sunstar, another good one!I'm not sure there has ever been a more comprehensive understanding of a mechanism of action in such a short period of time. See what all our hard-earned dollars have paid for?! I mean, most agents either work or they don't, and they sink or survive. Bavi- remains state-of-the-art while remaining on the shelf. Big pharma thinks sooner or later someone is going to parallel or surpass the science. So far, not.