In 1999, 22nd Century licensed to Vector Tobacco Ltd. (“Vector”) the nicotine-reduction technology currently used in Vector’s QUEST(TM) cigarette brand.
Vector gave their rights back to XXII after they paid for clinical trials. They thought they were worth more as a buy out candidate without the money losing agreement with XXII.
I think that Quest chemically alters the tobacco in order to reduce the nicotine content; I'm not a smoker but have heard that this process significantly alters the taste profile of the cigarette. 22C's special sauce is that by being able to grow tobacco which has reduced amounts of nicotine, the taste of the resulting cigs is much more comparable to "full nicotine" cigs.