the Y-90 RadioGel™ device that influence safety and efficacy are (1) the ability to place Y-90 particles directly into tumor tissue via injection and (2) yttrium-90 containment within the tumor after injection.

Advanced Medical Isotope Corporation has obtained an exclusive license to eight (8) patents related to the Y-90 RadioGel™ device technology for use in high-dose radiation therapy. The license was granted by *Battelle pursuant to an option between Battelle and AMI announced in February 2011. The Agreement grants AMI an exclusive license to make, have made, use and sell the Y-90 RadioGel™ device

Yttrium-90 is a well-established medical isotope with many applications in cancer treatment. The combination of insoluble Yttrium-90 particles and the polymer gel carrier offers physicians an opportunity to deliver a safe, effective treatment option at a low cost.

What are the advantages of RadioGel™?

Based upon its studies and analyses, or general application of experience with current brachytherapy devices and Yttrium-90, AMI believes that its brachytherapy products are likely to offer the following benefits, among others, for patients and medical professionals:

•Maximizing Therapeutic Index: The short-range beta particles emitted by Y-90 deliver radiation energy within a tight range. This enables radiation to be selectively delivered to target tissues while minimizing radiation dose to nearby normal tissues. High therapeutic indices imply that more radiation energy may be imparted to target tissues, with less radiation reaching adjacent normal tissues.

•Half Life: Y-90 has a half-life of just 2.7 days. Many traditional brachytherapy products use isotopes with longer half-lives such as 9.7 days for cesium-131, and sixty days for iodine-125.

•Optimized Delivery Method: Current brachytherapy devices place permanent metal seeds in the prostate by using up to 30 large needles. By contrast, AMI’s Y-90 RadioGel™ device is designed to be administered in a minimally invasive procedure with small-gauge needles.

•No Permanent Seeds Remaining: Current brachytherapy devices place permanent metal seeds in the tumor. AMI’s Y-90 RadioGel™ device utilizes a biodegradable, non-toxic polymer that is ultimately absorbed by the body. This eliminates the possibility of a long-term seed migration or other problems that may sometimes arise when seeds remain in the body.

•Good Safety Profile: Many traditional brachytherapy devices utilize isotopes that emit x-rays (akin to gamma radiation). X-rays or gamma radiation travels within and outside of the body and have long half-lives. AMI’s brachytherapy products use the Yttrium-90 isotope, which is a beta-emitter. The Yttrium-90 beta-emissions travel only a short distance and has a short half life of 2.7 days.

•Potential Lower Cost: Yttrium-90 supplies are readily accessible and are relatively inexpensive. The elimination of the metal or glass enclosures used in traditional brachytherapy seeds greatly reduces manufacturing costs.

What is the market for RadioGel™?
Reliable sources estimate that annual sales of brachytherapy products exceed $2 billion, about half of which are in the United States. The size of the U.S. brachytherapy market for prostate cancer brachytherapy is somewhere between $90 million and $130 million per year. The market for liver and breast cancer combined is comparable.

What are the steps for FDA clearance?

AMI met at the FDA offices to discuss next steps, expectations and required testing to progress towards obtaining marketing clearance for the Y-90 RadioGel™ device. The FDA and AMI team are working closely in order to obtain all appropriate data and benchmarks the FDA requires in order to proceed with providing final clearance for marketing the device in the United States.

In August, AMI announced a partnership with IsoTherapeutics Group, a third-party radiopharmaceutical R&D company, to provide commercialization support and conduct additional studies as requested by the FDA for the Y-90 RadioGel™ device. IsoTherapeutics has completed the first stage of the project, comprised of tech transfer, manufacturing and in vitro testing. The next stage, comprised of additional in vitro and in vivo testing. Upon completion of these studies AMI anticiptes submittal (direct de novo) for FDA clearance in 2016 for full commercialization in the U.S.

Are there other markets for RadioGel™? 

On March 15th, 2016, AMI announced the formation of a new, wholly-owned subsidiary, IsoPet Solutions Corporation, to focus on the vibrant and expanding veterinary oncology market.

