vid. from what i know and what i been trying to dig up is chugai drug works but it takes a toll on the liver. so as you say we will be watching very very closely here.
also brain mets. thinking ldk is out and chugai???
113 we knew 4/5 will be interesting to see were that goes.
There is very recent evidence of a patient doing well on Chugai for several months and just developed a number of brain mets.
It may very well be that Chugai is unable to deal with brain mets, and if that is the actual case, then 113 may very well be differentiated from the drug that just was fast tracked.
Perhaps we will get some clarifying data this weekend at ESMO,
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