If(!!) the data is nothing more than was previously reported (mildly elevated Alk Phos and conj bill after long chronic use) then yes, way overdone IMO. The problem is I don't trust the company. Anything meaningfully worse than the previously reported mild issues could kill MF indication - since in the spectrum of 'chronic' (like PV/ET) vs 'immanently fatal' (like AML) MF is a meaningfully closer to chronic.