For AP26113 too soon to tell, AP26113 just live from expectations. And BTW, ALK inhibitor market is not the same as in Ponatinib's. But compared to the niche, in which imatinib is, ponantinib has more potential.
pom: "why couldn't 113 have a good chance at being greater than pona?"
It can! Each drug is independent, has to run its own course thru the clinical/regulatory course, and 113 has shown great efficacy and promise. The Iclusig side effects issue has no relevance to 113's probability of success.