Replies to post #169686 on Biotech Values

[JohnWayne]

To be honest, I was really only drawn into this discussion for the sake of arguing about semantics, not about the actual science or underlying biology. I don't really know a whole lot about MF or have any interest in GERN or INCY. :)

That said, if I had a gun to my head I'd say that it sounds like it might be logical on paper to expect these early BM/PBM effects to translate into a full CR with additional follow-up, but that when dealing with medicine and human biology, I'd have a hard time saying that just because something is logical on paper it is any more likely to actually happen or be real. That's why "paradoxical" is such a relatively common word in medicine!

[BTH]

Biopearl, these are exactly points I have asked about (and JQ kindly opined). It is a reasonable assumption to think that (I would suspect).

Blood resolution leads to less stress on the liver and spleen. So Blood effect --> Spleen effect. If this is the case, it would suggest a delayed effect (whereas Jakafi with a completely different MOA is focused straight out of the gate at the secondary symptoms of MF, so naturally, those would come quickly).

But who am I to say anything...I'm no scientist or oncologist.