The IsoPet Solutions division will focus on bringing AMI’s yttrium-90 brachytherapy products to veterinary oncologists to treat dogs and cats suffering from tumor cancers. There are over 150 million pet dogs and cats, with over 1/3 of the households in the US owning at least one dog, and just under 1/3 owning at least one cat.  IsoPet Solutions is establishing the infrastructure necessary to provide product to veterinary clinics including regulatory clearances and compliance. The division will also provide product awareness and education to veterinary oncologists. AMI expects the initial treatments to be coordinated through the Chair of the Company’s Veterinary Medicine Advisory Board, Dr. Alice Villalobos and anticipate offering RedioGel™ for vet treatments in early Spring 2016.

Latest Press Releases

Jun 24, 2015 Advanced Medical Isotope Corporation Provides Commercialization and Strategic Plan  Update
Aug 28, 2015 Advanced Medical Isotope Corporation Announces Collaboration with IsoTherapeutics Group, LLC
Oct 7, 2015 Advanced Medical Isotope Corporation Completes Substantial Capital Restructuring Activities and Continues Product Development
Nov 17, 2015 Advanced Medical Isotope Corporation Reports Progress Towards Seeking FDA Clearance for the Y-90 RadioGel™ Device
Feb 1, 2016 Advanced Medical Isotope Corporation Featured in World Council on Isotopes Newsletter
Feb 16, 2016 Advanced Medical Isotope Corporation To Present at the SeeThruEquity & The Brewer Group 2nd Annual Investors Conference Feb 22nd, 2016
Feb 18, 2016  Advanced Medical Isotope Corporation CEO announces, "We Are the Next Generation"
March 1, 2016 Advanced Medical Isotope Corporation Appoints Dr. Ludwig E. Feinendegen to the Medical Advisory Board
March 14, 2016 Advanced Medical Isotope Corporation Appoints Dr. Alice Villalobos Chair of the Veterinary Medicine Advisory Board
March 15, 2016 Advanced Medical Isotope Corporation Launches IsoPet Solutions to focus on Veterinary Market
March 22, 2016 SeeThruEquity Initiates Coverage of Advanced Medical Isotope Corporation with Target Price of $.02
March 28, 2016 Advanced Medical Isotope Corporation Appoints Dr. Albert S. Denittis to the Medical Advisory Board

April 12, 2016 A New Audio Interview with Advanced Medical Isotope Corporation with
April 22, 2016 Advanced Medical Isotope Announces FDA Resubmission Progress; Stands Ready to Ship First Batch of  RadioGel for Veterinary Division
April 27, 2016 Dr. Albert S. DeNittis and Advance Medical Isoptope Founder CEO and Chairman, James C. Katzaroff, are Featured in a New Audio Interview at
May 26, 2016 Advanced Medical Isotope Corporation Announces Participation in Upcoming Investment Conferences
June 3, 2016  Advanced Medical Isotope Corporation to Present at the LD Micro Invitational

July 11, 2016  Advanced Medical Isotope Partners with Versant Medical Physics and Radiation Safety
July 19, 2016  Advanced Medical Isotope Corporation Provides Intellectual Property Update
Oct 6, 2016  Advanced Medical Isotope Corporation Announces Treatment of First Household


UPDATED 10/6/2016

Outstanding Shares 1,950,180,595
Authorized Shares     2,000,000,000

  • 1D
  • 1M
  • 2M
  • 3M
  • 6M
  • 1Y
  • 2Y
  • 3Y
  • 5Y
Current Price
Bid Ask Day's Range
ADMDD News: Current Report Filing (8-k) 10/17/2016 06:16:43 AM
#60262  Sticky Note This stock is bigger than the company. If Tcsxyz 07/27/16 08:25:42 PM
#59994  Sticky Note Addition of Dr Fisher is HUGE news microcaptrdr24 07/11/16 08:48:58 AM
#55396  Sticky Note Veterinary Market! Major Due Diligence! Why Revenue will nike242 03/16/16 10:52:22 AM
#52957  Sticky Note $ADMD recent news/filings mick 01/18/16 02:36:15 PM
#47440  Sticky Note The only topic to be discussed here is ADMD IH Admin [Dan] 09/27/15 02:45:52 PM
#61688   I see you write fiction novels!! WALLnut 10/22/16 06:02:25 PM
#61687   How about less than 24 months? 36 months? Never? Chief Slapaho 10/22/16 02:25:17 PM
#61686   Wow. Excellent summary of events, Tcsxyz. No spin-doctoring Chief Slapaho 10/22/16 01:52:02 PM
#61685   Let's review, Tcsxyz 10/22/16 01:04:03 PM
#61684   LMFAO! Chief Slapaho 10/21/16 11:05:04 PM
#61682   The first lizard treated with radiogel only needs DreDiZzlE 10/21/16 08:38:56 PM
#61681   DynAMIC!! A force that stimulates change WALLnut 10/21/16 05:15:36 PM
#61680   Wow! Your back already. Kool! WALLnut 10/21/16 03:49:28 PM
#61678   22% down so far validates this. Chief Slapaho 10/21/16 02:55:02 PM
#61677   A little Friday funnies! WALLnut 10/21/16 02:48:13 PM
#61676   Oh walnut, you crack me up dave359 10/21/16 02:29:59 PM
#61675   Heading south!! WALLnut 10/21/16 02:10:13 PM
#61674   Get back from what???? Chief Slapaho 10/21/16 02:06:27 PM
#61673   A little green never hurt anyone. WALLnut 10/21/16 02:05:19 PM
#61672   Ok!! Thanks for the heads up. WALLnut 10/21/16 02:03:21 PM
#61671   Calling a nice green close for this afternoon JayBPee 10/21/16 01:59:53 PM
#61670   Aww dang it!! PPS down again after 1 Chief Slapaho 10/21/16 01:53:07 PM
#61669   Aww dang it!! WALLnut 10/21/16 01:15:45 PM
#61668   LOL The Pumps gone, they aren't even trying HMONNY 10/21/16 12:44:10 PM
#61667   Pump dump pump dump scAMIC pump dump pump DreDiZzlE 10/20/16 12:53:20 PM
#61666   How is this POS scAMIc still trading? Nothing MerlotGoggles 10/20/16 12:47:56 PM
#61665   Call the TA. They will give it to Tcsxyz 10/20/16 12:22:04 PM
#61664   Between 50 and 60 million. WALLnut 10/20/16 12:05:19 PM
#61663   What is the new O/S? repete99 10/20/16 11:34:45 AM
#61662   I've heard more progress this year coming from WALLnut 10/19/16 08:38:44 PM
#61661   I'm ready to hear about progress. PR has Popeye 10/19/16 07:55:34 PM
#61660   Correct for once. Say 'bye bye' to Chief Slapaho 10/19/16 06:20:48 PM
#61659   That chart above indicates that it's time to WALLnut 10/19/16 05:53:40 PM
#61658   The (sc)AMIC PPS is still going to continue Chief Slapaho 10/19/16 05:16:21 PM
#61656   Your Welcome! WALLnut 10/19/16 04:18:13 PM
#61655   Nice 'prop-up' buy at the close. Chief Slapaho 10/19/16 04:16:16 PM
#61654   Deep green is gone. Chief Slapaho 10/19/16 03:48:24 PM
#61653   50 cents around the corner, great time to Eltp 10/19/16 03:37:02 PM
#61652   Whats up fellow ADMD investors? I get JayBPee 10/19/16 02:43:28 PM
#61651   Looking good!! WALLnut 10/19/16 02:08:32 PM
#61650   D means they did a RS... Weird·o 10/18/16 10:17:00 PM
#61648   buddy 5x is an embarrassment for this one HMONNY 10/18/16 04:09:53 PM
#61640   yeah, when you make 5x twice, now buying microcaptrdr24 10/18/16 03:28:39 PM
#61639   Pretty disgraceful, isn't it? Just another trade show Chief Slapaho 10/18/16 03:22:24 PM
#61638   So a big PR for the attendance of DR. EVIL 10/18/16 03:21:11 PM
#61637   Most longs do not have free shares. Most Chief Slapaho 10/18/16 03:20:15 PM
#61636   shining again? topgunbcn 10/18/16 03:15:39 PM
#61634   Speaking of fat... WALLnut 10/18/16 03:07:37 PM
#61633   I don't think they realize that most of Popeye 10/18/16 02:46:59 PM
#61632   it really is nuts....never seen anything like it microcaptrdr24 10/18/16 02:42:02 PM
#61631   You know what's crazy? I sold enough to Popeye 10/18/16 02:41:11 PM
#61630   asks who tough questions? the booth they will have? microcaptrdr24 10/18/16 02:19:20 PM
#61626   That's even worse ... a company whose product Chief Slapaho 10/18/16 01:22:18 PM
#61624   People were buying at the 52 week high DreDiZzlE 10/18/16 12:21:29 PM
#61623   More like dumping... DR. EVIL 10/18/16 10:57:04 AM